LOCUS       NM_021961               9417 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens TEA domain transcription factor 1 (TEAD1), mRNA.
ACCESSION   NM_021961 XM_928014 XM_940766
VERSION     NM_021961.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9417)
  AUTHORS   Chen,J., Li,L., Feng,Y., Zhao,Y., Sun,F., Zhou,X., Yiqi,D., Li,Z.,
            Kong,F. and Kong,X.
  TITLE     MKLN1-AS promotes pancreatic cancer progression as a crucial
            downstream mediator of HIF-1alpha through miR-185-5p/TEAD1 pathway
  JOURNAL   Cell Biol Toxicol 40 (1), 30 (2024)
   PUBMED   38740637
  REMARK    GeneRIF: MKLN1-AS promotes pancreatic cancer progression as a
            crucial downstream mediator of HIF-1alpha through miR-185-5p/TEAD1
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9417)
  AUTHORS   Isaac,R., Bandyopadhyay,G., Rohm,T.V., Kang,S., Wang,J.,
            Pokhrel,N., Sakane,S., Zapata,R., Libster,A.M., Vinik,Y.,
            Berhan,A., Kisseleva,T., Borok,Z., Zick,Y., Telese,F.,
            Webster,N.J.G. and Olefsky,J.M.
  TITLE     TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver
            fibrosis
  JOURNAL   Cell Metab 36 (5), 1030-1043 (2024)
   PUBMED   38670107
  REMARK    GeneRIF: TM7SF3 controls TEAD1 splicing to prevent MASH-induced
            liver fibrosis.
REFERENCE   3  (bases 1 to 9417)
  AUTHORS   Ju,J., Zhang,H., Lin,M., Yan,Z., An,L., Cao,Z., Geng,D., Yue,J.,
            Tang,Y., Tian,L., Chen,F., Han,Y., Wang,W., Zhao,S., Jiao,S. and
            Zhou,Z.
  TITLE     The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase
            to promote YAP signaling in gastric cancer
  JOURNAL   J Clin Invest 134 (10), e174587 (2024)
   PUBMED   38512451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9417)
  AUTHORS   Shi,X., Dang,X., Huang,Z., Lu,Y., Tong,H., Liang,F., Zhuang,F.,
            Li,Y., Cai,Z., Huo,H., Jiang,Z., Pan,C., Wang,X., Gu,C. and He,B.
  TITLE     SUMOylation of TEAD1 Modulates the Mechanism of Pathological
            Cardiac Hypertrophy
  JOURNAL   Adv Sci (Weinh) 11 (12), e2305677 (2024)
   PUBMED   38225750
  REMARK    GeneRIF: SUMOylation of TEAD1 Modulates the Mechanism of
            Pathological Cardiac Hypertrophy.
REFERENCE   5  (bases 1 to 9417)
  AUTHORS   Yoshii,H., Kajiya,M., Yoshino,M., Morimoto,S., Horikoshi,S.,
            Tari,M., Motoike,S., Iwata,T., Ouhara,K., Ando,T., Yoshimoto,T.,
            Shintani,T. and Mizuno,N.
  TITLE     Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory
            Properties of Mesenchymal Stem Cells
  JOURNAL   Stem Cell Rev Rep 20 (1), 347-361 (2024)
   PUBMED   37917410
  REMARK    GeneRIF: Mechanosignaling YAP/TAZ-TEAD Axis Regulates the
            Immunomodulatory Properties of Mesenchymal Stem Cells.
REFERENCE   6  (bases 1 to 9417)
  AUTHORS   Boam,D.S., Davidson,I. and Chambon,P.
  TITLE     A TATA-less promoter containing binding sites for ubiquitous
            transcription factors mediates cell type-specific regulation of the
            gene for transcription enhancer factor-1 (TEF-1)
  JOURNAL   J Biol Chem 270 (33), 19487-19494 (1995)
   PUBMED   7642633
REFERENCE   7  (bases 1 to 9417)
  AUTHORS   Fossdal,R., Magnusson,L., Weber,J.L. and Jensson,O.
  TITLE     Mapping the locus of atrophia areata, a helicoid peripapillary
            chorioretinal degeneration with autosomal dominant inheritance, to
            chromosome 11p15
  JOURNAL   Hum Mol Genet 4 (3), 479-483 (1995)
   PUBMED   7795606
REFERENCE   8  (bases 1 to 9417)
  AUTHORS   Kariya,K., Farrance,I.K. and Simpson,P.C.
