LOCUS       NM_001384899            3088 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens testis development related protein (TDRP), transcript
            variant 4, mRNA.
ACCESSION   NM_001384899 XM_006716232
VERSION     NM_001384899.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3088)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3088)
  AUTHORS   Wang,Y., Anderson,E.P. and Tatakis,D.N.
  TITLE     Whole transcriptome analysis of smoker palatal mucosa identifies
            multiple downregulated innate immunity genes
  JOURNAL   J Periodontol 91 (6), 756-766 (2020)
   PUBMED   31682009
  REMARK    GeneRIF: TDRP expression in healthy human palatal mucosa is
            strongly negatively correlated with serum cotinine levels
REFERENCE   3  (bases 1 to 3088)
  AUTHORS   Kan,M., Liu,F., Weng,X., Ye,J., Wang,T., Xu,M., He,L. and Liu,Y.
  TITLE     Association study of newly identified age-related macular
            degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese
            population
  JOURNAL   Diagn Pathol 9, 73 (2014)
   PUBMED   24667176
  REMARK    GeneRIF: Single nucleotide polymorphisms on genetic loci SOD2, MBP
            and C8orf42were not found significantly associated with advanced
            age-related macular degeneration in a Chinese cohort
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3088)
  AUTHORS   Wang,X., Jiang,H., Zhou,W., Zhang,Z., Yang,Z., Lu,Y., Lu,B.,
            Wang,X., Ding,Q. and Hu,R.
  TITLE     Molecular cloning of a novel nuclear factor, TDRP1, in
            spermatogenic cells of testis and its relationship with
            spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 394 (1), 29-35 (2010)
   PUBMED   20170638
  REMARK    GeneRIF: These current data demonstrated that as a nuclear factor,
            TDRP1 might play an important role in spermatogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090135.13 and AC083964.3.
            
            On Jul 1, 2020 this sequence version replaced XM_006716232.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.25249.1,
                                           SRR14038197.22183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324079.11/ ENSP00000315111.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC090135.13        57-241
            186-289             AC083964.3         130335-130438       c
            290-3088            AC083964.3         125787-128585       c
FEATURES             Location/Qualifiers
     source          1..3088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..3088
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /note="testis development related protein"
                     /db_xref="GeneID:157695"
                     /db_xref="HGNC:HGNC:26951"
                     /db_xref="MIM:619049"
     exon            1..185
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..635
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="testis development-related protein isoform 1"
                     /protein_id="NP_001371828.1"
                     /db_xref="CCDS:CCDS47759.1"
                     /db_xref="GeneID:157695"
                     /db_xref="HGNC:HGNC:26951"
                     /db_xref="MIM:619049"
                     /translation="MWKLGRGRVLLDEPPEEEDGLRGGPPPAAAAAAQAQVQGASFRG
                     WKEVTSLFNKDDEQHLLERCKSPKSKGTNLRLKEELKAEKKSGFWDNLVLKQNIQSKK
                     PDEIEGWEPPKLALEDISADPEDTVGGHPSWSGWEDDAKGSTKYTSLASSANSSRWSL
                     RAAGRLVSIRRQSKGHLTDSPEEAE"
     exon            186..289
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..3088
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2816
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="TDRP"
                     /gene_synonym="C8orf42; Inm01; TDRP1; TDRP2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtccg gcggccggga gggacgcgga gccacagccc gacgcacgga cggagggacg
