LOCUS       NM_001080477           10923 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens teneurin transmembrane protein 3 (TENM3), transcript
            variant 1, mRNA.
ACCESSION   NM_001080477 NM_018104 XM_371717
VERSION     NM_001080477.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10923)
  AUTHORS   Upadhyai,P., Shenoy,P.U., Banjan,B., Albeshr,M.F., Mahboob,S.,
            Manzoor,I. and Das,R.
  TITLE     Exome-Wide Association Study Reveals Host Genetic Variants Likely
            Associated with the Severity of COVID-19 in Patients of European
            Ancestry
  JOURNAL   Life (Basel) 12 (9), 1300 (2022)
   PUBMED   36143338
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10923)
  AUTHORS   Glessner,J.T., Chang,X., Mentch,F., Qu,H., Abrams,D.J., Thomas,A.,
            Sleiman,P.M.A. and Hakonarson,H.
  TITLE     COVID-19 in pediatrics: Genetic susceptibility
  JOURNAL   Front Genet 13, 928466 (2022)
   PUBMED   36051697
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10923)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   4  (bases 1 to 10923)
  AUTHORS   Xu,X., Wang,B., Chen,Y., Zhou,W. and Li,L.
  TITLE     Replicative verification of susceptibility genes previously
            identified from families with segregating developmental dysplasia
            of the hip
  JOURNAL   Ital J Pediatr 47 (1), 140 (2021)
   PUBMED   34174923
  REMARK    GeneRIF: Replicative verification of susceptibility genes
            previously identified from families with segregating developmental
            dysplasia of the hip.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10923)
  AUTHORS   Takano,I., Takeshita,N., Yoshida,M., Seki,D., Oyanagi,T.,
            Kimura,S., Jiang,W., Sasaki,K., Sogi,C., Kawatsu,M. and
            Takano-Yamamoto,T.
  TITLE     Ten-m/Odz3 regulates migration and differentiation of chondrogenic
            ATDC5 cells via RhoA-mediated actin reorganization
  JOURNAL   J Cell Physiol 236 (4), 2906-2919 (2021)
   PUBMED   32960451
  REMARK    GeneRIF: Ten-m/Odz3 regulates migration and differentiation of
            chondrogenic ATDC5 cells via RhoA-mediated actin reorganization.
REFERENCE   6  (bases 1 to 10923)
  AUTHORS   Williamson,K.A. and FitzPatrick,D.R.
  TITLE     The genetic architecture of microphthalmia, anophthalmia and
            coloboma
  JOURNAL   Eur J Med Genet 57 (8), 369-380 (2014)
   PUBMED   24859618
  REMARK    Review article
REFERENCE   7  (bases 1 to 10923)
  AUTHORS   Aldahmesh,M.A., Mohammed,J.Y., Al-Hazzaa,S. and Alkuraya,F.S.
  TITLE     Homozygous null mutation in ODZ3 causes microphthalmia in humans
  JOURNAL   Genet Med 14 (11), 900-904 (2012)
   PUBMED   22766609
  REMARK    GeneRIF: Null mutation in ODZ3 causes autosomal recessive
            microphthalmia in humans.
REFERENCE   8  (bases 1 to 10923)
  AUTHORS   Young,T.R. and Leamey,C.A.
  TITLE     Teneurins: important regulators of neural circuitry
  JOURNAL   Int J Biochem Cell Biol 41 (5), 990-993 (2009)
   PUBMED   18723111
  REMARK    Review article
REFERENCE   9  (bases 1 to 10923)
  AUTHORS   Ben-Zur,T., Feige,E., Motro,B. and Wides,R.
  TITLE     The mammalian Odz gene family: homologs of a Drosophila pair-rule
            gene with expression implying distinct yet overlapping
            developmental roles
  JOURNAL   Dev Biol 217 (1), 107-120 (2000)
   PUBMED   10625539
REFERENCE   10 (bases 1 to 10923)
  AUTHORS   Ben-Zur,T. and Wides,R.
  TITLE     Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
            chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
            chromosome Xq25
  JOURNAL   Genomics 58 (1), 102-103 (1999)
   PUBMED   10331952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131943.1, AF195420.1,
            AB040888.2, AC079226.7 and AK001336.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080477.3.
