LOCUS       NM_000459               4683 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens TEK receptor tyrosine kinase (TEK), transcript variant
            1, mRNA.
ACCESSION   NM_000459
VERSION     NM_000459.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4683)
  AUTHORS   Chacon-Camacho,O.F., Ordaz-Robles,T., Cid-Garcia,M.A.,
            Hofmann-Blancas,M.E., Ledesma-Gil,J., Garcia-Huerta,M.M.,
            Prado-Larrea,C., Cortes-Gonzalez,V., Lozano-Garza,R.I.,
            Garcia-Vega,D., Kim,J., Khang,R., Lee,E. and Zenteno,J.C.
  TITLE     TEK gene-related primary congenital glaucoma: Phenotypic features
            and mutational spectrum in a Mexican cohort of 10 unrelated
            families
  JOURNAL   Am J Med Genet A 194 (10), e63716 (2024)
   PUBMED   38847211
  REMARK    GeneRIF: TEK gene-related primary congenital glaucoma: Phenotypic
            features and mutational spectrum in a Mexican cohort of 10
            unrelated families.
REFERENCE   2  (bases 1 to 4683)
  AUTHORS   Yu,J., Brelen,M.E., Chan,C.K.M., Chen,Z.J., Mohamed,S., Yam,J.C.,
            Lam,D.S.C., Pang,C.P., Tham,C.C. and Chen,L.J.
  TITLE     Genetic association of TIE2 with diabetic retinopathy and diabetic
            macular edema
  JOURNAL   Asia Pac J Ophthalmol (Phila) 13 (3), 100068 (2024)
   PUBMED   38750959
  REMARK    GeneRIF: Genetic association of TIE2 with diabetic retinopathy and
            diabetic macular edema.
REFERENCE   3  (bases 1 to 4683)
  AUTHORS   Jin,P., Zhang,J., Sumariwalla,P.F., Ni,I., Jorgensen,B.,
            Crawford,D., Phillips,S., Feldmann,M., Shepard,H.M. and
            Paleolog,E.M.
  TITLE     Novel splice variants derived from the receptor tyrosine kinase
            superfamily are potential therapeutics for rheumatoid arthritis
  JOURNAL   Arthritis Res Ther 10 (4), R73 (2008)
   PUBMED   18593464
REFERENCE   4  (bases 1 to 4683)
  AUTHORS   Park,E.H., Lee,J.M. and Pelletier,J.
  TITLE     The Tie2 5' untranslated region is inhibitory to 5' end-mediated
            translation initiation
  JOURNAL   FEBS Lett 580 (5), 1309-1319 (2006)
   PUBMED   16457819
  REMARK    GeneRIF: the uORFs within the Tie2 5' UTR serve to decrease the
            percent of ribosomes competent for reinitiation as these traverse
            the mRNA 5' UTR, thus minimizing interference with the internal
            ribosome entry site
REFERENCE   5  (bases 1 to 4683)
  AUTHORS   Park,E.H., Lee,J.M., Blais,J.D., Bell,J.C. and Pelletier,J.
  TITLE     Internal translation initiation mediated by the angiogenic factor
            Tie2
  JOURNAL   J Biol Chem 280 (22), 20945-20953 (2005)
   PUBMED   15802272
  REMARK    GeneRIF: Tie2 mediates internal translation initiation
REFERENCE   6  (bases 1 to 4683)
  AUTHORS   Huang,L., Turck,C.W., Rao,P. and Peters,K.G.
  TITLE     GRB2 and SH-PTP2: potentially important endothelial signaling
            molecules downstream of the TEK/TIE2 receptor tyrosine kinase
  JOURNAL   Oncogene 11 (10), 2097-2103 (1995)
   PUBMED   7478529
REFERENCE   7  (bases 1 to 4683)
  AUTHORS   Dumont,D.J., Anderson,L., Breitman,M.L. and Duncan,A.M.
  TITLE     Assignment of the endothelial-specific protein receptor tyrosine
            kinase gene (TEK) to human chromosome 9p21
  JOURNAL   Genomics 23 (2), 512-513 (1994)
   PUBMED   7835909
REFERENCE   8  (bases 1 to 4683)
  AUTHORS   Seront,E., Boon,L.M. and Vikkula,M.
  TITLE     TEK-Related Venous Malformations
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301733
REFERENCE   9  (bases 1 to 4683)
  AUTHORS   Abu-Amero,K.K. and Edward,D.P.
