LOCUS       NM_144705               1512 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tektin 4 (TEKT4), transcript variant 1, mRNA.
ACCESSION   NM_144705
VERSION     NM_144705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Ge,L.P., Jin,X., Yang,Y.S., Liu,X.Y., Shao,Z.M., Di,G.H. and
            Jiang,Y.Z.
  TITLE     Tektin4 loss promotes triple-negative breast cancer metastasis
            through HDAC6-mediated tubulin deacetylation and increases
            sensitivity to HDAC6 inhibitor
  JOURNAL   Oncogene 40 (12), 2323-2334 (2021)
   PUBMED   33654196
  REMARK    GeneRIF: Tektin4 loss promotes triple-negative breast cancer
            metastasis through HDAC6-mediated tubulin deacetylation and
            increases sensitivity to HDAC6 inhibitor.
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Jiang,Y.Z., Yu,K.D., Peng,W.T., Di,G.H., Wu,J., Liu,G.Y. and
            Shao,Z.M.
  TITLE     Enriched variations in TEKT4 and breast cancer resistance to
            paclitaxel
  JOURNAL   Nat Commun 5, 3802 (2014)
   PUBMED   24823476
  REMARK    GeneRIF: TEKT4 germline variations in a high cis linkage are
            biologically relevant, as ectopic expression of variant TEKT4
            deregulates microtubule stability, antagonizes paclitaxel-induced
            stabilizing effect of microtubules and increases paclitaxel
            resistance.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Wu,W.B., Li,Y.S., Ji,X.F., Wang,Q.X., Gao,X.M., Yang,X.F., Pan,Z.H.
            and Feng,X.X.
  TITLE     [Expression of TEKT4 protein decreases in the ejaculated
            spermatozoa of idiopathic asthenozoospermic men]
  JOURNAL   Zhonghua Nan Ke Xue 18 (6), 514-517 (2012)
   PUBMED   22774605
  REMARK    GeneRIF: The expression of TEKT4 is significantly decreased in the
            ejaculated sperm of idiopathic asthenozoospermia patients.
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097374.3, BI832036.1 and BC021716.2.
            
            On Nov 22, 2018 this sequence version replaced NM_144705.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021716.2, SRR5189667.85672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295201.5/ ENSP00000295201.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC097374.3         44142-44154
            14-57               BI832036.1         2-45
            58-1512             BC021716.2         1-1455
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..1512
                     /gene="TEKT4"
                     /note="tektin 4"
                     /db_xref="GeneID:150483"
                     /db_xref="HGNC:HGNC:31012"
     exon            1..648
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1458
                     /gene="TEKT4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="tektin-4 isoform 1"
                     /protein_id="NP_653306.1"
                     /db_xref="CCDS:CCDS2005.1"
                     /db_xref="GeneID:150483"
                     /db_xref="HGNC:HGNC:31012"
                     /translation="MAQTVPPCELPCKEYDVARNTGAYTSSGLATASFRTSKYLLEEW
                     FQNCYARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDSTRTVGERLQDTHSWK
                     SELQREMEALAAETNLLLAQKQRLERALDATEVPFSITTDNLQCRERREHPNLVRDHV
                     ETELLKEAELIRNIQELLKRTIMQAVSQIRLNREHKETCEMDWSDKMEAYNIDETCGR
                     HHSQSTEVQAHPYSTTFQESASTPETRAKFTQDNLCRAQRERLASANLRVLVDCILRD
                     TSEDLRLQCDAVNLAFGRRCEELEDARYKLHHHLHKTLREITDQEHNVAALKQAIKDK
                     EAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAEQSLRN
                     LEDIHMSLEKDIAAMTNSLFIDRQKCMAHRTRYPTILQLAGYQ"
     exon            649..719
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..863
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1086
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1241
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1512
                     /gene="TEKT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT4"
                     /note="hexamer: AATAAA"
     polyA_site      1492
                     /gene="TEKT4"
     polyA_site      1512
                     /gene="TEKT4"
                     /note="major polyA site"
ORIGIN      
        1 ggtttacaca gtgtcaccca agcgactggg agccgcgtcc tgctctggga ctgagccgtt
       61 ggagctgccc cgctgaccgc actaggctga ccgcaaccgg ctgaccacac acagtcctca
      121 ctcccctggc cctggtgggc ggcaggcacc atggcgcaga cagtgccgcc ctgcgagctg
      181 ccctgcaaag agtacgacgt ggcccgtaac acgggcgcct acacgtcctc cggcctggcc
      241 accgccagct tccgcacctc caagtacctg ctggaggagt ggttccagaa ctgctatgct
      301 cgctaccacc aggccttcgc cgaccgcgac cagtcggagc ggcagcggca cgagagccag
      361 cagctggcca cagagaccca ggcgctggcg cagcgcacgc agcaagactc cacgcgcaca
      421 gtgggcgagc gactgcagga cacgcacagc tggaagtcgg agctgcagcg tgagatggag
      481 gcgctggctg cggagaccaa cttgctcctg gcccagaagc aacggctgga gcgcgccctg
      541 gacgccacag aggtgccctt ctccatcacc actgacaacc tgcagtgccg tgagcgccgc
      601 gagcacccca acctcgtgcg cgaccatgtg gaaacggagc tgctgaagga agccgagctc
      661 atccggaaca ttcaggagct gctgaagaga accatcatgc aagcagtgag ccagatccga
      721 ctgaaccggg agcacaagga gacctgcgag atggactggt cagacaagat ggaggcctac
      781 aacatcgacg agacctgcgg gcgccaccac agccagagca ccgaggtgca ggctcatccg
      841 tactccacca ccttccaaga gagcgcctcc accccggaga cccgggccaa gttcacgcag
      901 gacaatctgt gccgtgccca gcgcgagcgc ctggcctcgg ccaacctgcg ggtgctggtg
      961 gactgcatcc ttcgcgacac ctccgaggac ctgcggctcc agtgcgacgc cgtgaacctg
     1021 gccttcgggc gccgctgtga ggagctggag gacgcgcggt acaagctgca tcaccacctg
     1081 cacaagacac tgcgggaaat cacagatcag gaacacaacg tggcggcact gaagcaggcc
     1141 atcaaggaca aagaggcacc tctgcacgta gcccagaccc ggctgtacct gcgctcgcac
     1201 cggcccaaca tggagctgtg ccgtgacgca gcccagttca ggctgttgag tgaggtggag
     1261 gagctgaaca tgtccctcac agcactgcga gagaagcttc tagaagcgga gcagtccctg
     1321 cgcaacctcg aggacatcca catgagcctg gagaaggaca ttgccgccat gaccaacagt
     1381 ctcttcatcg accgccagaa gtgcatggcc catcgtactc gctaccccac catcctgcag
     1441 ctggctggct accagtgagc agcggcacgg tgcttccccc cagtccccca aataaacagc
     1501 gcgttagctt tc
//
