LOCUS       NM_005422               7353 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens tectorin alpha (TECTA), mRNA.
ACCESSION   NM_005422
VERSION     NM_005422.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7353)
  AUTHORS   Chen,R., Diaz-Miranda,M.A., Aref-Eshghi,E., Hartman,T.R.,
            Griffith,C., Morrison,J.L., Wheeler,P.G., Torti,E., Richard,G.,
            Kenna,M., Dechene,E.T., Spinner,N.B., Bai,R., Conlin,L.K.,
            Krantz,I.D., Amr,S.S. and Luo,M.
  TITLE     Characterization of a possible founder synonymous variant in TECTA
            in multiple individuals with autosomal recessive hearing loss
  JOURNAL   Hum Mutat 43 (12), 1837-1843 (2022)
   PUBMED   35870179
  REMARK    GeneRIF: Characterization of a possible founder synonymous variant
            in TECTA in multiple individuals with autosomal recessive hearing
            loss.
REFERENCE   2  (bases 1 to 7353)
  AUTHORS   Mei,X., Zhou,Y., Amjad,M., Yang,W., Zhu,R., Asif,M.,
            Hussain,H.M.J., Yang,T., Iqbal,F. and Hu,H.
  TITLE     Next-Generation Sequencing Identifies Pathogenic Variants in HGF,
            POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families
  JOURNAL   Neural Plast 2021, 5528434 (2021)
   PUBMED   33976695
  REMARK    GeneRIF: Next-Generation Sequencing Identifies Pathogenic Variants
            in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf
            Families.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7353)
  AUTHORS   Walls,W.D., Moteki,H., Thomas,T.R., Nishio,S.Y., Yoshimura,H.,
            Iwasa,Y., Frees,K.L., Nishimura,C.J., Azaiez,H., Booth,K.T.,
            Marini,R.J., Kolbe,D.L., Weaver,A.M., Schaefer,A.M., Wang,K.,
            Braun,T.A., Usami,S.I., Barr-Gillespie,P.G., Richardson,G.P.,
            Smith,R.J. and Casavant,T.L.
  TITLE     A comparative analysis of genetic hearing loss phenotypes in
            European/American and Japanese populations
  JOURNAL   Hum Genet 139 (10), 1315-1323 (2020)
   PUBMED   32382995
  REMARK    GeneRIF: A comparative analysis of genetic hearing loss phenotypes
            in European/American and Japanese populations.
REFERENCE   4  (bases 1 to 7353)
  AUTHORS   Zhou,C., Li,S., Song,Q., Liu,X. and Miao,Z.
  TITLE     [Diagnosis and reproductive guidance for a couple carrying a novel
            c.1893C>T mutation of the TECTA gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 36 (2), 147-150 (2019)
   PUBMED   30703234
  REMARK    GeneRIF: homozygous c.1893C>A mutation of the TECTA gene probably
            underlies the proband's hearing loss which conformed to an
            autosomal recessive inheritance
REFERENCE   5  (bases 1 to 7353)
  AUTHORS   Yamamoto,N., Mutai,H., Namba,K., Morita,N., Masuda,S., Nishi,Y.,
            Nakano,A., Masuda,S., Fujioka,M., Kaga,K., Ogawa,K. and
            Matsunaga,T.
  TITLE     Prevalence of TECTA mutation in patients with mid-frequency
            sensorineural hearing loss
  JOURNAL   Orphanet J Rare Dis 12 (1), 157 (2017)
   PUBMED   28946916
  REMARK    GeneRIF: TECTA mutations were identified in 6.0% of mid-frequency
            sensorineural hearing loss cases; these mutations were more
            frequent in patients with shallow U-shaped audiograms than those
            with U-shaped audiograms, and in families which have the family
            histories compatible with autosomal dominant than those with the
            family histories compatible with sporadic or autosomal recessive.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7353)
  AUTHORS   Verhoeven,K., Van Laer,L., Kirschhofer,K., Legan,P.K., Hughes,D.C.,
            Schatteman,I., Verstreken,M., Van Hauwe,P., Coucke,P., Chen,A.,
            Smith,R.J., Somers,T., Offeciers,F.E., Van de Heyning,P.,
            Richardson,G.P., Wachtler,F., Kimberling,W.J., Willems,P.J.,
            Govaerts,P.J. and Van Camp,G.
