LOCUS       NM_001146070            2645 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens tudor domain containing 3 (TDRD3), transcript variant
            1, mRNA.
ACCESSION   NM_001146070
VERSION     NM_001146070.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Qin,M., Fan,W., Li,L., Xu,T., Zhang,H., Chen,F., Man,J.,
            Kombe,A.J.K., Zhang,J., Shi,Y., Yao,X., Yang,Z., Hou,Z., Ruan,K.
            and Liu,D.
  TITLE     PRMT1 and TDRD3 promote stress granule assembly by rebuilding the
            protein-RNA interaction network
  JOURNAL   Int J Biol Macromol 277 (Pt 3), 134411 (2024)
   PUBMED   39097054
  REMARK    GeneRIF: PRMT1 and TDRD3 promote stress granule assembly by
            rebuilding the protein-RNA interaction network.
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Saha,S., Huang,S.N., Yang,X., Saha,L.K., Sun,Y., Khandagale,P.,
            Jenkins,L.M. and Pommier,Y.
  TITLE     The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and
            prevent deleterious TOP3B cleavage complexes
  JOURNAL   Nat Commun 14 (1), 7524 (2023)
   PUBMED   37980342
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Rosa,I.R., Barbosa,C.P., Ferrandez,C.A., Sonoda,B.D.B.,
            Christofolini,D.M., Trevisan,C.M., Lagana,A.S., Peluso,C. and
            Bianco,B.
  TITLE     Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve
            and reproductive outcomes: a cross-sectional study
  JOURNAL   JBRA Assist Reprod 27 (3), 428-435 (2023)
   PUBMED   37417852
  REMARK    GeneRIF: Involvement of SYCP2L and TDRD3 gene variants on ovarian
            reserve and reproductive outcomes: a cross-sectional study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Su,S., Xue,Y., Sharov,A., Zhang,Y., Lee,S.K., Martindale,J.L.,
            Li,W., Ku,W.L., Zhao,K., De,S., Shen,W., Sen,P., Gorospe,M., Xu,D.
            and Wang,W.
  TITLE     A dual-activity topoisomerase complex regulates mRNA translation
            and turnover
  JOURNAL   Nucleic Acids Res 50 (12), 7013-7033 (2022)
   PUBMED   35748872
  REMARK    GeneRIF: A dual-activity topoisomerase complex regulates mRNA
            translation and turnover.
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Stolk,L., Perry,J.R., Chasman,D.I., He,C., Mangino,M., Sulem,P.,
            Barbalic,M., Broer,L., Byrne,E.M., Ernst,F., Esko,T.,
            Franceschini,N., Gudbjartsson,D.F., Hottenga,J.J., Kraft,P.,
            McArdle,P.F., Porcu,E., Shin,S.Y., Smith,A.V., van Wingerden,S.,
            Zhai,G., Zhuang,W.V., Albrecht,E., Alizadeh,B.Z., Aspelund,T.,
            Bandinelli,S., Lauc,L.B., Beckmann,J.S., Boban,M., Boerwinkle,E.,
            Broekmans,F.J., Burri,A., Campbell,H., Chanock,S.J., Chen,C.,
            Cornelis,M.C., Corre,T., Coviello,A.D., d'Adamo,P., Davies,G., de
            Faire,U., de Geus,E.J., Deary,I.J., Dedoussis,G.V., Deloukas,P.,
            Ebrahim,S., Eiriksdottir,G., Emilsson,V., Eriksson,J.G.,
            Fauser,B.C., Ferreli,L., Ferrucci,L., Fischer,K., Folsom,A.R.,
            Garcia,M.E., Gasparini,P., Gieger,C., Glazer,N., Grobbee,D.E.,
            Hall,P., Haller,T., Hankinson,S.E., Hass,M., Hayward,C.,
            Heath,A.C., Hofman,A., Ingelsson,E., Janssens,A.C., Johnson,A.D.,
            Karasik,D., Kardia,S.L., Keyzer,J., Kiel,D.P., Kolcic,I.,
            Kutalik,Z., Lahti,J., Lai,S., Laisk,T., Laven,J.S., Lawlor,D.A.,
