LOCUS       NM_003216               4381 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens TEF transcription factor, PAR bZIP family member
            (TEF), transcript variant 1, mRNA.
ACCESSION   NM_003216
VERSION     NM_003216.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4381)
  AUTHORS   Hua,P., Cui,C., Chen,Y., Yao,Y., Yu,C.Y., Xu,L.G. and Liu,W.G.
  TITLE     Thyrotroph embryonic factor polymorphism predicts faster
            progression of Parkinson's disease in a longitudinal study
  JOURNAL   J Integr Neurosci 20 (1), 95-101 (2021)
   PUBMED   33834695
  REMARK    GeneRIF: Thyrotroph embryonic factor polymorphism predicts faster
            progression of Parkinson's disease in a longitudinal study.
REFERENCE   2  (bases 1 to 4381)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   3  (bases 1 to 4381)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4381)
  AUTHORS   Saleh,A.A., Gohar,S.F., Hemida,A.S., Elgharbawy,M. and Soliman,S.E.
  TITLE     Evaluation of ASPM and TEF Gene Expressions as Potential Biomarkers
            for Bladder Cancer
  JOURNAL   Biochem Genet 58 (3), 490-507 (2020)
   PUBMED   32274607
  REMARK    GeneRIF: Evaluation of ASPM and TEF Gene Expressions as Potential
            Biomarkers for Bladder Cancer.
REFERENCE   5  (bases 1 to 4381)
  AUTHORS   Rowsey,R.A., Smoley,S.A., Williamson,C.M., Vasmatzis,G.,
            Smadbeck,J.B., Ning,Y., Greipp,P.T., Hoppman,N.L., Baughn,L.B.,
            Ketterling,R.P. and Peterson,J.F.
  TITLE     Characterization of TCF3 rearrangements in pediatric
            B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq)
            identifies complex genomic rearrangements and a novel TCF3/TEF gene
            fusion
  JOURNAL   Blood Cancer J 9 (10), 81 (2019)
   PUBMED   31575852
  REMARK    GeneRIF: Characterization of rearrangements in pediatric
            B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq)
            identified a novel TCF3/TEF gene fusion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4381)
  AUTHORS   Krueger,D.A., Warner,E.A. and Dowd,D.R.
  TITLE     Involvement of thyrotroph embryonic factor in calcium-mediated
            regulation of gene expression
  JOURNAL   J Biol Chem 275 (19), 14524-14531 (2000)
   PUBMED   10799536
REFERENCE   7  (bases 1 to 4381)
  AUTHORS   Ossipow,V., Fonjallaz,P. and Schibler,U.
  TITLE     An RNA polymerase II complex containing all essential initiation
            factors binds to the activation domain of PAR leucine zipper
            transcription factor thyroid embryonic factor
  JOURNAL   Mol Cell Biol 19 (2), 1242-1250 (1999)
   PUBMED   9891058
REFERENCE   8  (bases 1 to 4381)
  AUTHORS   Hunger,S.P., Li,S., Fall,M.Z., Naumovski,L. and Cleary,M.L.
  TITLE     The proto-oncogene HLF and the related basic leucine zipper protein
            TEF display highly similar DNA-binding and transcriptional
            regulatory properties
  JOURNAL   Blood 87 (11), 4607-4617 (1996)
   PUBMED   8639829
REFERENCE   9  (bases 1 to 4381)
  AUTHORS   Khatib,Z.A., Inaba,T., Valentine,M. and Look,A.T.
  TITLE     Chromosomal localization and cDNA cloning of the human DBP and TEF
            genes
  JOURNAL   Genomics 23 (2), 344-351 (1994)
   PUBMED   7835883
REFERENCE   10 (bases 1 to 4381)
  AUTHORS   Drolet,D.W., Scully,K.M., Simmons,D.M., Wegner,M., Chu,K.T.,
            Swanson,L.W. and Rosenfeld,M.G.
  TITLE     TEF, a transcription factor expressed specifically in the anterior
            pituitary during embryogenesis, defines a new class of leucine
            zipper proteins
  JOURNAL   Genes Dev 5 (10), 1739-1753 (1991)
   PUBMED   1916262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA238847.1, U44059.1,
            AL035659.22, AL008582.11 and R38583.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003216.3.
