LOCUS       NM_017709               5654 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens terminal nucleotidyltransferase 5C (TENT5C), mRNA.
ACCESSION   NM_017709
VERSION     NM_017709.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5654)
  AUTHORS   Ma,Y., Xing,X., Cheng,C., Kong,R., Sun,L., Zhao,F., Zhang,D. and
            Li,J.
  TITLE     Hsa-miR-1269a up-regulation fosters the malignant progression of
            esophageal squamous cell carcinoma via targeting FAM46C
  JOURNAL   Mutat Res 827, 111832 (2023)
   PUBMED   37467675
  REMARK    GeneRIF: Hsa-miR-1269a up-regulation fosters the malignant
            progression of esophageal squamous cell carcinoma via targeting
            FAM46C.
REFERENCE   2  (bases 1 to 5654)
  AUTHORS   Zhang,W., Wu,C., Geng,S., Wang,J., Yan,C., Zhang,X., Zhang,J.J.,
            Wu,F., Pang,Y., Zhong,Y., Wang,J., Fu,W., Huang,X., Wang,W.,
            Lyu,X., Huang,Y. and Jing,H.
  TITLE     FAM46C-mediated tumor heterogeneity predicts extramedullary
            metastasis and poorer survival in multiple myeloma
  JOURNAL   Aging (Albany NY) 15 (9), 3644-3677 (2023)
   PUBMED   37155154
  REMARK    GeneRIF: FAM46C-mediated tumor heterogeneity predicts
            extramedullary metastasis and poorer survival in multiple myeloma.
REFERENCE   3  (bases 1 to 5654)
  AUTHORS   Zhang,H., Zhang,S.H., Hu,J.L., Wu,Y.T., Ma,X.Y., Chen,Y., Yu,B.,
            Liao,S., Huang,H. and Gao,S.
  TITLE     Structural and functional characterization of multiple myeloma
            associated cytoplasmic poly(A) polymerase FAM46C
  JOURNAL   Cancer Commun (Lond) 41 (7), 615-630 (2021)
   PUBMED   34048638
  REMARK    GeneRIF: Structural and functional characterization of multiple
            myeloma associated cytoplasmic poly(A) polymerase FAM46C.
REFERENCE   4  (bases 1 to 5654)
  AUTHORS   Manfrini,N., Mancino,M., Miluzio,A., Oliveto,S., Balestra,M.,
            Calamita,P., Alfieri,R., Rossi,R.L., Sassoe-Pognetto,M., Salio,C.,
            Cuomo,A., Bonaldi,T., Manfredi,M., Marengo,E., Ranzato,E.,
            Martinotti,S., Cittaro,D., Tonon,G. and Biffo,S.
  TITLE     FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act
            in Concert to Impair Clearing of Protein Aggregates and Autophagy
  JOURNAL   Cancer Res 80 (21), 4693-4706 (2020)
   PUBMED   32963011
  REMARK    GeneRIF: FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors
            That Act in Concert to Impair Clearing of Protein Aggregates and
            Autophagy.
REFERENCE   5  (bases 1 to 5654)
  AUTHORS   Fucci,C., Resnati,M., Riva,E., Perini,T., Ruggieri,E.,
            Orfanelli,U., Paradiso,F., Cremasco,F., Raimondi,A.,
            Pasqualetto,E., Nuvolone,M., Rampoldi,L., Cenci,S. and Milan,E.
  TITLE     The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3
            Proteins Integrates Protein and Secretory Homeostasis
  JOURNAL   Cell Rep 32 (12), 108162 (2020)
   PUBMED   32966780
  REMARK    GeneRIF: The Interaction of the Tumor Suppressor FAM46C with p62
            and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
REFERENCE   6  (bases 1 to 5654)
  AUTHORS   Tanaka,H., Kanda,M., Shimizu,D., Tanaka,C., Kobayashi,D.,
            Hayashi,M., Iwata,N., Yamada,S., Fujii,T., Nakayama,G.,
            Sugimoto,H., Fujiwara,M., Niwa,Y. and Kodera,Y.
