LOCUS       NM_001363764            2455 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TEPSIN adaptor related protein complex 4 accessory
            protein (TEPSIN), transcript variant 1, mRNA.
ACCESSION   NM_001363764 XM_005257067
VERSION     NM_001363764.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Mattera,R., Williamson,C.D., Ren,X. and Bonifacino,J.S.
  TITLE     The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate
            perinuclear distribution of AP-4 and its cargo ATG9A
  JOURNAL   Mol Biol Cell 31 (9), 963-979 (2020)
   PUBMED   32073997
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Frazier,M.N., Davies,A.K., Voehler,M., Kendall,A.K., Borner,G.H.,
            Chazin,W.J., Robinson,M.S. and Jackson,L.P.
  TITLE     Molecular Basis for the Interaction Between AP4 beta4 and its
            Accessory Protein, Tepsin
  JOURNAL   Traffic 17 (4), 400-415 (2016)
   PUBMED   26756312
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Mattera,R., Guardia,C.M., Sidhu,S.S. and Bonifacino,J.S.
  TITLE     Bivalent Motif-Ear Interactions Mediate the Association of the
            Accessory Protein Tepsin with the AP-4 Adaptor Complex
  JOURNAL   J Biol Chem 290 (52), 30736-30749 (2015)
   PUBMED   26542808
  REMARK    GeneRIF: The bivalency of the interactions contributes to a higher
            avidity of tepsin for AP-4.
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Borner,G.H., Antrobus,R., Hirst,J., Bhumbra,G.S., Kozik,P.,
            Jackson,L.P., Sahlender,D.A. and Robinson,M.S.
  TITLE     Multivariate proteomic profiling identifies novel accessory
            proteins of coated vesicles
  JOURNAL   J Cell Biol 197 (1), 141-160 (2012)
   PUBMED   22472443
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Cho,H., Orphanides,G., Sun,X., Yang,X.J., Ogryzko,V., Lees,E.,
            Nakatani,Y. and Reinberg,D.
  TITLE     A human RNA polymerase II complex containing factors that modify
            chromatin structure
  JOURNAL   Mol Cell Biol 18 (9), 5355-5363 (1998)
   PUBMED   9710619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027601.25.
            
            On Jun 2, 2019 this sequence version replaced NM_001363764.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.14062.1,
                                           SRR11853566.12547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000637944.2/ ENSP00000490393.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC027601.25        86356-86425         c
            71-143              AC027601.25        84757-84829         c
            144-235             AC027601.25        84350-84441         c
            236-329             AC027601.25        84078-84171         c
            330-397             AC027601.25        81351-81418         c
            398-476             AC027601.25        81008-81086         c
            477-548             AC027601.25        80802-80873         c
            549-752             AC027601.25        79685-79888         c
            753-927             AC027601.25        79217-79391         c
            928-1041            AC027601.25        78948-79061         c
            1042-1120           AC027601.25        78768-78846         c
            1121-1255           AC027601.25        77914-78048         c
            1256-2455           AC027601.25        75647-76846         c
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2455
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /note="TEPSIN adaptor related protein complex 4 accessory
                     protein"
                     /db_xref="GeneID:146705"
                     /db_xref="HGNC:HGNC:26458"
     exon            1..70
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1804
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetra-epsin; AP-4 complex accessory subunit tepsin; epsin
                     for AP-4; ENTH domain-containing protein 2; ENTH domain
                     containing 2; AP-4 accessory protein"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit tepsin isoform 1"
                     /protein_id="NP_001350693.1"
                     /db_xref="CCDS:CCDS86648.1"
                     /db_xref="GeneID:146705"
                     /db_xref="HGNC:HGNC:26458"
                     /translation="MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISH
                     ESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAA
                     AFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPH
                     STLQGFGYSKEHGRTGSAGEAFLSTIQKAAEVVASAMRPGPESPSTRRLLPRGDTYQP