            Liu,J., Lopez,L.M., Louwers,Y.V., Magnusson,P.K., Marongiu,M.,
            Martin,N.G., Klaric,I.M., Masciullo,C., McKnight,B., Medland,S.E.,
            Melzer,D., Mooser,V., Navarro,P., Newman,A.B., Nyholt,D.R.,
            Onland-Moret,N.C., Palotie,A., Pare,G., Parker,A.N., Pedersen,N.L.,
            Peeters,P.H., Pistis,G., Plump,A.S., Polasek,O., Pop,V.J.,
            Psaty,B.M., Raikkonen,K., Rehnberg,E., Rotter,J.I., Rudan,I.,
            Sala,C., Salumets,A., Scuteri,A., Singleton,A., Smith,J.A.,
            Snieder,H., Soranzo,N., Stacey,S.N., Starr,J.M., Stathopoulou,M.G.,
            Stirrups,K., Stolk,R.P., Styrkarsdottir,U., Sun,Y.V., Tenesa,A.,
            Thorand,B., Toniolo,D., Tryggvadottir,L., Tsui,K., Ulivi,S., van
            Dam,R.M., van der Schouw,Y.T., van Gils,C.H., van Nierop,P.,
            Vink,J.M., Visscher,P.M., Voorhuis,M., Waeber,G., Wallaschofski,H.,
            Wichmann,H.E., Widen,E., Wijnands-van Gent,C.J., Willemsen,G.,
            Wilson,J.F., Wolffenbuttel,B.H., Wright,A.F.,
            Yerges-Armstrong,L.M., Zemunik,T., Zgaga,L., Zillikens,M.C.,
            Zygmunt,M., Arnold,A.M., Boomsma,D.I., Buring,J.E., Crisponi,L.,
            Demerath,E.W., Gudnason,V., Harris,T.B., Hu,F.B., Hunter,D.J.,
            Launer,L.J., Metspalu,A., Montgomery,G.W., Oostra,B.A.,
            Ridker,P.M., Sanna,S., Schlessinger,D., Spector,T.D.,
            Stefansson,K., Streeten,E.A., Thorsteinsdottir,U., Uda,M.,
            Uitterlinden,A.G., van Duijn,C.M., Volzke,H., Murray,A.,
            Murabito,J.M., Visser,J.A. and Lunetta,K.L.
  CONSRTM   LifeLines Cohort Study
  TITLE     Meta-analyses identify 13 loci associated with age at menopause and
            highlight DNA repair and immune pathways
  JOURNAL   Nat Genet 44 (3), 260-268 (2012)
   PUBMED   22267201
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Yang,Y., Lu,Y., Espejo,A., Wu,J., Xu,W., Liang,S. and Bedford,M.T.
  TITLE     TDRD3 is an effector molecule for arginine-methylated histone marks
  JOURNAL   Mol Cell 40 (6), 1016-1023 (2010)
   PUBMED   21172665
  REMARK    GeneRIF: The TDRD3 is an effector molecule that promotes
            transcription by binding methylarginine marks on histone tails.
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Kashima,I., Jonas,S., Jayachandran,U., Buchwald,G., Conti,E.,
            Lupas,A.N. and Izaurralde,E.
  TITLE     SMG6 interacts with the exon junction complex via two conserved
            EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 24 (21), 2440-2450 (2010)
   PUBMED   20930030
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Linder,B., Plottner,O., Kroiss,M., Hartmann,E., Laggerbauer,B.,
            Meister,G., Keidel,E. and Fischer,U.
  TITLE     Tdrd3 is a novel stress granule-associated protein interacting with
            the Fragile-X syndrome protein FMRP
  JOURNAL   Hum Mol Genet 17 (20), 3236-3246 (2008)
   PUBMED   18664458
  REMARK    GeneRIF: propose a contribution of Tdrd3 to FMRP-mediated
            translational repression and suggest that the loss of the
            FMRP-Tdrd3 interaction caused by the I304N mutation might
            contribute to the pathogenesis of Fragile X syndrome
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Goulet,I., Boisvenue,S., Mokas,S., Mazroui,R. and Cote,J.