            
            Summary: This gene encodes a member of the teneurin transmembrane
            protein family. The encoded protein may be involved in the
            regulation of neuronal development including development of the
            visual pathway. Mutations in this gene have been associated with
            microphthalmia and developmental dysplasia of the hip. [provided by
            RefSeq, Jan 2023].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: HM005508.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142853, SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related       :: locus in the vicinity of
                                         disease-associated variant(s)
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000511685.6/ ENSP00000424226.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC131943.1         49398-49426
            30-1451             AF195420.1         30-1451
            1452-3728           AB040888.2         572-2848
            3729-3729           AC079226.7         106207-106207
            3730-6317           AB040888.2         2850-5437
            6318-8578           AK001336.1         1354-3614
            8579-10923          AC079226.7         163518-165862
FEATURES             Location/Qualifiers
     source          1..10923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.3-q35.1"
     gene            1..10923
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="teneurin transmembrane protein 3"
                     /db_xref="GeneID:55714"
                     /db_xref="HGNC:HGNC:29944"
                     /db_xref="MIM:610083"
     exon            1..75
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            76..382
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..8250
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     teneurin-3; ODZ3-like protein; tenascin-M3; protein Odd
                     Oz/ten-m homolog 3; odz, odd Oz/ten-m homolog 3;
                     testicular tissue protein Li 195"
                     /codon_start=1
                     /product="teneurin-3 isoform 1"
                     /protein_id="NP_001073946.1"
                     /db_xref="CCDS:CCDS47165.1"
                     /db_xref="GeneID:55714"
                     /db_xref="HGNC:HGNC:29944"
                     /db_xref="MIM:610083"
                     /translation="MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSS
                     ETLKAFDHDSSRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCEPATRRGLAFCAE
                     MGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDT
                     EHENKSDSENEQPASNQGQSTLQPLPPSHKQHSAQHHPSITSLNRNSLTNRRNQSPAP
                     PAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASG
                     SVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLF
                     GLNWQLQQTENDTFENGKVNSDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGELDIGR
                     RAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLD
                     GSRLIAREQRSLLETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFN
                     TIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLC
                     FSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGV
                     CIHGECHCSPGWGGSNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICS
                     VDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTI
                     EGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDP
                     DCCLQSSCQNQPYCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGE
                     SPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGASLT
                     LVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLS
                     TFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKITMTQSIIPFN
                     LMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESC
                     LDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVV
                     SSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRRIFPSGNVT
                     SVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGE
                     QCLPFDEARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGS
                     NDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIAA
                     GRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDG
                     EISLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIR
                     IRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYLYNFSYSNDND
                     ITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTY
                     HGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSR
                     EEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGT
                     ANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTK
                     TEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVD
                     YDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARH
                     TMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSE
                     ILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIFRFSEDGMVNAR
                     FDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAV
                     MTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEY
                     DVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQYR
                     LDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQF
                     FYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVF
                     SSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRW
                     TTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIP
                     GFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRA
                     GGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAFYLENLH
                     FTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADV
                     EMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGE
                     KRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIGRR"
     exon            383..661
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..899
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1138
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1261
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1476
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1687
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1789
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1984
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2185
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2371
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2518
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2735
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2855
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3117
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3385
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3529
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3779
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..4012
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4167
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..5042
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5218
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5219..5454
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5455..5751
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            5752..7363
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            7364..7494
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     exon            7495..10923
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9008..9013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="hexamer: AATAAA"
     polyA_site      9029
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="major polyA site"
     regulatory      10903..10908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="hexamer: AATAAA"
     polyA_site      10923
                     /gene="TENM3"
                     /gene_synonym="MCOPCB9; MCOPS15; ODZ3; ten-3; Ten-m3;
                     TEN3; TNM3"
                     /note="major polyA site"
ORIGIN      
        1 atcgcacctg gccatgaagg cttttagatg ggtctggagc ttggaggaga agtctgaact
       61 aaggataaac taaagagagg ccaatgagac ttgaaccctg agcctaagtt gtcaccagca
      121 ggactgatgt gcacacagaa ggaatgaagt atggatgtga aagaacgcag gccttactgc
      181 tccctgacca agagcagacg agagaaggaa cggcgctaca caaattcctc cgcagacaat
      241 gaggagtgcc gggtacccac acagaagtcc tacagttcca gcgagacatt gaaagctttt
      301 gatcatgatt cctcgcggct gctttacggc aacagagtga aggatttggt tcacagagaa
      361 gcagacgagt tcactagaca aggacagaat tttaccctaa ggcagttagg agtttgtgaa
      421 ccagcaactc gaagaggact ggcattttgt gcggaaatgg ggctccctca cagaggttac
      481 tctatcagtg cagggtcaga tgctgatact gaaaatgaag cagtgatgtc cccagagcat
      541 gccatgagac tttggggcag gggggtcaaa tcaggccgca gctcctgcct gtcaagtcgg
      601 tccaactcag ccctcaccct gacagatacg gagcacgaaa acaagtccga cagtgagaat
      661 gagcaacctg caagcaatca aggccagtct accctgcagc ccttgccgcc ttcccataag
      721 cagcactctg cacagcatca tccatccatc acttctctca acagaaactc cctgaccaat
      781 agaaggaacc agagtccggc cccgccggct gctttgcccg ccgagctgca aaccacaccc
      841 gagtccgtcc agctgcagga cagctgggtc cttggcagta atgtaccact ggaaagcagg
      901 catttcctat tcaaaacagg aacaggtaca acgccactgt tcagtactgc aaccccagga
      961 tacacaatgg catctggctc tgtttattca ccacctactc ggccactacc tagaaacacc
     1021 ctatcaagaa gtgcttttaa attcaagaag tcttcaaagt actgtagctg gaaatgcact
     1081 gcactgtgtg ccgtaggggt ctcggtgctc ctggcaatac tcctgtctta ttttatagca
     1141 atgcatctct ttggcctcaa ctggcagcta cagcagactg aaaatgacac atttgagaat
     1201 ggaaaagtga attctgatac catgccaaca aacactgtgt cattaccttc tggagacaat
     1261 ggaaaattag gtggatttac gcaagaaaat aacaccatag attccggaga acttgatatt
     1321 ggccgaagag caattcaaga gattcctccc gggatcttct ggagatcaca gctcttcatt
     1381 gatcagccac agtttcttaa attcaatatc tctcttcaga aggatgcatt gattggagta
     1441 tatggccgga aaggcttacc gccttcccat actcagtatg acttcgtgga gctcctggat
     1501 ggcagcaggc tgattgccag agagcagcgg agcctgcttg agacggagag agccgggcgg
     1561 caggcgagat ccgtcagcct tcatgaggcc ggctttatcc agtacttgga ttctggaatc
     1621 tggcatctgg ctttttataa tgatgggaaa aatgcagagc aggtgtcttt taataccatt
     1681 gttatagagt ctgtggtgga atgtccccga aattgccatg gaaatggaga atgcgtttct
     1741 ggaacttgcc attgttttcc aggatttctg ggtccggatt gttcaagagc cgcctgtcca
     1801 gtgttatgta gtggcaacgg gcagtactcc aagggccgct gcctgtgttt cagcggctgg
     1861 aagggcaccg agtgtgatgt gccgactacc cagtgtattg acccacagtg tgggggtcgt
     1921 gggatttgta tcatgggctc ttgtgcttgc aactcaggat acaaaggaga aagttgtgaa
     1981 gaagctgact gtatagaccc tgggtgttct aatcatggtg tgtgtatcca cggggaatgt
     2041 cactgcagtc caggatgggg aggtagcaat tgtgaaatac tgaagaccat gtgtccagac
     2101 cagtgctccg gccacggaac gtatcttcaa gaaagtggct cctgcacgtg tgaccctaac
