LOCUS       NM_001306137            7180 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tudor domain containing 15 (TDRD15), mRNA.
ACCESSION   NM_001306137 XM_011513417 XM_011533211
VERSION     NM_001306137.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7180)
  AUTHORS   Sandhu,M.S., Waterworth,D.M., Debenham,S.L., Wheeler,E.,
            Papadakis,K., Zhao,J.H., Song,K., Yuan,X., Johnson,T., Ashford,S.,
            Inouye,M., Luben,R., Sims,M., Hadley,D., McArdle,W., Barter,P.,
            Kesaniemi,Y.A., Mahley,R.W., McPherson,R., Grundy,S.M.,
            Bingham,S.A., Khaw,K.T., Loos,R.J., Waeber,G., Barroso,I.,
            Strachan,D.P., Deloukas,P., Vollenweider,P., Wareham,N.J. and
            Mooser,V.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     LDL-cholesterol concentrations: a genome-wide association study
  JOURNAL   Lancet 371 (9611), 483-491 (2008)
   PUBMED   18262040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010872.8.
            
            On Nov 22, 2019 this sequence version replaced NM_001306137.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EG328743.1, EG328744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405799.3/ ENSP00000384376.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC010872.8         119218-119296
            80-190              AC010872.8         122851-122961
            191-276             AC010872.8         130012-130097
            277-7180            AC010872.8         132715-139618
FEATURES             Location/Qualifiers
     source          1..7180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..7180
                     /gene="TDRD15"
                     /note="tudor domain containing 15"
                     /db_xref="GeneID:100129278"
                     /db_xref="HGNC:HGNC:45037"
     exon            1..79
                     /gene="TDRD15"
                     /inference="alignment:Splign:2.1.0"
     exon            80..190
                     /gene="TDRD15"
                     /inference="alignment:Splign:2.1.0"
     exon            191..276
                     /gene="TDRD15"
                     /inference="alignment:Splign:2.1.0"
     exon            277..7180
                     /gene="TDRD15"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..6084
                     /gene="TDRD15"
                     /note="tudor domain-containing protein 6-like"
                     /codon_start=1
                     /product="tudor domain-containing protein 15"
                     /protein_id="NP_001293066.1"
                     /db_xref="CCDS:CCDS77385.1"
                     /db_xref="GeneID:100129278"
                     /db_xref="HGNC:HGNC:45037"
                     /translation="MDSTSFLPTFLDVDLTISHIKCLPKDILVKFQGIKSNECEFDYH
                     VLQREIQHTPKVKNNVEIDEFCLVEERVSGEWQRGRVMEKKNELYTVLLIDRGEELRV
                     AGPQIASACGNLFELPPRVVFGIFANILPVGEKWSPKALNYFKSLVGIQVKGYVQAIL