            
            Summary: This gene encodes a member of the PAR (proline and acidic
            amino acid-rich) subfamily of basic region/leucine zipper (bZIP)
            transcription factors. It is expressed in a broad range of cells
            and tissues in adult animals, however, during embryonic
            development, TEF expression appears to be restricted to the
            developing anterior pituitary gland, coincident with the appearance
            of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind
            to, and transactivate the TSHB promoter. It shows homology (in the
            functional domains) with other members of the PAR-bZIP subfamily of
            transcription factors, which include albumin D box-binding protein
            (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin
            gene-binding protein (VBP); VBP is considered the chicken homologue
            of TEF. Different members of the subfamily can readily form
            heterodimers, and share DNA-binding, and transcriptional regulatory
            properties. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042476.2, SRR1660807.2128.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266304.9/ ENSP00000266304.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                DA238847.1         14-81
            69-1067             U44059.1           2-1000
            1068-3628           AL035659.22        99591-102151
            3629-4338           AL008582.11        101-810
            4339-4381           R38583.1           11-53               c
FEATURES             Location/Qualifiers
     source          1..4381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..4381
                     /gene="TEF"
                     /note="TEF transcription factor, PAR bZIP family member"
                     /db_xref="GeneID:7008"
                     /db_xref="HGNC:HGNC:11722"
                     /db_xref="MIM:188595"
     exon            1..260
                     /gene="TEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1015
                     /gene="TEF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thyrotroph embryonic factor; thyrotrophic embryonic
                     factor; TEF, PAR bZIP transcription factor"
                     /codon_start=1
                     /product="thyrotroph embryonic factor isoform 1"
                     /protein_id="NP_003207.1"
                     /db_xref="CCDS:CCDS14014.1"
                     /db_xref="GeneID:7008"
                     /db_xref="HGNC:HGNC:11722"
                     /db_xref="MIM:188595"
                     /translation="MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLME
                     NPPREARLDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLD
                     EFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTES
                     SLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPM
                     IKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALR
                     TEVAELRKEVGKCKTIVSKYETKYGPL"
     exon            261..578
                     /gene="TEF"
                     /inference="alignment:Splign:2.1.0"
     exon            579..799
                     /gene="TEF"
                     /inference="alignment:Splign:2.1.0"
     exon            800..4381
                     /gene="TEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4360..4365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEF"
                     /note="hexamer: ATTAAA"
     polyA_site      4381
                     /gene="TEF"
                     /note="major polyA site"
ORIGIN      
        1 gcagtagctg cccgtgtcgg cagctgcagc gggtcgcacg gctccggccc atctcggggg
       61 gcgggcgggg gaggcgaggt gcgcgagccg agtccggggc acgatgtccg acgcgggcgg
      121 cggaaagaag ccgcctgtgg acccgcaggc aggacccggt ccggggccgg ggcgcgcagc
      181 tggggaaagg ggcctgtcgg ggtccttccc cctggtcctg aagaagctga tggagaaccc
      241 cccgcgcgag gcgcgcctcg ataaggaaaa ggggaaggaa aagctggagg aggacgaggc
      301 cgcagccgcc agcaccatgg ctgtctcagc ctccctcatg ccacccatct gggacaagac
      361 catcccatat gatggcgaat ctttccacct ggagtacatg gacctggatg agttcctgct
      421 ggagaatggc atccccgcca gccccaccca cctggcccac aacctgctgc tgcctgtagc
      481 agagctagaa gggaaggagt ctgccagctc ttccacagca tccccaccat cctcctccac
      541 tgccatcttt cagccctctg aaaccgtgtc cagcacagaa tcttccctgg agaaggagag
      601 ggagactccc agtcccatcg accccaattg tgtggaagtg gatgtgaact tcaatccgga
      661 ccccgccgac ctggtgctct ccagtgtgcc aggcggggag ctcttcaacc ctcggaagca
