LOCUS       NM_015395               6545 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tectonin beta-propeller repeat containing 1 (TECPR1),
            mRNA.
ACCESSION   NM_015395
VERSION     NM_015395.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6545)
  AUTHORS   Kaur,N., de la Ballina,L.R., Haukaas,H.S., Torgersen,M.L.,
            Radulovic,M., Munson,M.J., Sabirsh,A., Stenmark,H., Simonsen,A.,
            Carlsson,S.R. and Lystad,A.H.
  TITLE     TECPR1 is activated by damage-induced sphingomyelin exposure to
            mediate noncanonical autophagy
  JOURNAL   EMBO J 42 (17), e113105 (2023)
   PUBMED   37409525
  REMARK    GeneRIF: TECPR1 is activated by damage-induced sphingomyelin
            exposure to mediate noncanonical autophagy.
REFERENCE   2  (bases 1 to 6545)
  AUTHORS   Cao,L. and Lin,F.
  TITLE     TECPR1 Induces Apoptosis in Non-Small Cell Lung Carcinoma via ATG5
            Upregulation-Induced Autophagy Promotion
  JOURNAL   Ann Clin Lab Sci 52 (4), 580-592 (2022)
   PUBMED   36197771
  REMARK    GeneRIF: TECPR1 Induces Apoptosis in Non-Small Cell Lung Carcinoma
            via ATG5 Upregulation-Induced Autophagy Promotion.
REFERENCE   3  (bases 1 to 6545)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 6545)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6545)
  AUTHORS   Wetzel,L., Blanchard,S., Rama,S., Beier,V., Kaufmann,A. and
            Wollert,T.
  TITLE     TECPR1 promotes aggrephagy by direct recruitment of LC3C
            autophagosomes to lysosomes
  JOURNAL   Nat Commun 11 (1), 2993 (2020)
   PUBMED   32532970
  REMARK    GeneRIF: TECPR1 promotes aggrephagy by direct recruitment of LC3C
            autophagosomes to lysosomes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6545)
  AUTHORS   Kim,J.H., Hong,S.B., Lee,J.K., Han,S., Roh,K.H., Lee,K.E.,
            Kim,Y.K., Choi,E.J. and Song,H.K.
  TITLE     Insights into autophagosome maturation revealed by the structures
            of ATG5 with its interacting partners
  JOURNAL   Autophagy 11 (1), 75-87 (2015)
   PUBMED   25484072
REFERENCE   7  (bases 1 to 6545)
  AUTHORS   Chen,D., Fan,W., Lu,Y., Ding,X., Chen,S. and Zhong,Q.
  TITLE     A mammalian autophagosome maturation mechanism mediated by TECPR1
            and the Atg12-Atg5 conjugate
  JOURNAL   Mol Cell 45 (5), 629-641 (2012)
   PUBMED   22342342
  REMARK    GeneRIF: The concerted interactions among TECPR1, Atg12-Atg5, and
            PtdIns(3)P provide the fusion specificity between autophagosomes
            and lysosomes and that the assembly of this complex initiates the
            autophagosome maturation process.
REFERENCE   8  (bases 1 to 6545)
  AUTHORS   Ogawa,M. and Sasakawa,C.
  TITLE     The role of Tecpr1 in selective autophagy as a cargo receptor
  JOURNAL   Autophagy 7 (11), 1389-1391 (2011)
   PUBMED   21795850
REFERENCE   9  (bases 1 to 6545)
  AUTHORS   Ogawa,M., Yoshikawa,Y., Kobayashi,T., Mimuro,H., Fukumatsu,M.,
            Kiga,K., Piao,Z., Ashida,H., Yoshida,M., Kakuta,S., Koyama,T.,
            Goto,Y., Nagatake,T., Nagai,S., Kiyono,H., Kawalec,M.,
            Reichhart,J.M. and Sasakawa,C.
  TITLE     A Tecpr1-dependent selective autophagy pathway targets bacterial
            pathogens
  JOURNAL   Cell Host Microbe 9 (5), 376-389 (2011)
   PUBMED   21575909
REFERENCE   10 (bases 1 to 6545)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091654.4.
            
            On May 17, 2019 this sequence version replaced NM_015395.2.
