LOCUS       NM_001199085            3745 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens tudor domain containing 5 (TDRD5), transcript variant
            1, mRNA.
ACCESSION   NM_001199085
VERSION     NM_001199085.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Babakhanzadeh,E., Khodadadian,A., Rostami,S., Alipourfard,I.,
            Aghaei,M., Nazari,M., Hosseinnia,M., Mehrjardi,M.Y.V., Jamshidi,Y.
            and Ghasemi,N.
  TITLE     Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in
            azoospermia
  JOURNAL   BMC Med Genet 21 (1), 33 (2020)
   PUBMED   32059713
  REMARK    GeneRIF: Here we evaluate gene and protein expression levels of
            four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular
            biopsy samples obtained from men with obstructive azoospermia (OA,
            n = 29), as controls, and various types of non-obstructive
            azoospermia containing hypospermatogenesis (HP, 28), maturation
            arrest (MA, n = 30), and Sertoli cell-only syndrome (SCOS, n = 32)
            as cases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3745)
  AUTHORS   Sun,Y.H., Jiang,F. and Li,X.Z.
  TITLE     Disruption of Tdrd5 decouples the stepwise processing of long
            precursor transcripts during pachytene PIWI-interacting RNA
            biogenesis
  JOURNAL   Biol Reprod 99 (4), 684-685 (2018)
   PUBMED   29733347
REFERENCE   3  (bases 1 to 3745)
  AUTHORS   Yabuta,Y., Ohta,H., Abe,T., Kurimoto,K., Chuma,S. and Saitou,M.
  TITLE     TDRD5 is required for retrotransposon silencing, chromatoid body
            assembly, and spermiogenesis in mice
  JOURNAL   J Cell Biol 192 (5), 781-795 (2011)
   PUBMED   21383078
REFERENCE   4  (bases 1 to 3745)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA418635.1, AK127370.1, BC089387.1 and BC144058.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001199085.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 2
            both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444136.6/ ENSP00000406052.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA418635.1         211-268
            59-1669             AK127370.1         1-1611
            1670-2468           BC089387.1         782-1580
            2469-3438           BC144058.1         2411-3380
            3439-3745           BC089387.1         2389-2695
FEATURES             Location/Qualifiers
     source          1..3745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..3745
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /note="tudor domain containing 5"
                     /db_xref="GeneID:163589"
                     /db_xref="HGNC:HGNC:20614"
                     /db_xref="MIM:617748"
     exon            1..294
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..540
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..3416
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 5; testicular tissue protein Li
                     194"
                     /codon_start=1
                     /product="tudor domain-containing protein 5 isoform 1"
                     /protein_id="NP_001186014.1"
                     /db_xref="CCDS:CCDS55663.1"
                     /db_xref="GeneID:163589"
                     /db_xref="HGNC:HGNC:20614"
                     /db_xref="MIM:617748"
                     /translation="MSEQERIQECLRKEIRSLLISTKDGLSPQELEKEYLLMVGNHLP
                     LRILGYRSTMELVLDMPDVVRVCPGAGGTVILKAIPDESTKGIASLVAKQRSSHKLRN
                     SMHKGRPSIYSGPRSHRRVPYRGRVAPILPAVVKSELKDLLALSPVLLSDFEKAFAKR