      721 caagtttgct gaggaggacc tgaagcccca gcctatgatc aaaaaggcca agaaggtctt
      781 tgtccccgac gagcagaagg atgaaaagta ctggacaaga cgcaagaaga acaacgtggc
      841 agctaaacgg tcacgggatg cccggcgcct gaaagagaat cagatcacca tccgggcagc
      901 cttcctggag aaggagaaca cagccctgcg gacggaggtg gccgagctac gcaaggaggt
      961 gggcaagtgc aagaccatcg tgtccaagta tgagaccaaa tacgggccct tgtaacccgt
     1021 gccccccgcc cgggcggggt actgcctgca cctcagacct ctgcctgggg gctccctgta
     1081 acccctcaca cgcgtggaga cttatgactc gtcgtgggcg catggcggcg cacctgctgc
     1141 aggagcggcc acgtctcagc ttcattatac catggcctgc gcacgtggcg acgtccctga
     1201 ggggccagtc tcctcactgg tggggaacgc aagagaatct gcgtagatgg gtgactcagc
     1261 cttagtttct attcttggat gtcccagttg aatcagaagg ggacctctgg agtacacacc
     1321 tctctcctgg gcgctcaggg tccctggact ctccctcagt ctccagcctg ggctgccgag
     1381 ggctatctct gcagaatgag ttgtgatcat tgtcacccta tgtcttctca ggtagcaggg
     1441 cgcgtttcca cttaaggtgt gtctgtcacg cacctcattc tccccagaca gtctttgagt
     1501 aacatctgtt cccatcttcc ttggaagcag gacacaccag ctcctccgtc agtgtctgca
     1561 tgggtagcag gctgcaggag tggggtctct gcacagcctg ggatggggct tggggctggg
     1621 gcctgcagca gaagtgtgcc cagcgtttct cggctcccgc accccttttc ccttatggct
     1681 ctgaggccat cggctgtctc tgcatttcat tggctgtgga ggagagactc ctaggatggc
     1741 tgctgtctga gccatgagtg ccagggctga gagaggcctc ttcatttcct ctccaggcta
     1801 ctcagaggcc atgtgaagct cgtttgtccc actagaccag gcctctgggc ctgctctttc
     1861 tttccaccca atgtccagtc ttggatcata gatttaaaag gaaaacccct cttatctagg
     1921 aggctttaac ttcctggacc ccaggattca ccttcctagt ggtgtttaga aaatgcctcc
     1981 acagccccct tccaccatgg gcatgagagc tggggtgtgt ttcttgagaa gctccctttt
     2041 ttcttgctct gctcaccggt gtggcctggg ctggagtgca ctctccctgg gggcagctgg
     2101 ggcctcgcaa ttcttgcttc aggatctctc ccatgcgagc tgcccggagg gtgtcagcag
     2161 ggcaagacac ctagtctaga gtcaccaagg tcacagtgcc actttcacgg gatagcaggc
     2221 tcttgggact tttacacagg cctagggtcc cctcagtctt ggtcccagga gatgggggcc
     2281 actcgtgagg ctggccatgc tgtggcttct cacagctgtg gtctcccctg cctcacaacg
     2341 actcctttct cttgtgtggc gggactcgcc cttttgctgt gctcagaaga ttcactgagg
     2401 aaactcatgg aagcctctgc tcatttgggt cactgggaca cccctgagat gggtgtgttt
     2461 atttgctcag ggcgggcagc ctatggtgaa gaggagacag aggcgatggg cgtgcttcgt
     2521 cctccgtaac actggcttta tttaccgtgg tggttcagag tcccaggccc tgacctctaa
     2581 agacttttca taacagacgt taagaccaag ccgtggacct caccccaggg gaatgccacg
     2641 gccctttggg gacctgcaca cccacctctc cgggggactt gacaaggggc cctgaggcca
     2701 agggaggtca ctcctccctc caggcccctg acttttactt tgtggttctc taaaaaccat
     2761 gtacacactt tcactctatt gtaaccacac agggcaggcg catccagcat gtcagtgtcc
     2821 tgccccgggc agctctccct cccgggcacg ctccctctgg cctggtggat caccaagagg
     2881 gcggttctca ttttgttatt agtggaagag ccttgagctt aaaagctctt cattttcttt
     2941 gccggaaagt atatggtttg tgtttttgca gttttatttt tttaaggatg gacactaaat
     3001 ctctggtgtc catgttccga gcccggtggc tgggatggtg gctcgatgtg tctcctcttt
     3061 atcccgccct ctgcctgttt ggtgccctcc cttctttccc ccaggcagtg ggtatcgggt
     3121 tctttcccaa agtgcttact tggaaagagt gtggctgctg gactcttttc gaaatgcccc
     3181 tctgagtcag gagcctggtg gggacaagat ggaggatgtc cacagaggct gacctgtggg
     3241 ggaaaagaag tgctcaggta aggttgtctc ctctcctgtc ctaaaaaaat ccatgcttgc
     3301 aggagagggt tggtgcctgc tcagtttctg tcgagggaat gggagtctcc tcggctccct
     3361 cctgggccct ctgcttcttg gaggccgacc gctggagact gcggctcctg tgcttggatc
     3421 tttgacatct gtcagtcact ggaggctaga gaagttgact ttaccttggc tttctgtggg
     3481 ttcccgatgg gcttggaagt gccgtctact tcctaagcat cctgtctaaa gctttgtggc
     3541 accctcagtg caacctcaga acagacaaat catgaatgag ctggaacttt gcaagaatat
     3601 tcatattata aatgtctcat ctgatggagg aacgtgtgca tttagagaga gggagagttt
     3661 tcaaggttta tggcaacttt gtggaggacc tgggtaactc ttacccttgg ccaaaggaag
     3721 aggttttcct gtctggcttc tgaggttgga gggggcactt agcagtgaac cttaagtctg
     3781 ggtacatgta accctgctga ggggctgtgc aggccgctcc tacggtcctt tggcctgagg
     3841 cagggcggga ggcatgcaag ccagtggggg aaaacccctc tgaagctggg cagccctcta
     3901 cctgggcccc gggagccgtg ctccttggaa cgcaaagggc cgaggagcat ctggttttca
     3961 tggcaaagct ctactccaga gctcctttaa catctgctaa ttaagtgcaa taaatttttc
     4021 tagaaaatgg caaagatgac ttccaggtgg atattgctct cttacggtgt tggggatgcc
     4081 agaacaccac ttggttttat ttttctaagt gcatgtgatg tgatagagtg tgtggggctc
     4141 tgtgtccttc cctgggagct ggcattccag cgggcccctc tctttacctt tgttggggga
     4201 aggaggcaag agagaaattc cttcttccca gccagagagg gcagaagcag accgtagccc
     4261 attggcctta tgtgcgtgtg tgcgtgcgag tgtgtcactg ctggtgggcc ggagtgatgt
     4321 ggtgggaggg aagccgggaa tgtatccttt tcagacaaaa ttaaatattt tgaaatgaga
     4381 a
//