  TITLE     Mutations in the human alpha-tectorin gene cause autosomal dominant
            non-syndromic hearing impairment
  JOURNAL   Nat Genet 19 (1), 60-62 (1998)
   PUBMED   9590290
  REMARK    Erratum:[Nat Genet 1999 Apr;21(4):449]
REFERENCE   7  (bases 1 to 7353)
  AUTHORS   Hughes,D.C., Legan,P.K., Steel,K.P. and Richardson,G.P.
  TITLE     Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9
            and human chromosome 11: a candidate for human autosomal dominant
            nonsyndromic deafness
  JOURNAL   Genomics 48 (1), 46-51 (1998)
   PUBMED   9503015
REFERENCE   8  (bases 1 to 7353)
  AUTHORS   Verhoeven,K., Van Camp,G., Govaerts,P.J., Balemans,W.,
            Schatteman,I., Verstreken,M., Van Laer,L., Smith,R.J., Brown,M.R.,
            Van de Heyning,P.H., Somers,T., Offeciers,F.E. and Willems,P.J.
  TITLE     A gene for autosomal dominant nonsyndromic hearing loss (DFNA12)
            maps to chromosome 11q22-24
  JOURNAL   Am J Hum Genet 60 (5), 1168-1173 (1997)
   PUBMED   9150164
REFERENCE   9  (bases 1 to 7353)
  AUTHORS   Van Camp,G., Willems,P.J. and Smith,R.J.
  TITLE     Nonsyndromic hearing impairment: unparalleled heterogeneity
  JOURNAL   Am J Hum Genet 60 (4), 758-764 (1997)
   PUBMED   9106521
  REMARK    Review article
REFERENCE   10 (bases 1 to 7353)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000646.4 and AP000826.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 26, 2020 this sequence version replaced NM_005422.3.
            
            Summary: The tectorial membrane is an extracellular matrix of the
            inner ear that contacts the stereocilia bundles of specialized
            sensory hair cells. Sound induces movement of these hair cells
            relative to the tectorial membrane, deflects the stereocilia, and
            leads to fluctuations in hair-cell membrane potential, transducing
            sound into electrical signals. Alpha-tectorin is one of the major
            noncollagenous components of the tectorial membrane.  Mutations in
            the TECTA gene have been shown to be responsible for autosomal
            dominant nonsyndromic hearing impairment and a recessive form of
            sensorineural pre-lingual non-syndromic deafness. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000392793.6/ ENSP00000376543.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AP000646.4         103909-104108
            201-265             AP000646.4         105331-105395
            266-399             AP000646.4         108497-108630
            400-687             AP000646.4         111877-112164
            688-825             AP000646.4         115738-115875
            826-991             AP000646.4         116219-116384
            992-1404            AP000646.4         120972-121384
            1405-1975           AP000826.5         66883-67453
            1976-2568           AP000826.5         69333-69925
            2569-3142           AP000826.5         71219-71792
            3143-3744           AP000826.5         79002-79603
            3745-4306           AP000826.5         87136-87697
            4307-4506           AP000826.5         94462-94661
