LOCUS       NM_173482               1757 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tektin like 1 (TEKTL1), mRNA.
ACCESSION   NM_173482
VERSION     NM_173482.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004659.1, AK097684.1 and AC104528.2.
            
            On Nov 22, 2018 this sequence version replaced NM_173482.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097684.1, BC035678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292574.4/ ENSP00000292574.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC004659.1         107029-107029
            2-1752              AK097684.1         1-1751
            1753-1757           AC104528.2         1557-1561
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1757
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /note="tektin like 1"
                     /db_xref="GeneID:126402"
                     /db_xref="HGNC:HGNC:26866"
     exon            1..670
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1600
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /note="coiled-coil domain-containing protein 105;
                     coiled-coil domain containing 105"
                     /codon_start=1
                     /product="tektin-like protein 1"
                     /protein_id="NP_775753.2"
                     /db_xref="CCDS:CCDS12322.1"
                     /db_xref="GeneID:126402"
                     /db_xref="HGNC:HGNC:26866"
                     /translation="MRVLVPPAERSQDTRVGAPAWREAAQAMARTAHILTDRCGQEAV
                     TMWQPKDSVLDPNVAHHLGRAAYIQPWRFRVEMIKGGGTLEKPPPGEGVTLWKGKMKP
                     PAWYARLPLPLHRKARALQTTEVVHAHARGARLTAARLGRAQHQINGRVRQLLRQREV
                     TDHRLSEVRKGLLINQQSVKLRGYRPKSEKVPDKADSMLTWEKEELKSMKRKMERDME
                     KSEVLLKTLASCRDTLNFCFKERLQAVDLMNQPLDKVLEQARRHSWVNLSRAPTPRTQ
                     GQKTPPPDPVGTYNPACALALNEAKRLLVESKDTLVEMAKNEVDVREQQLQISDRVCA
                     SLAQKASETLELKERLNMTLGLMRGTILRCTKYNQELYTTHGLIKGPLSKVHLETAEK
                     LDRPLVRMYQRHVGTQLPEAARLAQGTDKLQCHITYLEKNLDELLATHKNLSWGLNCK
                     NIGHEVDGNVVRLRLRQRQPHVCYEQAQRLVKDWDPRTPPPRSKSSADP"
     exon            671..775
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     exon            776..974
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1141
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1237
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1351
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1757
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1731..1736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /note="hexamer: ATTAAA"
     polyA_site      1757
                     /gene="TEKTL1"
                     /gene_synonym="CCDC105"
                     /note="major polyA site"
ORIGIN      
        1 agtacactgt ctctacaggc caggaaagag ttgtgtgtct ttggggtccc ttccgctccg
       61 cctagggttc ccggccaggc cgagagacca agcagggacc atgcgcgtgt tggtaccccc
      121 ggctgagcgc agccaggaca cacgcgttgg ggccccagca tggcgcgagg cagctcaggc
      181 catggcgagg accgcgcaca ttctgaccga tcgctgcggg caggaggcgg tgaccatgtg
      241 gcagcccaag gacagcgtgc tggacccgaa cgtggcccac cacctcggcc gcgccgccta
      301 catccagccc tggcgcttcc gcgtggagat gatcaaaggc ggcggcacct tggagaagcc
      361 gccgccaggc gagggcgtca cgctgtggaa gggcaagatg aagccgcccg cctggtacgc
      421 ccgcctgccg ctacccttgc accgcaaagc gcgcgccctg cagaccaccg aggtggtgca
      481 cgcgcacgcg cgtggagcgc gcctcaccgc cgcccgcctc ggccgcgcgc agcaccagat
      541 taacgggcgg gtgcgacagc tgctgcgcca gcgcgaggtc accgaccaca ggctcagcga
      601 agtgcgcaag ggtctgctta ttaaccagca gagcgtcaag ctgcggggct acaggcccaa
      661 gtctgagaag gtccctgaca aagctgacag tatgcttaca tgggagaaag aggagctgaa
      721 aagcatgaag aggaaaatgg agagagatat ggaaaaatca gaggtcctac tcaagaccct
      781 ggcctcctgc cgagacactc tgaacttctg cttcaaggag cggctccaag ccgtggacct
      841 catgaaccag cctctggaca aggttctgga gcaggccaga cgccactcat gggtgaacct
      901 ctcccgagcc cccactccac gcacacaggg tcagaaaacg cctcctccag accctgtggg
      961 cacctataac ccagcgtgcg ccttggcgct aaacgaagcc aagcggttgt tggtcgagtc
     1021 caaggacacc ttggtagaaa tggcaaagaa cgaggtggac gtccgggagc aacagctgca
     1081 gataagcgac cgtgtgtgtg cctcgctggc gcagaaggcg agcgagacct tggagctgaa
     1141 ggaaagatta aatatgacgt taggactgat gaggggaact atcctccggt gtacgaaata
     1201 taaccaagag ttgtacacca cccacggtct catcaagggt cctctgtcga aagttcacct
     1261 ggagaccgca gaaaagctgg acagacccct ggttcgcatg taccagagac acgtgggcac
     1321 ccaactcccg gaggctgcgc gcctcgcaca gggcaccgac aagctgcagt gccacatcac
     1381 gtacctggaa aagaacctgg acgagctgct cgccacgcac aagaacctca gctggggcct
     1441 caactgcaag aacatcgggc atgaggtgga cggcaacgtg gtgcgcctgc gcctgcgcca
     1501 gcggcaaccg cacgtgtgct acgagcaggc gcagcgcctg gttaaggact gggacccgcg
     1561 cacgccgccg ccgcgcagca agagcagcgc ggacccctag tgaccccagc gtcccccgcc
     1621 ccagccagct gattggatgc tggctgggac ctcggagagc agacacagcc ccatggccct
     1681 ccctctcccc tgacgcaccc tccctccaag caccctctag gagaattata attaaaaata
     1741 acaataatta tcatgta
//