  TITLE     Transcriptional enhancer factor-1 in cardiac myocytes interacts
            with an alpha 1-adrenergic- and beta-protein kinase C-inducible
            element in the rat beta-myosin heavy chain promoter
  JOURNAL   J Biol Chem 268 (35), 26658-26662 (1993)
   PUBMED   8253797
REFERENCE   9  (bases 1 to 9417)
  AUTHORS   Shimizu,N., Smith,G. and Izumo,S.
  TITLE     Both a ubiquitous factor mTEF-1 and a distinct muscle-specific
            factor bind to the M-CAT motif of the myosin heavy chain beta gene
  JOURNAL   Nucleic Acids Res 21 (17), 4103-4110 (1993)
   PUBMED   8396764
REFERENCE   10 (bases 1 to 9417)
  AUTHORS   Xiao,J.H., Davidson,I., Matthes,H., Garnier,J.M. and Chambon,P.
  TITLE     Cloning, expression, and transcriptional properties of the human
            enhancer factor TEF-1
  JOURNAL   Cell 65 (4), 551-568 (1991)
   PUBMED   1851669
  REMARK    GeneRIF: TEAD1 has non-AUG translation initiation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107881.16, BG720371.1,
            DR000961.1, BC115398.1, AB209858.1, CN420966.1, BU172369.1 and
            CA420177.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021961.5.
            
            Summary: This gene encodes a ubiquitous transcriptional enhancer
            factor that is a member of the TEA/ATTS domain family. This protein
            directs the transactivation of a wide variety of genes and, in
            placental cells, also acts as a transcriptional repressor.
            Mutations in this gene cause Sveinsson's chorioretinal atrophy.
            Additional transcript variants have been described but their
            full-length natures have not been experimentally verified.
            [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803616.77508.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968189, SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000527636.7/ ENSP00000435233.2
            non-AUG initiation codon :: PMID: 1851669
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC107881.16        37698-37698
            2-171               BG720371.1         69-238
            172-812             DR000961.1         9-649
            813-951             BC115398.1         305-443
            952-1320            BC115398.1         456-824
            1321-6403           AB209858.1         635-5717
            6404-6404           CN420966.1         146-146
            6405-8581           AB209858.1         5719-7895
            8582-9151           BU172369.1         56-625
            9152-9417           CA420177.1         18-283              c
FEATURES             Location/Qualifiers
     source          1..9417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..9417
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /note="TEA domain transcription factor 1"
                     /db_xref="GeneID:7003"
                     /db_xref="HGNC:HGNC:11714"
                     /db_xref="MIM:189967"
     exon            1..414
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..567
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..823
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..1902
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /exception="alternative start codon"
                     /note="non-AUG (AUU) translation initiation codon; protein
                     GT-IIC; transcriptional enhancer factor 1; transcription
                     factor 13; TEA domain family member 1 (SV40