  TITLE     Primary Congenital Glaucoma
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301314
REFERENCE   10 (bases 1 to 4683)
  AUTHORS   Partanen,J., Armstrong,E., Makela,T.P., Korhonen,J., Sandberg,M.,
            Renkonen,R., Knuutila,S., Huebner,K. and Alitalo,K.
  TITLE     A novel endothelial cell surface receptor tyrosine kinase with
            extracellular epidermal growth factor homology domains
  JOURNAL   Mol Cell Biol 12 (4), 1698-1707 (1992)
   PUBMED   1312667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355432.7, AL355433.6 and
            AL133411.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 16, 2020 this sequence version replaced NM_000459.4.
            
            Summary: This gene encodes a receptor that belongs to the protein
            tyrosine kinase Tie2 family. The encoded protein possesses a unique
            extracellular region that contains two immunoglobulin-like domains,
            three epidermal growth factor (EGF)-like domains and three
            fibronectin type III repeats. The ligand angiopoietin-1 binds to
            this receptor and mediates a signaling pathway that functions in
            embryonic vascular development. Mutations in this gene are
            associated with inherited venous malformations of the skin and
            mucous membranes. Alternative splicing results in multiple
            transcript variants. Additional alternatively spliced transcript
            variants of this gene have been described, but their full-length
            nature is not known. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035514.1, AB208796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380036.10/ ENSP00000369375.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            regulatory uORF        :: PMID: 16457819
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               AL355432.7         27808-28225         c
            419-730             AL355433.6         65115-65426         c
            731-841             AL355433.6         54652-54762         c
            842-994             AL355433.6         53628-53780         c
            995-1126            AL355433.6         50510-50641         c
            1127-1267           AL355433.6         49895-50035         c
            1268-1396           AL355433.6         42889-43017         c
            1397-1548           AL355433.6         39647-39798         c
            1549-1693           AL355433.6         37628-37772         c
            1694-1855           AL355433.6         32567-32728         c
            1856-1990           AL355433.6         30634-30768         c
            1991-2275           AL355433.6         25658-25942         c
            2276-2575           AL355433.6         20138-20437         c
            2576-2730           AL355433.6         18192-18346         c
            2731-2941           AL355433.6         16465-16675         c
            2942-3052           AL355433.6         14026-14136         c
            3053-3243           AL355433.6         10360-10550         c
            3244-3357           AL355433.6         9660-9773           c
            3358-3428           AL355433.6         5499-5569           c
            3429-3469           AL355433.6         4440-4480           c
            3470-3566           AL355433.6         3112-3208           c
            3567-3666           AL133411.9         6950-7049
            3667-4683           AL133411.9         7902-8918
FEATURES             Location/Qualifiers
     source          1..4683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..4683
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /note="TEK receptor tyrosine kinase"
                     /db_xref="GeneID:7010"
                     /db_xref="HGNC:HGNC:11724"
                     /db_xref="MIM:600221"
     exon            1..418
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..3741
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; angiopoietin-1 receptor; tyrosine-protein
                     kinase receptor TEK; tunica interna endothelial cell
                     kinase; tyrosine-protein kinase receptor TIE-2;
                     endothelial tyrosine kinase; tyrosine kinase with Ig and
                     EGF homology domains-2; TEK tyrosine kinase, endothelial"
                     /codon_start=1
                     /product="angiopoietin-1 receptor isoform 1 precursor"
                     /protein_id="NP_000450.3"
                     /db_xref="CCDS:CCDS6519.1"
                     /db_xref="GeneID:7010"
