LOCUS       NM_001366102            6612 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens tudor domain containing 12 (TDRD12), transcript
            variant 1, mRNA.
ACCESSION   NM_001366102 XM_011527472
VERSION     NM_001366102.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6612)
  AUTHORS   Babakhanzadeh E, Khodadadian A, Rostami S, Alipourfard I, Aghaei M,
            Nazari M, Hosseinnia M, Mehrjardi MYV, Jamshidi Y and Ghasemi N.
  TITLE     Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in
            azoospermia
  JOURNAL   BMC Med Genet 21 (1), 33 (2020)
   PUBMED   32059713
  REMARK    GeneRIF: Here we evaluate gene and protein expression levels of
            four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular
            biopsy samples obtained from men with obstructive azoospermia (OA,
            n = 29), as controls, and various types of non-obstructive
            azoospermia containing hypospermatogenesis (HP, 28), maturation
            arrest (MA, n = 30), and Sertoli cell-only syndrome (SCOS, n = 32)
            as cases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6612)
  AUTHORS   Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang
            C, Heman-Ackah SM, Hessa T, Guha R, Martin SE and Youle RJ.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 6612)
  AUTHORS   Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, Glazer NL,
            Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H,
            Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A,
            Teumer A, Pare G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC,
            Probst-Hensch NM, Kronenberg F, Tonjes A, Hayward C, Aspelund T,
            Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD,
            Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A,
            Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T,
            Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province
            M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS,
            Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N,
            Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I,
            Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF,
            Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF,
            Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D,
            Brandstatter A, Kollerits B, Kedenko L, Magi R, Stumvoll M, Kovacs
            P, Boban M, Campbell S, Endlich K, Volzke H, Kroemer HK, Nauck M,
            Volker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM,
            Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T,
            Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh
            J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I,
            Kramer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC,
            Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM and
            Fox CS.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   4  (bases 1 to 6612)
  AUTHORS   Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K,
            Maruyama M, Maeda M and Yamanaka S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008736.6 and AC008805.8.
            
            On Sep 22, 2018 this sequence version replaced XM_011527472.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000639142.2/ ENSP00000492643.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC008736.6         84769-85098         c
            331-489             AC008736.6         72982-73140         c
            490-626             AC008736.6         65873-66009         c
            627-746             AC008736.6         61965-62084         c
            747-802             AC008736.6         56334-56389         c
            803-888             AC008736.6         54996-55081         c
            889-1078            AC008736.6         48684-48873         c
            1079-1171           AC008736.6         47735-47827         c
            1172-1269           AC008736.6         32015-32112         c
            1270-1346           AC008736.6         31333-31409         c
            1347-1427           AC008736.6         27636-27716         c
            1428-1488           AC008736.6         14274-14334         c
            1489-1593           AC008736.6         13797-13901         c
            1594-1779           AC008736.6         10052-10237         c