                     transcriptional enhancer factor)"
                     /codon_start=1
                     /transl_except=(pos:622..624,aa:Met)
                     /product="transcriptional enhancer factor TEF-1"
                     /protein_id="NP_068780.2"
                     /db_xref="CCDS:CCDS7810.2"
                     /db_xref="GeneID:7003"
                     /db_xref="HGNC:HGNC:11714"
                     /db_xref="MIM:189967"
                     /translation="MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQ
                     EALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKS
                     RDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGM
                     IQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRL
                     VEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKEL
                     FGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVV
                     EKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVT
                     NRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD"
     exon            824..888
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..951
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1086
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1133
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1195
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1320
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1494
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1635
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1788
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..9417
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9392..9397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /note="hexamer: AATAAA"
     polyA_site      9393
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /note="major polyA site"
     polyA_site      9417
                     /gene="TEAD1"
                     /gene_synonym="AA; NTEF-1; REF1; TCF-13; TCF13; TEAD-1;
                     TEF-1"
                     /note="major polyA site"
ORIGIN      
        1 attccgaaca ttcttagcat cgctcgcgcc gcgccgcgcc gcctgagccg agccgagcct
       61 ctgctgccgc cgccgcggcc ccgccgcccg ccgcgggcgc ccaccaagca ctttgcagac
      121 tcgcttccac cctgcgggcc attccgcgcg gcggggcccg ggcccggggc ggccgcgtcc
      181 aggcacaggc catgcagtga cgccccccca cccctccacc tttgcccgga gcgcgggcag
      241 cagcccagcg cgccagccgg ccccggggca ggagcggtgc taggcagggg tggggtggcc
      301 gggcccaggg accgggagcc ggggagggag ccgggcaccg agcagagggc gggggaagcg
      361 gcgccgaagt ttgcctcgga ctcgccgggc gctgcggtgg ctccctgggc cgaggactgt
      421 tgctgccgct gccgccgccg cttcattgca cattcaagtg gaaaattttc aggagtcagc
      481 agaaacattg tgtccaaaaa agactgagtc gcagttacca ccaaacccag gaggagactc
      541 tccctggaaa acttcccttc cctttcggtt tattttcttg aaaaggctcc aggcttcggc
      601 ttggaaaatc ccaccgccaa aattgagccc agcagctgga gcggcagtga gagccctgcc
      661 gaaaacatgg aaaggatgag tgactctgca gataagccaa ttgacaatga tgcagaaggg
      721 gtctggagcc ccgacatcga gcaaagcttt caggaggccc tggctatcta tccaccatgt
      781 gggaggagga aaatcatctt atcagacgaa ggcaaaatgt atggtaggaa tgaattgata
      841 gccagataca tcaaactcag gacaggcaag acgaggacca gaaaacaggt gtctagtcac
      901 attcaggttc ttgccagaag gaaatctcgt gattttcatt ccaagctaaa ggatcagact
      961 gcaaaggata aggccctgca gcacatggcg gccatgtcct cagcccagat cgtctcggcc
     1021 actgccattc ataacaagct ggggctgcct gggattccac gcccgacctt cccaggggcg
