LOCUS       NM_006999               5030 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens terminal nucleotidyltransferase 4A (TENT4A),
            transcript variant 1, mRNA.
ACCESSION   NM_006999 XM_005248234
VERSION     NM_006999.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Li,Y., Misumi,I., Shiota,T., Sun,L., Lenarcic,E.M., Kim,H.,
            Shirasaki,T., Hertel-Wulff,A., Tibbs,T., Mitchell,J.E.,
            McKnight,K.L., Cameron,C.E., Moorman,N.J., McGivern,D.R.,
            Cullen,J.M., Whitmire,J.K. and Lemon,S.M.
  TITLE     The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA
            synthesis
  JOURNAL   Proc Natl Acad Sci U S A 119 (28), e2204511119 (2022)
   PUBMED   35867748
  REMARK    GeneRIF: The ZCCHC14/TENT4 complex is required for hepatitis A
            virus RNA synthesis.
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Swain,U., Friedlander,G., Sehrawat,U., Sarusi-Portuguez,A.,
            Rotkopf,R., Ebert,C., Paz-Elizur,T., Dikstein,R., Carell,T.,
            Geacintov,N.E. and Livneh,Z.
  TITLE     TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage
            Tolerance via Multiple Pathways That Are Mutated in Endometrial
            Cancer
  JOURNAL   Int J Mol Sci 22 (13), 6957 (2021)
   PUBMED   34203408
  REMARK    GeneRIF: TENT4A Non-Canonical Poly(A) Polymerase Regulates
            DNA-Damage Tolerance via Multiple Pathways That Are Mutated in
            Endometrial Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Shukla,S., Jeong,H.C., Sturgeon,C.M., Parker,R. and Batista,L.F.Z.
  TITLE     Chemical inhibition of PAPD5/7 rescues telomerase function and
            hematopoiesis in dyskeratosis congenita
  JOURNAL   Blood Adv 4 (12), 2717-2722 (2020)
   PUBMED   32559291
  REMARK    GeneRIF: Chemical inhibition of PAPD5/7 rescues telomerase function
            and hematopoiesis in dyskeratosis congenita.
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Kim,D., Lee,Y.S., Jung,S.J., Yeo,J., Seo,J.J., Lee,Y.Y., Lim,J.,
            Chang,H., Song,J., Yang,J., Kim,J.S., Jung,G., Ahn,K. and Kim,V.N.
  TITLE     Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs
            via mixed tailing
  JOURNAL   Nat Struct Mol Biol 27 (6), 581-588 (2020)
   PUBMED   32451488
  REMARK    GeneRIF: Viral hijacking of the TENT4-ZCCHC14 complex protects
            viral RNAs via mixed tailing.
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
            Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
            Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
            Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
            Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
            Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
            Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
            Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
            Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
            Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
            Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
            Campbell,H. and Schmitz,G.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
            EUROSPAN consortium
  TITLE     Genome-wide association study identifies novel loci associated with
            circulating phospho- and sphingolipid concentrations
  JOURNAL   PLoS Genet 8 (2), e1002490 (2012)
   PUBMED   22359512
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Jarjanazi,H., Kiefer,J., Savas,S., Briollais,L., Tuzmen,S.,
            Pabalan,N., Ibrahim-Zada,I., Mousses,S. and Ozcelik,H.
  TITLE     Discovery of genetic profiles impacting response to chemotherapy:
            application to gemcitabine
  JOURNAL   Hum Mutat 29 (4), 461-467 (2008)
   PUBMED   18330920
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   Carson,D.R. and Christman,M.F.
  TITLE     Evidence that replication fork components catalyze establishment of
            cohesion between sister chromatids
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8270-8275 (2001)
   PUBMED   11459963
  REMARK    Review article
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Wang,Z., Castano,I.B., De Las Penas,A., Adams,C. and Christman,M.F.
  TITLE     Pol kappa: A DNA polymerase required for sister chromatid cohesion
  JOURNAL   Science 289 (5480), 774-779 (2000)
   PUBMED   10926539
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Walowsky,C., Fitzhugh,D.J., Castano,I.B., Ju,J.Y., Levin,N.A. and
            Christman,M.F.
