LOCUS       NM_001114394            5100 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens terminal nucleotidyltransferase 2 (TENT2), transcript
            variant 1, mRNA.
ACCESSION   NM_001114394
VERSION     NM_001114394.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5100)
  AUTHORS   Yang,A., Bofill-De Ros,X., Stanton,R., Shao,T.J., Villanueva,P. and
            Gu,S.
  TITLE     TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and
            abundance
  JOURNAL   Nat Commun 13 (1), 5260 (2022)
   PUBMED   36071058
  REMARK    GeneRIF: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence
            and abundance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5100)
  AUTHORS   Inagaki,H., Hosoda,N. and Hoshino,S.I.
  TITLE     DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic
            polyadenylation machinery
  JOURNAL   Biochem Biophys Res Commun 553, 9-16 (2021)
   PUBMED   33756349
  REMARK    GeneRIF: DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic
            polyadenylation machinery.
REFERENCE   3  (bases 1 to 5100)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5100)
  AUTHORS   Hojo,H., Yashiro,Y., Noda,Y., Ogami,K., Yamagishi,R., Okada,S.,
            Hoshino,S.I. and Suzuki,T.
  TITLE     The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2
            for 3' adenylation and selective stabilization of microRNA-122
  JOURNAL   J Biol Chem 295 (2), 390-402 (2020)
   PUBMED   31792053
  REMARK    GeneRIF: The RNA-binding protein QKI-7 recruits the poly(A)
            polymerase GLD-2 for 3' adenylation and selective stabilization of
            microRNA-122.
REFERENCE   5  (bases 1 to 5100)
  AUTHORS   Chung,C.Z., Balasuriya,N., Manni,E., Liu,X., Li,S.S., O'Donoghue,P.
            and Heinemann,I.U.
  TITLE     Gld2 activity is regulated by phosphorylation in the N-terminal
            domain
  JOURNAL   RNA Biol 16 (8), 1022-1033 (2019)
   PUBMED   31057087
  REMARK    GeneRIF: The data demonstrate a novel phosphorylation-dependent
            mechanism to regulate Gld2 activity, revealing tumour suppressor
            miRNAs(miR-122) as a previously unknown target of Akt1-dependent
            signalling
REFERENCE   6  (bases 1 to 5100)
  AUTHORS   Wyman,S.K., Knouf,E.C., Parkin,R.K., Fritz,B.R., Lin,D.W.,
            Dennis,L.M., Krouse,M.A., Webster,P.J. and Tewari,M.
  TITLE     Post-transcriptional generation of miRNA variants by multiple
            nucleotidyl transferases contributes to miRNA transcriptome
            complexity
  JOURNAL   Genome Res 21 (9), 1450-1461 (2011)
   PUBMED   21813625
REFERENCE   7  (bases 1 to 5100)
  AUTHORS   Qi,L., Menzaghi,C., Salvemini,L., De Bonis,C., Trischitta,V. and
            Hu,F.B.
  TITLE     Novel locus FER is associated with serum HMW adiponectin levels
  JOURNAL   Diabetes 60 (8), 2197-2201 (2011)
   PUBMED   21700879
REFERENCE   8  (bases 1 to 5100)
  AUTHORS   Glahder,J.A., Kristiansen,K., Durand,M., Vinther,J. and Norrild,B.
  TITLE     The early noncoding region of human papillomavirus type 16 is
            regulated by cytoplasmic polyadenylation factors
  JOURNAL   Virus Res 149 (2), 217-223 (2010)
   PUBMED   20144904
  REMARK    GeneRIF: The authors show that the human CPEB1 can repress the
            activity of the reporter construct containing the HPV-16 early
            sequences. This repression can be counteracted by a human
            cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1.
REFERENCE   9  (bases 1 to 5100)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   10 (bases 1 to 5100)
  AUTHORS   Kwak,J.E., Wang,L., Ballantyne,S., Kimble,J. and Wickens,M.
