LOCUS       NM_003213               1710 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens TEA domain transcription factor 4 (TEAD4), transcript
            variant 1, mRNA.
ACCESSION   NM_003213
VERSION     NM_003213.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1710)
  AUTHORS   Li,F., Wang,X., Zhang,J., Zhang,J., Jing,X., Jiang,Q., Zhou,J.,
            Cao,L., Peng,H., Tong,D. and Huang,C.
  TITLE     RBM8A, a new target of TEAD4, promotes breast cancer progression by
            regulating IGF1R and IRS-2
  JOURNAL   J Transl Med 22 (1), 823 (2024)
   PUBMED   39232805
  REMARK    GeneRIF: RBM8A, a new target of TEAD4, promotes breast cancer
            progression by regulating IGF1R and IRS-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1710)
  AUTHORS   Tan,K., Wang,J., Su,X., Zheng,Y. and Li,W.
  TITLE     KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating
            the RANKL/OPG ratio on the compression side during orthodontic
            tooth movement
  JOURNAL   Prog Orthod 25 (1), 29 (2024)
   PUBMED   39129034
  REMARK    GeneRIF: KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by
            regulating the RANKL/OPG ratio on the compression side during
            orthodontic tooth movement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1710)
  AUTHORS   Zhu,M., Meglicki,M., Lamba,A., Wang,P., Royer,C., Turner,K.,
            Jauhar,M.A., Jones,C., Child,T., Coward,K., Na,J. and
            Zernicka-Goetz,M.
  TITLE     Tead4 and Tfap2c generate bipotency and a bistable switch in
            totipotent embryos to promote robust lineage diversification
  JOURNAL   Nat Struct Mol Biol 31 (6), 964-976 (2024)
   PUBMED   38789684
  REMARK    GeneRIF: Tead4 and Tfap2c generate bipotency and a bistable switch
            in totipotent embryos to promote robust lineage diversification.
REFERENCE   4  (bases 1 to 1710)
  AUTHORS   Chan,S.W., Lim,C.J., Huang,C., Chong,Y.F., Gunaratne,H.J.,
            Hogue,K.A., Blackstock,W.P., Harvey,K.F. and Hong,W.
  TITLE     WW domain-mediated interaction with Wbp2 is important for the
            oncogenic property of TAZ
  JOURNAL   Oncogene 30 (5), 600-610 (2011)
   PUBMED   20972459
REFERENCE   5  (bases 1 to 1710)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1710)
  AUTHORS   Appukuttan,B., McFarland,T.J., Davies,M.H., Atchaneeyasakul,L.O.,
            Zhang,Y., Babra,B., Pan,Y., Rosenbaum,J.T., Acott,T., Powers,M.R.
            and Stout,J.T.
  TITLE     Identification of novel alternatively spliced isoforms of RTEF-1
            within human ocular vascular endothelial cells and murine retina
  JOURNAL   Invest Ophthalmol Vis Sci 48 (8), 3775-3782 (2007)
   PUBMED   17652751
  REMARK    GeneRIF: Novel RTEF-1 transcripts are present within human ocular
            vascular endothelial cells and mouse neural retina during normal
            and retinopathy of prematurity development, and alternatively
            spliced products are produced under hyperoxic and hypoxic
            conditions
REFERENCE   7  (bases 1 to 1710)
  AUTHORS   Vassilev,A., Kaneko,K.J., Shu,H., Zhao,Y. and DePamphilis,M.L.
  TITLE     TEAD/TEF transcription factors utilize the activation domain of
            YAP65, a Src/Yes-associated protein localized in the cytoplasm
  JOURNAL   Genes Dev 15 (10), 1229-1241 (2001)
   PUBMED   11358867
REFERENCE   8  (bases 1 to 1710)
  AUTHORS   Jacquemin,P., Depetris,D., Mattei,M.G., Martial,J.A. and
            Davidson,I.
  TITLE     Localization of human transcription factor TEF-4 and TEF-5 (TEAD2,
            TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence
            in situ hybridization and radiation hybrid analysis
  JOURNAL   Genomics 55 (1), 127-129 (1999)
   PUBMED   9889009
REFERENCE   9  (bases 1 to 1710)
  AUTHORS   Stewart,A.F., Richard,C.W. 3rd, Suzow,J., Stephan,D.,
            Weremowicz,S., Morton,C.C. and Adra,C.N.
  TITLE     Cloning of human RTEF-1, a transcriptional enhancer
            factor-1-related gene preferentially expressed in skeletal muscle:
            evidence for an ancient multigene family
  JOURNAL   Genomics 37 (1), 68-76 (1996)
   PUBMED   8921372
  REMARK    GeneRIF: The paper described several reasons to designate the
            putative translation initiation codon as the leucine (TTG) codon,
            which is 7 codons upstream from the isoleucine (ATT) codon.
REFERENCE   10 (bases 1 to 1710)
  AUTHORS   Jacquemin,P., Hwang,J.J., Martial,J.A., Dolle,P. and Davidson,I.
  TITLE     A novel family of developmentally regulated mammalian transcription
            factors containing the TEA/ATTS DNA binding domain
  JOURNAL   J Biol Chem 271 (36), 21775-21785 (1996)
   PUBMED   8702974
  REMARK    GeneRIF: The paper described that the ORF of TEF-3 initiates with
            an ATT codon encoding isoleucine.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA210894.1, BC015497.1 and
            U63824.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003213.3.