     1081 ccggggttct ggccgggaat gattcaaaca gggcagccag gatcctcaca agacgtcaag
     1141 ccttttgtgc agcaggccta ccccatccag ccagcggtca cagcccccat tccagggttt
     1201 gagcctgcat cggccccagc tccctcagtc cctgcctggc aaggtcgctc cattggcaca
     1261 accaagcttc gcctggtgga attttcagct tttctcgagc agcagcgaga cccagactcg
     1321 tacaacaaac acctcttcgt gcacattggg catgccaacc attcttacag tgacccattg
     1381 cttgaatcag tggacattcg tcagatttat gacaaatttc ctgaaaagaa aggtggctta
     1441 aaggaactgt ttggaaaggg ccctcaaaat gccttcttcc tcgtaaaatt ctgggctgat
     1501 ttaaactgca atattcaaga tgatgctggg gctttttatg gtgtaaccag tcagtacgag
     1561 agttctgaaa atatgacagt cacctgttcc accaaagttt gctcctttgg gaagcaagta
     1621 gtagaaaaag tagagacgga gtatgcaagg tttgagaatg gccgatttgt ataccgaata
     1681 aaccgctccc caatgtgtga atatatgatc aacttcatcc acaagctcaa acacttacca
     1741 gagaaatata tgatgaacag tgttttggaa aacttcacaa ttttattggt ggtaacaaac
     1801 agggatacac aagaaactct actctgcatg gcctgtgtgt ttgaagtttc aaatagtgaa
     1861 cacggagcac aacatcatat ttacaggctt gtaaaggact gaacatggtt atttatatat
     1921 atagatatct gtatatacac acacacatat gtgcacacac acactctctc tccattatcg
     1981 aacgactgac tgtaaacctc accacacagg gtggtgccct ggccccgagg tcaccccgac
     2041 ttttctaaat cttgtttgag tgaagtcatt ttttcatgtg ttcatactat cattgtagct
     2101 gtgaagttct ggtacagttg taaaaagaga aattgagttg tttctctatg ttcttcagat
     2161 gtgcagccca caattcctcg ggaaaggtga acctgaacaa cccaagtctc tctctgcaga
     2221 gccctgtttc taattgtggt agaaaatatt gagacagagc atttgccatg ggacatttac
     2281 agcctttata caaatgtatt tagttctctt ttttccaaca taaaattctt gttttaagat
     2341 acaagtaaaa ttaatcttta aatataaatg taaattagta cacaaaacta agaatcttta
     2401 gacttatctt tgtaactaat tagggtggaa gttatgaaag aatgtaattc actaaattat
     2461 tttttaaatg aaaccttttt ttttcttttt gaaaccaaat gttaaactat agccttaaga
     2521 aatgcttggt agaagtgtcc taatgagaca aatttgtact tttatcctca aggttaacac
     2581 taatctccta atccattaaa ctcttgaaca ggtattacaa aggaagaaaa cttcacccct
     2641 tatccttaac atatatagta tatttaaaaa atataaaatt gtattgtact aatgtgatga
     2701 tggattattt aatgaaaaag aaaaaatggc tctttttgca ataagtagat acatactgaa
     2761 aaaatctaaa cttacaatgt ttatagtctt gtgtgtgcag ttatatttta tatggacgac
     2821 caaatttttt attaagatga gtaaatattt gaaccactga attttaataa caaaatttta
     2881 aaattggcat gaatacggaa tactgcactg tgagatgcaa agtatacaga atctgtggct
     2941 gggagaaaat ttcatcaaat agacaagtaa aaggctcatc agttttagca tctctgctcc
     3001 ccagaaaatt gtaagcatcc tcaccagcct gtggatacat tctttatttc tagtgaccca
     3061 atatgcatat taacctgcta taactagggc tatatgtgta ggtatgtgta tacatataca
     3121 caaatgcaca tatagagtta acacatttag tgaacacttg tttagtgtca ctcagtttgc
     3181 taggtgctga tatgtacgta tatctcaatg tgtctgtaga cttagataca tcctcttgaa
     3241 gcacatccat ttctttagcg tctctcagta agttacagta cttgtttgac ttaggtttaa
     3301 gaggcccagc tacctatctc tgaccttttc aaataggctc atttgggaga ttcttttgcc
     3361 aggagagatt caactttcca atctaagtat tccagagcat tgcccaggca gagttggttt
     3421 gatgtggcca gatgttttga gttatttccc ttaagtgttt cactggggag agaacaggga
     3481 gtgctcctcc agcttcccaa agaaatatgt ttttgtaagt ggtaggaaca tgtgcacaca
     3541 atagaacatg aaataagttt tttaacttgt aaaacatgtc aagatttttc caccaagcta
     3601 gaaaataaaa aacttagttc taccacatcc aattaactta cacaccccct tccctgtctc
     3661 aacacctgct ttgaccctgc ttttctatta ttacatcagt cagcatcttg tggtccctaa
     3721 catgaggatg tggctggctc gtgggaaaca gcaaaacact aagcctgacc tctcccaaat
     3781 tgggaagacc agaggagaaa gtgcaaaact gtccccattt ggaatgccca ttccttctag
     3841 aaaccagttg gacagtgctc ctctgccctt cataaacaga ctactgttgg gtccctgatt