                     /db_xref="HGNC:HGNC:11724"
                     /db_xref="MIM:600221"
                     /translation="MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTC
                     IASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC
                     EGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGS
                     FIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGP
                     ECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKS
                     YVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPG
                     WQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTV
                     LHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNA
                     PNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLE
                     PRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPI
                     FPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGE
                     WSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNED
                     QHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPAD
                     LGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNS
                     GTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKR
                     MKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
                     RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILV
                     GENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
                     IVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI
                     LVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA"
     exon            419..730
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..841
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..994
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1126
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1267
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1396
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1548
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1693
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1855
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1990
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2275
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2575
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2730
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2941
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3052
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3243
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3357
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3428
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3469
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3566
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3666
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..4683
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4656..4661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /note="hexamer: AATAAA"
     polyA_site      4683
                     /gene="TEK"
                     /gene_synonym="CD202B; GLC3E; TIE-2; TIE2; VMCM; VMCM1"
                     /note="major polyA site"
ORIGIN      
        1 ctctgcccct acagcagcag caaaagcagc agcagaagca acagcaacag ataagtgttt
       61 tgatgaattg cgagatggat agggcttgag tgcccccagc cctgctgata ccaaatgcct
      121 ttaagataca gcctttccca tcctaatcta caaaggaaac aggaaaaagg aacttaaaac
      181 tccctgtgct cagacagaaa tgagactgtt acagcctgct tctgtgctgt tccttcttgc
      241 ctctaacttg taaacaagac gtagtaggac gatgctaatg gaaagtcaca aaccgctggg
      301 tttttgaaag gatccttggg acctcatgca catttgtgga aactggatgg agagatttgg
      361 ggaagcatgg actctttagc cagcttagtt ctctgtggag tcagcttgct cctttctgga
      421 actgtggaag gtgccatgga cttgatcttg atcaattccc tacctcttgt atctgatgct
      481 gaaacatctc tcacctgcat tgcctctggg tggcgccccc atgagcccat caccatagga
      541 agggactttg aagccttaat gaaccagcac caggatccgc tggaagttac tcaagatgtg
      601 accagagaat gggctaaaaa agttgtttgg aagagagaaa aggctagtaa gatcaatggt
      661 gcttatttct gtgaagggcg agttcgagga gaggcaatca ggatacgaac catgaagatg
      721 cgtcaacaag cttccttcct accagctact ttaactatga ctgtggacaa gggagataac
      781 gtgaacatat ctttcaaaaa ggtattgatt aaagaagaag atgcagtgat ttacaaaaat
      841 ggttccttca tccattcagt gccccggcat gaagtacctg atattctaga agtacacctg
      901 cctcatgctc agccccagga tgctggagtg tactcggcca ggtatatagg aggaaacctc
      961 ttcacctcgg ccttcaccag gctgatagtc cggagatgtg aagcccagaa gtggggacct
     1021 gaatgcaacc atctctgtac tgcttgtatg aacaatggtg tctgccatga agatactgga
