LOCUS       NM_001367178            1920 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin epsilon and delta complex 1 (TEDC1),
            transcript variant 6, mRNA.
ACCESSION   NM_001367178
VERSION     NM_001367178.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Sarli,A., Al Sudani,Z.M., Vaghefi,F., Motallebi,F., Khosravi,T.,
            Rezaie,N. and Oladnabi,M.
  TITLE     Second report of TEDC1-related microcephaly caused by a novel
            biallelic mutation in an Iranian consanguineous family
  JOURNAL   Mol Biol Rep 51 (1), 181 (2024)
   PUBMED   38252227
  REMARK    GeneRIF: Second report of TEDC1-related microcephaly caused by a
            novel biallelic mutation in an Iranian consanguineous family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Breslow,D.K., Hoogendoorn,S., Kopp,A.R., Morgens,D.W., Vu,B.K.,
            Kennedy,M.C., Han,K., Li,A., Hess,G.T., Bassik,M.C., Chen,J.K. and
            Nachury,M.V.
  TITLE     A CRISPR-based screen for Hedgehog signaling provides insights into
            ciliary function and ciliopathies
  JOURNAL   Nat Genet 50 (3), 460-471 (2018)
   PUBMED   29459677
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Filipuzzi,I., Thomas,J.R., Pries,V., Estoppey,D., Salcius,M.,
            Studer,C., Schirle,M. and Hoepfner,D.
  TITLE     Direct Interaction of Chivosazole F with Actin Elicits Cell
            Responses Similar to Latrunculin A but Distinct from Chondramide
  JOURNAL   ACS Chem Biol 12 (9), 2264-2269 (2017)
   PUBMED   28796488
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   DeGrado-Warren,J., Dufford,M., Chen,J., Bartel,P.L., Shattuck,D.
            and Frech,G.C.
  TITLE     Construction and characterization of a normalized yeast two-hybrid
            library derived from a human protein-coding clone collection
  JOURNAL   Biotechniques 44 (2), 265-273 (2008)
   PUBMED   18330356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928654.1 and BX248074.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX248074.1, DRR138514.11005.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392523.9/ ENSP00000376308.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL928654.1         169664-169745
            83-1866             BX248074.1         1-1784
            1867-1920           AL928654.1         177613-177666
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..1920
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /note="tubulin epsilon and delta complex 1"
                     /db_xref="GeneID:283643"
                     /db_xref="HGNC:HGNC:20127"
     exon            1..277
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1618
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /note="isoform 6 is encoded by transcript variant 6;
                     uncharacterized protein C14orf80; tubulin epsilon and
                     delta complex protein 1"
                     /codon_start=1
                     /product="tubulin epsilon and delta complex protein 1
                     isoform 6"
                     /protein_id="NP_001354107.1"
                     /db_xref="CCDS:CCDS91958.1"
                     /db_xref="GeneID:283643"
                     /db_xref="HGNC:HGNC:20127"
                     /translation="MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKF
                     DRPEATSALWQLLFRVLSPLPAGNALASLALEVQARLVKSALCSQGYPRLALAQLPED
                     GSQGSRELLLALSWLLARGPVPEQMLAQARVPLGDEMTVCQCEALASPGPPAPHMEAE
                     GPVDVRHVQWLMGKLRFRWRQLVSSQQEQCALLSKIHLYTRGCHSDQSLSHLSVTEAE