            
            Summary: This gene encodes a tethering factor involved in
            autophagy. The encoded protein is found at autolysosomes, and is
            involved in targeting protein aggregates, damaged mitochondria, and
            bacterial pathogens for autophagy [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053591.1, AK292996.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447648.7/ ENSP00000404923.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC091654.4         76657-76763         c
            108-262             AC091654.4         75925-76079         c
            263-506             AC091654.4         70453-70696         c
            507-689             AC091654.4         69416-69598         c
            690-812             AC091654.4         69102-69224         c
            813-938             AC091654.4         67998-68123         c
            939-1113            AC091654.4         65601-65775         c
            1114-1214           AC091654.4         65382-65482         c
            1215-1316           AC091654.4         63040-63141         c
            1317-1462           AC091654.4         61307-61452         c
            1463-1953           AC091654.4         57952-58442         c
            1954-2099           AC091654.4         57358-57503         c
            2100-2255           AC091654.4         56335-56490         c
            2256-2405           AC091654.4         55755-55904         c
            2406-2563           AC091654.4         55492-55649         c
            2564-2691           AC091654.4         53570-53697         c
            2692-2794           AC091654.4         52545-52647         c
            2795-2891           AC091654.4         49537-49633         c
            2892-2971           AC091654.4         49332-49411         c
            2972-3028           AC091654.4         48193-48249         c
            3029-3209           AC091654.4         47521-47701         c
            3210-3345           AC091654.4         46917-47052         c
            3346-3438           AC091654.4         46192-46284         c
            3439-3545           AC091654.4         42467-42573         c
            3546-3665           AC091654.4         42223-42342         c
            3666-6545           AC091654.4         39155-42034         c
FEATURES             Location/Qualifiers
     source          1..6545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..6545
                     /gene="TECPR1"
                     /note="tectonin beta-propeller repeat containing 1"
                     /db_xref="GeneID:25851"
                     /db_xref="HGNC:HGNC:22214"
                     /db_xref="MIM:614781"
     exon            1..107
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..262
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..506
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..3779
                     /gene="TECPR1"
                     /codon_start=1
                     /product="tectonin beta-propeller repeat-containing
                     protein 1"
                     /protein_id="NP_056210.1"
                     /db_xref="CCDS:CCDS47648.1"
                     /db_xref="GeneID:25851"
                     /db_xref="HGNC:HGNC:22214"
                     /db_xref="MIM:614781"
                     /translation="MPNSVLWAVDLFGRVYTLSTAGQYWEMCKDSQLEFKRVSATTQC
                     CWGIACDNQVYVYVCASDVPIRRREEAYENQRWNPMGGFCEKLLLSDRWGWSDVSGLQ
                     HRPLDRVALPSPHWEWESDWYVDENFGGEPTEKGGWTYAIDFPATYTKDKKWNSCVRR
                     RKWIRYRRYKSRDIWAKIPSKDDPKELPDPFNDLSVGGWEITEEPVGRLSVWAVSLQG
                     KVWYREDVSHSNPEGSSWSLLDTPGEVVQISCGPHDLLWATLWEGQALVREGINRSNP