  TITLE     TDRD3, a novel Tudor domain-containing protein, localizes to
            cytoplasmic stress granules
  JOURNAL   Hum Mol Genet 17 (19), 3055-3074 (2008)
   PUBMED   18632687
  REMARK    GeneRIF: Tudor domain of TDRD3 was required for its recruitment to
            cytoplasmic stress granules.
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359920.15, EU643838.1, BC030514.1 and AK024660.1.
            
            On Jul 2, 2019 this sequence version replaced NM_001146070.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU643838.1, SRR14038193.4512678.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377881.8/ ENSP00000367113.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL359920.15        207292-207364
            74-186              EU643838.1         1-113
            187-211             BC030514.1         77-101
            212-2641            EU643838.1         139-2568
            2642-2645           AK024660.1         2475-2478
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.2"
     gene            1..2645
                     /gene="TDRD3"
                     /note="tudor domain containing 3"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
     exon            1..186
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2380
                     /gene="TDRD3"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 3"
                     /codon_start=1
                     /product="tudor domain-containing protein 3 isoform 1"
                     /protein_id="NP_001139542.1"
                     /db_xref="CCDS:CCDS53872.1"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
                     /translation="MAQVAGAALSQAGWYLSDEGIEACTSSPDKVNVNDIILIALNTD
                     LRTIGKKFLPSDINSGKVEKLEGPCVLQIQKIRNVAAPKDNEESQAAPRMLRLQMTDG
                     HISCTAVEFSYMSKISLNTPPGTKVKLSGIVDIKNGFLLLNDSNTTVLGGEVEHLIEK
                     WELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHVQVDSRELDRRKTLQVTMPVKPTN
                     DNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNMNAAGNRNREVLQKEKSTKSE
                     GKHEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSNKQKPVMG
                     PPLRGRGKGRGRIRSEDEEDLGNARPSAPSTLFDFLESKMGTLNVEEPKSQPQQLHQG
                     QYRSSNTEQNGVKDNNHLRHPPRNDTRQPRNEKPPRFQRDSQNSKSVLEGSGLPRNRG
                     SERPSTSSVSEVWAEDRIKCDRPYSRYDRTKDTSYPLGSQHSDGAFKKRDNSMQSRSG
                     KGPSFAEAKENPLPQGSVDYNNQKRGKRESQTSIPDYFYDRKSQTINNEAFSGIKIEK
                     HFNVNTDYQNPVRSNSFIGVPNGEVEMPLKGRRIGPIKPAGPVTAVPCDDKIFYNSGP
                     KRRSGPIKPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVV
                     KFIDYGNYEEVLLSNIKPIQTEAWEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPP
                     RARN"
     exon            187..271
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            272..337
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            338..498
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..640
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..712
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..862
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1003
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1160
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1286
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..2137
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2263
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2389
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2645