                     PLQMFLFEVPKIISQALELQLGRLVDGDSFRLIVEMLEEFPQQMPDLLQHKRPELSLG
                     NKDTSLDIQHVLDKLQPSLSVGSTESVKVSSALSPSKFYCQLIKWTPELENLTAHMTL
                     HYDTVCQETSPTCDNFGLLCVARRRNGQWHRGILQQLLPPNQVKIWFMDYGSSEAIPS
                     IYVKKLKQDFILVPLFSFPCSLTCLHSPDRDARIFQLSIFKQALLGQVVYAHIDWFNK
                     DECLYYVTLQTQESTVNSKCLLKTVGTQVLCPMSDSKISNILSETSVSDVNSFAVESF
                     MGNIEWSIDSLNKKGILKVGFPIKTVQMEIEAAYIAFIAYVLNPSNFWVRTNDHRNEF
                     QEIMKNINKFYDLCENDEMILRKPEPGLFCCARYSKDRRFYRAVITEINGYKINVYFL
                     DYGNTDSIPFFDVKILLPEFCELPALAMCCSLAHIFPVEDLWTKAAIDYFKKLVLNKA
                     ILLQVIAKKDDKYTVNIQSVEASENIDVISLMLQAGYAEYFQVELEYFPKSVSEYSML
                     NSESKNKVNIKKVISALLEGPKSKKYHSNNLVENNLSLPKSLAVNISEFKNPFTLSVG
                     PESSWPYKEYIFRPGTVLEVKCSCYYGPGDFSCQLQCKSEDLKLLMEQIQNYYSIHSD
                     PYEIGQTACVAKYSGKWCRAAVLTQVSKEVDIVFVDYGYQKRVLIEDLCAINPRFLLL
                     ESQAFRCCLNHFIEPVSCKLFSWTRKAFRDLWNFISSSRGLLTCIIYALVIIHPNHLY
                     NLVDLQSSFTSAKEFLMNRGSAQYITLSETFPSLFSLYSYCYSSFNIQIGSEEEVYIS
                     HIYSPQKFYCQLGRNNKDLEMIETKITESVNLQNFPKYDSNKMRVCISKYVEDGLSYR
                     ALAIPTDSSSEFQVYFVDFGNKQLVGENMLRAISAQFPELLFTPMQAIKCFLSDLRDV
                     DIPAEISSWFKDNFLGRSLKAIILSQESDGQLGIELYDGSQYINEKIKVLLHAYGKRH
                     CDQACCMEKSNKINENKRFTTSLKGKTGNNYRHNVINKPSPVTYSERKIDQLMHPKNI
                     HARFLKPSVCYKMEPVSKNKMKTSLNDGLKGIKIVPGAAHILENRRVGQKSVKVVSQS
                     FIRALNQTTSQNPYDLIRPQIKDLPQPQIYLNAKVKGYVSNISNPANFHIQLAENESV
                     IIRLADALNATARRLRERKSVKPLVGDLVVAEYSGDNAIYRAVIKKILPGNSFEVEFI
                     DYGNSAIVNTSKIYELQREFLTVPQLGIHAFLSGVKWNEPDEIWDDKTVDYFTSKVHN
                     KTVYCEFLKKHDQKWEVNMICDEKCVINELLKWKACSKLQKSALQMPQVLSQKVRPGD
                     NEMKKGKSNESEGSMNSNQQLFKIPLEEFKLGQLEKAEMLNVSKSGRFYVKLSKNKKI
                     LSDLIVLITKEEKKSPFLSMESIEKGLECLAKSKNTLKWHRSKVEEKYVDDKVLVFLV
                     DCGIYEIVPVCNTKLLSNEIRNIPRQAVPCKWIWFENSKNISFECLFADLEINILFLK
                     YLDAVWEVEILVDDLLLLEYLNLNTVPVEENKLRLAEIVYNIESKTPVSSCTIKSFTW
                     VQFQNDRQYSGIATAVSDPSDFSIQLEDFFDIMKYLFMLLSDLPETLQTLPQEFIIPG
                     SSCLFKYKSEDQWNRVEISEVSPQSLCLVLVDYGFSFYIRYSEIINLKVVPEELLNLP
                     RLSYPCILYGILPAKGKHWSEEAKIFFRDFLSKPDLVFQFREYHSETKLKVDVIHEKN
                     NLADILVASGLATYSKDSPHLDAITATESAKNPI"
     regulatory      7160..7165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRD15"
                     /note="hexamer: AATAAA"
     polyA_site      7180
                     /gene="TDRD15"
                     /note="major polyA site"
ORIGIN      
        1 gagtctcccg ccatcttggg ccctagcggt atttttccag ctctgggaag agcggcctga
       61 cccgcagcag agattcttgg tcttatttct gcattctgat ctgttccagt gaattatatt
      121 tccacaccag tactacacca gtaccacagt gtcttgagtg ctgtaacttt ataattagtc
