LOCUS       NM_006285               2530 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens testis associated actin remodelling kinase 1 (TESK1),
            transcript variant 1, mRNA.
ACCESSION   NM_006285
VERSION     NM_006285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Rodino-Janeiro,B.K., Martinez,C., Fortea,M., Lobo,B., Pigrau,M.,
            Nieto,A., Gonzalez-Castro,A.M., Salvo-Romero,E., Guagnozzi,D.,
            Pardo-Camacho,C., Iribarren,C., Azpiroz,F., Alonso-Cotoner,C.,
            Santos,J. and Vicario,M.
  TITLE     Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum
            of IBS-D patients may explain increased female predisposition to
            epithelial dysfunction
  JOURNAL   Sci Rep 8 (1), 2255 (2018)
   PUBMED   29396473
  REMARK    GeneRIF: In conclusion, deregulation of cytoskeleton dynamics
            through TESK1/CFL1 pathway underlies epithelial intestinal
            dysfunction in the small bowel mucosa of diarrhea-predominant
            irritable bowel syndrome, particularly in female patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Kim,J., Jo,H., Hong,H., Kim,M.H., Kim,J.M., Lee,J.K., Heo,W.D. and
            Kim,J.
  TITLE     Actin remodelling factors control ciliogenesis by regulating
            YAP/TAZ activity and vesicle trafficking
  JOURNAL   Nat Commun 6, 6781 (2015)
   PUBMED   25849865
  REMARK    GeneRIF: Actin remodelling factor TESK1 is a key player in the
            ciliogenesis control network in which YAP/TAZ and directional
            vesicle trafficking are integral components.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Johne,C., Matenia,D., Li,X.Y., Timm,T., Balusamy,K. and
            Mandelkow,E.M.
  TITLE     Spred1 and TESK1--two new interaction partners of the kinase
            MARKK/TAO1 that link the microtubule and actin cytoskeleton
  JOURNAL   Mol Biol Cell 19 (4), 1391-1403 (2008)
   PUBMED   18216281
  REMARK    GeneRIF: enhanced TESK1 activity results in increased stress fibers
            (via phospho-cofilin), but this can be blocked by elevating Spred1
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Toshima,J., Toshima,J.Y., Takeuchi,K., Mori,R. and Mizuno,K.
  TITLE     Cofilin phosphorylation and actin reorganization activities of
            testicular protein kinase 2 and its predominant expression in
            testicular Sertoli cells
  JOURNAL   J Biol Chem 276 (33), 31449-31458 (2001)
   PUBMED   11418599
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Toshima,J., Toshima,J.Y., Amano,T., Yang,N., Narumiya,S. and
            Mizuno,K.
  TITLE     Cofilin phosphorylation by protein kinase testicular protein kinase
            1 and its role in integrin-mediated actin reorganization and focal
            adhesion formation
  JOURNAL   Mol Biol Cell 12 (4), 1131-1145 (2001)
   PUBMED   11294912
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Rosok,O., Pedeutour,F., Ree,A.H. and Aasheim,H.C.
  TITLE     Identification and characterization of TESK2, a novel member of the
            LIMK/TESK family of protein kinases, predominantly expressed in
            testis
  JOURNAL   Genomics 61 (1), 44-54 (1999)
   PUBMED   10512679
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Toshima,J., Tanaka,T. and Mizuno,K.
  TITLE     Dual specificity protein kinase activity of testis-specific protein
            kinase 1 and its regulation by autophosphorylation of serine-215
            within the activation loop
  JOURNAL   J Biol Chem 274 (17), 12171-12176 (1999)
   PUBMED   10207045
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Toshima,J., Ohashi,K., Okano,I., Nunoue,K., Kishioka,M., Kuma,K.,
            Miyata,T., Hirai,M., Baba,T. and Mizuno,K.
  TITLE     Identification and characterization of a novel protein kinase,
            TESK1, specifically expressed in testicular germ cells
  JOURNAL   J Biol Chem 270 (52), 31331-31337 (1995)
   PUBMED   8537404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357874.13, BC067130.1 and
            AF507907.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006285.2.