                     FGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKSVTEEKPRGCPAGKIFT
                     QPFRMKQGSYSTGFPVAKPCFSQPTSNMEPPKQIMSMEKTSKLNVVETSRLNHTEKLN
                     QLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISKLLGEYEVIFKEQLSPK
                     KLGFLNVTELVGALSDILHVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVSSPP
                     RNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELNLAMANHD
                     IPPDAVPNKKLCRLPPLDTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRR
                     CYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNI
                     GIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGLKPLVGVV
                     DEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLALYTTSS
                     GGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILQDINDEKSLSHLKSESKEPL
                     KDSEFESLKTCNKSFEEDPKWSNPEPNDLKEENEDEIPTGMPCLESVTIGDDIWDENW
                     LPLQAKMGKGGDAASHLFTASLGGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLV
                     NGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSAD
                     GSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSVESSPEILKNEDFSSSRAI
                     TLYKDKRQESVDQLSLILSYECQISQKLYIPRSTATAALGAAARLATSRSLLHWYPSV
                     KRMEA"
     exon            541..948
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1139
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1223
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1280
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1434
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1607
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1828
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2041
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2108
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2309
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2468
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2630
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2813
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2957
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3168
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3745
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3726..3731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /note="hexamer: AATGAA"
     polyA_site      3745
                     /gene="TDRD5"
                     /gene_synonym="TUDOR3"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgcgg ggccgccgtc gcagctacct tcctgcgccg attcggagag ggccccctaa
       61 tctctactcg gcccgcacca gcagcgctgg cgtcagggcg cggtgggggc aagacgggtg
      121 actggcagca gggcggtgcc gggccgagaa gggcgcctca cctggcgcct cctgccttcc
      181 tttccacctc aggttgcaga gagccgccag ggcaggtgga agggccacgc cccgctcccg
      241 tgagggtcac cgagagacgt tgggggtggg gcagggaccc caaccctaga ccagtcctgt
      301 agggcacaat gtctgaacaa gagcgtatac aggaatgtct gcggaaggaa ataaggtcac
      361 ttctcatttc caccaaagat ggtttgagcc cacaggagtt ggagaaggag taccttttga
      421 tggttggcaa ccatctacca ctccgaatcc ttgggtatcg gtccactatg gagctggtat
      481 tggacatgcc tgatgttgtt cgtgtctgcc ccggtgcagg tggtactgta atactgaaag
      541 ccattccaga tgaatctacc aaaggaatag caagcttagt tgcaaaacag aggagcagcc
      601 ataagcttcg aaactcaatg cataagggaa gacctagtat ttattctgga ccgagatctc
      661 atcggcgagt accttaccga ggaagggttg cccctattct tccagctgtt gtgaagagtg
      721 agttgaagga cctgttggcg ttatctcctg ttcttctttc tgattttgaa aaggcatttg
      781 ccaaaagatt tggacgatca ttccaataca tgcaatatgg atttctctct atgtttgaag
      841 tgcttaatgc ggcttcagat gtcatttctg tagagcagac cagagcaggt tctttgttga