            4507-4890           AP000826.5         99422-99805
            4891-5177           AP000826.5         101716-102002
            5178-5473           AP000826.5         103656-103951
            5474-5584           AP000826.5         106854-106964
            5585-5787           AP000826.5         108159-108361
            5788-5951           AP000826.5         109635-109798
            5952-6200           AP000826.5         110258-110506
            6201-6363           AP000826.5         129413-129575
            6364-6451           AP000826.5         130661-130748
            6452-6568           AP000826.5         131345-131461
            6569-7353           AP000826.5         132287-133071
FEATURES             Location/Qualifiers
     source          1..7353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..7353
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /note="tectorin alpha"
                     /db_xref="GeneID:7007"
                     /db_xref="HGNC:HGNC:11720"
                     /db_xref="MIM:602574"
     exon            1..200
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            201..265
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..6669
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /note="alpha-tectorin"
                     /codon_start=1
                     /product="alpha-tectorin precursor"
                     /protein_id="NP_005413.2"
                     /db_xref="CCDS:CCDS8434.1"
                     /db_xref="GeneID:7007"
                     /db_xref="HGNC:HGNC:11720"
                     /db_xref="MIM:602574"
                     /translation="MNYSSFLRIWVSFIFALVQHQAQPRELMYPFWQNDTKTPKVDDG
                     SSSEIKLAIPVFFFGVPYRTVYVNNNGVVSFNVLVSQFTPESFPLTDGRAFVAPFWAD
                     VHNGIRGEIYYRETMEPAILKRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSST
                     TPVNTFQAVLVSDGSYTFTLFNYYEINWTTGTASGGDPLTGLGGVMAQAGFNGGNLTN
                     FFSLPGSRTPEIVNIQETTNVNVPGRWAFKVDGKEIDPANGCTSRGQFLRRGEVFWDD
                     LNCTVKCRCLDFNNEIYCQEASCSPYEVCEPKGKFFYCSAVETSTCVVFGEPHYHTFD
                     GFLFHFQGSCAYLLARQCLQTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNGYKILI
                     PKGSYGRVKVNDLVTSLPVTLDLGTVKIYQSGISTAVETDFGLLVTFDGQHYASISVP
                     GSYINSTCGLCGNYNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCT
                     QCDAATEALYFGSDYCGFLNKTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQ
                     AIQAYALVCQALGIPIGDWRTQTGCVSTVQCPSFSHYSVCTSSCPDTCSDLTASRNCA
                     TPCTEGCECNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGD
                     VYCFNKTCGSGEVCAVEDGYQGCFPKRETVCLLSQNQVLHTFDGASYAFPSEFSYTLL
                     KTCPERPEYLEIDINKKKPDAGPAWLRGLRILVADQEVKIGGIGASEVKLNGQEVELP
                     FFHPSGKLEIYRNKNSTTVESKGVVTVQYSDIGLLYIRLSTTYFNCTGGLCGFYNANA
                     SDEFCLPNGKCTDNLAVFLESWTTFEEICNGECGDLLKACNNDSELLKFYRSRSRCGI
                     INDPSNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVG
                     PWRTYDFCPLECPENSHFEECITCTETCETLTLGPICVDSCSEGCQCDEGYALLGSQC
