LOCUS       NM_005652               2996 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens telomeric repeat binding factor 2 (TERF2), mRNA.
ACCESSION   NM_005652
VERSION     NM_005652.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Liang,F., Rai,R., Sodeinde,T. and Chang,S.
  TITLE     TRF2-RAP1 represses RAD51-dependent homology-directed telomere
            repair by promoting BLM-mediated D-loop unwinding and inhibiting
            BLM-DNA2-dependent 5'-end resection
  JOURNAL   Nucleic Acids Res 52 (16), 9695-9709 (2024)
   PUBMED   39082275
  REMARK    GeneRIF: TRF2-RAP1 represses RAD51-dependent homology-directed
            telomere repair by promoting BLM-mediated D-loop unwinding and
            inhibiting BLM-DNA2-dependent 5'-end resection.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Khayat,F., Alshmery,M., Pal,M., Oliver,A.W. and Bianchi,A.
  TITLE     Binding of the TRF2 iDDR motif to RAD50 highlights a convergent
            evolutionary strategy to inactivate MRN at telomeres
  JOURNAL   Nucleic Acids Res 52 (13), 7704-7719 (2024)
   PUBMED   38884214
  REMARK    GeneRIF: Binding of the TRF2 iDDR motif to RAD50 highlights a
            convergent evolutionary strategy to inactivate MRN at telomeres.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Jiang,Y., Xu,J., Zeng,H., Lin,Z., Yi,Q., Guo,J. and Xiao,F.
  TITLE     miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a
            mouse model by targeting TERF2
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (4), 607-620 (2024)
   PUBMED   38414350
  REMARK    GeneRIF: miR-29b-1-5p exacerbates myocardial injury induced by
            sepsis in a mouse model by targeting TERF2.
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Xu,G.F., Zeng,Z., Zhang,Z.B., Zhang,X.M., Wang,M., Xiao,Q., Li,J.,
            Xie,X.Q., He,S., Fu,H.H., Liu,Y., Yang,Z.L., Chen,Y., Shi,J.,
            Wang,B., Qiu,H.Y., Zhou,Q., Liu,Y. and Chen,S.N.
  TITLE     The novel TERF2::PDGFRB fusion gene enhances tumorigenesis via
            PDGFRB/STAT5 signalling pathways and sensitivity to TKI in ph-like
            ALL
  JOURNAL   J Cell Mol Med 28 (3), e18114 (2024)
   PUBMED   38323741
  REMARK    GeneRIF: The novel TERF2::PDGFRB fusion gene enhances tumorigenesis
            via PDGFRB/STAT5 signalling pathways and sensitivity to TKI in
            ph-like ALL.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Wong,S.Y., Soman,A., Korolev,N., Surya,W., Chen,Q., Shum,W., van
            Noort,J. and Nordenskiold,L.
  TITLE     The shelterin component TRF2 mediates columnar stacking of human
            telomeric chromatin
  JOURNAL   EMBO J 43 (1), 87-111 (2024)
   PUBMED   38177309
  REMARK    GeneRIF: The shelterin component TRF2 mediates columnar stacking of
            human telomeric chromatin.
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Sakaguchi,A.Y., Padalecki,S.S., Mattern,V., Rodriguez,A.,
            Leach,R.J., McGill,J.R., Chavez,M. and Giambernardi,T.A.
  TITLE     Chromosomal sublocalization of the transcribed human telomere
            repeat binding factor 2 gene and comparative mapping in the mouse
  JOURNAL   Somat Cell Mol Genet 24 (3), 157-163 (1998)
   PUBMED   10226653
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   van Steensel,B., Smogorzewska,A. and de Lange,T.
  TITLE     TRF2 protects human telomeres from end-to-end fusions
  JOURNAL   Cell 92 (3), 401-413 (1998)
   PUBMED   9476899
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Bilaud,T., Brun,C., Ancelin,K., Koering,C.E., Laroche,T. and
            Gilson,E.
  TITLE     Telomeric localization of TRF2, a novel human telobox protein
  JOURNAL   Nat Genet 17 (2), 236-239 (1997)
   PUBMED   9326951
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Broccoli,D., Smogorzewska,A., Chong,L. and de Lange,T.
