LOCUS       NM_053285               3389 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens tektin 1 (TEKT1), mRNA.
ACCESSION   NM_053285
VERSION     NM_053285.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Newby,P.R., Pickles,O.J., Mazumdar,S., Brand,O.J., Carr-Smith,J.D.,
            Pearce,S.H., Franklyn,J.A., Evans,D.M., Simmonds,M.J. and
            Gough,S.C.
  CONSRTM   Wellcome Trust Case-Control Consortium (WTCCC)
  TITLE     Follow-up of potential novel Graves' disease susceptibility loci,
            identified in the UK WTCCC genome-wide nonsynonymous SNP study
  JOURNAL   Eur J Hum Genet 18 (9), 1021-1026 (2010)
   PUBMED   20442750
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Iguchi,N., Tanaka,H., Nakamura,Y., Nozaki,M., Fujiwara,T. and
            Nishimune,Y.
  TITLE     Cloning and characterization of the human tektin-t gene
  JOURNAL   Mol Hum Reprod 8 (6), 525-530 (2002)
   PUBMED   12029069
  REMARK    GeneRIF: tektin-t localized specifically to the principal piece of
            sperm flagella and to the post-acrosomal region; the h-tektin-t
            gene was assigned to chromosome 1
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Xu,M., Zhou,Z., Cheng,C., Zhao,W., Tang,R., Huang,Y., Wang,W.,
            Xu,J., Zeng,L., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human TEKTIN1 gene
  JOURNAL   Int J Biochem Cell Biol 33 (12), 1172-1182 (2001)
   PUBMED   11606253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014599.2 and AC034305.6.
            
            On Nov 22, 2018 this sequence version replaced NM_053285.1.
            
            Summary: This gene product belongs to the tektin family of
            proteins. Tektins comprise a family of filament-forming proteins
            that are coassembled with tubulins to form ciliary and flagellar
            microtubules. This gene is predominantly expressed in the testis
            and in mouse, tektin 1 mRNA was localized to the spermatocytes and
            round spermatids in the seminiferous tubules, indicating that it
            may play a role in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.226677.1,
                                           SRR1803613.67277.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338694.7/ ENSP00000341346.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1401              BC014599.2         13-1413
            1402-3389           AC034305.6         50072-52059         c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3389
                     /gene="TEKT1"
                     /note="tektin 1"
                     /db_xref="GeneID:83659"
                     /db_xref="HGNC:HGNC:15534"
                     /db_xref="MIM:609002"
     exon            1..81
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..288
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1355
                     /gene="TEKT1"
                     /codon_start=1
                     /product="tektin-1"
                     /protein_id="NP_444515.1"
                     /db_xref="CCDS:CCDS11083.1"
                     /db_xref="GeneID:83659"
                     /db_xref="HGNC:HGNC:15534"
                     /db_xref="MIM:609002"
                     /translation="MAKLLQPPPKFLPSEWHIANKNQYHRADAQRSRSERLVAESQRL
                     VDEIEKTTRKSQSDVNKKLEQRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKAL
                     ETLKEPLHITETCLAYREKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQ
                     IRMNRSAKYNLEKDLKDKFVALTIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWL
                     DFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTKDARD
                     KLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQ
                     YRLMKEVQEITHNVARLKETLAQAQAELKGLHRRQLALQEEIQVKENTIYIDEVLCMQ
                     MRKSIPLRDGEDHGVWAGGLRPDAVC"
     exon            289..454
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..583
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..727
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..950
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1147
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..3389
                     /gene="TEKT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1379..1384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1401
                     /gene="TEKT1"
                     /note="major polyA site"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT1"
                     /note="hexamer: AATAAA"