                     VTRSECGCNFEGHQLATNETFWVDLDCQIFCYCSGTDNRVHCETIPCKDDEYCMEEGG
                     LYYCQARTDASCIVSGYGHYLTFDGFPFDFQTSCPLILCTTGSRPSSDSFPKFVVTAK
                     NEDRDPSLALWVKQVDVTVFGYSIVIHRAYKHTVLVNSERLYLPLKLGQGKINIFSFG
                     FHVVVETDFGLKVVYDWKTFLSITVPRSMQNSTYGLCGRYNGNPDDDLEMPMGLLASS
                     VNEFGQSWVKRDTFCQVGCGDRCPSCAKVEGFSKVQQLCSLIPNQNAAFSKCHSKVNP
                     TFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGITVTGWRNYTSCTVTCPPNSHY
                     ESCVSVCQPRCAAIRLKSDCSHYCVEGCHCDAGYVLNGKSCILPHSCGCYSDGKYYEP
                     KQLFWNSDCTRRCRCFRRNVIQCDPRQCKSDEECALRNGVRGCFSTKTSYCLAAGGGV
                     FRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSAPNLTIISPVYFYINEE
                     QILINDRNTVKVNGTQVNVPFITGLATKIYSSEGFLVIDTSPDIQIYYNGFNVIKISI
                     SERLQNKVCGLCGNFNGDLTDDYVTLRGKPVVSSVVLAQSWKTNGMQKRPLAPSCNEL
                     QFSQYAAMCDNVHIQKMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYSHK
                     KFQLCGSLAAYGEACRSFGILSTEWIEKENCSGVVEDPCVGADCPNRTCELGNGRELC
                     GCIEPPPYGNNSHDIIDAEVTCKAAQMEVSISKCKLFQLGFEREGVRINDRQCTGIEG
                     EDFISFQINNTKGNCGNIVQSNGTHIMYKNTLWIESANNTGNIITRDRTINVEFSCAY
                     ELDIKISLDSVVKPMLSVINLTVPTQEGSFITKMALYKNASYKHPYRQGEVVLTTRDV
                     LYVGVFVVGADATHLILTLNKCYATPTRDSNDKLRYFIIEGGCQNLKDNTIGIEENAV
                     SLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTKEPKEQI
                     ISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLCSCVTGTLQEDGKSCRASNSSMELQV
                     WTLLLIMIQISLWHFVYKSGTTS"
     exon            266..399
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            400..687
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            688..825
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            826..991
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1404
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1975
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2568
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..3142
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3744
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..4306
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4506
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4890
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..5177
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            5178..5473
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..5584
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            5585..5787
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5951
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            5952..6200
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            6201..6363
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6451
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            6452..6568
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     exon            6569..7353
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7327..7332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /note="hexamer: AATAAA"