  TITLE     Human telomeres contain two distinct Myb-related proteins, TRF1 and
            TRF2
  JOURNAL   Nat Genet 17 (2), 231-235 (1997)
   PUBMED   9326950
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Bilaud,T., Koering,C.E., Binet-Brasselet,E., Ancelin,K.,
            Pollice,A., Gasser,S.M. and Gilson,E.
  TITLE     The telobox, a Myb-related telomeric DNA binding motif found in
            proteins from yeast, plants and human
  JOURNAL   Nucleic Acids Res 24 (7), 1294-1303 (1996)
   PUBMED   8614633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026464.7, HY046320.1,
            AF002999.1, CB216181.1 and BX090758.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005652.4.
            
            Summary: This gene encodes a telomere specific protein, TERF2,
            which is a component of the telomere nucleoprotein complex. This
            protein is present at telomeres in metaphase of the cell cycle, is
            a second negative regulator of telomere length and plays a key role
            in the protective activity of telomeres. While having similar
            telomere binding activity and domain organization, TERF2 differs
            from TERF1 in that its N terminus is basic rather than acidic.
            [provided by RefSeq, Jul 2008].
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF002999.1, SRR1803611.49458.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254942.8/ ENSP00000254942.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC026464.7         111109-111127       c
            20-143              HY046320.1         2-125
            144-1869            AF002999.1         106-1831
            1870-2294           CB216181.1         186-610
            2295-2427           AF002999.1         2255-2387
            2428-2996           BX090758.1         31-599
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2996
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /note="telomeric repeat binding factor 2"
                     /db_xref="GeneID:7014"
                     /db_xref="HGNC:HGNC:11729"
                     /db_xref="MIM:602027"
     exon            1..415
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1665
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /note="telomeric repeat binding protein 2; telomeric
                     DNA-binding protein; TTAGGG repeat-binding factor 2"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2"
                     /protein_id="NP_005643.2"
                     /db_xref="CCDS:CCDS10879.2"
                     /db_xref="GeneID:7014"
                     /db_xref="HGNC:HGNC:11729"
                     /db_xref="MIM:602027"
                     /translation="MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMA
                     GGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFY
                     FHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC
                     SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASK
                     ILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEP
                     YLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAF
                     KTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSEL
                     QPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPK
                     GKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYG
                     EGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN"
     exon            416..511
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..642
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..729
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..876
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..983
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1376
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1462
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1506
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2996
