LOCUS       NM_003214               2986 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TEA domain transcription factor 3 (TEAD3), transcript
            variant 1, mRNA.
ACCESSION   NM_003214
VERSION     NM_003214.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Wang,C., Chen,S., Li,X., Fan,L., Zhou,Z., Zhang,M., Shao,Y.,
            Shang,Z. and Niu,Y.
  TITLE     TEAD3 inhibits the proliferation and metastasis of prostate cancer
            via suppressing ADRBK2
  JOURNAL   Biochem Biophys Res Commun 654, 120-127 (2023)
   PUBMED   36907139
  REMARK    GeneRIF: TEAD3 inhibits the proliferation and metastasis of
            prostate cancer via suppressing ADRBK2.
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Li,J., Tiwari,M., Xu,X., Chen,Y., Tamayo,P. and Sen,G.L.
  TITLE     TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human
            Epidermal Proliferation
  JOURNAL   J Invest Dermatol 140 (10), 2081-2084 (2020)
   PUBMED   32142794
  REMARK    GeneRIF: TEAD1 and TEAD3 Play Redundant Roles in the Regulation of
            Human Epidermal Proliferation.
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Han,Z., Yu,Y., Cai,B., Xu,Z., Bao,Z., Zhang,Y., Bamba,D., Ma,W.,
            Gao,X., Yuan,Y., Zhang,L., Yu,M., Liu,S., Yan,G., Jin,M., Huang,Q.,
            Wang,X., Hua,B., Yang,F., Pan,Z., Liang,H. and Liu,Y.
  TITLE     YAP/TEAD3 signal mediates cardiac lineage commitment of
            human-induced pluripotent stem cells
  JOURNAL   J Cell Physiol 235 (3), 2753-2760 (2020)
   PUBMED   31541452
  REMARK    GeneRIF: YAP/TEAD3 signal mediates cardiac lineage commitment of
            human-induced pluripotent stem cells.
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Maeda,T., Mazzulli,J.R., Farrance,I.K. and Stewart,A.F.
  TITLE     Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in
            alpha 1-adrenergic agonist-stimulated cardiac myocytes
  JOURNAL   J Biol Chem 277 (27), 24346-24352 (2002)
   PUBMED   11986313
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Vaudin,P., Delanoue,R., Davidson,I., Silber,J. and Zider,A.
  TITLE     TONDU (TDU), a novel human protein related to the product of
            vestigial (vg) gene of Drosophila melanogaster interacts with
            vertebrate TEF factors and substitutes for Vg function in wing
            formation
  JOURNAL   Development 126 (21), 4807-4816 (1999)
   PUBMED   10518497
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Jiang,S.W., Wu,K. and Eberhardt,N.L.
  TITLE     Human placental TEF-5 transactivates the human chorionic
            somatomammotropin gene enhancer
  JOURNAL   Mol Endocrinol 13 (6), 879-889 (1999)
   PUBMED   10379887
  REMARK    GeneRIF: The paper described that the translation initiation codon
            for the TEF-5 protein was a non-AUG (AUA) codon.
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Jacquemin,P., Depetris,D., Mattei,M.G., Martial,J.A. and
            Davidson,I.
  TITLE     Localization of human transcription factor TEF-4 and TEF-5 (TEAD2,
            TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence
            in situ hybridization and radiation hybrid analysis
  JOURNAL   Genomics 55 (1), 127-129 (1999)
   PUBMED   9889009
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Jacquemin,P., Martial,J.A. and Davidson,I.
  TITLE     Human TEF-5 is preferentially expressed in placenta and binds to
            multiple functional elements of the human chorionic
            somatomammotropin-B gene enhancer
  JOURNAL   J Biol Chem 272 (20), 12928-12937 (1997)
   PUBMED   9148898
  REMARK    GeneRIF: The paper described that the translation initiation codon
            for the TEF-5 protein was a non-AUG (ATA) codon.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA856821.1, BC091488.1 and
            BC027877.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003214.3.
