LOCUS       NM_152630               3028 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens terminal nucleotidyltransferase 5D (TENT5D),
            transcript variant 2, mRNA.
ACCESSION   NM_152630
VERSION     NM_152630.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3028)
  AUTHORS   Chen,H., Lu,D., Shang,G., Gao,G. and Zhang,X.
  TITLE     Structural and Functional Analyses of the FAM46C/Plk4 Complex
  JOURNAL   Structure 28 (8), 910-921 (2020)
   PUBMED   32433990
REFERENCE   2  (bases 1 to 3028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3028)
  AUTHORS   Menezes,M.R., Balzeau,J. and Hagan,J.P.
  TITLE     3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and
            Disease
  JOURNAL   Front Mol Biosci 5, 61 (2018)
   PUBMED   30057901
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3028)
  AUTHORS   Mroczek,S., Chlebowska,J., Kulinski,T.M., Gewartowska,O.,
            Gruchota,J., Cysewski,D., Liudkovska,V., Borsuk,E., Nowis,D. and
            Dziembowski,A.
  TITLE     The non-canonical poly(A) polymerase FAM46C acts as an
            onco-suppressor in multiple myeloma
  JOURNAL   Nat Commun 8 (1), 619 (2017)
   PUBMED   28931820
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3028)
  AUTHORS   Bettoni,F., Filho,F.C., Grosso,D.M., Galante,P.A., Parmigiani,R.B.,
            Geraldo,M.V., Henrique-Silva,F., Oba-Shinjo,S.M., Marie,S.K.,
            Soares,F.A., Brentani,H.P., Simpson,A.J., de Souza,S.J. and
            Camargo,A.A.
  TITLE     Identification of FAM46D as a novel cancer/testis antigen using EST
            data and serological analysis
  JOURNAL   Genomics 94 (3), 153-160 (2009)
   PUBMED   19540335
  REMARK    GeneRIF: Overexpression of FAM46D is associated with neoplasms.
REFERENCE   6  (bases 1 to 3028)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   7  (bases 1 to 3028)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX506299.1 and BC030784.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_152630.4.
            
            Summary: Antibodies against the protein encoded by this gene were
            found only in plasma from cancer patients. While it may be a target
            for immunotherapy, the function of this gene is unknown. [provided
            by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537938.1, BC028710.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308293.6/ ENSP00000308575.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BX506299.1         3-21
            20-3028             BC030784.2         1-3009
FEATURES             Location/Qualifiers
     source          1..3028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..3028
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /note="terminal nucleotidyltransferase 5D"
                     /db_xref="GeneID:169966"
                     /db_xref="HGNC:HGNC:28399"
                     /db_xref="MIM:300976"
     exon            1..117
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /inference="alignment:Splign:2.1.0"
     exon            118..240
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /inference="alignment:Splign:2.1.0"
     exon            241..3028
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1428
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /EC_number="2.7.7.19"
                     /note="cancer/testis antigen 112; protein FAM46D; putative
                     nucleotidyltransferase FAM46D; family with sequence
                     similarity 46 member D; non-canonical poly(A) polymerase
                     FAM46D"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 5D"
                     /protein_id="NP_689843.1"
                     /db_xref="CCDS:CCDS14446.1"
                     /db_xref="GeneID:169966"
                     /db_xref="HGNC:HGNC:28399"
                     /db_xref="MIM:300976"
                     /translation="MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEVKPKDII
                     HVVKDQLIGQGIIVKDARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQVVKD
                     AVLDCLLDFLPKDVKKEKLSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLELK
                     FVSSLRRQFEFSVDSFQIVLDPMLDFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHL
                     QHKLICTRKPEEIRGGGLLKYCSLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQ
                     QKKIESYLHNHFIGEGMTKYDYLMTLHGVVNESTVCLMSYERRQILHLITMMALKVLG
                     ELNILPNTQKVTCFYQPAPYFAAEARYPIYVIPEPPPVSFQPYHPLHFRGSNGMS"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="TENT5D"
                     /gene_synonym="CT1.26; CT112; FAM46D"
                     /note="major polyA site"
ORIGIN      
        1 gcagcaagtg aggtgtagag aatgtgtgga gatcaggtga tgcagaactc tggtaaagga
       61 tgttagtctt cagagtaaga ctgttaaatt cagcaaagtc tactatcaga agacacgttt
      121 ttctggttgg tgtattactt tattcagtga taatatgaaa attactatct tcactgaagg
      181 atctactgaa taatcatttt aactcaacta tattgcattc ttgaaagcaa tcctttcaat
      241 tgatctactg acttcacaat gtctgaaatc agattcacca atctcacttg ggatcaagtt
      301 ataacactgg atcaagtgtt agatgaagta attccaattc atggaaaggg gaatttcccc
      361 acaatggagg taaaaccaaa agacatcatt catgttgtga aagatcaact catagggcaa
      421 ggaattattg ttaaagatgc cagattgaat ggttccgtag caagttacat acttgcaagc
      481 cacaatggaa tcagctataa ggatctggac gttatttttg gtgttgagct tccaggtaac
      541 gaagaatttc aggttgttaa agatgcagtt ctagactgtc tacttgactt tttaccaaaa
      601 gatgtaaaga aggaaaagct ctccccagat atcatgaaag acgcttacgt acagaaattg
      661 gtcaaggttt gcaatgggca tgattgttgg agtcttatct ccctttcaaa taacactggg
      721 aagaatttag aactaaaatt tgtgagttca ctcagacggc agtttgaatt tagtgtagat
      781 tcctttcaaa ttgttttgga tcccatgtta gacttctaca gtgacaaaaa tgccaagcta
      841 accaaagaat cctatcctgt tgtggtagct gaaagcatgt atggagactt ccaggaagca
      901 atgacacatt tgcaacacaa gctcatatgt accaggaaac ctgaagagat tagaggtggt
      961 ggccttctga agtactgcag cttgctggtt catggcttca agccagcctg tatgtcagaa
     1021 atcaaaaacc tagaacgtta tatgtgctct agattcttta ttgattttcc tcatatagaa
     1081 gaacagcaaa agaaaattga atcatacctc cacaaccatt tcataggtga aggaatgacc
     1141 aagtatgact accttatgac cttgcatgga gttgtgaatg aaagcactgt ttgcctcatg
     1201 agttatgaaa gaagacagat tctccacctg atcaccatga tggctttgaa agtacttgga
     1261 gaactaaata ttctacccaa tacacaaaag gtaacttgct tttatcagcc tgctccgtac
     1321 tttgcagctg aggcaaggta ccctatttat gtaatacctg agccaccccc cgttagcttc
     1381 cagccatacc acccactgca ctttcgtgga tcaaatggta tgagttaaaa aatacacatg
     1441 caaccataga aactttgatt taattaaaca ccatttaaaa gcaagtttcc aaatgtaaaa
     1501 ttcaagatct gtttttattt ttgtacagtt accaattatt ttcaattaca gttgatggaa
     1561 tagtagttac caactatttt tgatcaatta agccatcata gtaaatacaa tatctataaa
     1621 ccaaccactt taaatgtttt tcaaacgtta ttgactagct ataataactt tcaaatgttg
     1681 tgttcccctt gaagtgattt tcaaatcttt tgactacttg tgactttcaa atttactgtg
     1741 acaaatatat tagagatgcc tgcatctttg actataacat aaaaggacag attcatgttt
     1801 taaaattaag atgtacagtg aagtatcaaa ttttttatat tcagtcagtt cctttgttac
     1861 atttagttct ttttttctat tgaacaatac catcaataaa tgttcagtac ttaacagaaa
     1921 tgcctaattt caaaagcaac agattcagaa gacattaaaa ccctggactt ttcaagcatt
     1981 tttttttgac aattaaattg ggttggatac aaaaatccta ctatagttta aaggaatact
     2041 ggaaaaaaat ggttctggaa agccctggac attagtaatt tgtcatctat ataataaaac
     2101 atttagttaa tttgtggatt tgaataacaa taccatacag ctgtgcaact actactgaga
     2161 tcagatacag ggttttttgc ccctcaaaat aagttaaaac gaatgaaaat gaccagctct
     2221 gaatgtgaaa gctttctatc atcatctact acaaagagac tctaaatggc aaacaggaaa
     2281 aaaacaggca gaggtttata gccatagcat ttaccatttt atggcttatt tgaaaaacat
     2341 ctttatgttg agaaacattc catttcagta agttaaaata ttttcattgt aactaaatga
     2401 agcaggtttt tcattttgcc tttaccaaag atcattttct aacatgccac tcaagtgcct
     2461 cttcgtgtga atttttgcgt aacactataa tttattcaac aactgtatac ctttacagta
     2521 tatctaaata tatacttact acatcgagta tactgctaga aaaatctacc agtgggatta
     2581 aaaatgtatt ttcttcccat aatgaaaata attcatgacc aatattacct gaagtgtcag
     2641 aagaggagct gtcttaaatt aatatggatc aggccattgg aaaacttcag tatttccact
     2701 tggttatgat tttttgtgag tttccatttc agtttttatt gaccatcacg ttttctatca
     2761 caacatgacc tgacagttgt atcccgataa tttgccagtt atagactgtg cttatcttca
     2821 ctgtattaca atattggaca gaagtacacc aaatacggca ttttcaaata accaatattt
     2881 ctgagatgtt ttataccaca gcacaagtgg ccatcagtat atttttaaag aattatatat
     2941 cacagaaccc tgaggcttta aaacactatg gacttaccac tttcttgaca aagaatttgt
     3001 aattacaata aaatatttag aaatgaaa
//