  TITLE     FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with
            Resectable Gastric Cancer
  JOURNAL   Ann Surg Oncol 24 (11), 3438-3445 (2017)
   PUBMED   27770343
  REMARK    GeneRIF: Reduced FAM46C mRNA expression levels were associated with
            Gastric Cancer.
REFERENCE   7  (bases 1 to 5654)
  AUTHORS   Zhang,Q.Y., Yue,X.Q., Jiang,Y.P., Han,T. and Xin,H.L.
  TITLE     FAM46C is critical for the anti-proliferation and pro-apoptotic
            effects of norcantharidin in hepatocellular carcinoma cells
  JOURNAL   Sci Rep 7 (1), 396 (2017)
   PUBMED   28341836
  REMARK    GeneRIF: Study shows that FAM46C, a tumor suppressor for
            hepatocellular carcinoma, is important for the anti-proliferation
            and proapoptotic effects of norcantharidin.
            Erratum:[Sci Rep. 2017 Dec 11;7(1):17576. doi:
            10.1038/s41598-017-17244-x.. PMID: 29230037]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5654)
  AUTHORS   Barbieri,M., Manzoni,M., Fabris,S., Ciceri,G., Todoerti,K.,
            Simeon,V., Musto,P., Cortelezzi,A., Baldini,L., Neri,A. and
            Lionetti,M.
  TITLE     Compendium of FAM46C gene mutations in plasma cell dyscrasias
  JOURNAL   Br J Haematol 174 (4), 642-645 (2016)
   PUBMED   26456599
  REMARK    GeneRIF: data strengthen the growing evidence that the FAM46C gene
            is involved in the pathogenesis of MM as a potential tumour
            suppressor, although its role remains to be clarified.
REFERENCE   9  (bases 1 to 5654)
  AUTHORS   Boyd,K.D., Ross,F.M., Walker,B.A., Wardell,C.P., Tapper,W.J.,
            Chiecchio,L., Dagrada,G., Konn,Z.J., Gregory,W.M., Jackson,G.H.,
            Child,J.A., Davies,F.E. and Morgan,G.J.
  CONSRTM   NCRI Haematology Oncology Studies Group
  TITLE     Mapping of chromosome 1p deletions in myeloma identifies FAM46C at
            1p12 and CDKN2C at 1p32.3 as being genes in regions associated with
            adverse survival
  JOURNAL   Clin Cancer Res 17 (24), 7776-7784 (2011)
   PUBMED   21994415
  REMARK    GeneRIF: Data indicate that when cases with FAM46C deletion or
            mutation were considered together, they were strongly associated
            with impaired overall survival (OS) in the intensive treatment
            setting.
REFERENCE   10 (bases 1 to 5654)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD300120.1, BC036516.2 and AL365331.9.