            
            Summary: This gene product is a serine/threonine protein kinase
            that contains an N-terminal protein kinase domain and a C-terminal
            proline-rich domain. Its protein kinase domain is most closely
            related to those of the LIM motif-containing protein kinases
            (LIMKs). The encoded protein can phosphorylate myelin basic protein
            and histone in vitro. The testicular germ cell-specific expression
            and developmental pattern of expression of the mouse gene suggests
            that this gene plays an important role at and after the meiotic
            phase of spermatogenesis. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067130.1, D50863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336395.6/ ENSP00000338127.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL357874.13        13371-13392
            23-230              BC067130.1         1-208
            231-798             BC067130.1         220-787
            799-1334            AF507907.1         190-725
            1335-2530           BC067130.1         1324-2519
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..2530
                     /gene="TESK1"
                     /note="testis associated actin remodelling kinase 1"
                     /db_xref="GeneID:7016"
                     /db_xref="HGNC:HGNC:11731"
                     /db_xref="MIM:601782"
     exon            1..577
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2239
                     /gene="TESK1"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testicular protein kinase 1; dual specificity
                     testis-specific protein kinase 1; testis-specific kinase
                     1"
                     /codon_start=1
                     /product="dual specificity testis-specific protein kinase
                     1 isoform 1"
                     /protein_id="NP_006276.2"
                     /db_xref="CCDS:CCDS6580.1"
                     /db_xref="GeneID:7016"
                     /db_xref="HGNC:HGNC:11731"
                     /db_xref="MIM:601782"
                     /translation="MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRAL
                     RSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQ
                     LMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIA
                     RGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVV
                     GSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRT
                     LVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQG
                     SVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKI
                     KLLDTPSKPVLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRMET
                     ALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSP
                     RSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGL
                     PCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGA
                     RS"
     exon            578..699
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..748
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..895
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..978
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1069
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1153
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1243
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1358
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..2530
                     /gene="TESK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TESK1"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="TESK1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctgat ccccggcggc taagcggagc agccgccgcc cgcccgcccg cccgcctccg
       61 cccgcggcaa gccagcccgc cggcgccccg gagcgctgcc gccaccgtca ccgccaccgc
      121 ccggtccagg cccaagccca ggccctgcgc ggagcggagc ggcgcggcgt ccacccgggc
      181 ccagccagcc ggcgcggcgg gggcgggtcc aggatcttcg gcggatcttc cattctcagg
      241 gcgggagccg gagtccgggc gcccgggatc gggctgggcc cgcgcccatg gcaagcgcgg
      301 cctgcccggg ccctggggac cctgccatgt gaggcaggcc cgggctgggg gcccggccat
      361 ggccggggaa cggcccccac tgcggggccc tgggcccggg cctggagagg tgccggggga
      421 ggggcccccg gggccggggg gcacgggcgg aggcccgggc cggggccgcc cctcctccta
      481 ccgggctctc cgcagcgccg tgtctagcct ggcgcgtgtg gacgattttc actgcgcgga
      541 gaagatcggg gccggcttct tctctgaggt ctacaaggtt cggcaccgac agtcagggca
      601 agtcatggtg ctgaagatga acaagctccc cagtaaccgg ggcaacacac tacgggaagt
      661 gcagctgatg aaccggctca ggcaccccaa catcctaagg ttcatgggag tctgtgtgca
      721 ccagggacag ctgcacgctc ttacagagta tatgaatggg gggacattgg aacagctgct
      781 cagctcccct gaacccctgt cctggccggt caggctccac ctggccctgg acattgcccg
      841 aggcctgcgg tacctgcact ccaaaggtgt atttcaccgc gacctcacat ccaagaactg
      901 tctagtccga cgggaagatc gaggcttcac cgctgtcgtg ggtgacttcg ggctggccga
      961 aaagattcct gtgtataggg agggggcaag gaaggagcca ttggccgtgg tgggctcccc
     1021 atactggatg gctccagagg tgttacgggg tgagctgtat gatgagaagg ctgatgtctt
     1081 tgccttcggg attgtcctct gtgagctcat cgcccgagta cctgcagacc ctgactacct
     1141 accacgcact gaggactttg gcctggatgt gcctgctttc cgaactctgg tgggggatga
     1201 ctgcccactg cctttcttgc tcctggccat ccactgctgc aacctggaac ccagcacccg
     1261 tgcccccttc accgaaatta cccagcacct ggaatggatc ctggagcagc tgcctgagcc
     1321 agccccactc accaggaccg ccctgacaca caatcagggc tctgttgcaa gagggggtcc
     1381 ctctgccacg cttcccaggc cagatccccg gctttcccga agccggtcag acctcttcct
     1441 gcccccatca ccagaatcac cccccaactg gggggacaat ctgactcgag tcaacccctt
     1501 ctcactacgg gaagacctca ggggtggcaa gatcaagctc ttagacacac ccagcaagcc
     1561 agtcctgcct cttgtgccac catcaccatt cccatccact cagctgccct tggtgaccac
     1621 tccggagacc ctggtccagc ctgggacacc tgcccgccgc tgccgctcac taccctcatc
     1681 ccccgagctc ccccgccgta tggagacagc actgccaggt cctggccctc ccgctgtggg
     1741 cccctcggct gaagagaaga tggagtgcga gggcagcagc cctgagccgg aacctccagg
     1801 gccagcgccc cagctgcctc tggctgtggc cacagacaac ttcatcagca cctgttcctc
     1861 ggcctcccaa ccctggtccc ctagatcagg acccgtcctc aataacaatc ccccagctgt
     1921 ggtggtgaac tccccacaag gctgggctgg ggagccctgg aaccgggccc agcatagcct
     1981 gccccgggcg gcagccctgg agcggacaga accctcgcca cccccttcag ctccccggga
     2041 gcccgatgag gggctgccct gtcctggctg ctgcctcggc cccttcagct ttggcttcct
     2101 gtccatgtgc ccccgcccca caccagctgt tgcccgctac cgcaacctga actgtgaggc
     2161 gggcagtctc ctctgccacc gagggcacca cgccaagcca cccacaccca gcctgcagct
     2221 gcctggggca cgctcttagc agtggagccc gtggtctcag gcctccaact ttggccttca
     2281 ggacaccctg taagaacaga gcacacttgc tggacagtgc cagttccaga tgggctgacc
     2341 ggctcttctc cccgtgtagg ggagccccag catggactca agggacagag cacttccagt
     2401 cgaccccccg gctcgcgttc ccgtggggat cactgaacca gacacagcat tgctgacaca
     2461 tgagactaac acgtgcaatt atttaaaaag atttcaataa aactgcctgg ctggctccgg
     2521 gccgccccta
//