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2996
                     /gene="TERF2"
                     /gene_synonym="TRBF2; TRF2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcccgc gggcggctcg gaacgctgtt tctatcatgg ccgcgggagc cgggacggcg
       61 ggccccgctt ccggcccggg cgtcgtgcgt gacccagcgg cgtcacagcc gaggaagcgg
      121 cccggccggg agggcgggga gggcgcgcgg cgatcggaca cgatggcggg aggaggcggg
      181 agtagcgacg gcagcgggcg ggcagctggc aggcgggcgt cccgcagtag cgggcgggcc
      241 cggcgggggc gccacgagcc ggggctgggg ggcccggcgg agcgcggcgc gggggaggca
      301 cggctggaag aggcagtcaa tcgctgggtg ctcaagttct acttccacga ggcgctgcgg
      361 gcctttcggg gtagccggta cggggacttc agacagatcc gggacatcat gcaggctttg
      421 cttgtcaggc ccttggggaa ggagcacacc gtgtcccgat tgctgcgggt tatgcagtgt
      481 ctgtcgcgga ttgaagaagg ggaaaattta gactgttcct ttgatatgga ggctgagctc
      541 acaccactgg aatcagctat caatgtgctg gagatgatta aaacggaatt tacactgaca
      601 gaagcagtgg tcgaatccag tagaaaactg gtcaaggaag ctgctgtcat tatttgtatc
      661 aaaaacaaag aatttgaaaa ggcttcaaaa attttgaaaa aacatatgtc caaggacccc
      721 acaactcaga agctgagaaa tgatctcctg aatattattc gagaaaagaa cttggcccat
      781 cctgttatcc agaacttttc atatgagacc ttccagcaga agatgctgcg cttcctggag
      841 agccacctgg atgacgccga gccctacctc ctcacgatgg ccaaaaaggc tttgaaatct
      901 gagtccgctg cctcaagtac agggaaggaa gataaacagc cagcaccagg gcctgtggaa
      961 aagccaccca gagaacccgc aaggcagcta cggaatcctc caaccaccat tggaatgatg
     1021 actctgaaag cagctttcaa gactctgtct ggtgcacagg attctgaggc agcctttgca
     1081 aaactggacc agaaggatct ggttcttcct actcaagctc tcccagcatc accagccctc
     1141 aaaaacaaga gacccagaaa agatgaaaac gaaagttcag ccccggctga cggtgagggt
     1201 ggctcggaac tgcagcccaa gaacaagcgc atgacaataa gcagattggt cttggaggag
     1261 gacagccaga gtactgagcc cagcgcaggc ctcaactcct cccaggaggc cgcttcagcg
     1321 ccaccatcca agcccaccgt tctcaaccaa cccctccctg gagagaagaa tcccaaagta
     1381 cccaaaggca agtggaacag ctctaatggg gttgaagaaa aggagacttg ggtggaagag
     1441 gatgaactgt ttcaagttca ggcagcacca gatgaagaca gtacaaccaa tataacaaaa
     1501 aagcagaagt ggactgtaga agaaagcgag tgggtcaagg ctggagtgca gaaatatggg
     1561 gaaggaaact gggctgccat ttctaaaaat tacccatttg ttaaccgaac agctgtgatg
     1621 attaaggatc gctggcggac catgaaaaga cttggcatga actgaaacag gctttcattt
     1681 ccacagaatt cacaggagca tggttcctaa taatagcccc tgatagtctg ctctttcttt
     1741 ctttttcttt tttttttttt tttgagacag agtctcgctc tgtcacccag gctggagtgc
     1801 agtggcgtga tctcggctca ctgcgacctc cgtctcccgg gctcacgcca ttctcctgcc
     1861 tcagcctccc gagtagctgg gactacaggc gcccgccatc acgcccggct aatgttttgt
     1921 atttttagta gagacggggt ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc
     1981 gtgatccacc caactcggcc tcccaaagtg ctgggattac aggcatgagc caccgcgcct
     2041 ggcatctgct gtttctttca gaagctgggc tgggatgaga attttgggca acctccttcg
     2101 acgtggggga ggtcccattt ccacttcatc actgttggag atcatggagc taagaagcag
     2161 agccaagtcc acccatgtcc ttggcagaga tgacaggcac acagcttgtg cagtgccaga
     2221 atatcattag cgtttccctt ctttagtggt ttgcttaaat ttaaatccct ggtaatctgt
     2281 agaaccttct cctaggaaat ggtgaagtct attaggagcc acttgtgact ccatgacctg
     2341 ttaaaaccag caatgtgagt attatttgga gtaaatttgt tccacgtcaa gttctggcct
     2401 tctgatgcaa atgcaaagga acttagtctg ttatgaaccc aggttgatga cagaccagtc
     2461 cttgtggaat aagattccct ttaaaaactc tttagccagt cgtgacatca accctagacc
     2521 tgtctgcctt ggcatttgct gtcaacatct gctgggctat gtaggcaggt taatcctcca
     2581 cttctcatgt ggttgaacca gtgtgttttt tggtaaaatg gtgattgtag ataagattag
     2641 ttccctgatc ccctgccccc tgtcccctgc ctcttttccc aattcccttc cttatgctgg
     2701 acttttaaag cttaaaaaaa atccgattga atataaatgc ctaatttcat tctttgtgaa
     2761 atggttgctt cctcctgatt ccctaattgt gctgtgttcg tgtcttgcac tggaattcaa
     2821 cattcccttc tccttttgta ctgtgttgtg cttgctgtct ctcccggaca cccttaaaga
     2881 ctgtcttttt agcaaaaaat ttcagtaaag tgttttctgt aatctttttt taaaaggtga
     2941 gaactaatta ttgtccatac ttgtagcatt cttcattaaa gtcttgcttc tctcaa
//
