LOCUS       NM_025108               1633 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin epsilon and delta complex 2 (TEDC2), mRNA.
ACCESSION   NM_025108
VERSION     NM_025108.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Li,Y., Guo,B., Wang,L., Zhou,F., Yu,Z., Huang,Y., Chen,R.,
            Zhang,M., Zhang,K., Zheng,L., Jing,S., Hong,W. and Han,T.
  TITLE     TEDC2 plays an oncogenic role and serves as a therapeutic target of
            hepatocellular carcinoma
  JOURNAL   Dig Liver Dis 56 (5), 861-871 (2024)
   PUBMED   37867019
  REMARK    GeneRIF: TEDC2 plays an oncogenic role and serves as a therapeutic
            target of hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Liu,Y., Zhu,J., Shen,J., Lu,Y., Pan,K., Tong,C. and Wang,Y.
  TITLE     A pan-cancer analysis of the prognostic implication and oncogenic
            role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors
  JOURNAL   Front Immunol 14, 1272108 (2024)
   PUBMED   38239349
  REMARK    GeneRIF: A pan-cancer analysis of the prognostic implication and
            oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in
            human tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Fang,L., Yu,W., Zhu,P., Yu,G. and Ye,B.
  TITLE     TEDC2 correlated with prognosis and immune microenvironment in lung
            adenocarcinoma
  JOURNAL   Sci Rep 13 (1), 5006 (2023)
   PUBMED   36973475
  REMARK    GeneRIF: TEDC2 correlated with prognosis and immune
            microenvironment in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Breslow,D.K., Hoogendoorn,S., Kopp,A.R., Morgens,D.W., Vu,B.K.,
            Kennedy,M.C., Han,K., Li,A., Hess,G.T., Bassik,M.C., Chen,J.K. and
            Nachury,M.V.
  TITLE     A CRISPR-based screen for Hedgehog signaling provides insights into
            ciliary function and ciliopathies
  JOURNAL   Nat Genet 50 (3), 460-471 (2018)
   PUBMED   29459677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106820.4, AL559561.3 and BC018719.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025108.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018719.1, AK301929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361837.9/ ENSP00000355022.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC106820.4         43854-43858         c
            6-17                AL559561.3         1-12
            18-1633             BC018719.1         1-1616
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1633
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /note="tubulin epsilon and delta complex 2"
                     /db_xref="GeneID:80178"
                     /db_xref="HGNC:HGNC:25849"
     exon            1..62
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1338
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /note="uncharacterized protein C16orf59"
                     /codon_start=1
                     /product="tubulin epsilon and delta complex protein 2"
                     /protein_id="NP_079384.2"
                     /db_xref="CCDS:CCDS10468.2"
                     /db_xref="GeneID:80178"
                     /db_xref="HGNC:HGNC:25849"
                     /translation="MLPAGCSRRLVAELQGALDACAQRQLQLEQSLRVCRRLLHAWEP
                     TGTRALKPPPGPETNGEDPLPACTPSPQDLKELEFLTQALEKAVRVRRGITKAGERDK
                     APSLKSRSIVTSSGTTASAPPHSPGQAGGHASDTRPTKGLRQTTVPAKGHPERRLLSV
                     GDGTRVGMGARTPRPGAGLRDQQMAPSAAPQAPEAFTLKEKGHLLRLPAAFRKAASQN
                     SSLWAQLSSTQTSDSTDAAAAKTQFLQNMQTASGGPQPRLSAVEVEAEAGRLRKACSL
                     LRLRMREELSAAPMDWMQEYRCLLTLEGLQAMVGQCLHRLQELRAAVAEQPPRPCPVG
                     RPPGASPSCGGRAEPAWSPQLLVYSSTQELQTLAALKLRVAVLDQQIHLEKVLMAELL
                     PLVSAAQPQGPPWLALCRAVHSLLCEGGARVLTILRDEPAV"
     exon            63..161
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            162..232
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            233..641
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            642..695
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            696..786
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            787..898
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1000
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1191
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1633
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1612..1617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /note="hexamer: ATTAAA"
     polyA_site      1633
                     /gene="TEDC2"
                     /gene_synonym="C16orf59"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggca aattgcaagg agacgccgcc gccttcatgc tgccggcggg ctgctcgcgc
       61 cggctggtgg ccgagctgca gggcgccctg gacgcctgcg cacagcgaca attgcaattg
      121 gagcagagcc tgcgcgtttg ccgtcggctg ctgcatgcct gggaaccaac tgggacccgg
      181 gctttgaagc cacctccagg gccagaaact aatggagagg acccccttcc agcatgcaca
      241 cccagtccac aagacctcaa agagttggag tttctgaccc aggcactgga gaaggctgta
      301 cgagttcgaa gaggcatcac taaggccgga gagagagaca aggcccccag cctgaaatct
      361 aggtccattg tcacctcttc tggcacgaca gcctccgccc caccgcattc cccaggccaa
      421 gctggtggcc atgcttcaga cacgagaccc accaagggcc tccgccagac cacggtgcct
      481 gccaagggcc accctgagcg ccggctgctg tcagtggggg atgggacccg tgttgggatg
      541 ggagcccgaa cccccaggcc tggggcgggc ctcagggacc agcaaatggc cccatccgct
      601 gctcctcagg ccccagaagc cttcacactc aaggagaagg ggcacctgct gcggctgcct
      661 gcggcattca ggaaagcagc ttcccagaac tcgagcctgt gggcccagct cagttccaca
      721 cagaccagtg attccacgga tgccgccgct gccaaaaccc agttcctcca gaacatgcag
      781 acagcttcag gcgggcccca gcccaggctc agtgctgtgg aggtggaggc ggaggcgggg
      841 cgcctgcgga aggcctgctc gctgctgaga ctgcgcatga gggaggagct ctcggcagcc
      901 cccatggact ggatgcagga gtaccgctgc ctgctcacgc tggaggggct gcaggccatg
      961 gtgggccagt gtctgcacag gctgcaggag ctgcgtgcag cggtggcgga acagccacca
     1021 agaccatgtc ctgtggggag gccccccgga gcctcgccgt cctgtggggg tagagcggag
     1081 cctgcatgga gcccccagct gcttgtctac tccagcaccc aggagctgca gaccctggcg
     1141 gccctcaagc tgcgagtggc tgtgctggac cagcagatcc acttggaaaa ggtcctgatg
     1201 gctgaactcc tccccctggt aagcgctgca cagccgcagg ggccgccctg gctggccctg
     1261 tgccgggctg tgcacagcct gctctgcgag ggaggagcac gtgtccttac catcctgcgg
     1321 gatgaacctg cagtctgagc ctttcccatg ctgccctcgg cctgttcaga tggggattgg
     1381 gggtgtcttc cctggcactg tgctcgggga cccagagatg cctgtgcttc cctgggaaac
     1441 ctggtgaact ggaccaggtg gcctcactgg ctcttctcag gacaactaag cctgctggtc
     1501 agggctggct ttcagccttc ctaaggctcc tggactccag aggccagcgg ggagcctttc
     1561 ctggctccct ctgttttctc tcactgtaga ccaaagagcc gcttgtgtga tattaaagcc
     1621 actttagaaa gca
//
