LOCUS       NM_052943               2382 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens terminal nucleotidyltransferase 5B (TENT5B), mRNA.
ACCESSION   NM_052943
VERSION     NM_052943.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Hu,J.L., Liang,H., Zhang,H., Yang,M.Z., Sun,W., Zhang,P., Luo,L.,
            Feng,J.X., Bai,H., Liu,F., Zhang,T., Yang,J.Y., Gao,Q., Long,Y.,
            Ma,X.Y., Chen,Y., Zhong,Q., Yu,B., Liao,S., Wang,Y., Zhao,Y.,
            Zeng,M.S., Cao,N., Wang,J., Chen,W., Yang,H.T. and Gao,S.
  TITLE     FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase
            essential in human embryonic stem cells
  JOURNAL   Nucleic Acids Res 48 (5), 2733-2748 (2020)
   PUBMED   32009146
  REMARK    GeneRIF: FAM46B is uniquely and highly expressed in human
            pre-implantation embryos and pluripotent stem cells, but sharply
            down-regulated following differentiation.
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Liang,T., Ye,X., Liu,Y., Qiu,X., Li,Z., Tian,B. and Yan,D.
  TITLE     FAM46B inhibits cell proliferation and cell cycle progression in
            prostate cancer through ubiquitination of beta-catenin
  JOURNAL   Exp Mol Med 50 (12), 1-12 (2018)
   PUBMED   30532005
  REMARK    GeneRIF: these data show that FAM46B inhibits cell proliferation
            and cell cycle progression in PC through ubiquitination of
            beta-catenin
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Menezes,M.R., Balzeau,J. and Hagan,J.P.
  TITLE     3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and
            Disease
  JOURNAL   Front Mol Biosci 5, 61 (2018)
   PUBMED   30057901
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2382)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2382)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   8  (bases 1 to 2382)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   9  (bases 1 to 2382)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356390.24, CN311438.1 and BC014160.2.
            
            On Nov 22, 2018 this sequence version replaced NM_052943.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012790.2, SRR1803613.217523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289166.6/ ENSP00000289166.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL356390.24        21589-21596
            9-14                CN311438.1         1-6
            15-2382             BC014160.2         1-2368
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2382
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /note="terminal nucleotidyltransferase 5B"
                     /db_xref="GeneID:115572"
                     /db_xref="HGNC:HGNC:28273"
                     /db_xref="MIM:619069"
     exon            1..444
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1458
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /EC_number="2.7.7.19"
                     /note="protein FAM46B; putative nucleotidyltransferase
                     FAM46B; family with sequence similarity 46 member B;
                     non-canonical poly(A) polymerase FAM46B"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 5B"
                     /protein_id="NP_443175.2"
                     /db_xref="CCDS:CCDS294.2"
                     /db_xref="GeneID:115572"
                     /db_xref="HGNC:HGNC:28273"
                     /db_xref="MIM:619069"
                     /translation="MMPSESGAERRDRAAAQVGTAAATAVATAAPAGGGPDPEALSAF
                     PGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPTLSVQPRQIVQVVRSTLEEQGLHVH
                     SVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEASFQLTKAVVLACLLDFLPAGVS
                     RAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGKNVELKFVDSVRRQFEFSIDS