                     KGSSWSIVEPPGSENGVMHISVGVSVVWAVTKDWKVWFRRGVNSHNPCGTSWIEMVGE
                     MTMVNVGMNDQVWGIGCEDRAVYFRQGVTPSELSGKTWKAIIAARECDRSHSGSSSSL
                     LSAGCFFGDEVRGSGESAPSDTDASSEVERPGPGQILPAEPLDDSKNATGNSASGLGA
                     GRTAEDTVEDACPAEGSREARPNTHPGPAPTPAELPWTNIDLKEAKKVPSHSAAGFPE
                     TTSLSSLGLLPLGLEEPYGVDDHPLWAWVSGGGCVVEACAMPRWFTVQAGLSSSVHML
                     SLSITPAQTAAWRKQIFQQLTERTKRELENFRHYEQAVEQSVWVKTGALQWWCDWKPH
                     KWVDVRLALEQFTGHDGVRDSILFIYYVVHEEKKYIHIFLNEVVALVPVLNETKHSFA
                     LYTPERTRQRWPVRLAAATEQDMNDWLALLSLSCCESRKVQGRPSPQAIWSITCKGDI
                     FVSEPSPDLEAHEHPLPCDQMFWRQMGGHLRMVEANSRGVVWGIGYDHTAWVYTGGYG
                     GGCFQGLASSTSNIYTQSDVKCVHIYENQRWNPVTGYTSRGLPTDRYMWSDASGLQEC
                     TKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCW
                     ARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSE
                     LNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQPAGDCWYHIPS
                     PPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQ
                     VWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRS
                     SSQEQEPSAPPEAHGPVCC"
     exon            507..689
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..812
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..938
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1113
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1214
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1316
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1462
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1953
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2099
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2255
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2405
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2563
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2691
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2794
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2891
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2971
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3028
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3209
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3345
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3438
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3545
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3665
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..6545
                     /gene="TECPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5689..5694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TECPR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5724
                     /gene="TECPR1"
                     /note="major polyA site"
     polyA_site      5737
                     /gene="TECPR1"
ORIGIN      
        1 gccgcttccg gcccaccctc ttgcccggtc cccgggaggg ccggtccgct cctcccggac
       61 gccgaggacc taccaccgcg acttcgcccc gcccggcgcg ggcccaggac cctgatgtcg
      121 cttttgaaca gcccctgcac ctggcagcca gcgagctact gtagtaggca ttgccgactg
      181 tttgcatacc ggatgggagt gacagtgtaa tagaaaaaca agcaagaaac cttttaggta
      241 ggactcctaa ggctcagagg aagttacctc cagccgctgc catgcccaac tcagtgctgt
      301 gggcggtgga cctcttcggg agagtgtaca cgctgtccac agcaggccag tactgggaaa
      361 tgtgcaagga ctcccagctg gagttcaagc gcgtcagcgc caccacgcag tgctgctggg
      421 gcattgcctg tgacaaccag gtctacgtgt atgtgtgtgc cagcgatgtc cccatccgcc
      481 gccgagagga ggcctatgag aatcagcgct ggaatcccat gggcggcttc tgtgagaagc
      541 tcctgctgag tgaccgctgg gggtggagtg acgtgagtgg gctccagcac cggccgctgg
      601 acagggtggc actgccctcg ccgcactggg agtgggagtc tgactggtac gtggatgaga