                     AMMPSASHGPPTLGNLLPGAIPGPRAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSR
                     VSDSGSHSGSDSHSGASREPGDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSREEA
                     QHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSSDLLPQEHILLRTRP
                     WLQELSMGSPGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAV
                     PLPGSQVFLQPLSSTPVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAE
                     SRRWRPERIPGGTDSPKRGPSSCAWSRDSLFAGMELVACPRLVGAGAAAGESCPDAPR
                     APQTSSQRTAAKEPPGSEPSAFAFLNA"
     exon            71..143
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..235
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..329
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..397
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..476
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..548
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..752
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..927
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1041
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1120
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1255
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..2455
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="TEPSIN"
                     /gene_synonym="C17orf56; ENTHD2"
                     /note="major polyA site"
ORIGIN      
        1 agaccgggag gggacctgga tcatggctgc cgcgccgccg ctacgggacc gcctgagctt
       61 tctacaccgg ctcccgattc tcctgaaggg gacgtccgat gatgatgtcc cgtgtccggg
      121 ctacctgttt gaagagattg ctaaaatctc ccacgagtct ccgggcagca gccagtgcct
      181 gctggagtac ctcctgagcc gcctgcacag cagctccggc cacgggaagc tcaaggtgct
      241 gaagatcctg ctctatctgt gcagccacgg ctcctccttc ttcctgctca tcctcaaacg
      301 caactctgcc ttcatccagg aagctgcagc ttttgcaggg cccccagatc ctctgcacgg
      361 gaacagcttg taccagaagg ttcgcgcggc cgcgcaggac ttggggagca ccctgttctc
      421 ggacaccgtg ttgccgctgg ctccctccca gcctctgggg accccgcctg ccacaggcat
      481 gggctcccag gccaggccgc acagcaccct ccagggtttc ggctacagca aggaacacgg
      541 ccgcacgggc tcggcaggcg aagccttcct ctccaccatc cagaaggccg cagaggtggt
      601 ggccagcgcc atgcgccccg ggcccgagag tcccagtacc cggaggctcc tgccgcgggg
      661 tgacacctac cagcctgcca tgatgccttc agccagccac ggtcccccaa ccctggggaa
      721 cctactcccc ggggccattc caggtccccg agctgtgagg catcagcctg ggcaggccgg
      781 agggggctgg gatgagctgg acagcggccc cagctctcag aattcctccc agaacagcga
      841 cctgagcagg gtctcggact cgggcagtca ttccggcagc gacagccatt caggggccag
      901 ccgggagccg ggtgacctgg cagaaagggt cgaggtggtg gccctgagtg actgtcagca
      961 ggagttgagc ttggtgagga ctgtgactcg gggaccacgc gccttcctga gccgcgagga
     1021 ggcacagcac ttcatcaaag cgtgtggact gctcaactgt gaggccgtgc tgcagctgct
     1081 gacctgccac ctgcgtggga ccagtgaatg cacgcagctg agggcgctgt gtgccatcgc
     1141 ctccctgggg agcagcgacc tcctccccca ggagcacatc ctcctccgca cccggccgtg
     1201 gctgcaggag ctcagcatgg gcagcccggg acctgtgacc aacaaggcca ccaagatcct
     1261 gaggcacttt gaggcctcct gtgggcagct gtcccctgcc cggggcacct cagctgagcc
     1321 tggccccaca gccgccctcc caggcccatc tgacctgctg accgacgctg tgcctctccc
     1381 tgggagccag gtcttcctgc agcctctgag ttcaaccccg gtctcgtccc ggagccctgc
     1441 tccctcatct gggatgccgt ccagccctgt gcccacccca cccccagatg cctcccccat
     1501 tccagccccc ggagacccca gcgaggccga ggccagactg gcagaaagca ggcggtggag
     1561 acctgaacgg atcccagggg gcacggacag cccaaagaga ggccccagca gctgtgcgtg
     1621 gagccgcgac tccttgtttg ctggcatgga gctggtggcc tgtccccgcc tggtgggggc
     1681 tggggctgct gcgggagagt cctgtcctga tgctccccgc gccccccaaa catcgtccca
     1741 gaggacagca gccaaagagc ctcctggctc agagccgtca gctttcgcgt tcctgaacgc
     1801 ctgacccgat ggcctggccc tggagtcttc agcttcagct gctgtctggg gcggtctgtg
     1861 cttcctgagc agcctcaacc gtagctgcta cagtctccag gcagcttgac ttgagaggac
     1921 gaccctaggg ctacctcagt ttcccccatc tcctctgcca gaggctctgg ctatttggac
     1981 ttgaatccct acgagggatg gcaggtggca gggcttcaga aatgtcgatc tcagggctct
     2041 cagggggcag tccctgcctg tcttgctctc agacatgagg tttcttgtat gaatgcggaa
     2101 gcgactacca ggttccttat ttcattttga tctcagctcc ctccttcccc aggaggtcat
     2161 gagcagcaac aagccactgc tcccccgtcc catcggggtg ggctaggtgc tgaggctggg
     2221 tttggtgcat gtgggttgag ggtgtcttgt ccgggctgcc ttgtgctgtc tggcctgagg
     2281 ccatttcaag tctcagatcc ctacgtgatc cttccctggc tctcacctgc tcctttaggc
     2341 tgtaattgct tcctacacac gaagcctctg attggagcct ctggtccatc tcagaaaaac
     2401 cttccaagag cgctggggtt tatgctttct gaataaacac tactgtttac atgaa
//
