LOCUS       NM_017899                989 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tescalcin (TESC), transcript variant 1, mRNA.
ACCESSION   NM_017899
VERSION     NM_017899.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Dong,Y., Fan,B., Li,M., Zhang,J., Xie,S., Di,S., Jia,Q. and Gong,T.
  TITLE     TESC acts as a prognostic factor and promotes
            epithelial-mesenchymal transition progression in esophageal
            squamous carcinoma
  JOURNAL   Pathol Res Pract 253, 154964 (2024)
   PUBMED   38000203
  REMARK    GeneRIF: TESC acts as a prognostic factor and promotes
            epithelial-mesenchymal transition progression in esophageal
            squamous carcinoma.
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Zhang,R., Yang,F., Fan,H., Wang,H., Wang,Q., Yang,J. and Song,T.
  TITLE     Long non-coding RNA TUG1/microRNA-187-3p/TESC axis modulates
            progression of pituitary adenoma via regulating the NF-kappaB
            signaling pathway
  JOURNAL   Cell Death Dis 12 (6), 524 (2021)
   PUBMED   34021124
  REMARK    GeneRIF: Long non-coding RNA TUG1/microRNA-187-3p/TESC axis
            modulates progression of pituitary adenoma via regulating the
            NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Zhou,Z.G., Chen,J.B., Zhang,R.X., Ye,L., Wang,J.C., Pan,Y.X.,
            Wang,X.H., Li,W.X., Zhang,Y.J., Xu,L. and Chen,M.S.
  TITLE     Tescalcin is an unfavorable prognosis factor that regulats cell
            proliferation and survival in hepatocellular carcinoma patients
  JOURNAL   Cancer Commun (Lond) 40 (8), 355-369 (2020)
   PUBMED   32609436
  REMARK    GeneRIF: Tescalcin is an unfavorable prognosis factor that regulats
            cell proliferation and survival in hepatocellular carcinoma
            patients.
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Goltermann,J., Opel,N., Redlich,R., Repple,J., Kaehler,C.,
            Grotegerd,D., Dohm,K., Leehr,E.J., Bohnlein,J., Forster,K.,
            Meinert,S., Enneking,V., Emden,D., Leenings,R., Winter,N.R.,
            Hahn,T., Mikhail,S., Jansen,A., Krug,A., Nenadic,I., Rietschel,M.,
            Witt,S.H., Heilmann-Heimbach,S., Hoffmann,P., Forstner,A.J.,
            Nothen,M.M., Baune,B.T., Kircher,T. and Dannlowski,U.
  TITLE     Replication of a hippocampus specific effect of the tescalcin
            regulating variant rs7294919 on gray matter structure
  JOURNAL   Eur Neuropsychopharmacol 36, 10-17 (2020)
   PUBMED   32451266
  REMARK    GeneRIF: Replication of a hippocampus specific effect of the
            tescalcin regulating variant rs7294919 on gray matter structure.
REFERENCE   5  (bases 1 to 989)
  AUTHORS   Liang,S., Fuchs,S., Mymrikov,E.V., Stulz,A., Kaiser,M.,
            Heerklotz,H. and Hunte,C.
  TITLE     Calcium affects CHP1 and CHP2 conformation and their interaction
            with sodium/proton exchanger 1
  JOURNAL   FASEB J 34 (2), 3253-3266 (2020)
   PUBMED   31912575
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Levay,K. and Slepak,V.Z.
  TITLE     Tescalcin is an essential factor in megakaryocytic differentiation
            associated with Ets family gene expression
  JOURNAL   J Clin Invest 117 (9), 2672-2683 (2007)
   PUBMED   17717601
REFERENCE   7  (bases 1 to 989)
  AUTHORS   Gutierrez-Ford,C., Levay,K., Gomes,A.V., Perera,E.M., Som,T.,
            Kim,Y.M., Benovic,J.L., Berkovitz,G.D. and Slepak,V.Z.
  TITLE     Characterization of tescalcin, a novel EF-hand protein with a
            single Ca2+-binding site: metal-binding properties, localization in
            tissues and cells, and effect on calcineurin
  JOURNAL   Biochemistry 42 (49), 14553-14565 (2003)
   PUBMED   14661968
REFERENCE   8  (bases 1 to 989)
  AUTHORS   Li,X., Liu,Y., Kay,C.M., Muller-Esterl,W. and Fliegel,L.