     polyA_site      7353
                     /gene="TECTA"
                     /gene_synonym="DFNA12; DFNA8; DFNB21"
                     /note="major polyA site"
ORIGIN      
        1 cacttacctg tctctagtgc aggactaact taatttttgg ttttaagagt acgagattca
       61 gacattattt caggaatcag aaattattgg caacaagttg aggagaactg acatgaattc
      121 ttgttttacc taattttttc tggcttacca agatttggct taatatttct gactcagttc
      181 ctccagcctc tacagaacag gatgaattat tcatcattcc ttagaatttg ggtctctttc
      241 atcttcgcac ttgtacagca ccaagctcag cccagggagc tcatgtatcc attttggcag
      301 aatgacacca aaacccctaa agtagatgat ggaagctcat ctgagattaa gttggccatc
      361 ccagttttct tctttggcgt tccttaccgc actgtctatg tcaataacaa cggagttgtt
      421 tccttcaatg tgctagtgag ccagttcacg ccagaatcct ttcccctgac agatgggaga
      481 gccttcgtcg ccccattttg ggcagatgtg cacaatggaa ttcgaggcga gatctattac
      541 agagagacca tggagcctgc catcttgaaa agagccacca aggacatcag gaagtacttc
      601 aaagacatgg caaccttctc tgccacttgg gttttcattg tgacatggga ggaagtcacg
      661 ttttatggag gcagcagcac cacacctgtg aacaccttcc aggccgtcct agtgtccgat
      721 ggctcctata cattcaccct cttcaattat tacgaaatca actggaccac ggggacggcg
      781 agtggcggcg accccctgac aggtcttggt ggagtgatgg cacaggcagg atttaatggt
      841 ggaaacctca ccaatttctt cagcctcccg gggtcaagaa cccccgagat cgtgaatatc
      901 caggagacca caaacgtcaa tgttccaggc cgctgggcat ttaaagttga tggaaaggaa
      961 attgacccag ccaatggctg cacctcaagg ggacaattcc ttcggcgagg ggaggtgttt
     1021 tgggatgact tgaactgcac cgtcaagtgc cgctgtctgg atttcaacaa tgagatctac
     1081 tgccaggagg cttcctgtag cccctacgag gtgtgcgaac ccaaaggcaa attcttctac
     1141 tgcagcgctg tggagaccag cacatgcgtg gtgtttgggg agccacacta ccacactttt
     1201 gacggcttcc tcttccactt ccaaggctcc tgtgcctact tgctggcccg acagtgtttg
     1261 cagacttcca gcctcccttt cttcagtgtg gaggccaaga atgaacaccg cagaggttca
     1321 gccgtctcct gggtgaagga gctctcagtg gaggtgaatg gctacaagat tctcatcccc
     1381 aaaggaagct atggaagagt caaggttaat gacctagtga cttctttgcc tgtcacctta
     1441 gacttgggga cagtgaaaat ctaccagagt ggcatatcta ctgccgtgga aacagatttt
     1501 gggctcttag tgacttttga tggccagcac tacgcctcca tttccgtccc aggctcctat
     1561 ataaactcca cctgtggact ctgtggaaac tataataaaa acccactgga tgacttcctc
     1621 cgcccggatg gcaggccggc catgtctgtc ctggatctgg gagagagctg gcgtgtgtac
     1681 cacgcagact ggaagtgcga ctccggctgc gtcgacaact gcacccagtg cgacgctgcc
     1741 actgaagccc tctactttgg ctctgactac tgcggcttcc tcaacaagac agacggccct
     1801 ctgtgggagt gtggcactgt cgtggacccc actgcttttg tgcacagctg cgtgtatgac
     1861 ctgtgcagtg tgagggacaa tggcacgctc ctctgccaag ccatccaggc ctatgctctt
     1921 gtgtgccaag cccttggcat tccaattgga gactggcgaa cccagactgg gtgtgtgtcc
     1981 acagtgcagt gcccgagctt cagccactac tccgtgtgca caagcagctg ccccgacaca
     2041 tgctccgacc tgacggcctc gcggaactgc gccacgccgt gcacagaggg ctgcgagtgc
     2101 aaccagggct tcgtcctcag caccagccag tgcgtccctc tgcacaagtg cggctgcgac
     2161 ttcgacggcc actactacac catgggggag ttcttctggg ccacggccaa ctgcactgtg
     2221 caatgcctgt gcgaggaggg cggggacgtc tactgcttca acaagacctg cggcagcggg
     2281 gaggtgtgcg ccgtggagga cggctaccag ggctgcttcc ccaagcggga gaccgtgtgc
