LOCUS       NM_014466               1490 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tektin 2 (TEKT2), mRNA.
ACCESSION   NM_014466
VERSION     NM_014466.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Li,Y., Lin,H., Shu,S., Sun,Y., Lai,W., Chen,W., Hu,Z. and Peng,H.
  TITLE     Integrative transcriptome analysis reveals TEKT2 and PIAS2
            involvement in diabetic nephropathy
  JOURNAL   FASEB J 36 (11), e22592 (2022)
   PUBMED   36251411
  REMARK    GeneRIF: Integrative transcriptome analysis reveals TEKT2 and PIAS2
            involvement in diabetic nephropathy.
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Zhang,S.H., Zhang,J.H., Ding,X.P., Zhang,S., Chen,H.H. and
            Jing,Y.L.
  TITLE     Association of polymorphisms in tektin-t gene with idiopathic
            asthenozoospermia in Sichuan, China
  JOURNAL   J Assist Reprod Genet 33 (2), 181-187 (2016)
   PUBMED   26584823
  REMARK    GeneRIF: These results suggested that tektin-t variants (Arg/Cys +
            Cys/Cys) were probably one of the high risk genetic factors for
            idiopathic asthenozoospermia among males in Sichuan, China, while
            the R207H polymorphism may be associated with idiopathic
            asthenozoospermia risk.
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Bhilawadikar,R., Zaveri,K., Mukadam,L., Naik,S., Kamble,K., Modi,D.
            and Hinduja,I.
  TITLE     Levels of Tektin 2 and CatSper 2 in normozoospermic and
            oligoasthenozoospermic men and its association with motility,
            fertilization rate, embryo quality and pregnancy rate
  JOURNAL   J Assist Reprod Genet 30 (4), 513-523 (2013)
   PUBMED   23519396
  REMARK    GeneRIF: Levels of Tektin 2 and CatSper 2 proteins are positively
            associated with sperm motility parameters. Measurements of Tektin 2
            levels can be correlated with the clinical outcome of ICSI.
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Zuccarello,D., Ferlin,A., Garolla,A., Pati,M.A., Moretti,A.,
            Cazzadore,C., Francavilla,S. and Foresta,C.
  TITLE     A possible association of a human tektin-t gene mutation (A229V)
            with isolated non-syndromic asthenozoospermia: case report
  JOURNAL   Hum Reprod 23 (4), 996-1001 (2008)
   PUBMED   18227105
  REMARK    GeneRIF: This is the first description of human pathology linked to
            a tektin-family gene, since only murine models are available for
            these genes.
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Tanaka,H., Iguchi,N., Toyama,Y., Kitamura,K., Takahashi,T.,
            Kaseda,K., Maekawa,M. and Nishimune,Y.
  TITLE     Mice deficient in the axonemal protein Tektin-t exhibit male
            infertility and immotile-cilium syndrome due to impaired inner arm
            dynein function
  JOURNAL   Mol Cell Biol 24 (18), 7958-7964 (2004)
   PUBMED   15340058
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Iguchi,N., Tanaka,H., Nakamura,Y., Nozaki,M., Fujiwara,T. and
            Nishimune,Y.
  TITLE     Cloning and characterization of the human tektin-t gene
  JOURNAL   Mol Hum Reprod 8 (6), 525-530 (2002)
   PUBMED   12029069
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Wolkowicz,M.J., Naaby-Hansen,S., Gamble,A.R., Reddi,P.P.,
            Flickinger,C.J. and Herr,J.C.
  TITLE     Tektin B1 demonstrates flagellar localization in human sperm
  JOURNAL   Biol Reprod 66 (1), 241-250 (2002)
   PUBMED   11751288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138787.11.
            
            On Nov 25, 2018 this sequence version replaced NM_014466.2.