       61 ccggagcccg cctgaccatg tggaagctgg gccggggccg agtgctgctg gacgagcccc
      121 ccgaggagga ggacggcctg cgtggggggc cgccaccggc cgccgccgcc gccgcccagg
      181 cgcaggttca gggagcaagt ttccgaggtt ggaaagaagt gacttcactg tttaacaaag
      241 atgatgagca gcatctcctg gaaagatgta aatctcccaa gtccaaagga actaacttac
      301 gattaaaaga agagttgaag gcagagaaga aatctggatt ttgggacaat ttggttttaa
      361 aacagaatat acagtctaaa aaaccagatg aaattgaagg ttgggagcct ccaaaacttg
      421 ctcttgaaga catatcggct gaccctgagg acaccgtggg tggccaccca tcctggtcag
      481 gctgggagga tgacgccaag ggctcgacca agtacaccag cctggccagc tctgccaaca
      541 gctccaggtg gagcctgcgc gcggcaggga ggctggtgag catccgacgg cagagtaaag
      601 gccacctgac agatagcccg gaggaggcgg agtgaggggg gctgcgtggc aagtgtgccc
      661 cgacatggtg gccttttatg agtataccat gtagttgttg agtcttttcc gcgttagaaa
      721 gaatagagag tctacttttt gcctatattt gatatttgga cctctgtttc tttatttaat
      781 gaactctcac acacactgtg actccttggt gaacacgtgc agggattgta catttgattg
      841 ccttattgca gaaatattca cctatcagtc catgttttgc agaaactgga gatgtgaatt
      901 tatgatgctc tcccataata cagcagtaat gatttgcagt ttctcacaaa atgattttca
      961 tgctgctctg tgttgtagtt ctgtttcaga acttccgtac ctttttcttg tatgtagcac
     1021 gtataaatgc agctgtcatg cagttctttt cttttgctag aaaattagtc aggaggtaag
     1081 atgaatcttc caaagttatg ttaaattttg tttaacttga caaattaaac tttgttctta
     1141 ttaaacaaat acgtaaacaa atactggaaa agcaaagctt atatttggga gtaaaatgta
     1201 tcttaaaatg catgttcatc ttttgctgag ggaggaatag cttcttgtat gtccactgga
     1261 tagtaacagt ggttcttttt tggaatttta tttttacctc ttttgaactt ctaaatcggt
     1321 ccctttattt tcttaaaaca tttgctctct tttttgttta cagattaaag aagtatggat
     1381 caattttagt cagttgataa tttcatttag gaaacattgt cttgctcatt atagagagtt
     1441 aagactgtgc ataaaatact gaagtgcctc ttttttatta ggctcatatg tttgttcttg
     1501 caaagcgaga tgcctattgt gattggtgtt agatctgtaa gaagctgtgt tttttccaca
     1561 agaataatcg acgaccggtt tgagagcatc tctcgcgttc tttttctgtc tgcttactgt
     1621 ccttgacaat gtgatcctgc acagtatcag gtgccagtta tgcgtccctg gaaggttggc
     1681 tcttatcagc aagtcctgca gatatctctt agataaaagt ggtttgaaag aaaaggtata
     1741 tttttctttt ttgtttaaaa gtaaaataaa acctccagtt acactgtgca ttcccctcac
     1801 gtaaaaacaa gacaaaaacc ctttcctgag ttgctcggca tgcactcctg tgctgtttca
     1861 tgcatgtgga tgttccttcc gtttgttcct gtggaataac tgagtgtgcc tgatggcaga
     1921 acacactgca gtgttatcag tgtctgcatg ttttttaata gaacaggttt acttgatctg
     1981 tcatctgtta tgcaaaaaac agcaattact tttgcatcca tctagctaaa tctataatct
     2041 gtgtcaatca cttataccta tcaatcatcc gtatctattc acctgtcctc tatgtctgtc
     2101 ttctctcagt ctacatccat ctagccttct gtcaatcatc tacttttttt tttaatagaa
     2161 caagaagttt acttatcaag tcttgaaagg gggacatgtt tcaattggtg ttcaaacaaa
     2221 aattccagct tgtattagaa ccttgaaatg gtgaagttgt ggaggttttc tttgttccat
     2281 aatacagaga caagttcata atttttagta taacagctaa gttgacaaat tctaagtttc
     2341 ctcaggtaaa tagtcataac tgtccttttc cctagagaag tgcttgctgg gatagtaaaa
     2401 acatacacca tttcatgact tctgcaaata ctttccagcg gaagtcagtg taggtttgtt
     2461 tttggctaac atggtcttgc tgcgcaggaa tgtaaacact gtgtttgaaa ctctggaaat
     2521 cacgtgtgtg gggagatggg gacgcttccc atgttgtggg gagctctgtg gctgtgatgg
     2581 ctgcagttgc cgtgcctctg ttggaacgct aagtgcctgc aactcacgtc aatcatagaa
     2641 ttgtgacgca cagttggcaa aatagttctt tatgctattt ctcaaaattt gaggacaaac
     2701 ccagattggg attggaatat gcactgtaaa tcaaattttt cttatctaca aagactaatg
     2761 taaaaatgat tttttcttct gtgcctgatt aaattaactg tggtttttaa tataaatatt
     2821 tattggtgtg ctttgggaga aaaattatct tttcttgaaa gaagttatca aagcaaattt
     2881 attatcttca caagttaatg ggagaatgtg gttttgattc tgggtgtttg aattgtgtaa
     2941 acacacagct tccttgtgtg aagagagttg tcctgtgctc cttctactgt acttttttta
     3001 ttttttaata ggaaagtgat gtgcttcaga gaagggttcc tccttaatgt tgaggttttt
     3061 taaaaataaa aatactgttt ttaagctc
//
