LOCUS       NM_018975               2131 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TERF2 interacting protein (TERF2IP), transcript
            variant 1, mRNA.
ACCESSION   NM_018975
VERSION     NM_018975.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2131)
  AUTHORS   Swanson,M.J., Lewis,K.N., Carpenter,R., Whetzel,A. and Bae,N.S.
  TITLE     The human RAP1 and GFAPvarepsilon proteins increase gamma-secretase
            activity in a yeast model system
  JOURNAL   G3 (Bethesda) 13 (8) (2023)
   PUBMED   36929840
  REMARK    GeneRIF: The human RAP1 and GFAPvarepsilon proteins increase
            gamma-secretase activity in a yeast model system.
REFERENCE   2  (bases 1 to 2131)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2131)
  AUTHORS   Su,X., Chen,D., Zhu,L., Jia,H., Cai,J., Li,P., Han,B., Wang,D.,
            Li,H., Fan,J., Gu,M., Zhou,Y., Guan,H. and Wei,W.
  TITLE     SGSM2 inhibits thyroid cancer progression by activating RAP1 and
            enhancing competitive RAS inhibition
  JOURNAL   Cell Death Dis 13 (3), 218 (2022)
   PUBMED   35264562
  REMARK    GeneRIF: SGSM2 inhibits thyroid cancer progression by activating
            RAP1 and enhancing competitive RAS inhibition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2131)
  AUTHORS   Li,H., Liang,J., Wang,J., Han,J., Li,S., Huang,K. and Liu,C.
  TITLE     Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway
            in colorectal cancer and is inhibited by hsa-miR-6887-3p
  JOURNAL   Cancer Commun (Lond) 41 (6), 472-491 (2021)
   PUBMED   33638620
  REMARK    GeneRIF: Mex3a promotes oncogenesis through the RAP1/MAPK signaling
            pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
REFERENCE   5  (bases 1 to 2131)
  AUTHORS   Malinska,K., Deptula,J., Rogoza-Janiszewska,E., Gorski,B.,
            Scott,R., Rudnicka,H., Kashyap,A., Domagala,P., Hybiak,J.,
            Masojc,B., Cybulski,C., Kram,A., Boer,M., Kiedrowicz,M.,
            Lubinski,J. and Debniak,T.
  TITLE     Constitutional variants in POT1, TERF2IP, and ACD genes in patients
            with melanoma in the Polish population
  JOURNAL   Eur J Cancer Prev 29 (6), 511-519 (2020)
   PUBMED   32976206
  REMARK    GeneRIF: Constitutional variants in POT1, TERF2IP, and ACD genes in
            patients with melanoma in the Polish population.
REFERENCE   6  (bases 1 to 2131)
  AUTHORS   Li,B. and de Lange,T.
  TITLE     Rap1 affects the length and heterogeneity of human telomeres
  JOURNAL   Mol Biol Cell 14 (12), 5060-5068 (2003)
   PUBMED   14565979
REFERENCE   7  (bases 1 to 2131)
  AUTHORS   Loayza,D. and De Lange,T.
  TITLE     POT1 as a terminal transducer of TRF1 telomere length control
  JOURNAL   Nature 423 (6943), 1013-1018 (2003)
   PUBMED   12768206
REFERENCE   8  (bases 1 to 2131)
  AUTHORS   Hanaoka,S., Nagadoi,A., Yoshimura,S., Aimoto,S., Li,B., de Lange,T.
            and Nishimura,Y.
  TITLE     NMR structure of the hRap1 Myb motif reveals a canonical
            three-helix bundle lacking the positive surface charge typical of
            Myb DNA-binding domains
  JOURNAL   J Mol Biol 312 (1), 167-175 (2001)
   PUBMED   11545594
REFERENCE   9  (bases 1 to 2131)
  AUTHORS   Zhu,X.D., Kuster,B., Mann,M., Petrini,J.H. and de Lange,T.
  TITLE     Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and
            human telomeres
  JOURNAL   Nat Genet 25 (3), 347-352 (2000)
   PUBMED   10888888
REFERENCE   10 (bases 1 to 2131)
  AUTHORS   Li,B., Oestreich,S. and de Lange,T.
