LOCUS       NM_031898               1740 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tektin 3 (TEKT3), mRNA.
ACCESSION   NM_031898
VERSION     NM_031898.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Liu,Y., Li,Y., Meng,L., Li,K., Gao,Y., Lv,M., Guo,R., Xu,Y.,
            Zhou,P., Wei,Z., He,X., Cao,Y., Wu,H., Tan,Y. and Hua,R.
  TITLE     Bi-allelic human TEKT3 mutations cause male infertility with
            oligoasthenoteratozoospermia owing to acrosomal hypoplasia and
            reduced progressive motility
  JOURNAL   Hum Mol Genet 32 (10), 1730-1740 (2023)
   PUBMED   36708031
  REMARK    GeneRIF: Bi-allelic human TEKT3 mutations cause male infertility
            with oligoasthenoteratozoospermia owing to acrosomal hypoplasia and
            reduced progressive motility.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Roy,A., Yan,W., Burns,K.H. and Matzuk,M.M.
  TITLE     Tektin3 encodes an evolutionarily conserved putative testicular
            microtubules-related protein expressed preferentially in male germ
            cells
  JOURNAL   Mol Reprod Dev 67 (3), 295-302 (2004)
   PUBMED   14735490
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Inoue,K., Dewar,K., Katsanis,N., Reiter,L.T., Lander,E.S.,
            Devon,K.L., Wyman,D.W., Lupski,J.R. and Birren,B.
  TITLE     The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals
            unique genome architectural features and provides insights into the
            recent evolution of new genes
  JOURNAL   Genome Res 11 (6), 1018-1033 (2001)
   PUBMED   11381029
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC031688.1 and AF334676.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031898.2.
            
            Summary: This gene product belongs to the tektin family of
            proteins. Tektins comprise a family of filament-forming proteins
            that are coassembled with tubulins to form ciliary and flagellar
            microtubules. The exact function of this gene is not known.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.196785.1,
                                           SRR5189667.135257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395930.6/ ENSP00000379263.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-944               BC031688.1         8-951
            945-1740            AF334676.1         901-1696
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1740
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /note="tektin 3"
                     /db_xref="GeneID:64518"
                     /db_xref="HGNC:HGNC:14293"
                     /db_xref="MIM:612683"
     exon            1..80
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            81..114
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            115..722
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1616
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /note="testicular microtubules-related protein"
                     /codon_start=1
                     /product="tektin-3"
                     /protein_id="NP_114104.1"
                     /db_xref="CCDS:CCDS11169.1"
                     /db_xref="GeneID:64518"
                     /db_xref="HGNC:HGNC:14293"
                     /db_xref="MIM:612683"
                     /translation="MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTH
                     SLSLPWRPSTYYKVASNSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRS
                     NLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEI
                     IHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQ
                     LLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRN
                     TSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVTAN
                     EMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAF
                     LKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVH
                     IKATLEYDLAVKANSLYIDQEKCMSMRKSYPNTLRLVGFC"
     exon            723..806
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            807..877
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1021
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1244
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1399
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1740
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1709..1714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /note="hexamer: ATTAAA"
     polyA_site      1740
                     /gene="TEKT3"
                     /gene_synonym="SPGF81"
                     /note="major polyA site"
ORIGIN      
        1 agtcgagggc tgcaggtggt aggctgcgac cccttcctcc cacagcccct tcccgcccct
       61 cgccgggcat ccgccgacag gtacatacca agaaattgaa ttgctgagtc acaggagaga
      121 tttacaaata gtgttttggc atcatggaac gtgtaggttg tactttaacg acaacttacg
      181 cccaccctag accaacacca accaactttc taccagccat cagtaccatg gcctcaagct
      241 acagggaccg ctttccccac tccaatttga cccatagcct gagccttcct tggagaccca
      301 gcacatacta caaagtcgcc tccaattccc caagcgtggc cccgtactgc accagatcac
      361 agagggtgtc cgagaatacc atgcttccct ttgtttccaa cagaaccact ttcttcacaa
      421 gatacacacc ggatgactgg tacaggtcca atttaaccaa ctatcaagag tccaacactt
      481 cccgacataa ttcggagaaa ctaagagtgg atacatctcg cctgattcaa gacaaatatc
      541 aacaaacaag aaaaactcag gcagacacaa cccaaaatct gggagaacgt gtcaatgaca
      601 tagggttttg gaaatctgaa atcattcatg agttggatga aatgattgga gagacaaatg
      661 cacttactga tgtgaagaaa agactggagc gggctttgat ggagactgaa gcccctcttc
      721 aggtagcccg agaatgtcta tttcatcgag aaaagagaat gggaatcgac ctagttcacg
      781 atgaagttga agcacaactg ctgacggaag ttgatactat tctgtgttgt caagaaagaa
      841 tgaagctaca tttggataag gctattgccc aacttgcagc caacagagcg tcccagcatg
      901 agctggaaaa ggacctgagt gacaaacaga cggcttaccg gatcgacgac aaatgccacc
      961 acctgcgcaa cacatcagac ggtgtcggct acttccgcgg agtggagagg gtcgatgcaa
     1021 ctgtctcagt gcctgagtcc tgggccaaat ttacagatga caatattctc cgctcccaga
     1081 gtgaacgggc agcttccgct aagctaagag acgacattga aaacctcttg gttgtgactg
     1141 ccaatgagat gtggaatcaa ttcaacaaag tgaacttgtc tttcaccaat cgcattgctg
     1201 agactgcaga tgctaagaat aagattcaga cgcacttagc aaagaccctg caggagattt
     1261 tccagactga aatgaccata gaatccatca agaaggccat caaggacaag actgccttcc
     1321 tgaaggtggc tcagaccaga ctggatgagc gcacaagacg gccgaacatt gagttgtgcc
     1381 gagacatggc tcagctacgc cttgttaacg aggtacacga ggttgacgac accatccaga
     1441 ccctgcagca gcgcctgagg gatgcagagg acaccctgca gtcgctggtc cacatcaaag
     1501 ccacactcga gtatgacctg gctgtcaaag ccaattccct gtacatcgac caggaaaaat
     1561 gcatgagcat gcgcaagagc taccccaaca ccctccggct ggtcggcttc tgctagggac
     1621 cccaccgggt gtggttttga tacccctaag ttaaggctga gccagagcac tgtctcagca
     1681 tttgaaccga atgctaatat agtcacttat taaaggatta tgctgatgga aatgtaccaa
//