     3901 ccaggctggc ctgtgaagga ttgccccagg tgtccccttt cacggttgtc acatttacag
     3961 tgacttctgt tgaacacccc tcttagggat gtttcttttg ctcttatttc ctgcatcttt
     4021 ccttaaggga agccccatcc tctcccagga ccaggagttt atgaccaggc gagcacaaat
     4081 ggctaaaagc caagctgtcc tagaacttca gtgggagagc tgtctggttc atattctacc
     4141 caggaatggt acttttcagt gcagccagga gggctcttgg gatttccttt ccaaagcaca
     4201 aaaatactgg gacccaagaa gaacagctag aggacaactc tgttggcaca gagacgggga
     4261 cagcccagtc tgctgacctc acagggtcag ctgggccccc ctggtgcttc accacctgca
     4321 tcctcttgct cagaatgcct ttgcagttga gttttctggg tttctatgat tgaccttgag
     4381 gtttactcct tgctcttaca acatttctaa ggatttttaa aagtttactt cttgtcttgt
     4441 tcttctaaag ctttctccag gacagatatt ttccctgtct taaccactgg tccagtcatc
     4501 ccagtgggct tctctttgtc tctcccagat tagacctttg ggtgagattg gcatcacaac
     4561 atctaatctg agtctgtctt ttgtccttca ttctgtatgg cagtctccct ttgttataaa
     4621 agctttctaa agcatactaa agaagccttc ccagagcccc gtcttgcttc tcttccaggt
     4681 gctctatccc ctcgagaccc tctggtgcca ggcttgcttc acggccatct tgtgttgtca
     4741 ctgcagagtt tggaggccag ttttccacag cctaaacagg gaggagctgc agaatggggc
     4801 tctggtctct gggcattcat ttccctcata gaggctgaga ataaaacaag gacttattca
     4861 cacatgttct agaaccccag aatggcccaa gttacctgag accagggttt ctcaaccttg
     4921 acaccattga cattttggac tgggtaattc tttgttctgc agagctgtcc tttgcactgt
     4981 aggagattta ctaatatccc tggcctctac ccagtagtac cactagcacc tattccccac
     5041 ccagcgtgtc tccagatatt gtcaaatatc ccatcgggtg caaaatgatc cctggtcaag
     5101 atctgttgcc caagatgtta caggtcacaa tgaccacatt tgaaattgtt ttccctttca
     5161 ttttaccctg tgaaagcatc tctcctagag ccttgcaaga ggcaggtgac attgtgtcca
     5221 tatttcttcc tgtttcagaa cttctgtttc acaacaattt ctctctcgct acaagtattc
     5281 tttcactcag cactggggaa gttgggaaca gctggtcacc atcatccctt taatcaactc
     5341 acacctgttt aaagagtgtt tctgatttga ccttcatccc ttagtttact ggcgttaaaa
     5401 aaagtctcag caattttcat tatttctcgt gggtctcatt atcaaacctt tacttatttc
     5461 ggcatatttc ctctgggctt cttctagttt ctgccttaca agcaatgctg ttctgtaaat
     5521 ttattgaaac ctctggaaca tttcaccttt agagatggag gatggaagga ttggtaccag
     5581 aagagggcta agatacgttt tctgtcttga gctgaaagca cagtctactc tccttcgttt
     5641 tgtcgatgag aaagttgagg ccagagggga ggtgacatgt ttagagtcac ccagctggtt
     5701 agtgacagaa aaagcgtgag agttgtctag gattcctgcc actttggtcc ctggcctctc
     5761 ctgggggagg ctgctgttct taggtgctct aagcttaatc cctcagaatg tgtggacagg
     5821 tcagcttaga agagatgggg agattcagga tccccctgtg ccagagcaca gcctcaccgg
     5881 atgctgcttc ccacactgaa gtgtcctgtc cgaccattgc tatctgaggc atccacaagc
     5941 aggtaggaaa gctggcgagc cattttactt cctgaggaca attccccagc cacaggctct
     6001 gagtcaaatt tctatttggt aagcatccta gcagcaaagt cctgcactca gaccagccaa
     6061 aaaacagccc ccattccaag tacttggtgt caaaagtccc cgaacgactt ttaaacccaa
     6121 gtcttcttaa ggtttcagta ctgtggtggc tttagcagtt gtttttgtgc aactataaat
     6181 tatttaaatc atctgagatg acagtcaatt ttacaaacca ggtacatatt aatttgtata
     6241 attttgtata tgctctggta cactacctga actaacgaag ggtagaacta attctgtttg
     6301 tcagtgttca cacctgtaac attaggagga tatgtctgca ttgcttattt ctttatgttg
     6361 gtgtttctgt ggcaaagccc tgcacatggc atttctgaaa agccttaaat ctttaagatg
     6421 ttgcatgtag ggtatgcagt gcaaaaggct gcctcagaac tgtgagccct tttgtaagct
     6481 ggaagcattt ctcttactac tgttactttt gtaggaagtt ttcaattcag agctgccaaa
     6541 gtgttcccgt aagcagtgcc ttagtaatac cttagtcatg ccgccagcct tttcttacac
     6601 caattcctaa tgttcattta cgaattggcc caatattgga aacaaaacaa gcaaaaattg