     2161 tggactggcc cagactgctc aaacgaaata tgttctgtgg actgtggctc acacggcgtt
     2221 tgcatggggg ggacgtgtcg ctgtgaagaa ggctggacgg gcccagcctg taatcagaga
     2281 gcctgccacc cccgctgtgc cgagcacggg acctgcaagg atggcaagtg tgaatgcagc
     2341 cagggctgga atggagagca ctgcactatc gagggttgtc ctggtctgtg caacagcaat
     2401 ggaagatgta ccctggacca aaatggctgg cattgtgtgt gccagcctgg atggagagga
     2461 gcaggctgtg acgtagccat ggagactctt tgcacagata gcaaggacaa tgaaggagat
     2521 ggactcattg actgcatgga tcccgattgc tgcctacaga gttcctgcca gaatcagccc
     2581 tattgtcggg gactgccgga tcctcaggac atcattagcc aaagccttca atcgccttct
     2641 cagcaagctg ccaaatcctt ttatgatcga atcagtttcc ttataggatc tgatagcacc
     2701 catgttatac ctggagaaag tcctttcaat aagagccttg catctgtcat cagaggccaa
     2761 gtactgactg ctgatggaac tccacttatt ggagtaaatg tctcgttttt ccattaccca
     2821 gaatatggat atactattac ccgccaggac ggaatgtttg acttggtggc aaatggtggg
     2881 gcctctctaa ctttggtatt tgaacgatcc ccattcctca ctcagtatca tactgtgtgg
     2941 attccatgga atgtctttta tgtgatggat accctagtca tgaagaaaga agagaatgac
     3001 attcccagct gtgatctgag tggattcgtg aggccaaatc ccatcattgt gtcatcacct
     3061 ttatccacct ttttcagatc ttctcctgaa gacagtccca tcattcccga aacacaggta
     3121 ctccacgagg aaactacaat tccaggaaca gatttgaaac tctcctactt gagttccaga
     3181 gctgcagggt ataagtcagt tctcaagatc accatgaccc agtctattat tccatttaat
     3241 ttaatgaagg ttcatcttat ggtagctgta gtaggaagac tcttccaaaa gtggtttcct
     3301 gcctcaccaa acttggccta tactttcata tgggataaaa cagatgcata taatcagaaa
     3361 gtctatggtc tatctgaagc tgttgtgtca gttggatatg agtatgagtc gtgtttggac
     3421 ctgactctgt gggaaaagag gactgccatt ctgcagggct atgaattgga tgcgtccaac
     3481 atgggtggct ggacattaga taaacatcac gtgctggatg tacagaacgg tatactgtac
     3541 aagggaaacg gggaaaacca gttcatctcc cagcagcctc cagtcgtgag tagcatcatg
     3601 ggcaatgggc gaaggcgcag catttcctgc cccagttgca atggtcaagc tgatggtaac
     3661 aagttactgg ccccagtggc gctagcttgt gggatcgatg gcagtctgta cgtaggcgat
     3721 ttcaactatg tgcggcggat attcccttct ggaaatgtaa caagtgtctt agaactaagc
     3781 agcaacccag ctcatagata ctaccttgca acggatccag tcacgggaga tctgtacgtt
     3841 tctgacacaa acacccgcag aatttatcgc ccaaagtcac ttacgggggc aaaagacttg
     3901 actaaaaatg cagaagtcgt cgcagggaca ggggagcaat gccttccgtt tgacgaggcg
     3961 agatgtgggg atggagggaa ggccgtggaa gccacactca tgagtcccaa aggaatggca
     4021 gttgataaga atggattaat ctactttgtt gatggaacca tgattaggaa agttgaccaa
     4081 aatggaatca tatcaactct tctgggctct aacgatttga cttcagccag acctttaact
     4141 tgtgacacca gcatgcacat cagccaggta cgtctggaat ggcccactga cctagccatt
     4201 aaccctatgg ataactccat ttatgtcctg gataataatg tagttttaca gatcactgaa
     4261 aatcgtcaag ttcgcattgc tgctggacgg cccatgcact gtcaggttcc cggagtggaa
     4321 tatcctgtgg ggaagcacgc ggtgcagaca acactggaat cagccactgc cattgctgtg
     4381 tcctacagtg gggtcctgta cattactgaa actgatgaga agaaaattaa ccggataagg
     4441 caggtcacaa cagatggaga aatctcctta gtggccggaa taccttcaga gtgtgactgc
     4501 aaaaatgatg ccaactgtga ctgttaccag agtggagatg gctacgccaa ggatgccaaa
     4561 ctcagtgccc catcctccct ggctgcttct ccagatggta cactgtatat tgcagatcta
     4621 gggaatatcc ggatccgggc tgtgtcaaag aataagcctt tacttaactc tatgaacttc
     4681 tatgaagttg cgtctccaac tgatcaagaa ctctacatct ttgacatcaa tggtactcac
     4741 caatatactg taagtttagt cactggtgat tacctttaca attttagcta cagcaatgac
     4801 aatgatatta ctgctgtgac agacagcaat ggcaacaccc ttagaattag acgggaccca
     4861 aatcgcatgc cagttcgagt ggtgtctcct gataaccaag tgatatggtt gacaatagga
     4921 acaaatggat gtttgaaaag catgactgct caaggactgg aattagtttt gtttacttac
     4981 catggcaata gtggcctttt agccactaaa agtgatgaaa ctggatggac aacgtttttt
     5041 gactatgaca gtgaaggtcg tctgacaaat gttacgtttc caactggagt ggtcacaaac