            1780-1936           AC008736.6         6974-7130           c
            1937-2064           AC008736.6         6430-6557           c
            2065-2256           AC008736.6         4507-4698           c
            2257-2385           AC008736.6         4093-4221           c
            2386-2503           AC008736.6         2992-3109           c
            2504-2637           AC008736.6         2076-2209           c
            2638-2858           AC008736.6         1723-1943           c
            2859-2958           AC008805.8         88992-89091         c
            2959-3143           AC008805.8         86363-86547         c
            3144-3354           AC008805.8         85220-85430         c
            3355-3447           AC008805.8         82864-82956         c
            3448-3620           AC008805.8         81020-81192         c
            3621-3689           AC008805.8         78483-78551         c
            3690-3796           AC008805.8         75501-75607         c
            3797-3860           AC008805.8         70479-70542         c
            3861-3974           AC008805.8         70283-70396         c
            3975-4128           AC008805.8         70042-70195         c
            4129-4195           AC008805.8         69891-69957         c
            4196-6612           AC008805.8         67060-69476         c
FEATURES             Location/Qualifiers
     source          1..6612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..6612
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /note="tudor domain containing 12"
                     /db_xref="GeneID:91646"
                     /db_xref="HGNC:HGNC:25044"
     exon            1..330
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..4299
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1; tudor
                     domain-containing protein 12; ES cell associated
                     transcript 8; ES cell-associated transcript 8 protein;
                     putative ATP-dependent RNA helicase TDRD12"
                     /codon_start=1
                     /product="putative ATP-dependent RNA helicase TDRD12
                     isoform 1"
                     /protein_id="NP_001353031.1"
                     /db_xref="CCDS:CCDS92580.1"
                     /db_xref="GeneID:91646"
                     /db_xref="HGNC:HGNC:25044"
                     /translation="MLQLLVLKIEDPGCFWVIIKGCSPFLDHDVDYQKLNSAMNDFYN
                     STCQDIEIKPLTLEEGQVCVVYCEELKCWCRAIVKSITSSADQYLAECFLVDFAKNIP
                     VKSKNIRVVVESFMQLPYRAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYF
                     QNLLKATTQVEARLCAVEEDTFEVYLYVTIKDEKVCVNDDLVAKNYACYMSPTKNKNL
                     DYLEKPRLNIKSAPSFNKLNPALTLWPMFLQGKDVQGMEDSHGVNFPAQSLQHTWCKG
                     IVGDLRPTATAQDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRG
                     ITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQFLNPDPLRADGISDL
                     QQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPI
                     ARGCDVVVISHCESNPLLYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIF
                     ELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFL
                     RLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHL
                     IKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFT
                     CSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVP
                     LLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKD
                     ASHAVGVLRYLERADAKVPAELYEFTAGVLEAKEDKKAGRPLCPYLKAFGFCKDKRIC
                     PDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAE
                     MNEYFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEG
                     RTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLH
                     DAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKL
                     REDAKIPACEESLSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACLQSPQPEDT
                     GAEGGAESKTSSENQKPETLSGNTEGAFISRTAQPPLKSFHPQIKWFQKEDVVILKIR
                     IRNVKDYKCQYLRDRVVFSAWVGDKFYLADLELRGNIRKDDCQCVIRNDEPVITLAKE
                     RREAWCHLLRQRNPNVAFDFDHWEDCEEDSHFPKVVNSKNLPYTVTEVVEDSSSTSED
                     DDSESEREGE"
     exon            331..489
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            490..626