     2341 ctgctcagcc agaaccaggt gctgcacacc tttgacggcg cctcctacgc cttcccctcc
     2401 gagttctcct acaccctcct gaagacctgc cctgagcgcc cagagtactt ggaaatcgac
     2461 atcaacaaga agaagcccga tgcaggacct gcttggctgc ggggacttcg gatcctggtg
     2521 gccgaccagg aggtcaagat aggaggcatc ggggcttcgg aagtcaagtt gaatggtcag
     2581 gaagtggaat tgcctttttt ccatccttcg gggaagctgg aaatttatcg aaacaaaaac
     2641 agtacgacag tggagtccaa gggcgtggtg actgtccagt actcagacat aggtctattg
     2701 tacatccggc tgtccaccac atacttcaat tgcacagggg gcttgtgcgg cttctacaat
     2761 gccaacgcca gtgacgagtt ctgtctcccc aacggcaagt gcacggacaa cctggcagtg
     2821 ttcctggaaa gctggacaac tttcgaggag atctgcaatg gagagtgtgg ggacctgctg
     2881 aaggcctgca acaatgactc ggagctgctc aagttttatc gaagccgctc caggtgcggc
     2941 atcatcaacg acccctccaa cagctccttc ctggagtgcc atggggtggt gaacgtcact
     3001 gcctattacc gcacctgcct tttccgcctg tgccagagtg ggggcaatga gtcagagctc
     3061 tgtgactctg tggcccggta tgcaagcgcc tgcaagaatg cggacgtgga ggtggggccc
     3121 tggcggacct atgacttctg cccactggag tgcccagaga acagccactt tgaggagtgc
     3181 atcacatgta cagagacctg tgagaccctt accctgggcc ccatctgcgt ggatagctgc
     3241 tctgagggat gtcagtgtga tgagggctat gctctactgg gcagccagtg tgtcacgcgg
     3301 agtgagtgtg gctgcaactt tgaggggcac caacttgcca ccaatgagac cttctgggtg
     3361 gacctggact gccagatctt ctgctattgc agtggcacag acaacagggt ccactgcgag
     3421 accattccct gcaaggatga tgagtactgc atggaggaag gtggcctgta ctactgccaa
     3481 gcccgcaccg acgcctcctg catcgtctca ggctacggcc actacctcac ctttgatggc
     3541 ttcccctttg acttccagac cagctgccca ctcatcctgt gcaccacagg aagcaggcca
     3601 agctcagact ctttccccaa gtttgttgtc acagccaaga atgaggaccg ggacccgtca
     3661 ctggccttgt gggttaagca ggtggacgtg accgtgtttg gctacagcat cgtgatccac
     3721 cgagcttaca agcacactgt gctggtcaac agtgaacggc tctatctgcc cctgaagctg
     3781 gggcaaggga agataaatat cttttccttt ggcttccacg tggtggtgga aactgatttt
     3841 ggcctgaagg ttgtatatga ctggaagacc ttcctgtcca tcacagtccc tcggagcatg
     3901 cagaacagca cctatggtct gtgtggccgc tacaacggca accctgatga tgacctggag
     3961 atgcccatgg gtctgcttgc atcgagtgtc aatgagtttg ggcagagctg ggtgaagagg
     4021 gacaccttct gccaggtggg ctgtggggac cgctgtccgt cctgtgccaa ggtggaaggt
     4081 ttctccaaag tgcagcagct gtgcagcctg atccccaacc agaacgctgc cttctccaag
     4141 tgtcacagca aagttaaccc caccttcttc tataagaact gcctgtttga ctcttgcatc
     4201 gatgggggcg cggtgcagac cgcctgcagc tggctgcaga actacgccag cacctgccag
     4261 actcagggga ttacggtgac tggctggagg aattacacgt cctgcactgt cacctgccct
     4321 ccaaacagcc attacgagag ctgcgtgagt gtctgccagc cccgctgcgc cgccatccgc
     4381 ctgaagagtg actgcagcca ctactgcgtg gagggctgtc actgcgacgc tggctacgtc
     4441 ctcaacggca agagctgcat cctgccccac agctgcggct gctactccga tggcaaatat
     4501 tacgagccca agcagctatt ttggaacagc gactgcacgc ggcgctgccg ctgtttccgt
     4561 cgcaacgtga ttcagtgcga cccgcgccaa tgcaagtcag acgaggagtg tgcgctgcgc
     4621 aacggggtgc gcggctgctt cagcaccaag acctcctact gcctggcggc cggcggcggc
     4681 gtcttccgca ccttcgacgg cgccttcctg cgcttcccag ccaactgcgc cttcgtgctg
     4741 tccaccatct gccagaaact gcccgacatc tccttccagc ttatcatcaa cttcgacaag
     4801 tggtcggccc ccaacctcac catcatttcg cccgtctact tctacattaa cgaagagcag