      181 ttaaactcag atttagagtc tgattctaag gaaaaatagt ttcccaaatt tcacacaatt
      241 aattgagtac tgatatctga atcctgtgta tacagtaaaa tggattctac atctttctta
      301 ccaacatttt tagatgtgga tctgacaata tcacatatta aatgtcttcc caaggatatt
      361 ctggtgaaat ttcaaggcat aaagagtaat gaatgtgagt ttgactacca tgtattgcag
      421 agagaaatac aacatactcc aaaagtgaaa aataatgtgg aaattgatga attttgtttg
      481 gtggaagaaa gagtatctgg agaatggcag agaggaagag tcatggaaaa gaaaaatgaa
      541 ctctatacag tgctcctcat agatcgcgga gaagaactaa gagttgctgg tccacagatt
      601 gcttcagcct gtggcaattt atttgagcta ccgccacggg tagtatttgg tatttttgcg
      661 aatatactac cagttgggga aaaatggtcc cctaaagctt tgaattattt caagtcatta
      721 gtaggaatac aagtgaaagg ttatgtgcaa gctattttac ctctgcaaat gtttcttttt
      781 gaagtgccaa aaattatatc tcaggctctc gagttacaat taggaagact tgttgatgga
      841 gattcatttc gtcttattgt ggaaatgtta gaagaattcc ctcaacaaat gccagattta
      901 ttacaacata aaaggcctga attgtcatta ggtaataaag atacttcact tgatattcag
      961 catgttctgg ataagttgca gccatctttg tcagtaggaa gtactgaaag tgtaaaggta
     1021 tcatctgcat tgagcccaag taaattttat tgtcagttaa ttaaatggac tccagagcta
     1081 gaaaacttga cagcacatat gactttgcat tatgataccg tctgtcaaga aactagtccc
     1141 acgtgtgata attttggact gctttgtgtt gccagaaggc gaaatggaca gtggcataga
     1201 ggaattcttc agcagctctt gcccccaaat caagtaaaaa tttggtttat ggattatggc
     1261 agtagcgagg ctataccctc aatttatgta aagaaactta aacaggattt tattttagta
     1321 ccattatttt catttccatg ttctctgaca tgtttgcaca gtccagatag agatgcaaga
     1381 atatttcaac tgagtatatt taaacaggcc ttattaggac aagtggtata tgcacacatt
     1441 gattggttca ataaggatga gtgtttgtat tatgtgacat tacaaactca agagtctaca
     1501 gttaattcta agtgtctact gaagactgta ggcacacaag tactttgtcc gatgtctgat
     1561 tcaaaaatct ccaatatctt gagtgagaca agtgtgtctg atgtaaacag ctttgcagtt
     1621 gagagtttta tgggaaatat tgaatggtca atagactctc taaataaaaa aggcatttta
     1681 aaagtaggtt ttcccattaa aacagtacaa atggagatag aggctgccta catagctttt
     1741 atagcatatg tattaaaccc atcaaatttc tgggtacgca ctaatgacca tcggaatgaa
     1801 tttcaagaaa taatgaaaaa cataaacaaa ttttatgatt tgtgtgaaaa cgatgaaatg
     1861 attctaagaa aacctgaacc tggattattt tgttgtgcta gatatagcaa ggacagacgt
     1921 ttttacagag ctgtcatcac tgaaattaat ggttataaga ttaatgttta ttttttggat
     1981 tatggtaata ctgattccat accatttttt gatgtaaaaa ttttgcttcc agaattttgt
     2041 gagttgcctg ccttagcgat gtgctgttca cttgcacata tatttcctgt tgaagattta
     2101 tggactaagg ctgcaattga ttattttaaa aaattagttt tgaacaaagc aattttgctt
     2161 caggttatag caaaaaaaga tgacaagtac actgtaaata ttcaaagtgt tgaagcctca
     2221 gaaaatattg atgttatctc tcttatgtta caagctggat atgcagaata ttttcaagta
     2281 gaactagaat attttccaaa atctgtaagt gaatattcaa tgctaaattc agaatctaaa
     2341 aacaaagtta atattaaaaa agtcatatct gcccttcttg aaggacctaa atctaaaaag
     2401 taccattcaa ataacctggt ggaaaataac ttgtctttgc caaagtccct agctgttaat
     2461 atctcagaat ttaaaaatcc tttcaccttg tctgtgggac ctgagtcatc ctggccttat