  TITLE     Mammalian GLD-2 homologs are poly(A) polymerases
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4407-4412 (2004)
   PUBMED   15070731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA803910.1, AL833136.1, AK095818.1, BC047581.1, AC008482.5,
            AW302247.1 and DB302918.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001114394.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2771499.1,
                                           SRR14372079.1162415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453514.6/ ENSP00000397563.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               DA803910.1         29-152
            125-995             AL833136.1         132-1002
            996-2403            AK095818.1         623-2030
            2404-3502           BC047581.1         2117-3215
            3503-4363           AC008482.5         14534-15394         c
            4364-4849           AW302247.1         33-518              c
            4850-4968           DB302918.1         131-249             c
            4969-4969           AC008482.5         13928-13928         c
            4970-5097           DB302918.1         2-129               c
            5098-5100           AC008482.5         13797-13799         c
FEATURES             Location/Qualifiers
     source          1..5100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..5100
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /note="terminal nucleotidyltransferase 2"
                     /db_xref="GeneID:167153"
                     /db_xref="HGNC:HGNC:26776"
                     /db_xref="MIM:614121"
     exon            1..635
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..809
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..2127
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /EC_number="2.7.7.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     poly(A) RNA polymerase GLD2; TUTase 2; terminal
                     uridylyltransferase 2; PAP-associated domain-containing
                     protein 4; PAP associated domain containing 4; poly(A) RNA
                     polymerase D4, non-canonical"
                     /codon_start=1
                     /product="poly(A) RNA polymerase GLD2 isoform 1"
                     /protein_id="NP_001107866.1"
                     /db_xref="CCDS:CCDS4048.1"
                     /db_xref="GeneID:167153"
                     /db_xref="HGNC:HGNC:26776"
                     /db_xref="MIM:614121"
                     /translation="MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQN
                     ADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTV
                     VNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQI
                     LELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCL
                     VVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCV
                     EFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLV
                     LMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLL
                     GFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQK
                     FDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR"
     exon            810..899
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1137
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1252
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1344
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1423
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1493
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1570