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            627..746
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            747..802
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            803..888
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1078
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1171
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1269
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1346
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1427
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1488
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1593
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1779
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1936
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2064
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2256
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2385
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2503
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2637
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2858
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2958
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3143
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3354
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3447
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3620
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3689
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3796
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3860
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3974
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3975..4128
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4195
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..6612
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6586..6591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /note="hexamer: AATAAA"
     polyA_site      6612
                     /gene="TDRD12"
                     /gene_synonym="ECAT8"
                     /note="major polyA site"
ORIGIN      
        1 ctgctcagcg tgcgcgggca tccggtgggt gcgggaggcc cgaggccagg caggcaggga
       61 tcccgcagcg aggggctggt tactgccagg acggagcgca ttgcctcgag ccgaccccgg
      121 ggtccgcgag ggctcctggg gacgaggagt gtggggcacc tgccgcgggg ggcccaggcg
      181 ctaaaggtgg agggaaggaa cgcactcgcg gcgggggcct ggccggggcg gacgcagcca
      241 gcctcacccg cgacggtagg ggacttccag ggcgaggggg cccatctgcc ctcgggcgcc
      301 aggaggatgc tccagctcct ggtgctgaag attgaagatc caggttgctt ctgggttatt
      361 ataaaagggt gtagtccctt tttagatcat gatgtcgatt atcaaaaatt aaatagtgcc
      421 atgaatgact tctacaacag cacgtgtcaa gatatagaaa taaaaccctt aacattggaa
      481 gaaggacagg tgtgtgtggt ctattgtgag gagctaaagt gctggtgcag ggccattgtc
      541 aaatcaatta cgtcttccgc agaccagtac ctggcagaat gtttccttgt ggactttgcc
      601 aagaacattc cagtcaaatc taaaaacatc cgagttgtag tagaatcgtt tatgcagctt
      661 ccctatagag caaaaaaatt cagcctgtac tgcacaaagc ctgtcacatt acacattgac
      721 ttctgccgag acagtactga cattgtacct gccaagaagt gggacaatgc agctattcag
      781 tactttcaga accttctgaa agcaactacc caggtggaag ccagattatg tgctgtggaa
      841 gaagatacat ttgaggttta cctttatgta actataaaag atgaaaaagt ttgtgttaat
      901 gatgatcttg ttgcaaagaa ctatgcttgt tatatgtcac ctacaaagaa taaaaacctt
      961 gattatttag aaaaaccaag attgaatata aaatcagcac cctccttcaa taaactcaat
     1021 ccagcactta cactctggcc aatgtttttg caaggaaaag atgttcaagg aatggaagat
     1081 tcacatggtg taaattttcc ggcacaatct ctgcaacata catggtgcaa gggtattgtc
     1141 ggtgacctca ggccaacagc cacagcacag gacaaagctg taaaatgtaa tatggattca
     1201 ttgagagatt cacctaaaga caaatctgaa aagaaacacc attgcatctc tttaaaagat
     1261 acaaataagc gtgttgaatc ctcagtgtac tggccagcaa aaagaggcat aaccatatat
     1321 gctgatccag atgtaccaga agcaagtgct ttaagtcaga agtcaaatga gaaacctctt
     1381 agattgactg agaagaaaga atatgatgag aagaatagct gtgtgaaatt actgcagttt
     1441 ttaaatcctg atcctttgag agctgacgga atctctgatc tccagcagtt gcagaagctg
     1501 aagggcctgc agccgcccgt ggtagtgctc cggaacaaga tcaagccctg cttaaccatt
     1561 gactcgtcgc cgctgtcagc agacctgaag aaggctcttc aaagaaataa gtttccgggc
     1621 cccagccaca ctgaatctta ctcttggcct cccatagcgc gtggctgtga tgtggttgtc
     1681 atttctcact gtgaaagcaa ccctttgctc tacctcctac cagtgttgac agttttgcaa
     1741 acaggagcct gctacaagtc attaccaagt agaaatggac ctctcgcagt catcgtgtgc
     1801 cctgggtgga agaaggccca atttattttt gaattattgg gagaatatag catgtcctcc