  TITLE     The topoisomerase-related function gene TRF4 affects cellular
            sensitivity to the antitumor agent camptothecin
  JOURNAL   J Biol Chem 274 (11), 7302-7308 (1999)
   PUBMED   10066793
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122710.3, KC424495.1,
            BC084567.1, BC143882.1, AK289857.1 and AB005754.3.
            
            On Nov 22, 2018 this sequence version replaced NM_006999.5.
            
            Summary: The protein encoded by this gene is a DNA polymerase that
            is likely involved in DNA repair. In addition, the encoded protein
            may be required for sister chromatid adhesion. Alternatively
            spliced transcript variants that encode different isoforms have
            been described. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF089896.1, BC084567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230859.8/ ENSP00000230859.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               AC122710.3         35515-36126
            613-1240            KC424495.1         1-628
            1241-2093           BC084567.1         1-853
            2094-2094           BC143882.1         839-839
            2095-3191           BC084567.1         855-1951
            3192-3333           AK289857.1         2021-2162
            3334-5030           AB005754.3         2069-3765
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..5030
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /note="terminal nucleotidyltransferase 4A"
                     /db_xref="GeneID:11044"
                     /db_xref="HGNC:HGNC:16705"
                     /db_xref="MIM:605198"
     exon            1..1268
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..2931
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /EC_number="2.7.7.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     topoisomerase-related function protein 4-1; polymerase
                     (DNA directed) sigma; terminal uridylyltransferase 5; DNA
                     polymerase sigma; poly(A) RNA polymerase D7,
                     non-canonical; DNA polymerase kappa; PAP-associated
                     domain-containing protein 7; TRAMP-like complex
                     polyadenylate polymerase; non-canonical poly(A) RNA
                     polymerase PAPD7; terminal guanylyltransferase"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 4A isoform 1"
                     /protein_id="NP_008930.2"
                     /db_xref="CCDS:CCDS3871.2"
                     /db_xref="GeneID:11044"
                     /db_xref="HGNC:HGNC:16705"
                     /db_xref="MIM:605198"
                     /translation="MDPRVAWIQPEQKGPANALWMQIWETSQGVGRGGSGFASYFCLN
                     SPALDTAAAAGAAGRGSGGLGPALPAASPPPPGPTAPAALPPALLTALGPAAEGARRL
                     HKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGGGRGGAFFNFADGAPSAP
                     GTANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLNYLLSGSRAAALSGGGGPG
                     AQAPRPGTPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLW
                     PTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDK
                     ATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRD
                     LNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTG
                     IRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAY
                     IVLSHAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRI
                     KIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSASSVSSLSGSDVDSDT
                     PPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPPPT
                     LGVAPVPCRQAGVEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGS