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1699
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1743
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1880
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1972
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2052
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..5100
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /note="hexamer: AATAAA"
     polyA_site      3495
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /note="major polyA site"
     regulatory      5072..5077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
                     /note="hexamer: AATAAA"
     polyA_site      5100
                     /gene="TENT2"
                     /gene_synonym="APD4; GLD2; PAPD4; TUT2"
ORIGIN      
        1 atccggggtc acgtcggtct tccgggtgtc tttgacaggg ttttctacgc cgctttttcg
       61 gcgacttttt gctcttccgc tttttgccac cgcccccaac cttctatatc cttgcagccc
      121 ctaccttttc ttgtgttgct cctcccctgg cagccgtgag gggggttaga tctcagccgg
      181 agccggagct gggcctagct gtcccacggg ccaccactac ctcctttggt tcgggagaaa
      241 gctacgacca agtacgccca gctcgggcct tagaacttct gaacgggcag tgcgggtagg
      301 ccctgcttag cccttcccgg aggacacctg tgagtttagg gggtttcgga gaggaacgca
      361 gcagtgtagg cccaggtcgg cggcggggca cgggaaactt ttccgaaacg gtagcgtttt
      421 gttttgcgtg ggaggttcca gcagtatctc ttggttattc caaatttatg ggcggcatct
      481 gggctgctgt acattttgaa gaatcttagg accgcttact ttgcttactc gttttctatt
      541 cctcgcgtac tgcctcgtcc accactccag gaccaaaaga ggaagatagt cttgggaccc
      601 ttgcatggtg tttcaaaggg tggtgaagaa ctaaggtaga agaatacatg ttcacttcca
      661 gtgaacaaga gcatgttccc aaactcaatt ttgggtcgcc cacccttcac tccaaatcat
      721 caacaacata ataacttctt taccctgtca cctactgttt attcacacca gcagcttata
      781 gatgcacaat tcaactttca gaatgcagac ttgtctagag ctgtgtcatt acagcagctg
      841 acatatggaa atgtcagtcc aatacagacc tcagcttccc cattatttcg aggaaggaag
      901 agattaagcg atgaaaaaaa ccttcctctt gacggtaaac ggcaacgttt ccattcaccc
      961 caccaagagc caactgtagt taaccagata gtgcctttat caggtgaacg aagatactca
     1021 atgccaccat tgtttcatac acattatgta ccagatatag tcagatgtgt tccacctttt
     1081 cgagaaattg catttttaga acctagagaa atcacactgc ctgaggccaa agataagttg
     1141 agtcagcaga tactggagtt atttgaaaca tgtcagcagc aaataagtga tttaaagaag
     1201 aaagaactct gtcgaacaca gctgcagaga gaaattcagc tgttatttcc acaaagcaga
     1261 ctttttttgg ttgggtcctc tttaaatgga tttggtaccc ggagcagtga tggtgattta
     1321 tgcctagttg ttaaggaaga accatgtttt tttcaggtaa atcagaagac tgaagcacgg
     1381 catatactca ccttagtcca taaacacttc tgtactagac tttcgggcta cattgagaga
     1441 cctcagctga ttcgagcaaa agtgccaatt gtgaagttca gggataaagt cagttgtgtg
     1501 gagtttgact tgaatgtaaa caatattgtt ggaataagaa acacattcct tctcagaact
     1561 tatgcatacc ttgaaaatcg agttcgtccg ttagtgctgg tgattaagaa gtgggcaagt
     1621 caccatcaga taaatgatgc cagtcgtggt actttaagca gctatagtct tgtattgatg
     1681 gttttgcact atttacaaac cctacctgaa cccatccttc catccctcca aaaaatttac
     1741 ccagagtctt ttagtcctgc tatacagctg caccttgtac atcaagctcc atgtaatgtt
     1801 cctccttacc tctcaaagaa tgaatcaaac cttggggacc tcttactggg ctttcttaaa
     1861 tattatgcta cagaatttga ctggaatagt caaatgattt cagttcgtga agccaaagcc
     1921 attccaaggc ctgatggtat tgaatggaga aataaataca tctgtgtaga agaacctttt
     1981 gatggaacaa atacagccag agcagtgcac gaaaagcaga aatttgatat gatcaaggat
     2041 caatttttaa agtcatggca cagattgaaa aacaagagag atttgaacag tatactacct
     2101 gtaagagctg ctgtcctgaa aagataactg gcctctattt cttaataaat tcttccaaga
     2161 aataaagaac aatagtttca tcataataca ttatgtttac ctccatcata gttgcttttt
