LOCUS       NM_007170               3071 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens testis associated actin remodelling kinase 2 (TESK2),
            transcript variant 1, mRNA.
ACCESSION   NM_007170
VERSION     NM_007170.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Oussalah,A., Siblini,Y., Hergalant,S., Chery,C., Rouyer,P.,
            Cavicchi,C., Guerrini,R., Morange,P.E., Tregouet,D., Pupavac,M.,
            Watkins,D., Pastinen,T., Chung,W.K., Ficicioglu,C., Feillet,F.,
            Froese,D.S., Baumgartner,M.R., Benoist,J.F., Majewski,J.,
            Morrone,A., Rosenblatt,D.S. and Gueant,J.L.
  TITLE     Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC
            inherited disorder of intracellular metabolism of vitamin B12
  JOURNAL   Clin Epigenetics 14 (1), 52 (2022)
   PUBMED   35440018
  REMARK    GeneRIF: Epimutations in both the TESK2 and MMACHC promoters in the
            Epi-cblC inherited disorder of intracellular metabolism of vitamin
            B12.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Toshima,J., Toshima,J.Y., Takeuchi,K., Mori,R. and Mizuno,K.
  TITLE     Cofilin phosphorylation and actin reorganization activities of
            testicular protein kinase 2 and its predominant expression in
            testicular Sertoli cells
  JOURNAL   J Biol Chem 276 (33), 31449-31458 (2001)
   PUBMED   11418599
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Rosok,O., Pedeutour,F., Ree,A.H. and Aasheim,H.C.
  TITLE     Identification and characterization of TESK2, a novel member of the
            LIMK/TESK family of protein kinases, predominantly expressed in
            testis
  JOURNAL   Genomics 61 (1), 44-54 (1999)
   PUBMED   10512679
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB161528.1, DA990759.1,
            AB057597.1 and BC033085.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007170.2.
            
            Summary: This gene product is a serine/threonine protein kinase
            that contains an N-terminal protein kinase domain that is
            structurally similar to the kinase domains of testis-specific
            protein kinase-1 and the LIM motif-containing protein kinases
            (LIMKs). Its overall structure is most related to the former,
            indicating that it belongs to the TESK subgroup of the LIMK/TESK
            family of protein kinases. This gene is predominantly expressed in
            testis and prostate. The developmental expression pattern of the
            rat gene in testis suggests an important role for this gene in
            meitoic stages and/or early stages of spermiogenesis. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027573.1, AB057597.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372086.4/ ENSP00000361158.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB161528.1         6-17
            13-312              DA990759.1         16-315
            313-2551            AB057597.1         310-2548
            2552-2681           BC033085.1         2081-2210
            2682-3015           AB057597.1         2677-3010
            3016-3071           BC033085.1         2545-2600
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3071
                     /gene="TESK2"
                     /note="testis associated actin remodelling kinase 2"
                     /db_xref="GeneID:10420"
                     /db_xref="HGNC:HGNC:11732"
                     /db_xref="MIM:604746"
     exon            1..312
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..620
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..2114
                     /gene="TESK2"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity testis-specific protein kinase 2; testicular
                     protein kinase 2; testis-specific kinase 2"
                     /codon_start=1
                     /product="dual specificity testis-specific protein kinase
                     2 isoform 1"
                     /protein_id="NP_009101.2"
                     /db_xref="CCDS:CCDS41323.1"
                     /db_xref="GeneID:10420"
                     /db_xref="HGNC:HGNC:11732"
                     /db_xref="MIM:604746"
                     /translation="MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYR
                     ALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEV
                     QLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDI
                     AVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVG
                     SPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHM
                     VGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGL
                     LEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDG
                     AARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGTMPLADWQEPLAPP
                     IRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQ
                     AHEAMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPAGSTPATFSTSGIGLQTQ
                     GKQDG"
     exon            621..742
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..791
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..938
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1021
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1106
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1190
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1277
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1395
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3071
                     /gene="TESK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3050..3055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TESK2"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="TESK2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcgcggc ccgggagctc agcagagcta ccagctgccc tgttggcttc gctggtcgga
       61 tcgtcctcct ggccccgcca aacaggcggg gggagcggcc ccgactgtgg ggccatggca
      121 gtagtctcct cgttcgccgc cgccgctagc ctagctgagt cgccggcttc tgcgctaggg
      181 gctcccaccg cctccgcagg ctaaggagcc gctgccacca acgagctgtg agggttacta
      241 tgctccctct ttgccgccgt ctcctcctct tgcccgcgca ggcacccctc tggctgctca
      301 gtcctgcctc agtgtcaaac cagaagagaa gtaaaattca acaaaaattt atgtgtggag
      361 ttccttctta aaagaagaaa aaagtgatta tttagactat ggatcggagc aaacggaatt
      421 caattgcagg atttcctcca cgtgtggagc gtcttgaaga gtttgaagga ggtggtggag
      481 gagaaggaaa tgtgagccag gtgggaagag tttggccatc ttcgtatcga gctcttataa
      541 gtgccttttc cagactgacg cgtttggatg atttcacctg tgaaaaaata gggtctggct
      601 tcttttctga agtgttcaag gtacgacacc gagcttctgg tcaggtgatg gctcttaaga
      661 tgaacacatt gagcagtaac cgggcaaaca tgctgaaaga agtacagctc atgaatagac
      721 tctcccatcc caacatcctt aggttcatgg gtgtatgtgt tcatcaagga caattgcatg
      781 cacttacaga gtatatcaac tccgggaacc tggaacagtt gctagacagt aacctgcatt
      841 tgccttggac tgtgagggta aaactggcct atgacatagc agtgggcctc agctaccttc
      901 acttcaaagg catttttcat cgggacctca catctaagaa ctgcctgata aagagggatg
      961 agaatggtta ctctgcagtg gtagctgact ttggcctggc tgagaagatc cccgatgtca
     1021 gcatggggag tgagaagctg gccgtggtgg gttccccatt ctggatggca cctgaggttc
     1081 tccgagatga gccctataat gaaaaggcag atgtgttctc ttatggtatc atcctctgcg
     1141 agatcatcgc ccgcatccag gccgatccgg actatcttcc ccgcacagag aatttcgggc
     1201 tggactatga tgctttccag cacatggtgg gagactgtcc cccagatttt ctgcaactta
     1261 ctttcaactg ctgtaacatg gatcccaaac tgcgcccatc ttttgtggag attgggaaga
     1321 ccctggagga aattctgagc cgcctacagg aagaagagca ggagagggat aggaagctgc
     1381 agcccacagc caggggactc ttggagaaag cacctggggt gaagcgacta agctcactgg
     1441 atgacaagat cccccacaag tcaccatgcc caagacgtac catctggctg tctcgaagcc
     1501 agtcagatat cttttcccgt aagcccccac gtacagtgag tgtcttggac ccatactacc
     1561 ggccacgaga tggtgctgcc cgcaccccca aagtcaaccc ttttagtgct cgccaggacc
     1621 tcatgggggg caagatcaag ttttttgacc tgcccagcaa gtctgtcatc tctctggtat
     1681 ttgacctgga tgcaccaggg cccggaacta tgcccctggc tgactggcag gagcccctgg
     1741 ccccacctat tcgccggtgg cgttccttgc ctggttcgcc tgagttcttg catcaagagg
     1801 cttgtccatt tgtgggccgg gaagaatcgc tatctgatgg gcccccacca cgcctaagta
     1861 gtctcaagta cagagttaaa gagatcccac cattccgggc atctgcccta ccagctgctc
     1921 aagcccatga ggctatggac tgctccattc tccaggaaga aaatggtttt gggtccaggc
     1981 cccaggggac cagtccatgc cctgcgggtg cttctgagga gatggaggta gaagaaaggc
     2041 cagcaggctc aactccagcc accttctcca cctcaggcat aggcctgcaa acccagggaa
     2101 agcaggatgg gtgagggggt ttagtccctg cctcaccttg gggatggacc ttcagctgaa
     2161 accatatggc cccctaggtg cacagccttg attcttccct ggagcctaca gagcaggcag
     2221 gctaggccaa gccaggctca acttctgggc tcccagtgcc cattggctgt gtatgacggg
     2281 aggcagcagt gagaggcctt cctagttagg gccaacagct gataccaagc ctctgaaatc
     2341 cagcaaggag gtctgcctcc caccagaccc tctccagtgt acttccccag ataggaccag
     2401 aggatgtcta gttctaggct gagctggcag gcagctatta ccccggttct ttccccaccc
     2461 caggtctgtc tcttgccttt tcttggggca tataagctac tgagtggaac atggagctga
     2521 tcaagaggcc gtaatggtca tggctgtttc ccagacctga atattggggt gcttcttgcc
     2581 agtattctaa gacatttgag taattgctgt ttgcacttac tgcatggtca gaccacgtca
     2641 ctacatttct atgcaagggg acagcaaggc agcgtggtgg tcatggctct tagctaacct
     2701 attcaaagac cttttcctgt tgattaatct attttcatat ttataaagga gtcttaatgt
     2761 tctgccccat aagactttca accttgtggt tgggagtggg gctggttttg taggccctag
     2821 ggcctgcttc tatgtattta tcaacatgtg atacattcaa ttggttaaat ggtttataca
     2881 gggactgatt tgcttccctt cctgccatgg ctggagcttt gggaacagtc tgtccttaca
     2941 gagctgcaat aagaaataac caaagatgaa gctggtcaaa tattttcata acttgcttct
     3001 gttgattttt ttttttgtaa aactttccca agacattttc agacttaaaa ataaagtcag
     3061 tgttacaggt g
//