                     HGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR"
     exon            1269..1392
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1439
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1560
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1668
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1797
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2011
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2138
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2239
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2412
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2571
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2736
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..5030
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5013..5018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /note="hexamer: AATAAA"
     polyA_site      5030
                     /gene="TENT4A"
                     /gene_synonym="LAK-1; LAK1; PAPD7; POLK; POLS; TRF4;
                     TRF4-1; TRF41; TUTASE5"
                     /note="major polyA site"
ORIGIN      
        1 cttcccccgc gctgtcgccg ccgagagtgt cttttcaccg ccgccgccgc cgccgccgca
       61 ggagcgccga gccagcggcg cgagcgtgac tgagggctag ccgcacgggc ggcggcgcct
      121 cccgcgggtc cttcagccgc tcggcgcctg ggcccgcccc ctcggccccg ccgcccgccc
      181 ttctccgatg gcctctcccc gcggcccgag tggaacgccg ccgccgccgc ggcccccgcg
      241 cccgccccgc gccgcgtgaa gcgggagccc ggagaccgca gccgcccgct gggacgcgcc
      301 aagcgccgga gccgcccgcc gcggcctgcc ggggcccatc accgccgccg ccgccccacg
      361 ccggagcccg acgggagcgc ggctagagca ggaggccggg gctcggcccg cccgccgccg
      421 ccgccgccgc cgccgccacc ggcccaggcc cgtccgtccg tccgtgcgcg cgcggccggg
      481 cctcggggcg cggcgggggc ggggccgcgt cggggcgggc gggcgcgcgg gccccgcggg
      541 ggcggcgcgt ggatggatcc gcgcgtggcc tggatccagc ccgagcagaa ggggccggcc
      601 aatgccctgt ggatgcagat ctgggagacc tcgcagggcg tgggccgcgg cggctcgggc
      661 ttcgcgtcct atttctgcct caactcgccg gcgctggaca cggcggccgc ggcgggggcg
      721 gccgggcggg gcagtggcgg cctgggcccc gcgctgcccg ccgcgtcgcc cccgccgccc
      781 ggccccaccg cgcccgccgc gctgcccccc gcgctgctga cggcgctggg gcccgcggcc
      841 gagggcgcgc ggcgcttgca caagtcgccg tcgctgtcgt cctcgtcgtc gtcctcctcg
      901 tccaacgcgg agtcgggcac cgagagcccc ggctgctcgt cgtcgtcctc cagcagcgcc
      961 tcgctgggcc ggccgggcgg cggccgcggc ggcgccttct tcaacttcgc cgacggcgcg
     1021 cccagcgccc ctggcacagc caacgggcac cccgggccgc gcggccccgc gcccgccggc
     1081 tccccgtcgc agcaccagtt ccacccgggt cgccggaaac gcgagaacaa ggccagcacc
     1141 tacggcctca actacctgct gtccggcagc cgcgcggccg ctctcagcgg agggggcggc
     1201 cccggggccc aggcgccgcg gcccggcacc ccgtggaaga gccgcgcgta cagcccgggc
     1261 atccagggac tacatgagga aataattgac ttttataact tcatgtcccc ttgtcctgaa
     1321 gaagcagcta tgagaagaga ggtggtgaaa cggatcgaaa ctgtggtgaa agacctttgg
     1381 ccgacggctg atgtacagat atttggcagc tttagtacag gtctttatct tccaactagc
     1441 gacatagacc tggtggtctt cgggaaatgg gagcgtcctc ctttacagct gctggagcaa
     1501 gccctgcgga agcacaacgt ggctgagccg tgttccatca aagtccttga caaggctacg
     1561 gtaccaataa taaagctcac agatcaggag actgaagtga aagttgacat cagctttaac
     1621 atggagacgg gcgtccgggc agcggagttc atcaagaatt acatgaagaa atattcattg
     1681 ctgccttact tgattttagt attgaaacag ttccttctgc agagggacct gaatgaagtt
     1741 tttacaggtg gaattagctc atacagccta attttaatgg ccattagctt tctacagttg
     1801 catccaagaa ttgatgcccg gagagctgat gaaaaccttg gaatgcttct tgtagaattt
     1861 tttgaactct atgggagaaa ttttaattac ttgaaaaccg gtattagaat caaagaagga
     1921 ggtgcctata tcgccaaaga ggagatcatg aaagccatga ccagcgggta cagaccgtcg
     1981 atgctgtgca ttgaggaccc cctgctgcca gggaatgacg ttggccggag ctcctatggc
