LOCUS       NM_138501               1139 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens trans-2,3-enoyl-CoA reductase (TECR), transcript
            variant 1, mRNA.
ACCESSION   NM_138501 XM_001132190 XM_001132196
VERSION     NM_138501.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Zhou,Y., Lv,R., Ye,R.D., Ren,R. and Yu,L.
  TITLE     The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with
            trans-2-enoyl-CoA reductase involved in substrates transfer in very
            long chain fatty acid elongation
  JOURNAL   Biochem Biophys Res Commun 704, 149588 (2024)
   PUBMED   38422897
  REMARK    GeneRIF: The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with
            trans-2-enoyl-CoA reductase involved in substrates transfer in very
            long chain fatty acid elongation.
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Kato,R., Takenaka,Y., Ohno,Y. and Kihara,A.
  TITLE     Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty
            acid elongation cycle and its cooperative action with fatty acid
            elongases
  JOURNAL   J Biol Chem 300 (2), 105656 (2024)
   PUBMED   38224948
  REMARK    GeneRIF: Catalytic mechanism of trans-2-enoyl-CoA reductases in the
            fatty acid elongation cycle and its cooperative action with fatty
            acid elongases.
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 1139)
  AUTHORS   Wakashima,T., Abe,K. and Kihara,A.
  TITLE     Dual functions of the trans-2-enoyl-CoA reductase TER in the
            sphingosine 1-phosphate metabolic pathway and in fatty acid
            elongation
  JOURNAL   J Biol Chem 289 (36), 24736-24748 (2014)
   PUBMED   25049234
  REMARK    GeneRIF: Data indicate that trans-2-enoyl-CoA reductase TER is
            involved in both very long-chain fatty acids (VLCFAs) synthesis and
            sphingosine degradation within sphingolipids.
REFERENCE   6  (bases 1 to 1139)
  AUTHORS   Caliskan,M., Chong,J.X., Uricchio,L., Anderson,R., Chen,P.,
            Sougnez,C., Garimella,K., Gabriel,S.B., dePristo,M.A., Shakir,K.,
            Matern,D., Das,S., Waggoner,D., Nicolae,D.L. and Ober,C.
  TITLE     Exome sequencing reveals a novel mutation for autosomal recessive
            non-syndromic mental retardation in the TECR gene on chromosome
            19p13
  JOURNAL   Hum Mol Genet 20 (7), 1285-1289 (2011)
   PUBMED   21212097
  REMARK    GeneRIF: Exome sequencing reveals a novel mutation for autosomal
            recessive non-syndromic mental retardation in the TECR gene on
            chromosome 19p13.
REFERENCE   7  (bases 1 to 1139)
  AUTHORS   Hashmi,G., Shariff,T., Seul,M., Vissavajjhala,P., Hue-Roye,K.,
            Charles-Pierre,D., Lomas-Francis,C., Chaudhuri,A. and Reid,M.E.
  TITLE     A flexible array format for large-scale, rapid blood group DNA
            typing
  JOURNAL   Transfusion 45 (5), 680-688 (2005)
   PUBMED   15847654
  REMARK    GeneRIF: Observational study of genetic testing. (HuGE Navigator)
            Erratum:[Transfusion. 2005 Jun;45(6):1045]
REFERENCE   8  (bases 1 to 1139)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
REFERENCE   9  (bases 1 to 1139)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   10 (bases 1 to 1139)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB491783.1 and BC007801.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138501.5.
            
            Summary: This gene encodes a multi-pass membrane protein that
            resides in the endoplasmic reticulum, and belongs to the steroid
            5-alpha reductase family. The elongation of microsomal long and
            very long chain fatty acid consists of 4 sequential reactions. This
            protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to
            saturated acyl-CoA. Alternatively spliced transcript variants have
            been found for this gene.[provided by RefSeq, Apr 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.394292.1,
                                           SRR5189661.13331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215567.10/ ENSP00000215567.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DB491783.1         35-116
            83-1139             BC007801.2         60-1116
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1139
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /note="trans-2,3-enoyl-CoA reductase"
                     /db_xref="GeneID:9524"
                     /db_xref="HGNC:HGNC:4551"
                     /db_xref="MIM:610057"
     exon            1..118
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1030
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /EC_number="1.3.1.93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptic glycoprotein SC2; glycoprotein, synaptic 2;
                     very-long-chain enoyl-CoA reductase; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="very-long-chain enoyl-CoA reductase isoform 1"
                     /protein_id="NP_612510.1"
                     /db_xref="CCDS:CCDS12313.1"
                     /db_xref="GeneID:9524"
                     /db_xref="HGNC:HGNC:4551"
                     /db_xref="MIM:610057"
                     /translation="MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWY
                     PARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIY
                     LLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRN
                     IFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDL
                     RPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFT
                     QMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL"
     exon            119..169
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            170..221
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            222..266
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            267..370
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            371..486
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            487..592
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            593..665
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            666..709
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            710..767
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            768..856
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            857..902
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1139
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /note="hexamer: AATAAA"
     polyA_site      1139
                     /gene="TECR"
                     /gene_synonym="GPSN2; MRT14; SC2; TER"
                     /note="major polyA site"
ORIGIN      
        1 gtttagtcta tcgctgcggt tgcgagcgct gtagggagcc tgtgctgtgc cgcgcagtta
       61 ggcagcagca gccgcggagc agtagccgcc gtgggaggga gccatgaagc attacgaggt
      121 ggagattctg gacgcaaaga caagggagaa gctgtgtttc ttggacaagg tggagcccca
      181 cgccaccatt gcggagatca agaacctctt cactaagacc catccgcagt ggtaccccgc
      241 ccgccagtcc ctccgcctgg accccaaggg caagtccctg aaggatgagg atgttctgca
      301 gaagctgccc gtgggcacca cggccacact gtacttccgg gacctggggg cccagatcag
      361 ctgggtgacg gtcttcctaa cagagtacgc ggggcccctt ttcatctacc tgctcttcta
      421 cttccgagtg cccttcatct atggccacaa atatgacttt acgtccagtc ggcatacagt
      481 ggtgcacctc gcctgcatct gtcactcatt ccactacatc aagcgcctgc tggagacgct
      541 cttcgtgcac cgcttctccc atggcactat gcctttgcgc aacatcttca agaactgcac
      601 ctactactgg ggcttcgccg cgtggatggc ctattacatc aatcaccctc tctacactcc
      661 ccctacctac ggagctcagc aggtgaaact ggcgctcgcc atctttgtga tctgccagct
      721 cggcaacttc tccatccaca tggccctgcg ggacctgcgg cccgctgggt ccaagacgcg
      781 gaagatccca taccccacca agaacccctt cacgtggctc ttcctgctgg tgtcctgccc
      841 caactacacc tacgaggtgg ggtcctggat cggtttcgcc atcatgacgc agtgtctccc
      901 agtggccctg ttctccctgg tgggcttcac ccagatgacc atctgggcca agggcaagca
      961 ccgcagctac ctgaaggagt tccgggacta cccgcccctg cgcatgccca tcatcccctt
     1021 cctgctctga gcgctcaccc ctgctgaggc tcagcccctc aacccggtgg cattctgggg
     1081 gaggagtggg gcccacagct ctccagcacc cggaataaag cccgcctgcc ccagtcgga
//