                     /gene="TDRD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRD3"
                     /note="hexamer: AATAAA"
     polyA_site      2645
                     /gene="TDRD3"
                     /note="major polyA site"
ORIGIN      
        1 actgagcatg cccagttgca gagccgacca gaggagtttt ttcttttctt ttcttttttt
       61 ttttttaagg gggggggtct caagtaggag gcctccccat cacccccacc ccagcccccc
      121 accacccccg gcctaagcag ctaccatggc ccaggtggcc ggcgcggcgt tgtcccaggc
      181 gggttggtat ctttcagatg aaggcattga agcttgcaca agctctccag acaaagtcaa
      241 tgtaaatgac atcatcctga ttgctctcaa tacagatctg agaacaattg gcaagaaatt
      301 cctccccagt gacatcaata gtggaaaggt agaaaagctc gaaggtccat gtgttttgca
      361 aattcaaaaa attcgcaatg ttgctgcacc aaaggataat gaagaatctc aggctgcacc
      421 aaggatgctg cgattacaga tgactgatgg tcatataagt tgcacagcag tagaatttag
      481 ttatatgtca aaaataagcc tgaacacacc acctggaact aaagttaagc tctcaggcat
      541 tgttgacata aaaaatggat tcctgctctt gaatgactct aacaccacag ttcttggtgg
      601 tgaagtggaa caccttattg agaaatggga gttacagaga agcttatcaa aacacaatag
      661 aagcaatatt ggaactgaag gtggaccacc gccttttgtg ccttttggac agaagtgtgt
      721 atctcatgtc caagtggata gcagagaact tgatcgaaga aaaacattgc aagttacaat
      781 gcctgtcaaa cctacaaatg ataatgatga atttgaaaag caaaggacgg ctgctattgc
      841 tgaagttgca aagagcaagg aaaccaagac atttggagga ggtggtggtg gtgctagaag
      901 taatctcaat atgaatgctg ctggtaaccg aaatagggaa gttttacaga aagaaaagtc
      961 aaccaaatca gagggaaaac atgaaggtgt ctatagagaa ctggttgatg agaaagctct
     1021 gaagcacata acggaaatgg gcttcagtaa ggaagcatcg aggcaagctc ttatggataa
     1081 tggcaacaac ttagaagcag cactgaacgt acttcttaca agcaataaac agaaacctgt
     1141 tatgggtcct cctctgagag gtagaggaaa aggcaggggg cgaataagat ctgaagatga
     1201 agaggacctg ggaaatgcaa ggccatcagc accaagcaca ttatttgatt tcttggaatc
     1261 taaaatggga actttgaatg tggaagaacc taaatcacag ccacagcagc ttcatcaggg
     1321 acaatacaga tcatcaaata ctgagcaaaa tggagtaaaa gataataatc atctgagaca
     1381 tcctcctcga aatgatacca ggcagccaag aaatgaaaaa ccgcctcgtt ttcaaagaga
     1441 ctcccaaaat tcaaagtcag ttttagaagg cagtggatta cctagaaata gaggttctga
     1501 aagaccaagt acttcttcag tatctgaagt atgggctgaa gacagaatca aatgtgatag
     1561 accgtattct agatatgaca gaactaaaga tacttcatat cctttaggtt ctcagcatag
     1621 tgatggtgct tttaaaaaaa gagataactc tatgcaaagc agatcaggaa aaggtccctc
     1681 ctttgcagag gcaaaagaaa atccacttcc tcaaggatct gtagattata ataatcaaaa
     1741 acgtggaaaa agagaaagcc aaacatctat tcctgattat ttttatgaca ggaaatcaca
     1801 aacaataaat aatgaagctt tcagtggtat aaaaattgaa aaacatttta atgtaaatac
     1861 tgattatcag aatccagttc gaagtaatag tttcattggt gttccaaatg gagaagtaga
     1921 aatgccactg aaaggaagac gaataggacc tattaagcca gcaggacctg tcacagctgt
     1981 accctgtgat gataaaatat tttacaatag tgggcccaaa cgaagatctg ggccaattaa
     2041 gccagaaaaa atactagaat catctattcc tatggagtat gcaaaaatgt ggaaacctgg
     2101 agatgaatgt tttgcacttt attgggaaga caacaagttt taccgggcag aagttgaagc
     2161 cctccattct tcgggtatga cagcagttgt taaattcatt gactacggaa actatgaaga
     2221 ggtgctactg agcaatatca agcccattca aacagaggca tgggaggaag aaggcaccta
     2281 cgatcaaact ctggagttcc gtaggggagg tgatggccag ccaagacgat ccactcggcc
     2341 aacccaacag ttttaccaac caccccgggc tcggaactaa taggaaaaga ctctttgtga
     2401 agaaacgagc cagtgactga aacaccctgg tggaaacctg ttgacagacc ttccactttc
     2461 tcttcagaat aagtagctgt ggtggatatt attatttgaa gaaagaaaaa acagatttta
     2521 gggtggaaaa aacagtcaac tcacacaaag aatggaaaaa aatactgagt taaattaagc
     2581 aaataccttt tacaagtgaa aggaagaatt tttcttctgc cgtcaataaa accattgtgc
     2641 tatta
//