     2521 aaagaatata tttttagacc aggaacagtt cttgaagtta aatgttcctg ttattatggc
     2581 ccaggtgact tttcatgcca gctccaatgt aagtcagaag acctaaaatt actaatggag
     2641 caaattcaga attactatag tattcattct gatccttatg agattgggca gactgcttgt
     2701 gttgctaagt attctgggaa gtggtgtaga gctgctgttt tgactcaagt atcaaaagaa
     2761 gttgacatag tgtttgttga ttatggttac caaaaaaggg ttttaattga agatctttgt
     2821 gcaattaacc cacgttttct cttgttagaa agccaagcct tcagatgttg tcttaaccat
     2881 tttattgagc ctgttagttg taaattattc agttggacaa gaaaagcatt cagagacttg
     2941 tggaatttta tctcttcatc tagagggtta ttgacttgta tcatctatgc cttagttatt
     3001 atacatccaa accatttata taacttagtg gatttacagt cctcatttac tagtgcaaaa
     3061 gaatttctta tgaatcgtgg ctctgctcag tatatcacat tatcagagac attcccatct
     3121 ttatttagtc tttacagtta ctgttattct tcctttaata tacaaattgg aagtgaagaa
     3181 gaagtatata tatctcacat atatagtccc caaaagtttt attgccagct tggcagaaat
     3241 aataaagatc tagagatgat agaaacaaaa atcacagaga gtgttaacct ccaaaatttt
     3301 ccaaaatatg attctaataa aatgagagtg tgcatatcta agtatgtaga ggatggtctc
     3361 tcatacagag ctttagcaat accaacagat tcatcatctg agtttcaagt ctattttgta
     3421 gactttggaa ataagcaatt agtaggagaa aatatgttga gggccatttc agctcagttt
     3481 ccagagttgt tgtttacacc tatgcaagct attaagtgtt ttttgtcaga tcttagggat
     3541 gtagatattc cagcagaaat cagtagttgg tttaaagaca atttcttggg aagatcatta
     3601 aaggcgataa tattgtccca ggagtcagat ggacagcttg gtatagaatt gtatgatgga
     3661 tctcaatata taaatgagaa aattaaagtg ttgcttcatg cttatggaaa aagacattgt
     3721 gaccaagcat gctgcatgga aaagagtaat aaaataaatg agaataagag atttactact
     3781 tctttgaaag gcaaaacagg aaacaactat cgccataatg tgataaataa acctagtcca
     3841 gtaacatatt ccgaaagaaa aatagaccaa ttgatgcatc ccaaaaatat acatgccagg
     3901 tttttgaagc catcagtttg ttataaaatg gaacctgtgt caaaaaacaa aatgaagact
     3961 tctttgaatg atgggcttaa aggtataaaa attgtccctg gagctgcaca tattcttgag
     4021 aacaggcgtg tgggccaaaa atcagtaaag gttgtatcac agtcttttat cagagcatta
     4081 aatcaaacaa cctcacaaaa cccatatgac cttattaggc cacagatcaa agaccttcct
     4141 caaccgcaaa tttatttgaa tgccaaagtt aaagggtatg tatctaatat cagtaatcca
     4201 gcgaatttcc atattcagct tgctgagaat gaaagtgtaa ttatcagact tgctgatgct
     4261 ctaaatgcaa cagcaaggag attgagagag agaaaatcag ttaaacctct agtgggagat
     4321 cttgtagttg cagaatattc tggtgacaat gccatttaca gggcagttat taagaaaatt
     4381 ttgccaggaa attcttttga agtagaattt attgactatg gtaactctgc aatagtaaac
     4441 acatctaaaa tttacgaact tcagagggaa tttttaactg ttcctcagct aggaatccat
     4501 gcttttctta gtggagtaaa atggaatgag cctgatgaaa tatgggatga caaaactgtg
     4561 gattatttta cttcgaaagt acataacaaa acagtttatt gtgaattttt gaaaaagcat
     4621 gatcagaaat gggaagtaaa tatgatttgt gatgaaaaat gtgtcattaa tgaactactg
     4681 aaatggaaag catgttcaaa actgcagaag tcagcattgc agatgcctca ggttctctct
     4741 caaaaggtga ggccaggtga taatgaaatg aagaaaggaa aatcaaatga gtctgaaggt
     4801 tctatgaatt caaaccaaca gctgtttaaa attcctttgg aagaattcaa acttggacaa