                     MLRDPEGGQQVSGAGAAQNLDLAYPKCLHSFCTPGMGPRTFWNDLWLVCEQPGLLPGD
                     WAAPLDPGGASACSLLSPFRALLRTLERENQRLEAVLAWRRSELVFWRWMDTVLGTCA
                     PEVPAAASQPTFLPWVPERGGGELDLVVRELQALEEELREAAERRRAAWEAKAGGCGR
                     GPEWSAARRASREAVEKELGALQQCWERDGGPAQPHGPHRLVRREDGAAGDRDLRAAV
                     VIRTLRSQEACLEAVLRRLQGQCRQELARLVGARPGLIWIPPPGR"
     exon            278..356
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            357..559
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            560..715
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            716..814
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1021
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1108
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1288
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1920
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /note="hexamer: AATAAA"
     polyA_site      1901
                     /gene="TEDC1"
                     /gene_synonym="C14orf80"
                     /note="major polyA site"
ORIGIN      
        1 aggttccagc cggagcggta actgggcgca ggtcccagcc gccgcactaa acccggcccg
       61 tgcggtgatt ggacgcaggc cccgggccgc ggcggaggcg ggcgatccga aagaggctgg
      121 tgctggctgc atggggaggc ggcggcagcg ggtggacccc gcggctgggg cccgggccgg
      181 ggccctgcct gaggccatcg ccgcgttgag tcggtcgctg ccctcgggac ccagccccga
      241 gatcttccgc cgcgccaagt tcgaccgtcc ggaggcgacc tccgcgctct ggcagctcct
      301 cttccgtgtg ctctcgccac tccctgcggg caacgccttg gcatcgctcg ccctggaggt
      361 ccaagcccgc ttggtgaagt cagcactatg ctcccagggc tacccgaggc tggcactggc
      421 acaactacct gaggatggct cgcagggcag tcgggagctg ctgctggctc tgtcctggct
      481 cttggcccga ggacctgtgc ccgagcagat gctggcccag gcccgagtgc ctctgggtga
      541 cgagatgact gtgtgccagt gtgaggccct ggccagccct ggcccacctg caccccacat
      601 ggaagcagag ggtcctgtgg atgtccgcca tgtgcagtgg ctgatgggaa agctgcggtt
      661 ccggtggcgc cagctggtgt ccagtcagca ggagcagtgc gccctcctga gcaagatcca
      721 cctgtacaca cgcggctgcc acagcgacca gagccttagc catctgtctg tcactgaagc
      781 agagatgctc agggacccag agggaggcca gcaggtttct ggagcgggag ctgcccaaaa
      841 cctggacctg gcctacccaa agtgcctgca ctccttctgc actcctggga tgggtcccag
      901 aaccttctgg aatgatctgt ggctggtatg tgagcagcca ggtctgctgc cgggtgactg
      961 ggcagcaccc ttggatcctg gtggggcctc agcctgcagc ctgctctccc cttttagggc
     1021 gctgctgcgg actctggagc gtgagaacca gcgcctggag gctgtcctgg cgtggcggcg
     1081 ctctgagctg gtcttctggc ggtggatgga cacggtcctg ggcacctgtg ccccggaggt
     1141 gcctgctgca gcctcacagc ccaccttcct gccctgggtc cccgagcgcg ggggtggcga
     1201 gttggacctg gtagtgcggg agctgcaggc actggaggag gagctgcggg aggctgcgga
     1261 gcgcaggcgg gcggcctggg aggccaaggc tggaggctgt ggacgggggc cagagtggag
     1321 tgccgcgcgg cgggcctctc gggaggctgt ggaaaaggag ctgggagctc tacagcagtg
     1381 ctgggagcga gacggtggcc cggcccagcc ccatgggcca caccggctgg tgagacgaga
     1441 ggatggggca gcaggggacc gggacctgcg ggcagctgtg gtgatcagga cgctgaggag
     1501 ccaggaggcc tgcctggagg cggtgctacg tcgactacag ggacagtgtc ggcaggaact
     1561 ggccaggctg gtgggagccc gccctggtct catctggatc ccgccacctg gacgctgagg
     1621 gcctgtcgac gggccctcgt gtgggaagcc tgccctggcc cagcctggct gggtcttgga
     1681 ggagcagatt ccaaggccag gtggccgcag ggacgatgca gatgcagagc ccacgtcaca
     1741 tgctcgctcc aggggtgggg ctgggctgac tctggccgga tcccaggcct gtggctagca
     1801 gcactgggga caggaatggc tggtcccttg aggaggtcgt gacaggctca gcctggtggt
     1861 ctggagggga ctcggaaata aattgtagca gctttcctgc cgctggccct ccccctgcca
//