            
            On Nov 24, 2018 this sequence version replaced NM_017709.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.376579.1,
                                           SRR1660809.226558.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369448.4/ ENSP00000358458.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CD300120.1         93-97
            6-333               BC036516.2         1-328
            334-5654            AL365331.9         22214-27534
FEATURES             Location/Qualifiers
     source          1..5654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..5654
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="terminal nucleotidyltransferase 5C"
                     /db_xref="GeneID:54855"
                     /db_xref="HGNC:HGNC:24712"
                     /db_xref="MIM:613952"
     exon            1..106
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /inference="alignment:Splign:2.1.0"
     exon            107..5654
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1309
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /EC_number="2.7.7.19"
                     /note="protein FAM46C; putative nucleotidyltransferase
                     FAM46C; family with sequence similarity 46 member C;
                     non-canonical poly(A) polymerase FAM46C"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 5C"
                     /protein_id="NP_060179.2"
                     /db_xref="CCDS:CCDS896.1"
                     /db_xref="GeneID:54855"
                     /db_xref="HGNC:HGNC:24712"
                     /db_xref="MIM:613952"
                     /translation="MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTL
                     EITLKDIVQTVRSRLEEAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTE
                     AEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNK
                     NGKNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGD
                     FEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFI
                     DFPDILEQQRKLETYLQNHFAEEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLIS
                     LLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFSNYYVAHPPVTYSQPYPTWLPCN"
     regulatory      1890..1895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="hexamer: AATAAA"
     polyA_site      1920
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="major polyA site"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="hexamer: AATAAA"
     polyA_site      2058
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="major polyA site"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="hexamer: ATTAAA"
     polyA_site      2150
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
     polyA_site      2178
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
     regulatory      5631..5636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
                     /note="hexamer: AATAAA"
     polyA_site      5654
                     /gene="TENT5C"
                     /gene_synonym="FAM46C"
ORIGIN      
        1 ggctcactcg gtgccgctgc ctaggggctg tagaggtcgc gccgctcctg ctggggcctg
       61 cccacgccaa ggacctgcct ctgtcgcctc ctcttctatt gcccagtttc cccagccaga
      121 acatcccctg aagatggcag aggagagcag ctgtaccagg gattgcatgt ccttcagcgt
      181 gctcaactgg gatcaggtta gccggctgca tgaggtcctc actgaagttg tacctatcca