     5101 ctgcatgggg acatggacaa ggctatcaca gtggacattg agtcatctag ccgagaagaa
     5161 gatgtcagca tcacttcaaa tctgtcctcg atcgattctt tctacaccat ggttcaagat
     5221 cagttaagaa acagctacca gattggttat gacggctccc tcagaattat ctacgccagt
     5281 ggcctggact cacactacca aacagagccg cacgttctgg ctggcaccgc taatccgacg
     5341 gttgccaaaa gaaacatgac tttgcctggc gagaacggtc aaaacttggt ggaatggaga
     5401 ttccgaaaag agcaagccca agggaaagtc aatgtctttg gccgcaagct cagggttaat
     5461 ggcagaaacc tcctttcagt tgactttgat cgaacaacaa agacagaaaa gatctatgac
     5521 gaccaccgta aatttctact gaggatcgcc tacgacacgt ctgggcaccc gactctctgg
     5581 ctgccaagca gcaagctgat ggccgtcaat gtcacctatt catccacagg tcaaattgcc
     5641 agcatccagc gaggcaccac tagcgagaaa gtagattatg acggacaggg gaggatcgtg
     5701 tctcgggtct ttgctgatgg taaaacatgg agttacacat atttagaaaa gtccatggtt
     5761 cttctgcttc atagccagcg gcagtacatc ttcgaatacg atatgtggga ccgcctgtct
     5821 gccatcacca tgcccagtgt ggctcgccac accatgcaga ccatccgatc cattggctac
     5881 taccgcaaca tatacaaccc cccggaaagc aacgcctcca tcatcacgga ctacaacgag
     5941 gaagggctgc ttctacaaac agctttcttg ggtacaagtc ggagggtctt attcaaatac
     6001 agaaggcaga ctaggctctc agaaatttta tatgatagca caagagtcag ttttacctat
     6061 gatgaaacag caggagtcct aaagacagta aacctccaga gtgatggttt tatttgcacc
     6121 attagataca ggcaaattgg tcccctgatt gacaggcaga ttttccgctt tagtgaagat
     6181 gggatggtaa atgcaagatt tgactatagc tatgacaaca gctttcgagt gaccagcatg
     6241 cagggtgtga tcaatgaaac gccactgcct attgatctgt atcagtttga tgacatttct
     6301 ggcaaagttg agcagtttgg aaagtttgga gttatatatt atgatattaa ccagatcatt
     6361 tctacagctg taatgaccta tacgaagcac tttgatgctc atggccgtat caaggagatt
     6421 caatatgaga tattcaggtc gctcatgtac tggattacaa ttcagtatga taacatgggt
     6481 cgggtaacca agagagagat taaaataggg ccctttgcca acaccaccaa atatgcttat
     6541 gaatatgatg ttgatggaca gctccaaaca gtttacctca atgaaaagat aatgtggcgg
     6601 tacaactacg atctgaatgg aaacctccat ttactgaacc caagtaacag tgcgcgtctg
     6661 acaccccttc gctatgacct gcgagacaga atcactcgac tgggtgatgt tcaatatcgg
     6721 ttggatgaag atggtttcct acgtcaaagg ggcacggaaa tctttgaata tagctccaag
     6781 gggcttctaa ctcgagttta cagtaaaggc agtggctgga cagtgatcta ccgttatgac
     6841 ggcctgggaa ggcgtgtttc tagcaaaacc agtctaggac agcacctgca gtttttttat
     6901 gctgacttaa cttatcccac taggattact catgtctaca accattcgag ttcagaaatt
     6961 acctccctgt attatgatct ccaaggacat ctttttgcca tggaaatcag cagtggggat
     7021 gaattctata ttgcatcgga taacacaggg acaccactgg ctgtgttcag tagcaatggg
     7081 cttatgctga aacagattca gtacactgca tatggggaaa tctattttga ctctaatatt
     7141 gactttcaac tggtaattgg atttcatggt ggcctgtatg acccactcac caaattaatc
     7201 cactttggag aaagagatta tgacattttg gcaggacggt ggacaacacc tgacatagaa
     7261 atctggaaaa gaattgggaa ggacccagct ccttttaact tgtacatgtt taggaataac
     7321 aaccctgcaa gcaaaatcca tgacgtgaaa gattacatca cagatgttaa cagctggctg
     7381 gtgacatttg gtttccatct gcacaatgct attcctggat tccctgttcc caaatttgat
     7441 ttaacagaac cttcttacga acttgtgaag agtcagcagt gggatgatat accgcccatc
     7501 ttcggagtcc agcagcaagt ggcgcggcag gccaaggcct tcctgtcgct ggggaagatg
     7561 gccgaggtgc aggtgagccg gcgccgggcc ggcggcgcgc agtcctggct gtggttcgcc
     7621 acggtcaagt cgctgatcgg caagggcgtc atgctggccg tcagccaggg ccgcgtgcag
     7681 accaacgtgc tcaacatcgc caacgaggac tgcatcaagg tggcggccgt gctcaacaac
     7741 gccttctacc tggagaacct gcacttcacc atcgagggca aggacacgca ctacttcatc
     7801 aagaccacca cgcccgagag cgacctgggc acgctgcggt tgaccagcgg ccgcaaggcg
     7861 ctggagaacg gcatcaacgt gacggtgtcg cagtccacca cggtggtgaa cggcaggacg
     7921 cgcaggttcg cggacgtgga gatgcagttc ggcgcgctgg cgctgcacgt gcgctacggc