            
            Summary: This gene product is a member of the transcriptional
            enhancer factor (TEF) family of transcription factors, which
            contain the TEA/ATTS DNA-binding domain. It is predominantly
            expressed in the placenta and is involved in the transactivation of
            the chorionic somatomammotropin-B gene enhancer. Translation of
            this protein is initiated at a non-AUG (AUA) start codon. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF142482.1, BC091488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000338863.13/ ENSP00000345772.8
            non-AUG initiation codon :: PMID: 10379887
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression, longest
                                        protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DA856821.1         29-98
            71-2953             BC091488.1         1-2883
            2954-2986           BC027877.1         2697-2729
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..2986
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /note="TEA domain transcription factor 3"
                     /db_xref="GeneID:7005"
                     /db_xref="HGNC:HGNC:11716"
                     /db_xref="MIM:603170"
     exon            1..182
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            183..433
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1539
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (AUA) translation initiation codon; TEA domain
                     family member 5; transcriptional enhancer factor 5;
                     transcriptional enhancer factor TEF-5 (DTEF-1); TEA domain
                     family member 3"
                     /codon_start=1
                     /transl_except=(pos:232..234,aa:Met)
                     /product="transcriptional enhancer factor TEF-5 isoform 1"
                     /protein_id="NP_003205.2"
                     /db_xref="CCDS:CCDS47414.1"
                     /db_xref="GeneID:7005"
                     /db_xref="HGNC:HGNC:11716"
                     /db_xref="MIM:603170"
                     /translation="MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQ
                     EALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKV
                     REYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSR
                     FWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDR
                     TIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFP
                     EKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTK
                     VCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLE
                     NFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD"
     exon            434..498
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..561
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            562..573
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            574..711
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            712..761
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            762..823
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..957
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1131
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1272
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1425
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..2986
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /note="hexamer: ATTAAA"
     polyA_site      2986
                     /gene="TEAD3"
                     /gene_synonym="DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5"
                     /note="major polyA site"
ORIGIN      