  TITLE     Identification of human Rap1: implications for telomere evolution
  JOURNAL   Cell 101 (5), 471-483 (2000)
   PUBMED   10850490
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307901.1, BC022428.1 and
            AA769291.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018975.3.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000669.1, SRR1660805.235161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300086.5/ ENSP00000300086.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK307901.1         37-49
            14-2129             BC022428.1         1-2116
            2130-2131           AA769291.1         30-31               c
FEATURES             Location/Qualifiers
     source          1..2131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..2131
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /note="TERF2 interacting protein"
                     /db_xref="GeneID:54386"
                     /db_xref="HGNC:HGNC:19246"
                     /db_xref="MIM:605061"
     exon            1..780
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1310
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /note="TRF2-interacting telomeric RAP1 protein;
                     TERF2-interacting telomeric protein 1; repressor/activator
                     protein 1 homolog; dopamine receptor-interacting protein
                     5"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2-interacting
                     protein 1"
                     /protein_id="NP_061848.2"
                     /db_xref="CCDS:CCDS32491.1"
                     /db_xref="GeneID:54386"
                     /db_xref="HGNC:HGNC:19246"
                     /db_xref="MIM:605061"
                     /translation="MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLST
                     LILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLG
                     PASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTG
                     NALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPE
                     AADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIH
                     ITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQ
                     AFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVAR
                     RIEFRKK"
     exon            781..905
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..2131
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2131
                     /gene="TERF2IP"
                     /gene_synonym="DRIP5; RAP1"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgcgc ttcgcggcag aggcgtctgc ggtgacagct cagtcagttg agctctgtgt
       61 gccaggcgct cgcgaggggg tagctcttct agtagtgctc ggcgtcagac atggcggagg
      121 cgatggattt gggcaaagac cccaacgggc ccacccattc ctcgactctg ttcgtgaggg
      181 acgacggcag ctccatgtcc ttctacgtgc ggcccagccc ggccaagcgt cggctgtcga
      241 cgctcatcct gcacggcggc ggcaccgtgt gccgagtgca ggagcccggg gccgtgctgc
      301 tggcccagcc cggggaggcg ctggccgagg cctcgggtga tttcatctcc acgcagtaca
      361 tcctggactg cgtggagcgc aacgagaggc tggagctgga ggcctatcgg ctgggccccg
      421 cctcggcggc ggacaccggc tcggaagcaa agcccggggc cctggccgag ggcgccgcgg
      481 agccggagcc gcagcggcac gccgggcgga tcgccttcac ggatgcggac gacgtagcca
      541 tccttaccta cgtgaaggaa aatgcccgct cgcccagctc cgtcaccggt aacgccttgt
      601 ggaaagcgat ggagaagagc tcgctcacgc agcactcgtg gcagtccctg aaggaccgct
      661 acctcaagca cctgcggggc caggagcata agtacctgct gggggacgcg ccggtgagcc
      721 cctcctccca gaagctcaag cggaaggcgg aggaggaccc ggaggccgcg gatagcgggg
      781 aaccacagaa taagagaact ccagatttgc ctgaagaaga gtatgtgaag gaagaaatcc
      841 aggagaatga agaagcagtc aaaaagatgc ttgtggaagc cacccgggag tttgaggagg
      901 ttgtggtgga tgagagccct cctgattttg aaatacatat aactatgtgt gatgatgatc
      961 cacccacacc tgaggaagac tcagaaacac agcctgatga ggaggaagaa gaagaagaag
     1021 aaaaagtttc tcaaccagag gtgggagctg ccattaagat cattcggcag ttaatggaga
     1081 agtttaactt ggatctatca acagttacac aggccttcct aaaaaatagt ggtgagctgg
     1141 aggctacttc cgccttctta gcgtctggtc agagagctga tggatatccc atttggtccc
     1201 gacaagatga catagatttg caaaaagatg atgaggatac cagagaggca ttggtcaaaa
     1261 aatttggtgc tcagaatgta gctcggagga ttgaatttcg aaagaaataa ttggcaagat
     1321 aatgagaaaa gaaaaaagtc atggtaggtg aggtggttaa aaaaaattgt gaccaatgaa
     1381 ctttagagag ttcttgcatt ggaactggca cttattttct gaccatcgct gctgttgctc
     1441 tgtgagtcct agatttttgt agccaagcag agttgtagag ggggataaaa agaaaagaaa
     1501 ttggatgtat ttacagctgt ccttgaacaa gtatcaatgt gtttatgaaa ggaagatcta
     1561 aatcagacag gagttggtct acatagtagt aatccattgt tggaatggaa cccttgctat
     1621 agtagtgaca aagtgaaagg aaatttagga ggcataggcc atttcaggca gcataagtaa
     1681 tctcctgtcc tttggcagaa gctcctttag attgggatag attccaaata aagaatctag
     1741 aaataggaga agatttaatt atgaggcctt gaacacggat tatccccaaa cccttgtcat
     1801 ttcccccagt gagctctgat ttctagactg ctttgaaaat gctgtattca ttttgctaac
     1861 ttagtatttg ggtaccctgc tctttggctg ttcttttttt ggagcccttc tcagtcaagt
     1921 ctgccggatg tctttcttta cctacccctc agttttcctt aaaacgcgca cacaactcta
     1981 gagagtgtta agaataatgt tacttggtta atgtgttatt tattgagtat tgtttgtgct
     2041 aagcattgtg ttagatttaa aaaattagtg gattgactcc actttgttgt gttgttttca
     2101 ttgttgaaaa taaatataac tttgtattcg a
//