     7981 atgaccctgg acgaggagaa ggcgcgcatc ctggagcagg cgcggcagcg cgcgctcgcc
     8041 cgggcctggg cgcgcgagca gcagcgcgtg cgcgacggcg aggagggcgc gcgcctctgg
     8101 acggagggcg agaagcggca gctgctgagc gccggcaagg tgcagggcta cgacgggtac
     8161 tacgtactct cggtggagca gtaccccgag ctggccgaca gcgccaacaa catccagttc
     8221 ctgcggcaga gcgagatcgg caggaggtaa cgcccgggcc gcgcccgccg agccgctcac
     8281 gccctgccca cattgtcctg tggcacaacc cgagtgggac tctccaacgc ccaagagcct
     8341 tcctcccggg ggaatgagac tgctgttacg acccacaccc acaccgcgaa aacaaggacc
     8401 gcttttttcc gaatgacctt aaaggtgatc ggctttaacg aatatgttta catatgcata
     8461 gcgctgcact cagtcggact gaacgtagcc agaggaaaaa aaaatcatca aggacaaagg
     8521 cctcgacctg ttgcgctggg ccgtctgttc cttctaggca ctgtatttaa ctaactttaa
     8581 aaaagaaaaa aaaatgtgta cagtgtttcc aaatagtccc gaattgtcga cctttgctta
     8641 caagaagtag tctgtctgca taggatgtga tagctatctc tgttcatttt acaatgtggg
     8701 gcaaagttac tgtttctaga caacccaact gctttccctg tgcagctttg tagaaggaca
     8761 ttggcacagt gacttctgcg gcggggattt attaatggat tttacaatgc taacgtggtt
     8821 tcccttcggg gaaaaaactg gcaactagaa tccttgtcac tgataagcaa aggaaatcct
     8881 gatttttttg taaattatgt gagacaagtt gtttatggat ttttatatga attacaattt
     8941 actgtacatc aaatcttagt ctcagaggag ttaatttatg taaagtgttt aaaaatttat
     9001 acttaaaaat aaaatgataa aaacgtgaac tgtgtgattt ttttaaaagg attgcacctt
     9061 ttgttatctg ttatagctgt acagtatgaa ttattatatt gtagagatat aacaacttat
     9121 gcctataatg tccagaagtg ttaatatttt tgtattaggt tgaaaaaatg tgcaagcttc
     9181 tatcactaga tggataggac cgtgcaattc taggtgggtg gcgaatcaga gagctccttt
     9241 ctcttccctc tctcacgcat caggccagtg tcctcagcat tgtcaactga gaggcacagt
     9301 agacaactag ggctggtgga atgtaaggga agaagattga aaaaacggga ggaagggttc
     9361 tctggccctc tctcaacctt gcaagtcaat ggggagttgt tgatataatt aaccccgagg
     9421 tttttactgt tactgttcca aagctctgtc tcttgatgga ggagagacca catcagatgc
     9481 tggggaaata ggaggaggaa aggttctgat gtagtcgtga tcctaaacac gtgtcttaag
     9541 atctaggaaa gacagcagaa accgagcagt ggtgggtgag ccagatggag ccggtcaggg
     9601 ttactctaag cccacatgac caaaccatct tggggggctg gtttgaatga cagcctctgc
     9661 tctgtctcgg ggaagccggg ggtggcagat ccagctggaa gtgaactgac agccgcgccc
     9721 tcctgcacac atgcatgcac gcgtgtggga acgagcccag ccgccatctg cacttccgtg
     9781 tcggctcagc tctgacaaat ctctttcctg agcactaaat tcagccacga aaatattttt
     9841 agaagatatt tctcagttca tcgagctata gtacacactg ttttcctcta tgtataatgg
     9901 tgataaaata tagcaagtga acatgtcgta aatataaagg ttcaagtgat gtattgaaaa
     9961 taattttcta actgctttgt atgtatcaca tactctaaat tgcacagtag gcgtgtttat
    10021 taaacagatg attggctggg aaagtttcaa aatagctact gaatttacag tatcagtgct
    10081 attactgtct ttgtgtattt ggtagagcat accgaagtaa ttaatcttct aatgaatgct
    10141 gatgatattt tattagaatg aaagcacaga ttagcattaa tattttttat tctggaaatc
    10201 ctttggcaag tattatgaag cccaaattta gaaaactatg agatttcaaa ccacataaac
    10261 atgattctgt tttccatttt attttttaac tgttaggtat ttgcagttct gttccgtgga
    10321 acttctgcag gcctgtattt agcatgctgt aagtactttt gggtgaaata ggctctgagt
    10381 ctaaattctc agacatgttt ctgatgtatt accatgaaaa gcttgtgcca catgacagaa
    10441 gtgagatcat agtcttaacc tcttcttgac gtggactggt cttcactcgg gcaccgataa
    10501 ataacagatt tggagtatct cctggtgctt attttagatg atgaagtcaa atcaacccaa
    10561 ttagtgtcct gttagtaggt ataatgagcc tatttctttc taaaaagact tgtgatctgg
    10621 acatgctttt acaagaaata gtgaccttgg ggaatatgta aacaaaagac ctttttctaa
    10681 gagttgggag ggggtggggg actgtataat gaaaagaatt agcttacaaa aaagaaattg
    10741 atattcaaag tattttaggc aaagccagtc aaaatgcttt catgatattt tgagatgtaa
    10801 attttgtctg atttgtattg ttcttttcat ttgccttctt aactttatat gtgacctgaa
    10861 ttttccataa cttgatgact atagattgca cctaggcatt ccaataaaag ccaacccaat
    10921 gtg
//
