LOCUS       NM_001256660            2175 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TEA domain transcription factor 2 (TEAD2), transcript
            variant 3, mRNA.
ACCESSION   NM_001256660
VERSION     NM_001256660.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Yoo,H.B., Moon,J.W., Kim,H.R., Lee,H.S., Miyabayashi,K., Park,C.H.,
            Ge,S., Zhang,A., Tae,Y.K., Sub,Y., Park,H.W., Gee,H.Y., Notta,F.,
            Tuveson,D.A., Bang,S., Kim,M.Y. and Roe,J.S.
  TITLE     A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like
            Differentiation and Metastasis of Pancreatic Cancer
  JOURNAL   Gastroenterology 165 (1), 133-148 (2023)
   PUBMED   36907523
  REMARK    GeneRIF: A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like
            Differentiation and Metastasis of Pancreatic Cancer.
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Saito,Y., Yin,D., Kubota,N., Wang,X., Filliol,A., Remotti,H.,
            Nair,A., Fazlollahi,L., Hoshida,Y., Tabas,I., Wangensteen,K.J. and
            Schwabe,R.F.
  TITLE     A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of
            Hepatocellular Carcinoma via ANLN and KIF23
  JOURNAL   Gastroenterology 164 (7), 1279-1292 (2023)
   PUBMED   36894036
  REMARK    GeneRIF: A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the
            Growth of Hepatocellular Carcinoma via ANLN and KIF23.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Joo,J.S., Cho,S.Y., Rou,W.S., Kim,J.S., Kang,S.H., Lee,E.S.,
            Moon,H.S., Kim,S.H., Sung,J.K., Kwon,I.S., Eun,H.S. and Lee,B.S.
  TITLE     TEAD2 as a novel prognostic factor for hepatocellular carcinoma
  JOURNAL   Oncol Rep 43 (6), 1785-1796 (2020)
   PUBMED   32323824
  REMARK    GeneRIF: TEAD2 as a novel prognostic factor for hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Zhang,H., Liu,C.Y., Zha,Z.Y., Zhao,B., Yao,J., Zhao,S., Xiong,Y.,
            Lei,Q.Y. and Guan,K.L.
  TITLE     TEAD transcription factors mediate the function of TAZ in cell
            growth and epithelial-mesenchymal transition
  JOURNAL   J Biol Chem 284 (20), 13355-13362 (2009)
   PUBMED   19324877
  REMARK    Erratum:[J Biol Chem. 2019 Apr 12;294(15):5808. doi:
            10.1074/jbc.AAC119.008436.. PMID: 30979850]
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Zhao,B., Ye,X., Yu,J., Li,L., Li,W., Li,S., Yu,J., Lin,J.D.,
            Wang,C.Y., Chinnaiyan,A.M., Lai,Z.C. and Guan,K.L.
  TITLE     TEAD mediates YAP-dependent gene induction and growth control
  JOURNAL   Genes Dev 22 (14), 1962-1971 (2008)
   PUBMED   18579750
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Jacquemin,P., Depetris,D., Mattei,M.G., Martial,J.A. and
            Davidson,I.
  TITLE     Localization of human transcription factor TEF-4 and TEF-5 (TEAD2,
            TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence
            in situ hybridization and radiation hybrid analysis
  JOURNAL   Genomics 55 (1), 127-129 (1999)
   PUBMED   9889009
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Jacquemin,P., Hwang,J.J., Martial,J.A., Dolle,P. and Davidson,I.