     4861 cttgaaaaag ctgaaatgct taatgtttca aaaagtggaa gattttatgt gaagttatcc
     4921 aaaaataaaa aaattttatc agatttaata gtattaatta cgaaagaaga aaaaaaatcc
     4981 ccttttttat caatggaaag tattgaaaaa ggtttagaat gcttggcaaa atctaaaaat
     5041 accttgaaat ggcatcgatc aaaagtagaa gaaaagtatg ttgatgataa agtacttgtt
     5101 tttttagtag attgtggtat ctatgaaata gtacctgtat gtaataccaa gctgcttagt
     5161 aatgaaataa gaaacattcc tagacaagct gtaccttgta aatggatttg gtttgaaaat
     5221 tctaagaaca tatcatttga gtgcttattt gctgatttgg aaataaatat tcttttcctg
     5281 aaatatttag atgctgtttg ggaagtagaa attttggtag atgacctgtt acttttggaa
     5341 tacttaaatt tgaatacagt tcctgttgaa gaaaacaaac ttagacttgc agaaattgtt
     5401 tacaacattg aatctaagac tcctgtatca tcatgcacaa taaaatcatt tacttgggtt
     5461 caattccaaa atgataggca gtattctggt attgcaactg ctgtttctga tccatcagac
     5521 ttcagtattc agttagaaga tttctttgac ataatgaaat acctttttat gttgctttct
     5581 gatctaccag agaccttaca aacattgcct caggagttca taattcccgg ttctagttgt
     5641 ttgttcaaat ataaatcgga agatcagtgg aatagagtag aaatttctga agtctcacct
     5701 cagtctttat gtcttgtgtt ggttgactat ggattttctt tttatatacg ttattcagaa
     5761 attataaatc ttaaagttgt tcctgaggaa cttttgaatt tgccaaggct gagttatcca
     5821 tgtattttat atggtatctt acctgctaaa ggaaaacatt ggagtgaaga agccaaaatc
     5881 ttttttcgag atttcctaag taaaccagac ttagtttttc agtttaggga atatcattct
     5941 gaaacaaaac tgaaagtaga tgtcattcat gagaaaaaca atttggcaga tatattagtt
     6001 gcatctggtc tcgcaactta ttctaaagat tcacctcatc ttgatgcaat tactgctact
     6061 gaatctgcta aaaatccaat ataaattaca aagtaagcct attttcccat tgttagatca
     6121 aaattgttac aaaaaacaaa atataaattt tacatacact gagaaacaaa agtgtaaaca
     6181 aatctacaaa gaggaaagat gtctgtaaga acctcttaag gaaaattcgt attagtaaaa
     6241 gatcacattc tagaaattta acagtgagaa agaaagttgg tagtggaaaa catttccaga
     6301 gtaccatttt gtttgataca tgtacaacag cttcattttg ggaactgcct gatggtttga
     6361 agaacagcag tcacgttgaa gacatttttg aaaaactacc aactgaagga atacaggaaa
     6421 ataagacaat gaacttgaga acagcagtaa aaacattgca tgataataaa aaaaaacaca
     6481 gaacacttaa aaggtaaaca gacattttta taaagtagat tattttctgt agattctttt
     6541 tatttgattc tttaaaagtt tttcatgtac taacatccaa attgaaaata tgttgcagga
     6601 aaacttacta gaaaatctgg ataaacggat gaactggaag tggccactac gattttaaaa
     6661 cgttgcttca ctatctttac attttttgaa tggtgaagtt tttagaatgt agtgaaagat
     6721 tttaaccaca catgcatgca cacacgcatg acgtttcaca aataatttca agggtttcat
     6781 aaaactccta aatgtctgta gatctcatgt taataaatct tgctattatt agtgagcttc
     6841 ctgcgcttat tttgaagaat catttttctg ttatatatag ttttatatca tatgaaatgt
     6901 ctttaggttt tttgagtgtg cttctagcat atttctgaac cagataaatt tataaataaa
     6961 ctgactagca tattttctct taagtctttt aaatgtcaaa ctgatactaa aatattgtta
     7021 aaattttaat attttatgca ctacagtatt gtctgatttt gtttatccac attacattca
     7081 ttttctgtat ggattagtta ctgaggattt tgtaggctgt aaagaatgtt ccccggcaaa
     7141 tgtttgtttt gactttataa ataaaatgta tattattcca
//