      241 cggacgaggc aactttccaa ccttggagat aactctgaag gacatcgtcc agaccgtccg
      301 cagtcggctg gaggaggcag gcatcaaagt gcacgacgtc cggctgaatg gctccgcagc
      361 tggccacgtt ttggtcaaag acaatggctt gggctgcaaa gacctggacc taatcttcca
      421 tgtggctctt ccaacagagg cagaatttca gctggttaga gatgtggttc tgtgttccct
      481 tctgaacttc ctgccagagg gtgtgaacaa gctcaaaatc agtccagtca ctctgaagga
      541 ggcatatgtg cagaagctag tgaaggtttg cacggacact gaccgctgga gcctgatctc
      601 cctctccaac aagaacggga agaacgtgga gctgaagttt gtcgactcca ttcggcgtca
      661 gtttgagttc agtgtggact ctttccaaat catcctggat tctttgcttt tcttctatga
      721 ctgttccaat aatcccatct ctgagcactt ccaccccacc gtgattgggg agagcatgta
      781 cggggacttt gaggaagctt ttgaccatct gcagaacaga ctgatcgcca ccaagaaccc
      841 agaagaaatc agaggcgggg gacttctcaa gtacagcaac cttcttgtgc gggacttcag
      901 gcccacagac caggaagaaa tcaaaactct agagcgctac atgtgctcca ggttcttcat
      961 cgacttcccg gacatccttg aacagcagag gaagttggag acttaccttc aaaaccactt
     1021 cgctgaagaa gagagaagca agtacgacta cctcatgatc cttcgcaggg tggtgaacga
     1081 gagcaccgtg tgtctcatgg ggcatgaacg caggcagact ctgaacctca tctccctcct
     1141 ggccttgcgt gtgctggcgg aacaaaacat catccccagt gccaccaacg tcacctgtta
     1201 ctaccagccg gccccttacg tcagtgatgg caacttcagc aactactacg ttgcccatcc
     1261 tccagtcacc tacagccagc cttaccctac ctggctgccc tgtaactaac cttgagacct
     1321 gagggtttcc acagtgggaa ccccaatagg gctagggctc tcaggtaggg gagcctcctt
     1381 ctagatgtag gcatttggct tttaaagggg aactcagctc tgattctgct tttttttttt
     1441 tttttccttt gtgtacccat tggaatgggt ctacagtgta tcatgagcca accctcaaag
     1501 gacccgtatt acagtgccac gttggaaaac gctacaggaa gcatgaccta tccacatctt
     1561 tccaagatag acactaacat gtcatgtccc aaacattagc acgtgggggt tgagctctgt
     1621 gcagtaatcg agattgggag aatttgggca gcgcgtgaga agtgctaagc tacttgtttt
     1681 ctcacttgag cccgggtagg ctgtgttggc cctcacttgg gattctcagc agttacatga
     1741 aagttgtgct gataatctct tctcttgtac caattttagt caggcagaaa atggtaaaca
     1801 tgagggtgct cttgtgactt aatttttgtt caagggacta aattgcttat gtttattccc
     1861 tgtcagcgga gtggagaatg tcattcatca ataaaccaaa gccaatagct ggagaattga
     1921 gatctggttg aaagtggttt atggtttaca tgctgtacta tcctgaggaa ttgcgagata
     1981 ttgctgaggg gaaaaaaaaa tgaccttttc ttgaaatgta acttgaaaac aaaataaaat
     2041 gtggaacata atgtttaatt agaattgtgg tggtggtagt ggaaggggat aattgtaaat
     2101 aggaaacatg aatgttcatt tttttcttta aagaattctt attaaatggc tccctgcctt
     2161 ttttttcttt tttcctcatc agctctttca tggctgaatt ttgttttatt cttcctaaga
     2221 ctgaggattg tgctgagtcc agagtcattg tggtaactga catgagggtc ttcccatgtt
     2281 ttaactggaa acccactttg gtcacattcc aagtatgaca cagctgttct tctggagtac
     2341 tttagctatt ttttgttttt gttcttttcg tttttttttt ttccaaaaat agtgacttcc
     2401 ttctccaggt gtgtttgaca gcaactcaat tcaggaattt cggtagaact gagtgacctg
     2461 tggaactgct ttagaatcta acctgctgtc ttcgtgctct gtgtgaaggg gaagctgggg
     2521 ggttagcatg aagtctggcc ttgtgtgcat tggagcttcc aaggcacttt gaaatcattc
     2581 cagtatattt gggaagaatt gagtgaatga gaatgctctt ccttattctg gtagatttga
     2641 cttgtttata attctgcact ttagaagaaa aacagtgtta atctgtagtt gaaagaaagc
     2701 ttagtagatg agagagttct aggctactgt ggctttttcc agtagattta gatgagatta
     2761 tgtgttttga aatgttttgt gggatccctt agaaagcatc acttcagggc agagacactc
     2821 aatattgcca gccagcttgg gttctaaagt gatttaatca aattcatgct cctgatcttt
     2881 tttttccccc ttcctttggc tatgaaaacc caaagcccgg agtgattgtt ttctccttgc