  TITLE     The Na+/H+ exchanger cytoplasmic tail: structure, function, and
            interactions with tescalcin
  JOURNAL   Biochemistry 42 (24), 7448-7456 (2003)
   PUBMED   12809501
REFERENCE   9  (bases 1 to 989)
  AUTHORS   Mailander,J., Muller-Esterl,W. and Dedio,J.
  TITLE     Human homolog of mouse tescalcin associates with Na(+)/H(+)
            exchanger type-1
  JOURNAL   FEBS Lett 507 (3), 331-335 (2001)
   PUBMED   11696366
REFERENCE   10 (bases 1 to 989)
  AUTHORS   Perera,E.M., Martin,H., Seeherunvong,T., Kos,L., Hughes,I.A.,
            Hawkins,J.R. and Berkovitz,G.D.
  TITLE     Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding
            protein, Col9a3, and renin are expressed in the mouse testis during
            the early stages of gonadal differentiation
  JOURNAL   Endocrinology 142 (1), 455-463 (2001)
   PUBMED   11145610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB452909.1, BC015221.1 and AI372964.1.
            
            On Nov 24, 2018 this sequence version replaced NM_017899.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015221.1, SRR14038193.1622048.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335209.12/ ENSP00000334785.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB452909.1         31-43
            14-985              BC015221.1         1-972
            986-989             AI372964.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.22"
     gene            1..989
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /note="tescalcin"
                     /db_xref="GeneID:54997"
                     /db_xref="HGNC:HGNC:26065"
                     /db_xref="MIM:611585"
     exon            1..192
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..779
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcineurin B homologous protein 3; calcineurin-like EF
                     hand protein 3"
                     /codon_start=1
                     /product="calcineurin B homologous protein 3 isoform 1"
                     /protein_id="NP_060369.3"
                     /db_xref="CCDS:CCDS9183.3"
                     /db_xref="GeneID:54997"
                     /db_xref="HGNC:HGNC:26065"
                     /db_xref="MIM:611585"
                     /translation="MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRK
                     ENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTM
                     DEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADG
                     AMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH"
     exon            193..262
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            263..343
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            344..483
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            484..545
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            546..653
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            654..701
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     exon            702..989
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      959..964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /note="hexamer: AATAAA"
     polyA_site      989
                     /gene="TESC"
                     /gene_synonym="CHP3; TSC"
                     /note="major polyA site"
ORIGIN      
        1 ggaacccgcg gctccgagcc ttcgccggcg tcccgacccg aggccggacc cgaggccagt
       61 cccgccgctg cgcagccgaa gccagtgcgg ggcctgagag ggacgcgcgc cccggggccc
      121 ccgccgcggg caccatgggc gctgcccact ccgcgtctga ggaggtgcgg gagctcgagg
      181 gcaagaccgg cttctcatcg gatcagatcg agcagctcca tcggagattt aagcagctga
      241 gtggagatca gcctaccatt cgcaaggaga acttcaacaa tgtcccggac ctggagctca
      301 accccatccg atccaaaatt gttcgtgcct tcttcgacaa caggaacctg cgcaagggac
      361 ccagtggcct ggctgatgag atcaatttcg aggacttcct gaccatcatg tcctacttcc
      421 ggcccatcga caccaccatg gacgaggaac aggtggagct gtcccggaag gagaagctga
      481 gatttctgtt ccacatgtac gactcggaca gcgacggccg catcactctg gaagaatatc
      541 gaaatgtggt cgaggagctg ctgtcgggaa accctcacat cgagaaggag tccgctcgct
      601 ccatcgccga cggggccatg atggaggcgg ccagcgtgtg catggggcag atggagcctg
      661 atcaggtgta cgaggggatc accttcgagg acttcctgaa gatctggcag gggatcgaca
      721 ttgagaccaa gatgcacgtc cgcttcctta acatggaaac catggccctc tgccactgac
      781 ccaccgccac ctccgcggag aaactgcact ttgcaatggg gccgcctccc cgcgtagctg
      841 gagcagccca ggcccggcgg acagcctctt cctgcagcgc cggtacatag ccaaggctcg
      901 tctgcgcacc ttgtgtcttg tagggtatgg tatgtgggac ttcgctgttt ttatctccaa
      961 taaaaaaaaa aaaaaggttt gttaattaa
//
