LOCUS       NM_001113324             974 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TEN1 subunit of CST complex (TEN1), mRNA.
ACCESSION   NM_001113324
VERSION     NM_001113324.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Takai,H., Aria,V., Borges,P., Yeeles,J.T.P. and de Lange,T.
  TITLE     CST-polymerase alpha-primase solves a second telomere
            end-replication problem
  JOURNAL   Nature 627 (8004), 664-670 (2024)
   PUBMED   38418884
  REMARK    GeneRIF: CST-polymerase alpha-primase solves a second telomere
            end-replication problem.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Zaug,A.J., Goodrich,K.J., Song,J.J., Sullivan,A.E. and Cech,T.R.
  TITLE     Reconstitution of a telomeric replicon organized by CST
  JOURNAL   Nature 608 (7924), 819-825 (2022)
   PUBMED   35831508
  REMARK    GeneRIF: Reconstitution of a telomeric replicon organized by CST.
REFERENCE   3  (bases 1 to 974)
  AUTHORS   He,Q., Lin,X., Chavez,B.L., Agrawal,S., Lusk,B.L. and Lim,C.J.
  TITLE     Structures of the human CST-Polalpha-primase complex bound to
            telomere templates
  JOURNAL   Nature 608 (7924), 826-832 (2022)
   PUBMED   35830881
  REMARK    GeneRIF: Structures of the human CST-Polalpha-primase complex bound
            to telomere templates.
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Dos Santos,G.A., Viana,N.I., Pimenta,R., de Camargo,J.A.,
            Guimaraes,V.R., Romao,P., Candido,P., Ghazarian,V., Reis,S.T.,
            Leite,K.R.M. and Srougi,M.
  TITLE     Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may
            have a key position in oncology
  JOURNAL   Cancer Genet 262-263, 80-90 (2022)
   PUBMED   35134616
  REMARK    GeneRIF: Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST)
            complex may have a key position in oncology.
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Kasbek,C., Wang,F. and Price,C.M.
  TITLE     Human TEN1 maintains telomere integrity and functions in
            genome-wide replication restart
  JOURNAL   J Biol Chem 288 (42), 30139-30150 (2013)
   PUBMED   24025336
  REMARK    GeneRIF: TEN1 likely functions in conjunction with CTC1 and STN1 at
            the telomere and elsewhere in the genome.
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Chen,L.Y. and Lingner,J.
  TITLE     CST for the grand finale of telomere replication
  JOURNAL   Nucleus 4 (4), 277-282 (2013)
   PUBMED   23851344
  REMARK    GeneRIF: The mammalian CST (CTC1-STN1-TEN1) complex is directly
            involved at several stages of telomere end formation and CST seems
            to play critical roles in coordinating telomerase elongation and
            fill-in synthesis to complete telomere replication.
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Bryan,C., Rice,C., Harkisheimer,M., Schultz,D.C. and Skordalakes,E.
  TITLE     Structure of the human telomeric Stn1-Ten1 capping complex
  JOURNAL   PLoS One 8 (6), e66756 (2013)
   PUBMED   23826127
  REMARK    GeneRIF: data indicate that hTen1 is critical for the telomeric
            function of hCST, both in telomere protection and downregulation of
            telomerase function
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Chen,L.Y., Redon,S. and Lingner,J.
  TITLE     The human CST complex is a terminator of telomerase activity
  JOURNAL   Nature 488 (7412), 540-544 (2012)
   PUBMED   22763445
  REMARK    GeneRIF: the human CST (CTC1, STN1 and TEN1) complex, previously
            implicated in telomere protection and DNA metabolism, inhibits
            telomerase activity through primer sequestration and physical
            interaction with the protection of telomeres 1 (POT1)-TPP1
            telomerase processivity factor
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
  REMARK    GeneRIF: Ctc1-Stn1-Ten1 is a replication protein A (RPA)-like
            complex that is not directly involved in conventional DNA
            replication at forks but plays a role in DNA metabolism frequently
            required by telomeres.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047782.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001113324.2.
            
            Summary: C17ORF106, or TEN1, appears to function in a
            telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1
            (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed
            19854130]).[supplied by OMIM, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047782.1, SRR1163655.70280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397640.6/ ENSP00000380762.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               BC047782.1         21-994
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..974
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /note="TEN1 subunit of CST complex"
                     /db_xref="GeneID:100134934"
                     /db_xref="HGNC:HGNC:37242"
                     /db_xref="MIM:613130"
     exon            1..272
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            273..370
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..650
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /note="telomeric pathways in association with Stn1, number
                     1; protein telomeric pathways with STN1 homolog; telomere
                     length regulation protein TEN1 homolog; TEN1 telomerase
                     capping complex subunit homolog; TEN1, CST complex
                     subunit"
                     /codon_start=1
                     /product="CST complex subunit TEN1"
                     /protein_id="NP_001106795.2"
                     /db_xref="CCDS:CCDS45780.2"
                     /db_xref="GeneID:100134934"
                     /db_xref="HGNC:HGNC:37242"
                     /db_xref="MIM:613130"
                     /translation="MMLPKPGTYYLPWEVSAGQVPDGSTLRTFGRLCLYDMIQSRVTL
                     MAQHGSDQHQVLVCTKLVEPFHAQVGSLYIVLGELQHQQDRGSVVKARVLTCVEGMNL
                     PLLEQAIREQRLYKQERGGSQ"
     exon            371..528
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /inference="alignment:Splign:2.1.0"
     exon            529..974
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /inference="alignment:Splign:2.1.0"
     regulatory      946..951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /note="hexamer: AATAAA"
     polyA_site      974
                     /gene="TEN1"
                     /gene_synonym="C17orf106"
                     /note="major polyA site"
ORIGIN      
        1 cctttggcgc gtgagtgaca gcggcccaga cagagggggc gatgtccgcg tcgtggctgg
       61 ggccggtcgc ggggcagact aatcccctgc tcctggccag gggaggctcc cgagcggatc
      121 ctcgggaaag gggctccgaa ggtcaagaaa ctgccctgct gggcgtccgg ggagtgggaa
      181 aataaagcac tttttgtatc ccgcccctcc cccgtcacgt gaccacgcga ggcggaaaga
      241 agaaatccga ggaccggcga cgcctagaac aggagcccat gatgctgccc aaacctggga
      301 cctattacct cccctgggag gttagtgcag gccaagttcc tgatgggagc acgctgagaa
      361 catttggcag gttgtgcctc tatgacatga ttcagtccag agtaacactg atggctcagc
      421 acggatccga tcagcaccag gttcttgtct gtaccaagtt ggtggagccc ttccacgccc
      481 aggtgggctc cctgtacatc gtcctcgggg agctccagca tcagcaggac agaggctccg
      541 tggtgaaggc gcgcgtgctg acctgtgtgg aggggatgaa cctgcccttg ttggaacaag
      601 ccatccggga gcagagactg tacaagcagg agcggggcgg cagccagtag gaaacagcag
      661 cctagcaaca ccctcacctg cttcagagcc cgaaccctct ggagctgcag gagcccggga
      721 gagcacagac gcctccccag cgacggcctt gtctggagct cgaaagccga ggggcgggtg
      781 atgaatccag ccccttcccc tactttggga ttggctcagc aatgagaacc cagaaagcat
      841 gccataaatc cgacagcccc accccaggag actgcaggtg gccgagcttg ggcgccgggg
      901 ccgtgcttgg tgtggggcca tggagggttc cagaaggtcc tggtgaataa aggcccaggg
      961 ggcgtgctct tgaa
//