     1081 gaatgcattt gccctcctgg gtttatggga aggacgtgtg agaaggcttg tgaactgcac
     1141 acgtttggca gaacttgtaa agaaaggtgc agtggacaag agggatgcaa gtcttatgtg
     1201 ttctgtctcc ctgaccccta tgggtgttcc tgtgccacag gctggaaggg tctgcagtgc
     1261 aatgaagcat gccaccctgg tttttacggg ccagattgta agcttaggtg cagctgcaac
     1321 aatggggaga tgtgtgatcg cttccaagga tgtctctgct ctccaggatg gcaggggctc
     1381 cagtgtgaga gagaaggcat acagaggatg accccaaaga tagtggattt gccagatcat
     1441 atagaagtaa acagtggtaa atttaatccc atttgcaaag cttctggctg gccgctacct
     1501 actaatgaag aaatgaccct ggtgaagccg gatgggacag tgctccatcc aaaagacttt
     1561 aaccatacgg atcatttctc agtagccata ttcaccatcc accggatcct cccccctgac
     1621 tcaggagttt gggtctgcag tgtgaacaca gtggctggga tggtggaaaa gcccttcaac
     1681 atttctgtta aagttcttcc aaagcccctg aatgccccaa acgtgattga cactggacat
     1741 aactttgctg tcatcaacat cagctctgag ccttactttg gggatggacc aatcaaatcc
     1801 aagaagcttc tatacaaacc cgttaatcac tatgaggctt ggcaacatat tcaagtgaca
     1861 aatgagattg ttacactcaa ctatttggaa cctcggacag aatatgaact ctgtgtgcaa
     1921 ctggtccgtc gtggagaggg tggggaaggg catcctggac ctgtgagacg cttcacaaca
     1981 gcttctatcg gactccctcc tccaagaggt ctaaatctcc tgcctaaaag tcagaccact
     2041 ctaaatttga cctggcaacc aatatttcca agctcggaag atgactttta tgttgaagtg
     2101 gagagaaggt ctgtgcaaaa aagtgatcag cagaatatta aagttccagg caacttgact
     2161 tcggtgctac ttaacaactt acatcccagg gagcagtacg tggtccgagc tagagtcaac
     2221 accaaggccc agggggaatg gagtgaagat ctcactgctt ggacccttag tgacattctt
     2281 cctcctcaac cagaaaacat caagatttcc aacattacac actcctcagc tgtgatttct
     2341 tggacaatat tggatggcta ttctatttct tctattacta tccgttacaa ggttcaaggc
     2401 aagaatgaag accagcacgt tgatgtgaag ataaagaatg ccaccatcac tcagtatcag
     2461 ctcaagggcc tagagcctga aacagcatac caggtggaca tttttgcaga gaacaacata
     2521 gggtcaagca acccagcctt ttctcatgaa ctggtgaccc tcccagaatc tcaagcacca
     2581 gcggacctcg gaggggggaa gatgctgctt atagccatcc ttggctctgc tggaatgacc
     2641 tgcctgactg tgctgttggc ctttctgatc atattgcaat tgaagagggc aaatgtgcaa
     2701 aggagaatgg cccaagcctt ccaaaacgtg agggaagaac cagctgtgca gttcaactca
     2761 gggactctgg ccctaaacag gaaggtcaaa aacaacccag atcctacaat ttatccagtg
     2821 cttgactgga atgacatcaa atttcaagat gtgattgggg agggcaattt tggccaagtt
     2881 cttaaggcgc gcatcaagaa ggatgggtta cggatggatg ctgccatcaa aagaatgaaa
     2941 gaatatgcct ccaaagatga tcacagggac tttgcaggag aactggaagt tctttgtaaa
     3001 cttggacacc atccaaacat catcaatctc ttaggagcat gtgaacatcg aggctacttg
     3061 tacctggcca ttgagtacgc gccccatgga aaccttctgg acttccttcg caagagccgt
     3121 gtgctggaga cggacccagc atttgccatt gccaatagca ccgcgtccac actgtcctcc
     3181 cagcagctcc ttcacttcgc tgccgacgtg gcccggggca tggactactt gagccaaaaa
     3241 cagtttatcc acagggatct ggctgccaga aacattttag ttggtgaaaa ctatgtggca
     3301 aaaatagcag attttggatt gtcccgaggt caagaggtgt atgtgaaaaa gacaatggga
     3361 aggctcccag tgcgctggat ggccatcgag tcactgaatt acagtgtgta cacaaccaac
     3421 agtgatgtat ggtcctatgg tgtgttacta tgggagattg ttagcttagg aggcacaccc
     3481 tactgcggga tgacttgtgc agaactctac gagaagctgc cccagggcta cagactggag
     3541 aagcccctga actgtgatga tgaggtgtat gatctaatga gacaatgctg gcgggagaag
     3601 ccttatgaga ggccatcatt tgcccagata ttggtgtcct taaacagaat gttagaggag
     3661 cgaaagacct acgtgaatac cacgctttat gagaagttta cttatgcagg aattgactgt
     3721 tctgctgaag aagcggccta ggacagaaca tctgtatacc ctctgtttcc ctttcactgg
     3781 catgggagac ccttgacacc tgctgagaaa acatgcctct gccaaaggat gtgatatata
     3841 agtgtacata tgtgctgtac acctgggacc ttcaccactg tagatcccat gcatggatct
     3901 atgtagtatg ctctgactct aataggactg tatatactgt tttaagaatg ggctgaaatc
     3961 agaatgcctg tttgtggttt catatgcaat aatatatttt tttaaaaatg tggacttcat
     4021 aggaaggcgt gagtacaatt agtataatgc ataactcatt gttgtcctag atattttgat
     4081 atttaccttt atgttgaatg ctattaaatg ttttcctgtg tcaaagtaaa atattgttaa
     4141 taaacctaac aatgaccctg atagtacagg ttaagtgaga gaactatatg aattctaaca
     4201 agtcataggt taatatttaa gacactgaaa aatctaagtg atataaatca gattcttctc
     4261 tctcaatttt atccctcacc tgtagcagcc agtcccgttt catttagtca tgtgaccact
     4321 ctgtcttgtg tttccacagc ctgcaagtca gtccaggatg ctaacatcta aaaatagact
     4381 taaatctcat tgcttacaag cctaagaatc tttagagaag tatacataag tttaggataa
     4441 aataatggga ttttcttttc ttttctctgg taatattgac ttgtatattt taagaaataa
     4501 cagaaagcct gggtgacatt tgggagacat gtgacattta tatattgaat taatatccct
     4561 acatgtattg cacattgtaa aaagttttag ttttgatgag ttgtgagttt accttgtata
     4621 ctgtaggcac actttgcact gatatatcat gagtgaataa atgtcttgcc tactcacgtc
     4681 tca
//