  TITLE     A novel family of developmentally regulated mammalian transcription
            factors containing the TEA/ATTS DNA binding domain
  JOURNAL   J Biol Chem 271 (36), 21775-21785 (1996)
   PUBMED   8702974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG334109.1, AL832240.1 and BC007556.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001256660.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            contains an alternate exon and uses an alternate splice site in the
            5' coding region, but maintains the reading frame, compared to
            variant 1. Variants 3 and 4 encode the same isoform (2), which is
            longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832240.1, SRR14038193.2297451.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593945.6/ ENSP00000469640.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BG334109.1         43-76
            35-850              AL832240.1         1-816
            851-2175            BC007556.1         840-2164
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2175
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /note="TEA domain transcription factor 2"
                     /db_xref="GeneID:8463"
                     /db_xref="HGNC:HGNC:11715"
                     /db_xref="MIM:601729"
     exon            1..84
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            85..322
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1446
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /note="isoform 2 is encoded by transcript variant 3;
                     transcriptional enhancer factor TEF-4; TEA domain family
                     member 2"
                     /codon_start=1
                     /product="transcriptional enhancer factor TEF-4 isoform 2"
                     /protein_id="NP_001243589.1"
                     /db_xref="CCDS:CCDS59406.1"
                     /db_xref="GeneID:8463"
                     /db_xref="HGNC:HGNC:11715"
                     /db_xref="MIM:601729"
                     /translation="MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGV
                     WSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSS
                     HIQVLARRKSREIQSKLKALNVDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQ
                     ASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPS
                     PPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVR
                     QIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVS
                     SQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLH
                     KLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
                     D"
     exon            323..387
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..450
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            451..462
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            463..570
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..629
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            630..694
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            695..837
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1011
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1179
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1332
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2175
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /note="hexamer: GATAAA"
     polyA_site      2175
                     /gene="TEAD2"
                     /gene_synonym="ETF; TEAD-2; TEF-4; TEF4"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgcccc gcccgcccgc ggctccccag ccccaggccg ggaggtagga aggcgccggc
       61 gggagtcggg gatcctgctt tggggcccag atgggggaac cccgggctgg ggccgccctg
      121 gacgatggca gcggctggac gggcagtgag gaaggcagtg aggagggtac cggcggcagt
      181 gagggggctg ggggtgacgg gggcccggat gcagaggggg tgtggagccc agacattgag
      241 cagagcttcc aggaggccct ggccatctat ccaccctgcg gccgccggaa aataattttg
      301 tctgatgaag gcaagatgta tggtcggaat gaactgatcg cccgctacat caagctgaga
      361 acggggaaga cccgaactcg aaaacaggtt tctagtcaca tccaggtttt ggcccgaagg
      421 aaatcaaggg aaatccagtc caagttgaag gctctgaacg tggaccaggt ttccaaggac
      481 aaggctttcc agacaatggc aaccatgtcc tctgcccagc tcatctccgc gccttctctg
      541 caggccaaac tgggtcccac tggtcctcag gcctctgagc ttttccagtt ttggtctgga
      601 ggatctgggc ccccctggaa tgttccagat gtgaagccat tctcacagac accgttcacc
      661 ttgtcactga ctcccccatc tactgacctc ccagggtacg agccccccca agccctctca
      721 cccctgcccc cacctacccc atcgccccca gcctggcagg ctcggggcct gggcaccgcc
      781 cggttgcagc tggtagagtt ctcagccttc gtggaaccgc cagatgcagt tgattcttac
      841 cagaggcacc tgttcgtgca catcagccag cactgcccca gccccggagc gccgccgctc
      901 gagagtgtgg acgtccggca gatctacgac aaattccctg agaaaaaggg tggcctccga
      961 gagctatatg atcgtggccc cccccatgcc ttcttcctgg tcaagttctg ggcggacctg
     1021 aactggggcc caagtggtga ggaggcaggg gccggtggca gcatcagcag tggtggcttc
     1081 tacggagtga gcagccagta tgagagcctg gaacacatga ccctcacctg ttcctccaag
     1141 gtctgctctt ttggcaagca ggtggtggag aaggtggaga cggaacgggc ccagctggag
     1201 gacggcagat ttgtgtaccg cctgctgcgc tcgcccatgt gcgagtacct ggtgaatttc
     1261 ttgcacaagt tgcggcagct gcctgagcga tacatgatga acagcgtcct ggaaaacttc
     1321 accatcctcc aggtggtgac aaacagagac acccaggaac tgctgctctg caccgcctat
     1381 gtcttcgagg tctccaccag cgagcgtggg gcccagcatc acatttaccg cctggtcagg
     1441 gactgaaggg ggaccccaaa actggctcac cccccagaac accctcctcc cagggagggt
     1501 cctccagctc acctcatgct tcttatttgg ggagagggct gtgatgtaaa ggggttgacc
     1561 tcagaggcct aagcaactgg ggccatcccc cccattagag gggcccccaa aacttggttg
     1621 gagagctgaa caggctggga ctgaggaaag gataaacccc gatattggga cctcacagtg
     1681 ggtgtctgaa aggacagatc actccggagt atcagggatt gtggggacag gagtgagaca
     1741 accccccagg tacagcactg gcttttcttt tcagcccctg acaggccacc cccactcctc
     1801 tgcatgtctt ggagagcgct agttacacat tggcttgtcc cctttacttt ttcccagcca
     1861 cccctccccc tgaaatttct gcccctctct accaccctca ctccatgacc tgtgagatca
     1921 caaagtgaag atgaaccctt tctgtgcagg agcagagcca ggtgggccct ggacattttt
     1981 ttttttttta atataacgag atatttataa gtgggtgcta gggtcttgac tttatctccg
     2041 ctgcacaagc agtgtgttga actttctaat ctcatccctc tcctaagtga gccctgagct
     2101 agacggtttc cttcctcccc tctcaaagtt tgtttgtttg tgttctgaca gaggataaag
     2161 ctattttacc aaaaa
//