      661 attttggagg tgaacccact gagaaagggg ggtggacgta cgccatcgac tttcccgcca
      721 cctacacgaa agacaagaag tggaattctt gtgtgcggcg ccggaagtgg atccggtaca
      781 ggagatacaa gtcccgggac atctgggcca agatcccctc gaaggatgac cccaaggagc
      841 tgcccgaccc cttcaacgac ctctctgtag ggggctggga gatcacggag gagcctgtgg
      901 gccgcctgtc agtgtgggct gtgtctctgc agggcaaggt gtggtacaga gaggacgtca
      961 gccactccaa ccccgaaggg tcctcctggt ccctgctgga cacccccggg gaggtggttc
     1021 agatcagctg tgggccccac gacctcctgt gggccacact ctgggaggga caggccctgg
     1081 tccgggaagg aatcaacagg agcaatccca aaggaagttc ctggtccatc gtggagcctc
     1141 ctggatctga aaacggggtc atgcacatct cggtgggagt cagcgtggtc tgggctgtca
     1201 ccaaggactg gaaggtgtgg ttccgaagag gcgtcaactc tcacaatccc tgcggcacca
     1261 gttggattga gatggttggt gagatgacga tggtgaacgt gggaatgaac gaccaggtgt
     1321 ggggcattgg ctgtgaggac cgagccgtgt acttccggca gggtgtcacc cccagcgagc
     1381 tcagtgggaa gacctggaaa gccatcatcg cggcccgaga gtgtgaccgg tcacactctg
     1441 gcagctcgtc tagtctcctc agtgccggct gcttcttcgg tgatgaggtg aggggtagtg
     1501 gcgagtctgc ccccagcgac accgatgcct cctcggaagt cgagagacca gggcctggcc
     1561 agattctccc tgcagaacct ctagacgatt ccaagaatgc cacagggaac tcagcctcag
     1621 gcctgggggc tggcaggacc gcagaagata ccgtggaaga tgcctgccca gccgagggca
     1681 gcagggaggc cagacccaac acgcaccccg gcccggcccc caccccggcc gagctgccct
     1741 ggaccaatat tgacctcaag gaggccaaga aagtgcccag ccactcggcc gctggcttcc
     1801 ccgagaccac cagcctctcc tctctggggc tcctcccact gggcttggag gagccgtatg
     1861 gggtggatga ccacccgctg tgggcctggg tgtcgggagg cggctgcgtg gtggaggcat
     1921 gtgccatgcc cagatggttc actgtccagg cgggcctgtc ctcctcggta cacatgctgt
     1981 ccctgtccat cacgccggcc cagaccgctg cctggaggaa gcagatcttc cagcagctca
     2041 cggaaaggac caagcgggag ctggagaact tcagacacta cgagcaggcc gtggagcagt
     2101 cggtgtgggt gaagaccggg gcgctgcagt ggtggtgcga ctggaagccc cacaagtggg
     2161 tggacgtgcg cttggccctg gagcagttca cggggcacga cggcgtccgg gacagcatcc
     2221 tcttcatcta ctatgtggtc cacgaggaga agaagtacat ccacatattc ctgaatgagg
     2281 tggtggcgct ggtcccagtg ctgaacgaga ccaagcactc ctttgccctg tacacccctg
     2341 agcggacacg gcagaggtgg ccggtgcgtc tggctgctgc caccgagcag gacatgaatg
     2401 actggctcgc cctgctcagc ctgtcttgct gcgagagccg gaaggtgcag ggccgcccgt
     2461 ccccgcaggc catctggtcc atcacctgca agggggacat cttcgtgagc gagcccagcc
     2521 cagacctgga ggcccacgag caccccctgc cctgcgacca gatgttttgg cggcagatgg
     2581 gaggccacct gcggatggtg gaggccaaca gccggggcgt ggtgtggggc atcggctatg
     2641 accacacggc ctgggtatac acaggcggct atggaggcgg ctgcttccaa ggcctggcca
     2701 gcagcaccag taacatctac acgcagtcag acgtgaagtg tgttcacatc tatgagaacc
     2761 agcgctggaa ccccgtcaca ggctacacca gcaggggtct gcccacggac cggtacatgt
     2821 ggagcgatgc ctcggggctg caggagtgca cgaaggctgg cacgaagccc ccgtccctgc
     2881 agtgggcctg ggtttccgac tggttcgtgg atttcagcgt tccggggggc acggaccagg
     2941 aggggtggca gtatgccagc gacttccctg cctcatacca tgggtccaaa acgatgaagg
     3001 attttgtgag gaggaggtgc tgggccagaa aatgcaagct ggtgaccagt gggccctggc
     3061 tggaggtgcc ccccatcgcc ctcagggacg tgtccatcat cccggagagc ccgggtgccg
     3121 aggggagtgg gcacagcatc gccctctggg ccgtcagcga caagggggat gtgctgtgcc
     3181 gcctgggcgt gtcggagctc aaccctgcgg gctcctcctg gctgcacgtt ggcaccgacc
     3241 agcccttcgc ctccatctcc atcggggcct gctaccaggt gtgggccgtg gcaagggacg
     3301 gctccgcctt ctaccgggga tccgtgtacc cctcgcagcc agccggtgac tgctggtacc
     3361 acatcccgtc cccaccgaga cagaggctga agcaggtgtc cgcggggcag acgtcggtgt
     3421 atgccctgga tgagaatgga aacctgtggt atcgccaagg gatcacgccc agctacccgc
     3481 agggctccag ctgggagcac gtgtccaaca acgtgtgccg agtgtccgtg gggcccctgg
     3541 accaggtctg ggtgatcgcc aacaaagtgc agggcagcca cagcctgagc cgggggacag