                     FQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEALEHLRHRVIATRSPEEIRG
                     GGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVEQRRTLERYLEAHFGGA
                     DAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALAEQGPAATAALAWRP
                     PGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN"
     exon            445..2382
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2361..2366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /note="hexamer: AATAAA"
     polyA_site      2382
                     /gene="TENT5B"
                     /gene_synonym="FAM46; FAM46B"
                     /note="major polyA site"
ORIGIN      
        1 aggcgctagg gtcggttagt cgtcgccgtc tgaggtgttc cctggctttg tctcgccgtc
       61 gttgccgccc cgtccctgcc ttcgtgcccc ccgccttggc ccctgcccag ccgctctccc
      121 tgtcctcctc cccttaacca cccccacggt ttctgccgtc ggggcccggg ggccgggcgg
      181 atgatgccgt cggagagcgg agctgagcgc agggaccggg cggctgctca ggtggggacg
      241 gctgcggcca cggcggtggc cacggcagcc ccggcaggcg gcggccccga cccggaggcc
      301 ttatcggcct tccccggacg gcacctgagt gggctgagct ggccacaggt gaagcgactg
      361 gacgctcttc tgagcgagcc gattcccatt cacgggcgcg gcaacttccc cacgctgagc
      421 gtgcagcccc ggcagatcgt gcaggtggtc cgcagcaccc tggaggagca gggactacat
      481 gtgcacagtg tgcggctgca tggttcagct gccagccacg tgctgcaccc tgagagtggc
      541 ctgggctaca aggatctgga cctggtgttc cgggtggacc tgcgcagtga ggcatccttc
      601 cagctgacca aggcagtggt gctggcctgc ctactagact tcctgccggc cggtgtgagc
      661 cgggccaaga tcacgccact gacactcaag gaggcatacg tgcagaagct ggtgaaagtg
      721 tgcacagact cggaccgctg gagcctcatc tcactgtcca acaagagcgg caagaacgtg
      781 gagctcaagt ttgtggactc ggtgagacgc cagtttgaat tcagcataga ctccttccag
      841 atcatcctgg actccctgtt gctctttggc cagtgctcgt ccactcccat gtctgaggcc
      901 ttccacccaa cggtcacagg cgaaagcctg tacggggact tcaccgaggc cctggagcac
      961 ctgcggcacc gtgtcatcgc cacgcgcagt cccgaggaga tccgaggtgg tggcctcctc
     1021 aagtactgcc acctcctggt gcggggcttc cggccccggc ccagcaccga tgtgcgcgcc
     1081 ctgcagcgct acatgtgctc ccgcttcttc atcgactttc cagacctggt ggagcagcgg
     1141 cgcaccctag agcgctacct ggaggcccac ttcggtgggg cagatgcagc ccgccgttac
     1201 gcctgcctgg tgacactgca ccgggtggtc aacgagagca ccgtgtgcct catgaaccac
     1261 gagcgccgcc agacgctgga cctcattgcc gcactggcgc tgcaggcact ggctgagcag
     1321 ggcccagctg ccactgccgc cctggcctgg cgccctccag gcactgacgg ggttgtgcca
     1381 gccactgtca attactacgt gacccccgtg caacctctcc tggctcacgc ctatcccacc
     1441 tggctgcctt gtaactgact cagaccctgg ccagaaggga agggactggg cctcacgggg
     1501 tggggtgggg cctccaagag tgtgtggagg acatgaccag aggcgcagaa tgtgccagga
     1561 ggcccagcac tgcagggttg ggcctttgat tgaacagacc agactttccc gagcacgagg
     1621 cccctgtggg cttaatgcca gcctggggct ctcagcagga ggaccctttg gttattgcat
     1681 cacacttttg gaccagcatg ccggtggggt gcaggcgcca tttgtcttgg aagtcaattt
     1741 ccttcaggag acaaagcaag tttggggtgg tagccttaat gcccagcacc ttggattgat
     1801 tcccatggtc taagagggtc tttttgacta aggccagcct gtggtgatcc cagcagcttt
     1861 ggagggcctg cagcccacac actgactgat acatggtatg ttacagggac ttgtcacttt
     1921 ggatcaggct gggccactac agggcctgat gggccaactt gggtaatcac tgggaggagg
     1981 gaaactgagg cccgaggcag atacctgggt ttggggaggg ctgggtttag cccggttctc
     2041 tgaactacat acccccagct gtgaagcctt cctcttgagg ggttgaggtg ggcagtatac
     2101 aggagccaag cagcccaggg tgggtcgcag cccaggcccc ttccagggtg ccactccttt
     2161 cccccttgtg ttgcaaggag ccctcctgcc tgggagcttg ttctttggaa ggtgctgagc
     2221 ctgaatttgc cacagtcaag tcaacgttcc caccccactg gcttggttac agggctctca
     2281 catggggtag gggagccata ctcccacccc cttgcgtatt cccctgggtt tgttgatatt
     2341 ttgcactctt aacacctgcc aataaagacg gtctacactg aa
//