     polyA_site      3260
                     /gene="TEKT1"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEKT1"
                     /note="hexamer: AATAAA"
     polyA_site      3389
                     /gene="TEKT1"
ORIGIN      
        1 gttctgcaag agctggaagc tccagttggg gtaaggaggc tcccatcccg agcttgcgta
       61 gtggttctgt gtggcgctga ggaatttgga aacctcaaat ggctaaacta ttacaacctc
      121 cacccaagtt cctgccctca gagtggcaca ttgctaacaa gaaccagtac cacagagcag
      181 acgctcaaag gtcccgatca gaacgcctgg tcgcagaaag ccagaggctt gtggatgaaa
      241 ttgaaaagac cacaagaaaa tctcaaagcg atgtgaacaa gaaactagaa cagagactcg
      301 aggaagtcca gttctggaag aaggagttag atgacaaact tgagcagctt gtgaatgtaa
      361 ctgatgatct actcatatat aagatcagat tggaaaaagc cctggagacc ttgaaagagc
      421 ccttgcacat cactgagaca tgcctggcat acagggagaa gcgcattggc attgacctgg
      481 tgcacgacac agtggagcat gagctgataa aggaggctga gatcatccag ggcattatgg
      541 ctctgctgac ccgtaccttg gaggaggctt ccgagcagat tcggatgaac cgctctgcca
      601 agtacaatct tgagaaggat ttgaaggaca agtttgtggc cctgaccata gatgatatct
      661 gcttctcgct caacaacaac tcaccaaaca tcagatattc tgagaacgcc gtgaggattg
      721 agccaaactc cgtgagtctg gaagactggt tggacttctc cagcaccaat gtggagaagg
      781 ctgacaagca gcggaacaac tccctgatgc tgaaagccct ggtggatcga atcctgtccc
      841 agacagccaa tgatctgcgc aagcagtgtg atgtggtgga cacggcattc aagaatgggc
      901 tgaaggatac aaaggatgcc agggacaagc tggctgatca tctggccaag gtcatggaag
      961 agattgcttc ccaggagaaa aatattacag ctcttgaaaa ggccatcctt gaccaagaag
     1021 ggccagccaa ggtggctcat acgcgcttgg agaccaggac acaccggccg aacgtggagc
     1081 tgtgtcgtga tgtcgcacaa tataggctaa tgaaggaggt tcaagagatc acccacaatg
     1141 tcgcaagatt gaaggaaact ttagcccaag ctcaggcaga gctgaaaggg ctgcatcgca
     1201 gacagcttgc cctgcaggag gagatccagg tcaaagagaa caccatttat atcgacgaag
     1261 tgctgtgtat gcagatgagg aaatccatcc cacttcggga tggggaagac catggggtct
     1321 gggctggggg cctccgccct gatgctgtct gctaatagta gggctagttc caattctcat
     1381 taaaccacat tgtaaacagt agttacagta gtacagagct ctcatttcag gctggcgggg
     1441 cctctagcca gcctgctgca acctcttggc tggcattcca agcctgctca gggggctgat
     1501 tttggggcga gtttcttctc ttatgctggt gtggtgtttg cctaacaatt caactccata
     1561 ttttagcaca ggccactctt acaatatcac aggacttggg gccccaggac agggtttcaa
     1621 gacatttcag ttcagattca attcaataaa gtagttgggc tggatcacct gtgtagacca
     1681 tgcccctctt gctcatgaga tgggatgcta acctttctct tggctctcaa aatttctttt
     1741 ctctagaaaa taatgtgttt tttttctctt aaatactcaa ataacataaa gaaaaagaac
     1801 aaaattccat tcattcaagt caatgggttc aagtcaatgg ttaagactgt aggttccgga
     1861 gtctgccatc tgagtatagg acctccaata gtccccactc acagggctat aggggcgttg
     1921 aatgagatca cctccgtaaa gggcttcata ctgagcctgt atcatggggc agtgagtgtt
     1981 taatgaatgt gagccattgt gagcagtccc accctatacc aacataattt ctgcacaatt
     2041 gtactcatgg cataaactca atttcaggat tatttttttc cttcactgct aattattgca
     2101 agcctttgtt catgttgcta aattgtcttt ataattattt taatggttac gtacctcttt
     2161 acaagttttc agcaagactg ttttatatac ttactgtttc ttttccaaaa agagttcaac
     2221 ttgtgggagg ctgccttccg ctgagctgca gcaggtcaga gatctatgtg ggtgactgtc
     2281 aaaggaagac atttgctgtg ggaaactgct catttgttcc ttattccgct aacattgaag
     2341 gaacactttc catggacgag gcttaccatc tcagcaccct cccatgtgtg aagctgctgc
     2401 tacactctgc taacatttgg ttccccggtg ctcatggaca gctgacggtg tggggctcag
     2461 gagacctagc ttctagttgc aacactgcca ggaaagtttc tctccttctt taggaccacc
     2521 tgtaaagtaa ggaaaggact atatcgtctg gaactcttcc tgtccttgct gttccctgaa
     2581 tctggctgtc tagctgcaca tacggtgtca tagggcacaa tgataatgca gagtgtgggc
     2641 ctaattcctg ggagctttgc aatctaggtg ctccttggtc cagagactct ttgccatcag
     2701 aaagggatgt tcccaatctg ggatggagaa accccctttg aggccaaaag cactggctta
     2761 attctgttaa ttctgatcta tgccacccca gtgctgaacg tctcctctca gagtgctcag
     2821 caaatacaca gcccttccca tgcctcaatc aaggagggag gcccctctct gctcactggg
     2881 aagcctctgg gtgcttttct gctctggctc ggaagagtcc aaataagcct tcccagctca
     2941 ctgggcagac ctcagagttt ctgctaactt agcagggttt tgaggtctgt cccagaggat
     3001 gtggctggca gggtgtgaag acactgggca aaatccttcc ttgtgaatac agctctcaga
     3061 ggcagccagc ctcagtggtg gattcagatc ccaggctctg cagggagatg tgattcagat
     3121 cagctggtgg atcagctcca cgctctacct gtgatgtgat ccccgccaag ttactcaact
     3181 tccccgagct tcagttgcct aatctgtaaa taagactaat aaagcctaga ttggcgagat
     3241 aacgtgtgga agactctcaa cacagtgtct ggaacatgct gcttttaagg gaaatgtgat
     3301 tttgattatg gttgaggcca tttctcaaca tgtagacata aaatgcggaa acatctaaga
     3361 tttcaataaa gcaatgtttt gttagtaaa
//