     2221 tcatagttct tgttttcatg ttttattttt aaaaagacat ataaagattg catattttat
     2281 tatgacattt cctaataaac ccctttgatt taaaaatgta tttttaaaaa tgtttacatt
     2341 gatgatgagt aatattgcat gtgttttcag gtgatcagat aaaatatatt ttgggaaatt
     2401 aactgaacaa ataaaaagtt tttgatataa cttcaattaa ttgtaccaca tgctaatcct
     2461 gaagagatgt gtagaatttt ggaaagggtc taattcatac atgcttaaag tataacctac
     2521 gttagatagt ttgttgtcaa agtctgttct agtaaagtga agattcaagt cagttgttca
     2581 gttacttgaa gcaaaacgaa atctttcatt tcagtcaaat cactgcagtc atgaaatact
     2641 gaacaattgc cttaagtctt tgcttgactc actgggatag actgaggctt tgggtgtgtc
     2701 tgtattagca tttcattagt acttcacatg cttttgatgt actcttgaga ttgctttaaa
     2761 ttttgtattg aaacaacaat acattttgca ctgtagtaat gggagcacta actcttacaa
     2821 cagttagtga atcgttttaa agaatcagtt cagtgtagac attttgaaaa gattgtttcc
     2881 tgtgctttac gatagcttag tgcaatgtgc acttctgttt tacttgccat tttcctgctc
     2941 tgttttctct gtgacatgaa gcaacagaaa ctgagatcaa agttaagatt atatcctgtt
     3001 tgtagtatca gatatttttc tgtgtacaat tataggattg taatctaaac tggaattttt
     3061 aggcagtaag tcaccacaaa atgttttaga taagacacaa taaaattatt ataaataaaa
     3121 gcttaatgtt tgtaaaaaat ctctttttta gtatttcttt tttcacatga aagaagtggt
     3181 ggctgctaaa aaaaaagcta cagtgtttat taagggtctt tttgatttat gtaaatattt
     3241 gtaaattggt cagtgcctgt aaatttaaat ataaaaagta accttgaaaa cagttttaac
     3301 tttttcaaaa gaactatgtc caacattttt tagacctgct gtagtacagt tttgtacctc
     3361 taacgtattt tttttttgca gaccaaatgc taaaactttt gcttttcttt gacttgtaaa
     3421 aggtgcacat tttcattttc ttccttaagt tcaaattttt gtatgatgtc aaatgcaata
     3481 aaatttatat atggacattg ttgaggtgcc ttttttttct gtgaaaatct ttgctttgag
     3541 atgagaccga ggctgtagtt atcatctaga actgaactaa atctacttat tagccagcta
     3601 acgacatcaa tatcttatgt ctctggcatt atgaggaatg aaagtttaca catagtgaat
     3661 tttttagatt cctgatgtgt aacacttttt atgcatttga gcttttcata ttttgggggg
     3721 gaatttttcc taaaatttac actgtgcatc tcttaatcag aatgtactga gtagagttaa
     3781 tattctagtg atgactgggt aatcattata agcattagtc atagtactat tcagtaatac
     3841 tgtgcaactt tcagggatgg gtaagtatgt accctctgcc tctacagtat tatgacattt
     3901 cctaataaaa ccccagaatt taccatggtg tgggttcctt cactgtcact gttttctcag
     3961 ttttcagtgg ccccacactt actactgctt ttctttgttt taccacgaaa aacagatcaa
     4021 gaagtcacta aacttagacc caattctata tcagtagact gaggcctgaa attatgcaca
     4081 cataactggc caaatatcag ataagtgaac tgttaatata tgagagaatt ttctggactt
     4141 ttaagttatt aatctcaatt atttgtgtgg tgagtactaa attattttct gtttgtgttg
     4201 atctgtccat ttctgtatat agttgtccct cagtatattg agggattgat tccaggtcaa
     4261 ccccgtcctc ttcagatacc aaaatccaca gatactcaag tcccttatat aaaatggtgt
     4321 agtgtttgca tatatcctac acacattctc ttgatacttt aaatcatctc taaattacct
     4381 gatacgtaat acaatgtaaa tgctatgtaa atagttgtta tactgtattg tttagggaat
     4441 aataatgaca agacaaaaag tctatacctg ttcggtacag atgcaaccat tctgcctcct
     4501 ccctaccccc tcccaaatat ttttcatcct ggttgaattc acaaatccta catggttacg
     4561 gagggttgac tgtatttgca tatgttgtta aagtggtgtt taaaatgtgc aatctgtact
     4621 acaattctaa attttggatt gatttgaact aggatctttg caaataaatc tcatagacat
     4681 taatgtttgt aagaaatttt taattaaatg atggaaggaa catagaatgg ctacctgtga
     4741 ttttgattag tgtttaacag attgccacag ctgtgattga attccttttg tactggatga
     4801 gcatggtcat ttgggattac tgatggtgaa gtctagctgg tgttaagaga ataaatattg
     4861 ctgatgctaa acctggttta gtgagctgtg gaagccttga ctctgctgtt ttccctcctt
     4921 atgccccact agctgatgta tctgtactgt aattcaatga tttacagttc attacctcca
     4981 gacataatgc atgcatacca gctcgtgtaa ctggtgaata atccccagct tacagtcata
     5041 tttaacaact ctgtgacttg ctataattaa aaataaatgt taactcttct agccatcaaa
//