     3601 tgtgtcatcg caccggcgtg cagcctcacg agcccaaggg ccacggctgg gactacggca
     3661 tcgggggagg ctgggaccat atctctgtcc gggccaatgc caccagggcc ccccggagct
     3721 cgtcccagga gcaggagccg agtgccccac cagaggccca tggccccgtc tgctgctgag
     3781 gcccccccac acacctacat gcagggacgg tgcccagttt gggggatcaa ggctgagcca
     3841 ttcttgtgct ggagtgtgca ccgtgggagc aatgtggccc aggtggactc aggagggaac
     3901 ctggccccaa ggctgcggcc acttcagagg cactggctga gacggccctg aaatgtgaag
     3961 ctccgcggac actcccacac gtgtccccgt ctgcgaggag tcccggggtg tggggcatgg
     4021 ggtggggctg cacctcccag aggcccctcc cacccttccc ttcccctctc ccttctgcct
     4081 ttccaggact agaaccggga acctggagcc ctccgggaac gccggccctg gggcagcaga
     4141 gccaggatgg agccctcctg agctggcatc tcagacagca cccgggcccg ccacccctca
     4201 ccaagagaga tggccatggg gctcagggcc tctttaccat gtgcagtgac catttctcag
     4261 agcaggactt gcaaagaggc tttaatttca aaagtgaagg aaggaggcca ggcgccgtgg
     4321 ctcacgcctg taatcccagc actttgggag gctgaggtgg gcagatcacc taggtcaaga
     4381 gtttcaaacc agacgggcca acatggtgaa accccatctc tgctaaaaat acaaaaaaaa
     4441 aaaaattagc tgggcatggt ggtgggtgcc tgtaatccca gctactcggg aggctgaggc
     4501 aggagaatcg tttgaacccg ggaggcggag gctgcagtga gccgagatca tgccactgca
     4561 ctccagcctg ggcgacagag actccatctc aaaaaaaaaa aaaaaaaaaa gtgaaggaag
     4621 gagacagcag attggaaata acactggagt ggatgggatg tcctcttccc tgagggggcc
     4681 ggggtaccag acgggaggct gggagaggat gagaggctgc cccatggctg gaggcagtgt
     4741 ccgtgtgtgc agtcaccatc atcaaccccc attcggcccc ttccccagat gcgctggtga
     4801 caggggcttc ttggatgtca aatcatgttg taggagggtg cagactgcgg gcttctgtgg
     4861 ggagcagtac tactgtgtct gtcggcagtg gccatgggac cctcagcccg tcctgtacat
     4921 ggagcagggt gcacagtcac cctccatcct gtggcgagag gctggcccgg cccggccagg
     4981 cgaggcagaa ggtgtcggcc aagtggcccc gaccccatcc cgcagtctct cagctgcttt
     5041 ttattacctc tgtgccccat ttgggagttt gcttcctcca cctggacact ttgcccggga
     5101 ggtcatcaga gcccaacccc aggctctgct cggttggaga ggggatgact tcaccaccac
     5161 ctgaccttcc tagggtcctg gtctcactgt cagctggggg tccgttgtgt gtatttgtac
     5221 agttttgctg tatggggttt gtcacccaaa agctgatgct gagaaaggcc tccctggggc
     5281 ccctcccgcg ggcatctgag agacctggtg ttccagtgtt tctggaaatg ggtcccagtg
     5341 ccgccggctg tgaagctctc agatcaatca cgggaagggc ctggcggtgg tggccacctg
     5401 gaaccaccct gtcctgtctg tttacatttc actatcaggt tttctctggg cattacgatt
     5461 tgttccccta caacagtgac ctgtgcattc tgctgtggcc tgctgtgtct gcaggtggct
     5521 ctcagcgagg tacggggagg gcgtcaccct gcagaacggc agagtgacgc gtcctctcgc
     5581 tgctgagcac cagctgttta cctgccctgc atcacttcct cggatacttt actcaataag
     5641 catttcccct ggagtgtccg tgccctggtg ttttttatcg atacgttgat taaaacgcgt
     5701 ggttccccgt gtgcctgaag cagacattgc tgtgaaatct tttatttttg ttttatgaca
     5761 cagcatcaat ttcatgaata ctttgaaagg gccattagaa aaaataagag ccaatttggg
     5821 tcatttgaga aacattttca gcacaattac agtgggggca cgggccgttc ggctccagct
     5881 gggttttccc agatgcaaca atcgcggttc tggcttctcc actggtgggg atggggatcg
     5941 cgccttcgga gctctcaggg cgcctgtctg tcgggggctg ggtgcgtcca cagccccggg
     6001 ggatggcgcg tggcgtagcc caggaacggc atgtgggtgg gtctctgacc tgcttgtgca
     6061 gggacttgag ggacctcatc ccgatggccg aggcaggggc tccccacggg ataaaaggat
     6121 ccggcctggc cttggggtcc aagaggaggg ccaagggagt ggacctggcc cctgtcccct
     6181 ctcctcctcg aaacactgga caccctgaag cgagactatg gctgctgagg atcctgtgtg
     6241 atgtggccgc ggggcgtccc ctctggcctc aggggaagaa ggactgggcg gctcggccca
     6301 ggtcaccctc taggaagcag aggaggtgca ggtgccagtt cagggcagaa agaaagagcc
     6361 actgaggcca ttgtcctgaa ggcggtgacc cccaggcact cctgctgccc cccaggaagc
     6421 cctgggctgc gctggacacc gggccgagtc tccgtcttct ggaccgaggc tcttctgggc
     6481 tttcaggctc agctcgtcgg tccattcagc aagttcaggg gcagactgag ccctgctctg
     6541 gccat
//