     2941 tttaagcagt gaagttatcc taatgcaaaa gagcttagta gaaaatgagt ggtttacctt
     3001 tttttctaaa agtatatttt caagtttatt ctggaatgtg atgtcttggt cctcttaaaa
     3061 gcagatcagc catgactgaa actcaaggct tagctggtat ctatgttgtg ctacattagg
     3121 tgactagaag ccacttctta gtgtaatcag ctcctgtttc cctgtgagcc ttagttatat
     3181 tttaattcag tggctttgag tcaaggccgg ttctaattga ggggacccag tgtgcttcag
     3241 tgttaagagt ggggcaatga agagtgaacc ccaatgaaga gtgatcccaa ctttggaaac
     3301 tatctggtca ttcatgacct taaaaagctg ccatggtggt caaatggcat gtgtttgcac
     3361 aaaaatgacc gatgtgttta accaaagctt tgaaatgtga tgaagccacc aacataagca
     3421 cttgcctaac agaaatcagt atttcttcta cttagaaggc ttggggccca gggtaatgag
     3481 gcaccagatg aagataagat ctgcatcaag gaattaaatt tccagtttgt ccttggggtt
     3541 ctttctgctt atgttttttc ccccccatct ggtaatagtc ctcttctgag aatgaaagga
     3601 ggcacagaag ttgcgagaaa gacccagtcc ccagtctttg ccaccattgc accatggttg
     3661 tctcggagtc ccttcacctg acctttttag tcagctcaga tctttttgta gtttgagaat
     3721 agacctattc aagagctatc agggttaaaa gctgcactga ccaaagctgt acttttaaaa
     3781 cacaacccct gggctagtga tgtctctact tgctctatga gccttttgcc agcctcagaa
     3841 taggcgaggt aaccttgaat ttcagggccc tggaaactct agctgaaacc tgcctttcct
     3901 aatgctcaca caagcaccag gtaccctgag cttatactga gtccagtggt tcctatttta
     3961 tgtgtgtgtg tatgtgtgtg tgttgagtaa catgaaactt ggcagtagca gagagcactg
     4021 aagttcacat gcaagttcta atctaaagtt aagcagtctc ttatttgttt cgggactctg
     4081 atttgactct ttttctgatg ctttcggcat gtctgcagcc tgttctccta gcctgctgct
     4141 tggagtcagg ttgagcatca gtgagatgaa gacagtacct tttcctctca cattggcaga
     4201 atagcacgca ctagatgcct gaccttgagc tctagtctcc cctttaaatc ttaccttggc
     4261 agtaacacat tattcctcat tcaataattt caatgctgaa actgaactct attactaatg
     4321 ccttccaatc agagttcctg atggggatgc ctgtgggatg gcccacacct gggggacctg
     4381 gcagatgggg tgagttgggt aaggaagatg atgcttagtt cctgatagat gctacagatg
     4441 tagtttggca tttcagtttt tgtccagttt gattttcact ggggtttgag tcacagcaag
     4501 ctgtgtatga acttgtgttt tgtggtgaca cattaataat caaattgcta aaaccctgaa
     4561 tctgcttatt cttcagcttc acctctgcac taacccctta cccttatggt acgtcaggat
     4621 tttaactagt actgctttgt tgactttggg aaatggtgcc actcaaaagc aacttcctaa
     4681 cttgaggaat aactcctttg tagtttactt tctggtactg gttggtgcct tgtattggga
     4741 tacagctata ttcttagctc aaatgtcctc tttttgagag caaagtagtt atccaatggt
     4801 gagacgagac cctgacgctc atagaggcca ttccttcctg ggtgtcggac cagggctctg
     4861 tgtcagggaa aaccttctgg gtggactttg taagaatcca gtttccaagg ttagattcac
     4921 atccttaatc ttgcagagac tagaatttca cagctcgctt tggaacatat tccaattcaa
     4981 ccagttaaaa tcagaggacc aagtcgtggg ggaggggggc ggtgttgagg agaggtattt
     5041 ttaaagatct ggcaactttt caggattatt tgtggagaac tctaaggtta agatcaggaa
     5101 ataaaagact gtgtgtgtgt gtgtgtgtgc gtgtgtgtgt tcaagtgcct aaatcttgtt
     5161 tacctatcac tttaaaaaaa taattgaagt gtaagctaaa taaaatgctt ggagttttgc
     5221 ctgggctagt gagagttggt gcaaattctt gtgtgtgttt gcataggaag gtgagatgac
     5281 catctactaa agaggaagta gctaaataca gatctgtggg tgtttttaaa aaaactcaac
     5341 ctatctggtg ttttatttta atggataaaa atgtaatttt tctaaggtag caacttattt
     5401 ccaaattaat atagatgaaa aatagatacc aattagacta aattgaaagc tttttgttct
     5461 atatttgcat agcctttgaa atatttctta gtgcctagga ggtctgggga ttcctctttc
     5521 gtggtggtca ctaaccttac ttgatgcaga taaaatcact tgtcaatgca aaatgtgtta
     5581 gaacttgata aagctttgag tttgagaaat aaaggtatat ttaaaattta aataaaactt
     5641 gtcatttatg ctca
//