            
            Summary: This gene product is a member of the transcriptional
            enhancer factor (TEF) family of transcription factors, which
            contain the TEA/ATTS DNA-binding domain. It is preferentially
            expressed in the skeletal muscle, and binds to the M-CAT regulatory
            element found in promoters of muscle-specific genes to direct their
            gene expression. Alternatively spliced transcripts encoding
            distinct isoforms, some of which are translated through the use of
            a non-AUG (UUG) initiation codon, have been described for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1), and initiates translation from a non-AUG (UUG) codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63824.1, BC015497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000359864.8/ ENSP00000352926.3
            non-AUG initiation codon :: PMID: 8921372
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA210894.1         86-102
            18-1705             BC015497.1         1-1688
            1706-1710           U63824.1           1663-1667
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..1710
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /note="TEA domain transcription factor 4"
                     /db_xref="GeneID:7004"
                     /db_xref="HGNC:HGNC:11717"
                     /db_xref="MIM:601714"
     exon            1..85
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..178
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..433
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1512
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (UUG) translation initiation codon;
                     transcriptional enhancer factor 3; transcription factor
                     13-like 1; related transcription enhancer factor 1B;
                     transcriptional enhancer factor TEF-3; transcriptional
                     enhancer factor 1-related; transcription factor RTEF-1;
                     TEA domain family member 4"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-3 isoform 1"
                     /protein_id="NP_003204.2"
                     /db_xref="CCDS:CCDS31729.1"
                     /db_xref="GeneID:7004"
                     /db_xref="HGNC:HGNC:11717"
                     /db_xref="MIM:601714"
                     /translation="MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWS
                     PDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHI
                     QVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVS
                     GFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRS
                     VASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPE
                     KKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKV
                     CSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLEN
                     FTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE"
     exon            434..498
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..561
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..690
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..734
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..790
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..930
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1104
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1245
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1398
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1710
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1678..1683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      1710
                     /gene="TEAD4"
                     /gene_synonym="EFTR-2; hRTEF-1B; RTEF1; TCF13L1; TEF-3;
                     TEF3; TEFR-1"
                     /note="major polyA site"
ORIGIN      
        1 attccgcgca ttccagcgtc ctcctcgcac actcgaggcc agggggcggg agggccgcag
       61 ctccggcgcc gccgcgtccc gccagaacga tcgccgcggc cggaagagtt ggcgctcggg
      121 gcggactcct tggaactggc ttagcgcacc catcccacct tcccgcaccc tgggaccggt
      181 ccaacgagcg ctcctccaag cggagccttg gagggcacgg ccggcaccat tacctccaac
      241 gagtggagct ctcccacctc ccctgagggg agcaccgcct ctgggggcag tcaggcactg
      301 gacaagccca tcgacaatga cgcagagggc gtgtggagcc cggatattga gcagagtttc
      361 caggaggccc tcgccatcta cccgccctgt ggcaggcgca aaatcatcct gtcggacgag
      421 ggcaagatgt atggtcggaa cgagctgatt gcccgctaca tcaagctccg gacagggaag
      481 acccgcacca ggaagcaggt ctccagccac atccaggtgc tggctcgtcg caaagctcgc
      541 gagatccagg ccaagctaaa ggaccaggca gctaaggaca aggccctgca gagcatggct
      601 gccatgtcgt ctgcacagat catctccgcc acggccttcc acagtagcat ggccctcgcc
      661 cggggccccg gccgcccagc agtctcaggg ttttggcaag gagctttgcc aggccaagcc
      721 ggaacgtccc atgatgtgaa gcctttctct cagcaaacct atgctgtcca gcctccgctg
      781 cctctgccag ggtttgagtc tcctgcaggg cccgccccat cgccctctgc gcccccggca
      841 cccccatggc agggccgcag cgtggccagc tccaagctct ggatgttgga gttctctgcc
      901 ttcctggagc agcagcagga cccggacacg tacaacaagc acctgttcgt gcacattggc
      961 cagtccagcc caagctacag cgacccctac ctcgaagccg tggacatccg ccaaatctat
     1021 gacaaattcc cggagaaaaa gggtggactc aaggatctct tcgaacgggg accctccaat
     1081 gccttttttc ttgtgaagtt ctgggcagac ctcaacacca acatcgagga tgaaggcagc
     1141 tccttctatg gggtctccag ccagtatgag agccccgaga acatgatcat cacctgctcc
     1201 acgaaggtct gctctttcgg caagcaggtg gtggagaaag ttgagacaga gtatgctcgc
     1261 tatgagaatg gacactactc ttaccgcatc caccggtccc cgctctgtga gtacatgatc
     1321 aacttcatcc acaagctcaa gcacctccct gagaagtaca tgatgaacag cgtgctggag
     1381 aacttcacca tcctgcaggt ggtcaccaac agagacacac aggagacctt gctgtgcatt
     1441 gcctatgtct ttgaggtgtc agccagtgag cacggggctc agcaccacat ctacaggctg
     1501 gtgaaagaat gagagactcg gggagcaggg aggggggaag agacgtgtgt gcaggaaacg
     1561 gggacgtggg gaggggacct gcaggggcag ccccctgaag tgccaagaga gctgagagga
     1621 gcagttgtga ctctacccag gaacaaactg tgcctgaacc tgaggtgccc aaccccaaat
     1681 aaacccaaga tgctgtgtat tttcagagga
//