     4861 attctcatca acgaccggaa cacggtcaag gtgaatggca cacaagtgaa tgttccattt
     4921 ataactggtt tggcaaccaa aatctacagc agtgaggggt ttctggtgat tgacaccagc
     4981 ccagacatcc agatatacta caatggtttc aacgtcatta aaatcagcat cagcgagagg
     5041 ctgcagaaca aagtgtgcgg tctctgtggc aacttcaacg gggacctaac agatgattat
     5101 gtgaccttgc gagggaagcc ggtggtaagc agcgtggtgc tggcccagag ctggaaaacc
     5161 aatggcatgc agaagagacc tcttgccccc agctgcaacg agctgcagtt ctcacagtat
     5221 gcagccatgt gtgacaatgt gcacatccag aagatgcagg gtgatggcta ctgcctgaag
     5281 ctcaccgaca tgaagggctt cttccagccc tgctatgggc ttctcgatcc cctcccattc
     5341 tacgagtcct gctacctgga cggctgctac agccacaaga agttccagct gtgcggctcc
     5401 ctggccgcct acggggaggc ctgccgctcc ttcgggatcc ttagcaccga gtggattgag
     5461 aaggagaatt gctcaggagt ggttgaagat ccctgtgtgg gggcggactg tcccaaccga
     5521 acttgcgagc tgggcaatgg cagggagctg tgtggctgca tcgagccacc cccctatgga
     5581 aataactcac atgacattat cgatgcagag gtgacctgca aagcagccca aatggaagtg
     5641 tccatatcta agtgcaagct cttccagctc ggttttgaga gggagggcgt gaggatcaat
     5701 gacagacagt gcaccggcat cgagggggaa gattttatct cctttcagat caacaacacc
     5761 aaagggaatt gtggaaacat tgtgcagtcc aatggcacgc atatcatgta taaaaacaca
     5821 ctctggatcg aaagcgccaa caacactggc aacatcatca ccagggaccg cacgatcaat
     5881 gtggaatttt catgtgctta tgagctggat atcaagatct ccttggattc tgttgtgaag
     5941 cctatgctaa gtgtaattaa cctgacagtt ccaacccaag aaggcagctt catcaccaag
     6001 atggctctct acaaaaacgc ctcctacaaa catccttacc gccagggtga agtagtgttg
     6061 acgactcgag atgtgctgta tgtaggggtt tttgtggttg gagctgacgc cacacattta
     6121 atcctaacac tcaacaaatg ctatgccaca cccacccgag atagcaatga taagctccga
     6181 tatttcatca ttgaaggagg gtgtcagaac ctcaaagata acaccattgg catcgaggag
     6241 aatgcagtct ccctgacctg tcgctttcac gtcaccgtct ttaaattcat aggggattac
     6301 gacgaagttc accttcactg tgcagtgtca ctctgcgact cagaaaagta ctcctgtaaa
     6361 atcacttgcc cacacaattc caggattgcc acagattaca caaaagagcc caaagaacag
     6421 atcatttcag tgggacctat taggagaaaa aggctggact ggtgtgagga caatggaggg
     6481 tgtgagcaga tttgcacgag ccgggtggat gggcctctct gcagctgtgt aacaggaacc
     6541 ctgcaggagg acggcaagag ctgcagagcc tctaattctt caatggaact tcaagtctgg
     6601 acgcttcttc tcatcatgat ccagatttca ttatggcatt ttgtctataa atcaggcacg
     6661 acctcataat taactcaagg ttgctatata aagtactgta atttacttac ttcaacaccc
     6721 tgtaggataa aaagtgtgtg cccttaagtc aaaacctatt tgaaagtgtc cagcatctca
     6781 aaatgatgcc acctgcctcc aatggtccaa ggtccagaaa ccagcgacca tccaagctcc
     6841 tctttcagag tatgaaacgg ggcttctaca agccagttat ggaaagtatc tctcttgtgt
     6901 aaaattccca aacagttgtc actagagact ttggttcaca tgaaaaacca gtaaaggaaa
     6961 aaaattctgg ttagagaaat ctgactggaa atctgaccag agaaatctgt caagccagtg
     7021 ctatttctgg atcacagttt tttacagaga gagggcctgt tggaacgatt ttgaagtgat
     7081 gactggaagg tttgactccc tctaaggaat cttgctggtg tttggaagtg tccgatctac
     7141 gttatgcacg tgttctgtct atgaggcgct tctccaccca ctgtgtcctt caaccttgcc
     7201 atggcagctt tggccactgg ggatattgtt gacctgggga accccaccca ctctcctacc
     7261 ccctcgaacc caatcccttc tctttttaca aatcaaccaa atacttttta atgtgtttta
     7321 tccttaaata aactttgtgt tcaagtattc tca
//