        1 aacacaaact ttccgtcccg ctcgctccct cctccgcgct cggcgcctcc cgctccagcc
       61 cggctcattc cgcacattcc ggccagcccc ctccccacga ccccccttcc ccggcccccc
      121 ttgcggctcc ctcgggcccg gcggagcggc ccggccggag cgcccccgcg agctcggacc
      181 aggctcagcc gcccagtggg ctcaggccca gagcccagag caaccagcac aatagcgtcc
      241 aacagctgga acgccagcag cagccccggg gaggcccggg aggatgggcc cgagggcctg
      301 gacaaggggc tggacaacga tgcggagggc gtgtggagcc cggacatcga gcagagcttc
      361 caggaggccc tggccatcta cccgccctgc ggccggcgga agatcatcct gtcagacgag
      421 ggcaagatgt acggccgaaa tgagttgatt gcacgctata ttaaactgag gacggggaag
      481 actcggacga gaaaacaggt gtccagccac atacaggttc tagctcggaa gaaggtgcgg
      541 gagtaccagg ttggcatcaa ggccatgaac ctggaccagg tctccaagga caaagccctt
      601 cagagcatgg cgtccatgtc ctctgcccag atcgtctctg ccagtgtcct gcagaacaag
      661 ttcagcccac cttcccctct gccccaggcc gtcttctcca cttcctcgcg gttctggagc
      721 agcccccctc tcctgggaca gcagcctgga ccctctcagg acatcaagcc ctttgcacag
      781 ccagcctacc ccatccagcc gcccctgccg ccgacgctca gcagttatga gcccctggcc
      841 ccgctcccct cagctgctgc ctctgtgcct gtgtggcagg accgtaccat tgcctcctcc
      901 cggctgcggc tcctggagta ttcagccttc atggaggtgc agcgagaccc tgacacgtac
      961 agcaaacacc tgtttgtgca catcggccag acgaaccccg ccttctcaga cccacccctg
     1021 gaggcagtag atgtgcgcca gatctatgac aaattccccg agaaaaaggg aggattgaag
     1081 gagctctatg agaaggggcc ccctaatgcc ttcttccttg tcaagttctg ggccgacctc
     1141 aacagcacca tccaggaggg cccgggagcc ttctatgggg tcagctctca gtacagctct
     1201 gctgatagca tgaccatcag cgtctccacc aaggtgtgct cctttggcaa acaggtggta
     1261 gagaaggtgg agactgagta tgccaggctg gagaacgggc gctttgtgta ccgtatccac
     1321 cgctcgccca tgtgcgagta catgatcaac ttcatccaca agctgaagca cctgcccgag
     1381 aagtacatga tgaacagcgt gctggagaac ttcaccatcc tgcaggtggt cacgagccgg
     1441 gactcccagg agaccctgct tgtcattgct tttgtcttcg aagtctccac cagtgagcac
     1501 ggggcccagc accatgtcta caagctcgtc aaagactagg gtgccctctg cgcctcctta
     1561 aggatgcagg gtgagcatct cctctccaca cctgcctggc acccctgggg gggtccagga
     1621 ttgaggattc atctacctgc caggcctcag gcccaggacc caggaggcct ccccacctac
     1681 cccagcacac acactccctg ccactgttct gcgctttaat tgtgggagaa gagaggagag
     1741 gagggctcag cggtggggca gcctgtccgg ggcgctgacc caccatcacc ctgctctgcc
     1801 cagcctcgcg tgacctcaga gaggtgggga taggggacac cttcagcctc cagcatgtgt
     1861 ggccactgta cccccaccca cccttggggg agcatgatgg gcaggtgagg gcaggatgga
     1921 gaccaaggga gtcagtgagc agaggccctg ggagtgtccg gttggggttg gactgaggac
     1981 agaggggccc acacttcctt gcccctttgt gtcccaggcc tggtgcccag actccttgca
     2041 tggcttgtgt ggtcctcaga ctccgcacag cgagcgtagg tctctgggtt tcagatgaag
     2101 tgcccaggct ccaggaagtt gagggaccca caggagaggt gggcagagct ggagttctca
     2161 tccagggctg cttgtcccca gagcccaggt ttatactacc tccctggggc gggggctggc
     2221 cgcagggtag gggagaggct ctgcagtgtg gagtggagcc tcatcgaggg gcgctgggtt
     2281 aggggagcac ctgtttcaga ctgggcatga agaagggagc acagcagcta ctagacccca
     2341 ttagcacctc attagcccac aagccagcca ggggccccag gaagatgggg caccccccag
     2401 caccctccag attgagagca aggtagagga aggagtccca gcctctgggc agaccagagg
     2461 cccagaggga gagagtagca gaaggctttt gatttttctc ttgcctgagg cttgaatctg
     2521 acaaaccctt ggtgggcact gctcccttag gttcttcccc acctcaatct acctgcctag
     2581 agtagcagct cccagaccca gttctgggac tgaaggttaa cccttcacct gctgtccctt
     2641 cttaacaccc aggcccccag agccagctgg gcctgtccag cagccacctg tgggtattta
     2701 tgagtttcat atgaagtact gtgccccttc ccttcctcat cccgaccctg cccgagcttc
     2761 ctgaaggtcc tcactgtttg catatcgctc aggccacctc caaaccccac ctaggtttta
     2821 taatgtatat tatatatttt tttgtgtatt tttaaaatcc agctgtgatg ggttatatca
     2881 taaatgcagc ttggggttgg agcaggggcc ctcaaaggcc cagctcctgc tcaaaaaaaa
     2941 aaaaaaaaaa aaattaaagt tatttgtttg tgggtcagtc atgtaa
//