     6661 tcttcatttt tgttttgtaa gcccattttt tctccagttc tataggaaac tgactgcttg
     6721 gtgtaaaatc cgaaactgga cacaagtcag ttctttcacc acactcaaat gtatatacca
     6781 aaacaaaagg ttgcaacttc atagtttact atgaaaagca aattgtactt tttaatgttg
     6841 ccttttaaat tcatgaccaa atacttagct atttgtgaat cttctgcact ctagcatgaa
     6901 agtgcctttg gtttgagatt ccagcttaga aaagtgctgc cataataacg ataatttgta
     6961 gagagaccaa aaatattttg agatcaccgt aatgcctttg gtttaccggg atgagtaacc
     7021 aaccacaggc ctctgttcac aagagcacga cgtggtcccc gcctgctgct agtctgtctg
     7081 ccactggggg cctcccaaca tccatagcac acttcagcgg aaggacccca gaaactgttg
     7141 tgtttgtgtg tgctgatgac ctagtgtgtc atttcacctc gtcacccagc cctgcgtccg
     7201 gatgagggga cttctgcaca aatgacagaa tctcggctgg tggacagata ctacagcttt
     7261 ctcctcctcc ttgtgttcgt gttcagtctc tgtggagact ttcttttcca ttcaaatgac
     7321 agtgcgcact tatctggttt acacaatgat accattttga aagttggaag cctcaaactg
     7381 agacgacagt gcagaacaaa acaaaagtga gttagggtcg ttaaaattga agtgttcttc
     7441 ttagggcaaa catgttgact ccgagtattg tgtatgaatg tgctacgaga aacttccaaa
     7501 gagcaccatt cacaatttgg cattttcaaa gaatgttcca gccctcaaag gggcaactct
     7561 ttaaagtcct tgttggcttt tatccaaacc ttgtagaaat tgggaaagct gatagaggta
     7621 aggaagacga gtgaaaagga caagaaggcc aaacaccagc caaaaagaaa ctaggaaaaa
     7681 aagattttct ttgctaatat agatgtaaaa ataacatcag acatctttga aaattagcct
     7741 ctaaactctt aatacatacg ttctgtgtgt ctctacctgg cgtctttaag aatatcctct
     7801 ctgggctctg aaattttagg agtgattctt atccactcca agttgtaagt atttgtagaa
     7861 atttgtgcaa acaaacaaaa actatcaaat gaaaagaaaa tgtactcaac ctaacttata
     7921 gttagcagct ggaattctca actcttccct gccagcacta taccacagtg tggaagaaat
     7981 tagtcaaatg cttgttttcc tgcttctctt ttcaactgtt actgtgcttt gtttgaaagt
     8041 agttttctct ctcaaagccg ttgcttatat cgttaagaat gaaggtttgt gtttaaaatt
     8101 tattgcattg caaagggtag tttcactgaa gtcatgcacc attaaataag atgaaatatt
     8161 tgtatttatt gtcctacttc ctaagccgta acttcttttc ctctgtgaat ttgcattgag
     8221 tcactcatgc tacactacat cgctttagta tttgagatgg catttatgtt tcctctcgtt
     8281 tatcatgaaa tggggtcaga ttccatcaga ttccacctct gtcaggtgga ctcttgtctg
     8341 ccttccatga tgagattttt tttctccttc ccctttcttt aagagaggct gacagatcta
     8401 ggtgtcaatc aattggaaac cagtctctga ttttttttca ttagttattt tctatcatta
     8461 gtttcactgt gtaaattaga tatcaactgc acttctttaa aaaaaaatac atctccctat
     8521 tacctccttg aaagatttac ttctgtaggc ctttttcaat aggctcatga ctgcagacaa
     8581 ggaaaaaaaa agtaaaaaca aaaacagtat gtgcctgaaa atgacaaaaa aaaaatttgt
     8641 aacatttaaa aaagaaacct gaatagcctt taattcttta ataatacact taaattttat
     8701 gtaaatcggt tttcgccacg tgtgtttgtt cacattctaa atgacttaat gggattctca
     8761 cggtctgtgt ctttgtgtca cgtgtataaa atgggcttgt gatgtaagcg tttcatctgg
     8821 tcagtggttc ctttgatatt gtactgctgc tgggagtggg ctgtggaacc tgccttcggg
     8881 taactgggtt cctcttgggt agattggaga gatgggggtg ggcgtgggca aattctcaca
     8941 catgttttct taacctattt gcagaaactt tcaaaaggca tttgattaaa cctcttggca
     9001 gtacagtatt cttgtatttg ttaacgtctg tgtttaggta ctggtacctt tttgttttaa
     9061 aatgttctaa gtgttggctt taaagtgaat ttatctttag tatgatagtt atatgaaaat
     9121 tataggattt gtgtgcagag aattttttta taaagtgctt tgtaaaaaaa aaaaaatgta
     9181 ttctagcttt tgcggtacat atgtgtgata actttaatac ccatgacagt taagtgcaat
     9241 tatttcatca ctctaaaaat gctatttttg tgtcagttcc tgcaggtgtt ttcatgtctt
     9301 tgcaaagtga cacattttga tgccttcttg ataaagtggt agacattttg tagctttcta
     9361 gaaactttgt attcatacgg tatcaatgaa aaataaagaa aatgaaagtg tgggtca
//