            
            Summary: This gene product belongs to the tektin family of
            proteins. Tektins comprise a family of filament-forming proteins
            that are coassembled with tubulins to form ciliary and flagellar
            microtubules. This gene is expressed in the testis and its protein
            is localized to the flagella of the sperms, indicating that it may
            play a role in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF054910.1, SRR5189667.198951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000207457.8/ ENSP00000207457.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL138787.11        41919-41974         c
            57-264              AL138787.11        40991-41198         c
            265-390             AL138787.11        40780-40905         c
            391-596             AL138787.11        40027-40232         c
            597-740             AL138787.11        39221-39364         c
            741-855             AL138787.11        39023-39137         c
            856-963             AL138787.11        38757-38864         c
            964-1107            AL138787.11        38486-38629         c
            1108-1187           AL138787.11        38261-38340         c
            1188-1490           AL138787.11        37793-38095         c
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..1490
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /note="tektin 2"
                     /db_xref="GeneID:27285"
                     /db_xref="HGNC:HGNC:11725"
                     /db_xref="MIM:608953"
     exon            1..56
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            57..264
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1401
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /note="testicular tektin B1-like protein; tektin 2
                     (testicular); tektin-B1"
                     /codon_start=1
                     /product="tektin-2"
                     /protein_id="NP_055281.2"
                     /db_xref="CCDS:CCDS401.1"
                     /db_xref="GeneID:27285"
                     /db_xref="HGNC:HGNC:11725"
                     /db_xref="MIM:608953"
                     /translation="MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARV
                     LRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQN
                     LQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFE
                     QLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQW
                     DDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVY
                     SELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQA
                     QYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMD
                     TRRKLTVPAERFVPEVDTFTRTTNSTLSPLKSCQLELA"
     exon            265..390
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            391..596
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            597..740
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            741..855
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            856..963
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1107
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1187
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1490
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /note="hexamer: AATAAA"
     polyA_site      1490
                     /gene="TEKT2"
                     /gene_synonym="h-tektin-t; TEKTB1; TEKTIN-T"
                     /note="major polyA site"
ORIGIN      
        1 ggtgccaaac actggagctc agagcggggg gcgcggagag cgaagcggga aaggaggtgg
       61 tgtctgtgaa caggcctagg ggtttctgac ccttctggtt tctgtgccat ggccacgctg
      121 agcgtcaagc caagtcggcg cttccagctg cccgactggc acactaacag ctacctgcta
      181 tccaccaatg cccagctgca gcgagatgct tcccatcaga tccgccagga ggcccgggtg
      241 ctccgcaacg agaccaacaa ccagaccatt tgggatgaac atgacaacag gactcgactg
      301 gtggagagga ttgatactgt caaccggtgg aaggagatgc tggacaagtg tctgacagat
      361 ttagatgccg agatcgatgc cctgacacag atgaaggagt cagcagagca aaacctgcag
      421 gccaagaacc tgcctctgga tgtggccatt gagtgcctga ccctgcggga aagccggcga
      481 gacattgatg tggtgaagga ccctgtggag gatgagctgc ataaagaggt ggaggtcatc
      541 gaggccacca agaaggcctt gcaacagaag gtcagccagg ccttcgagca gctctgcctc
      601 ttgcaggaag tccaacagca gctcaactcc gaccatcggg gcaaaatgga gacactagag
      661 atcgacagag gctgtctctc tctcaacctc agatccccaa acatctcgct gaaggttgac
      721 cccacacgtg tacctgatgg ctccaccaca ctccagcagt gggatgactt cagtcggttc
      781 aacaaggacc gagcggaggc tgagatgaag gcagccacag agctgaggga ggccactgct
      841 ctaactattg ctgagaccaa caacgagctt gaagcccaga gagttgcaac ggaatttgcc
      901 ttcaggaagc ggctgcggga gatggagaaa gtgtacagtg agctcaagtg gcaagagaag
      961 aataccttgg aggagatcgc tgagctgcag gaggacatcc ggcacctgga ggaggatctg
     1021 cgcacaaagc tcctgagcct gaagctgtcc catacccggc tagaggccag aacctaccgg
     1081 cccaacgtgg aactctgccg ggaccaggca cagtacggcc tcaccgacga ggttcaccag
     1141 ctagaggcaa ccatcgctgc cctgaagcag aagctggcgc aagcacagga cgcactggac
     1201 gccctgtgca agcacctggc ccggctgcag gctgacattg cctgcaaggc caactccatg
     1261 ctgctggaca ccaagtgcat ggacacacgg cgcaagctga ccgtgcctgc tgagaggttc
     1321 gtgcctgagg tggacacctt cacacgtacc acaaatagca ccctgagtcc actcaaaagc
     1381 tgccagctgg agctggccta gccttggagg actgcaggag gagggcaggg ttgggtgggc
     1441 aatggaagga gggaggagag aaatgaatgg aataaatgca gaggatctca
//