     2041 gccatgcagg tgaagcaggt cttcgattat gcctacatag tgctcagcca tgctgtgtca
     2101 ccgctggcca ggtcctatcc aaacagagac gccgaaagta ctttaggaag aatcatcaaa
     2161 gtaactcagg aggtgattga ctaccggagg tggatcaaag agaagtgggg cagcaaagcc
     2221 cacccgtcgc caggcatgga cagcaggatc aagatcaaag agcgaatagc cacatgcaat
     2281 ggggagcaga cgcagaaccg agagcccgag tctccctatg gccagcgctt gactttgtcg
     2341 ctgtccagcc cccagctcct gtcttcaggc tcctcggcct cttctgtgtc ttcactttct
     2401 gggagtgacg ttgattcaga cacaccgccc tgcacaacgc ccagtgttta ccagttcagt
     2461 ctgcaagcgc cagctcctct catggccggc ttacccaccg ccttgccaat gcccagtggc
     2521 aaacctcagc ccaccacttc cagaacactg atcatgacaa ccaacaatca gaccaggttt
     2581 actatacctc caccgaccct aggggttgct cctgttcctt gcagacaagc tggtgtagaa
     2641 ggaactgcgt ctttgaaagc cgtccaccac atgtcttccc cggccattcc ctcagcgtcc
     2701 cccaacccgc tctcgagccc tcatctgtat cataagcagc acaacggcat gaaactgtcc
     2761 atgaagggct ctcacggcca cacccaaggc ggcggctaca gctctgtggg tagcggaggt
     2821 gtgcggcccc ctgtgggcaa caggggacac caccagtata accgcaccgg ctggaggagg
     2881 aaaaaacaca cacacacacg ggacagtctg cccgtgagcc tcagcagata atggctcctg
     2941 gctgcgtcag cctcccccac ccctctgcag actgccccgc ggcctcggcc accggcaggg
     3001 gaaccgagac cagcaccccg cacgtcagcc gggctcgcgg cacgcccgcc gctgatcact
     3061 ctgcatgttt cttcgtgtgg tggtcgcgtc catcttcaag aacagctcgt tgtgctcatc
     3121 tgtgaagcct tattaaacgt ggacgttgtt ttctgccttc ccaggattct tccttcagtg
     3181 ctgaggcagg tcgggctcag gaactgcagg gacgtgaaca tgcgcttgcg gtttgaggta
     3241 gccgtgtctg ttccttcgcg gtttgctatt ttcatttcct gttcgtcaaa gcagcagagg
     3301 agatcaaacc ccgttcgtgt gtctttcctc cacggataag cttgggaggt cattgtttta
     3361 ctgccctcac attttgtttg aaatttcaga actgtttttc tatgtaaata ttgaaaactt
     3421 atgatttgtg caataactca gatatttttt atttaatttc ctattttcac ataagttata
     3481 tttaagggag gagggaattt tttttaaaca agcttaggtc ctttcccgag ctgcattttc
     3541 taagttgggt catcgtgtcg gctggttgtc tgacgagcat cgttacaaac accatgatga
     3601 ggggtttggg gttttatttt gatgtctttt cttttggtcg gaagtgagtg aaggagccag
     3661 gtcgccctga aggttttcca aagggcttgg ctccagagcc acctggcaga ctgcccgtgg
     3721 ccctgctgtc gggccccagg ccgttgtcct gctctgacca cagagtttta atgttttggt
     3781 tttcacttct tttaaactgg acaacaaatc cagcatttca agtgccagaa gtataacttt
     3841 ctaaggagag aagggttgtc acattataaa atctttagga aaatgtgaac tggaaaacgc
     3901 ttcggtcagt tttagtgaca tagcctgtga tgatgggtct ggtgactatt attgcggacc
     3961 gtggtaccca gttttaggaa tgtggagaaa ggaattctgt tgattccgtt gaggaatctg
     4021 tagcgtatgc attcgttctg ttaagagcaa atctaggaga agtgcttcag ctgcccagtg
     4081 cgccgtgggg agtgttttaa cggatcgtgt cgcaggagag cacagcccag cgttggggcc
     4141 gggaccgctg gcgcccgacg tcggaagcat acaggtatac tatgcaagtg tattctgcca
     4201 caacaaccac tgtctttgtt accttttttt gaacaagaat atatccatcc tgcctaaccc
     4261 tgagtttttg gagcaccaca gttgtcctgg gagttggttg catcttgtag gccatctgac
     4321 ttcctgtttt taaaacgggg gtctggtctt gctaaacact acaggtaggt tggtctttga
     4381 agtccactag tggagaatgt caagacaaga tacttattac catgacatct gatgcatgtg
     4441 cagcagtggg gagttctaga ttgatctctg aatgtgatcg acgcccagca aggacaagct
     4501 ttaaaatgtc tgcggtctgc ccttttgaag caggactggc tcactctgtc attgggagct
     4561 gtcagctgcg actgcaggtt ctctaggagg cattccagaa tagagtagca cactgtgtct
     4621 gcagttctcg atgaccgaaa gttatcaaaa atatttaaaa tatttaaatt gtgaacctat
     4681 tgataaagaa tatttataaa aactgatctg taggcctgta ctaatctcta cgcattagca
     4741 atattgactg taaacccaca ttaaggaaac cactacgggt ctggcagtgc gtgtcccgtg
     4801 gggtgtgcat tttaaaactc gattcataga cacaggtacc atgttccatt tccgtcatgg
     4861 tgaagcaaat gaattggcct ggctaccact gtggtcgcgt gctacaggtt tgacaaaaag
     4921 atatcatgtt tcgatttttt tgtgtgtgga caacaatatg gaagctaaaa ttgacatatt
     4981 tttatgtaaa gtttttctat tctttgattt ttaataaact ttggaaacca
//