      901 tgctaaagaa gagtgtaaca gaggaaaagc cgagaggatg tccagcaggt aaaattttta
      961 cccagccatt tagaatgaaa caagggtcat actccacagg ctttccggta gcaaagccat
     1021 gcttttcaca acccacttca aacatggaac caccgaagca aataatgagc atggaaaaga
     1081 cttccaagtt aaatgtagtg gagacttcaa gactgaatca cactgaaaaa ttaaaccagc
     1141 tggagaacac attcaaatca gttattgcac agattggacc tggaggaact atcagttcag
     1201 aactaaaaca taagataaaa tttgttgtat ctaagttccc agagggtttg tttatttcta
     1261 aactgcttgg agagtatgag gtaattttta aagagcaact atcaccaaaa aaattaggct
     1321 tcttaaatgt gacagaactt gttggagctc ttagtgacat tctccatgtt gagttcagga
     1381 aaggacacca agacttacta gtgtttgatg cggataagaa gcctctacca cctgttcagt
     1441 cagataagaa aatagaagcc aaagcttgtg tctccagtcc acctagaaat tcattgtcta
     1501 ctgctgctgt caaagagact gtatggaatt gcccttcaaa aaaacaaaaa gagccacaac
     1561 agaagatttg caagaagcct aatctggtgg taaagccttt acagctgcaa gtagaaacaa
     1621 acaaatcaga gctcaacttg gcaatggcaa atcatgacat cccgccagac gctgtgccga
     1681 acaagaaatt atgcagactc ccaccattag acaccagttc cctcataggg gtctttgtgg
     1741 agtatatcat ctctcctagt caattctaca tccggatcta tagcagggat tcgtcagagt
     1801 tactcgaaga catgatgatt gaaatgcggc gctgttattc taatcagctg gtttctgatc
     1861 gatatgtcat gccagaatgt tttattcagc cgggacatct ctgttgtgta aggatttctg
     1921 aggataagtg gtggtatcgg gtcattatcc atcgagtcct tgagaaacag gaagttgaag
     1981 tgttctaccc agactttgga aatattggaa ttgttcagaa gtcctccctg aggttcctca
     2041 agtgctgcta cacaaagctt ccagctcagg ctatcccttg ttctttggct tgggtgagac
     2101 cagtagagga acactggaca tcgaaagcta ttttgcagtt ccagaagttg tgcggtttga
     2161 agccattagt gggggtagtg gatgaatatg tagatggaat ccttaacatt tttttgtgtg
     2221 acacatcctc aaacgaagat gtctatttcc atcatgtctt gagaacagag ggccatgcta
     2281 ttgtatgccg agaaaatatc tcttctaagg gtttcagtga gctcaaccct ttagctttat
     2341 acacgacatc cagtggaggg ccagaggaca ttgtcttgac agaactgggt tatccttccc
     2401 agcagcacta ttttaatgaa gaccgaaaga taagtccaca gtcaaaagag agtgagttac
     2461 gtatcttgca agatattaat gatgaaaagt ctttaagtca tcttaaatct gagtcaaagg
     2521 agccattaaa ggattctgaa tttgagtctt tgaaaacctg taataagagc tttgaagaag
     2581 atccaaagtg gtccaaccca gaaccaaacg atctgaagga agaaaatgag gatgagatcc
     2641 ccactggaat gccatgcctg gagtcagtga ccataggtga tgatatttgg gatgagaact
     2701 ggttacctct acaggctaag atgggaaaag gaggtgatgc tgcctcccat ctatttactg
     2761 caagccttgg tggaaagaat cagtattcat catgtaaaga aatgccacag aaggactggt
     2821 gtttttctac ccctaaagat acatgggatg attcttggca gccttcaggc cttgtaaatg
     2881 gaacgaaagt agaagttcat aagccagaag tactgggtgc tcaggaaaaa aatactggca
     2941 caaacaggac tcaaaagcaa ctagacataa atggttcttc agattcttcc acactgccca
     3001 aattggaaga attctgtacc tctcttaccc agtcagagca gtcagcagac gggagccagt
     3061 ctgaacccaa caacagtcag actcagccaa agcaaattca gctttccaca gcagcaccct
     3121 gttcaacaac tgcagtggat gattccgcag aaaagccctc tggttctgtg gaaagctcac
     3181 cagagatcct aaagaatgaa gatttttcta gcagccgtgc tattacattg tacaaagaca
     3241 agcgtcaaga atctgtagac cagctgtctt tgattttgtc ttatgagtgc cagatttctc
     3301 agaagctcta cattcctcga agtacagcca ctgctgcctt aggtgctgcc gcacggttag
     3361 ctacatccag gagcctccta cactggtacc ccagtgtgaa aaggatggaa gcatgaggga
     3421 gggagggagg agggagaaaa acagaatcca gccgcttagg ctttgatgaa ctcccaggcc
     3481 aaaatgagga gttattgaag caaaatagta tcttgatcat tgatactttt gtctttctgt
     3541 gactatatgt tagctttatt atgctaacag tctactttga tgtgtaagta agtattgata
     3601 tttactgtta atcttgattt ttcttgattt tattctgtgt cattttgttc acctttgttt
     3661 ttaatgtagt ttaaaggaat ttgttttttt gtgtttgttt ttcttgtaca ttatcatgac
     3721 tgataaatga aaattgaaaa actaa
//
