LOCUS       NM_152448               1296 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens telomere repeat binding bouquet formation protein 2
            (TERB2), mRNA.
ACCESSION   NM_152448
VERSION     NM_152448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Salas-Huetos,A., Tuttelmann,F., Wyrwoll,M.J., Kliesch,S.,
            Lopes,A.M., Goncalves,J., Boyden,S.E., Woste,M., Hotaling,J.M.,
            Nagirnaja,L., Conrad,D.F., Carrell,D.T. and Aston,K.I.
  CONSRTM   GEMINI Consortium
  TITLE     Disruption of human meiotic telomere complex genes TERB1, TERB2 and
            MAJIN in men with non-obstructive azoospermia
  JOURNAL   Hum Genet 140 (1), 217-227 (2021)
   PUBMED   33211200
  REMARK    GeneRIF: Disruption of human meiotic telomere complex genes TERB1,
            TERB2 and MAJIN in men with non-obstructive azoospermia.
            Erratum:[Hum Genet. 2021 Jan;140(1):229. doi:
            10.1007/s00439-020-02244-1.. PMID: 33377991]
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    GeneRIF: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to
            the nuclear envelope
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Dunce,J.M., Milburn,A.E., Gurusaran,M., da Cruz,I., Sen,L.T.,
            Benavente,R. and Davies,O.R.
  TITLE     Structural basis of meiotic telomere attachment to the nuclear
            envelope by MAJIN-TERB2-TERB1
  JOURNAL   Nat Commun 9 (1), 5355 (2018)
   PUBMED   30559341
  REMARK    GeneRIF: complementary structured illumination microscopy studies
            and biochemical findings reveal a telomere attachment mechanism in
            which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then
            displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind
            telomeric DNA and form a mature attachment plate.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Shibuya,H., Hernandez-Hernandez,A., Morimoto,A., Negishi,L.,
            Hoog,C. and Watanabe,Y.
  TITLE     MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging
            Telomere Cap
  JOURNAL   Cell 163 (5), 1252-1266 (2015)
   PUBMED   26548954
  REMARK    Erratum:[Cell. 2018 May 3;173(4):1058. doi:
            10.1016/j.cell.2018.04.025.. PMID: 29727665]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090888.4 and BC029537.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152448.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.120236.1,
                                           SRR5189667.202605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340827.4/ ENSP00000340644.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC090888.4         58807-58824
            19-884              BC029537.1         4-869
            885-885             AC090888.4         80938-80938
            886-1290            BC029537.1         871-1275
            1291-1296           AC090888.4         81344-81349
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..1296
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /note="telomere repeat binding bouquet formation protein
                     2"
                     /db_xref="GeneID:145645"
                     /db_xref="HGNC:HGNC:28520"
                     /db_xref="MIM:617131"
     exon            1..96
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..695
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /codon_start=1
                     /product="telomere repeats-binding bouquet formation
                     protein 2"
                     /protein_id="NP_689661.1"
                     /db_xref="CCDS:CCDS10115.1"
                     /db_xref="GeneID:145645"
                     /db_xref="HGNC:HGNC:28520"
                     /db_xref="MIM:617131"
                     /translation="MFQGQRGWFCGSVSQDLRQFWVAEGGTISDPRAADFLFSCDASH
                     PDTLRIYQSLDYIEDNATVFHAYYLSAVANAKIKNSVALGHFILPPACLQKEIRRKIG
                     SFIWEQDQHFLIEKHDEVTPNEIKTLRENSELATEHKKELSKSPEKHFIRTPVVEKQM
                     YFPLQNYPVNNMVTGYISIDAMKKFLGELHDFIPGTSGYLAYHVQNEINMSAIKNKLK
                     RK"
     exon            97..178
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     exon            179..318
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     exon            319..380
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     exon            381..466
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     exon            467..555
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1296
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1266..1271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /note="hexamer: AATAAA"
     polyA_site      1296
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcaca tctccacagg cttggcgacg ccatgtttca agggcagcgc ggttggtttt
       61 gcggcagcgt tagccaggat ctgaggcaat tctgggtggc tgaaggggga acgatcagtg
      121 acccgcgagc cgccgacttc ttgttcagct gtgatgcctc gcacccagac acgctgagaa
      181 tatatcagag ccttgattac atagaagata atgctacagt ttttcatgcc tactatctct
      241 ctgcggtagc taatgccaaa ataaaaaact cggtggcttt gggtcatttc attcttcctc
      301 ctgcgtgcct gcaaaaagaa ataagaagaa aaattggtag ttttatttgg gaacaagacc
      361 aacattttct gatagaaaag catgatgaag taacaccaaa tgaaataaag acccttaggg
      421 aaaacagtga actagcaaca gagcacaaaa aagaattatc caaaagccca gaaaagcatt
      481 ttataagaac tccagttgta gaaaagcaga tgtacttccc tctacagaat tacccagtta
      541 acaacatggt aacaggttat atatcaattg atgccatgaa gaaattcctt ggggagctac
      601 atgacttcat tcctggaacc tcaggatatt tggcatatca tgttcaaaat gaaattaata
      661 tgtctgctat aaaaaacaaa ttgaagagga aatagtaaat taaattgtaa ataccttggc
      721 atttattttc tataaaatat tatacagatg tgcatatcat aaaatgctcc cttttggtac
      781 tgggggatag tgaaatggga aataattttt ctgtttctca aagtatatct ttaggaaata
      841 cagaatcatt ttggttctgt gttttgacat ttttccccta gcttttaaca acatgttcaa
      901 atattctcaa tgcacagttg ttaatgagta attgccgtta aaatatattt cataagaagt
      961 ctcaatctca aactctccat ctctcaatcc tcctcctcct cctctttctt gctttctctt
     1021 ttccctctct ctttctctcc tccccttctc tctttctgtc tttcaaatgt tcttttggct
     1081 ttaacattct attaattata ttttttctag attgaatact gtgaatgcta agttttatta
     1141 atctggtcat cttattttga ttttaaaaat taggatgcta gttgcattct gaattactgt
     1201 ttctggtttg aaacatggag aaaaacattt taataattca tatttcatgt tggatggttt
     1261 ctaataataa atatctcaaa agtgacttaa cataaa
//