     1861 aggcctcttc atcctgtgct attaacaatt gggctccata aagaggaagc caaaaataca
     1921 aagcttccaa ggggctgtga tgtgattgtt acgaccccat acagcctgct gaggcttctc
     1981 gcctgtcaga gcctgctgtt cctcaggctc tgccacctga tcctggatga ggtagaggtg
     2041 ctattcttgg aagccaatga acagatgttt gctatattag ataactttaa aaaaaatatt
     2101 gaagttgaag aaagggaatc tgcaccacat cagattgttg cagttggagt tcattggaac
     2161 aaacatatag aacatctcat caaagagttc atgaatgatc cctacattgt gatcacagcc
     2221 atggaagagg ctgctctcta tggcaatgtc caacaggtag tacatctttg cctagaatgt
     2281 gaaaaaactt cttctttact ccaagctctt gattttattc caagtcaggc acaaaagacc
     2341 ttgatcttca cctgctctgt agctgaaaca gaaatagtgt gtaaggtagt agaaagcagt
     2401 tcaatatttt gcttgaagat gcataaagaa atgattttta acttacaaaa tgttttagaa
     2461 cagtggaaga agaagttaag ttctggctct caaattatat tagccctcac agacgactgc
     2521 gtcccactct tggccatcac cgatgccacg tgtgtgattc acttcagttt ccctgcctca
     2581 ccaaaagttt ttggtggacg cctgtattgc atgtctgatc attttcacgc tgaacagggt
     2641 tctcctgcag aacagggaga taagaaagcc aaatctgtct tgctgctgac ggagaaagat
     2701 gcgagccatg cggtgggcgt cctgcgctac ttggagcgag cggacgccaa ggtccccgca
     2761 gagctgtacg agttcaccgc aggagttctg gaagccaaag aagataagaa agccggaagg
     2821 cctctttgtc catatctgaa ggcttttggt ttttgcaaag acaaaaggat ctgtcctgac
     2881 cgacaccgta ttaatccaga aacggacttg cccaggaaac tgtccagcca agccctacct
     2941 tcatttggat acattaaaat aatacctttt tatattttga atgcaacaaa ttactttggc
     3001 cgtatagttg ataaacacat ggatctttat gcaactctca atgctgaaat gaatgagtat
     3061 tttaaggatt ctaataaaac aactgtggaa aaggtggaga agtttggatt gtatggatta
     3121 gcagaaaaaa cgctttttca cagggttcag gtgttggaag tgaaccaaaa agaagacgcc
     3181 tgggccctgg atgacatcct tgtagagttc atcgatgaag gcaggacggg gctcgtcaca
     3241 agggaccagc tgctgcatct cccagaacat ttccacacac ttcccccgca ggctgtggag
     3301 tttattgtct gtagggtgaa acctgctgac aacgaaatag aatggaatcc gaaggttact
     3361 aggtacattc atcataaaat tgttggaaaa ttgcatgatg caaaagtgat cctggctttg
     3421 ggaaatacag tttggattga tccaatggtg cacattacaa acctttccag tttaaaaacc
     3481 tctgtcattg attataatgt tcgagctgaa attttgtcca tgggcatggg cattgataat
     3541 ccagaacaca tagaacaact gaaaaaatta cgcgaagatg ctaagatacc agcttgtgaa
     3601 gaaagcctaa gccagacccc gccgagggtg acagggacca gtcctgctca agaccaggat
     3661 catccatccg aggagcaggg ggggcagggg acgcctccag cagaagatgc tgcttgcctg
     3721 cagagccccc agcctgagga cacgggtgca gaaggagggg ctgagtccaa gacgagctca
     3781 gaaaaccaga agcctgaaac tttatctgga aacactgaag gtgccttcat tagcagaact
     3841 gcacagccgc ctctgaaaag cttccaccca caaataaaat ggttccaaaa agaagatgtc
     3901 gtcatcttaa agataagaat aaggaatgta aaggactaca agtgtcagta tttaagggat
     3961 agagtcgttt tcagtgcttg ggtgggagac aaattttacc tggctgatct ggagctgcgg
     4021 ggcaacataa ggaaagatga ctgccaatgt gtgattagaa acgatgaacc tgtaatcact
     4081 ctggccaaag agagaaggga ggcatggtgt cacctactca gacagaggaa ccccaacgtg
     4141 gcttttgatt ttgatcactg ggaagactgt gaagaggaca gccacttccc caaggtagtg
     4201 aattctaaaa acctgccgta cacagtgaca gaggtggttg aagacagtag cagcacttca
     4261 gaggatgacg acagtgagag tgaaagagaa ggtgaatgac gtcctcaaga gcggctggaa
     4321 gatgttgaac aaaaatggat attgccatgt gaccgacagt taagaaaaca gtcagtcata
     4381 accaaatctt tttcttttct tttctttttt tttttttttt tttttttttg agacagagtc
     4441 ttgctctgtc ggccaggctg gagtgcagtg gcatgatctt ggctcactgc aacctctgcc
     4501 tcacaggctc aagcaattct cctgcctcag cctcccgagt agctgggatt acaggcatgt
     4561 gccaccatgc ctgaccaatt tttgtatttt tagtagagac agggtttcac catgttggac
     4621 aggctggtct cgaactcctg acctcaggta atcctcccac ctcagcctcc caaagtgctg
     4681 ggattacagg tgtgagccac cacacccggc caaccaaatc tttctttacc tcaaggataa
     4741 atgattactg tcaccttgtg gtgctggact tgataacggt gagaaattct tcattgactt
     4801 aaaaataggc tgatgataag accatcaaag gagggtggac acagagaaac agcaggtgtg
     4861 gtctgattcc gccggcttgt ctgtcctgtc tggcgcctct cgccactcac cctggcagag
     4921 cagacatgca tctgggtgat gaaatgcact gtctggagtc agtccattca ttttttttca
     4981 cctagacctt tgctacattg ctacaaacct gatcttacac atataaattg aggtttctaa
     5041 tgtacacact tagactcagc aactgttgaa ccagcccttt caaccatgag atagtgggat
     5101 ttaacataac catctatgtg aattgatagt gttagcattc ttggatagtg atagctcctc
     5161 agagtaagtt gacttctgat gaagagatag tccagggata gaaattggat tgctcagtaa
     5221 gacccaggcc tttccggggt gaagctgctg gttctaaaca atcccttgga cctgcagagt
     5281 cctgagcaaa tggcacaaag gttgcttttt agtggaaatt cacaagggcc tgtggggtgc
     5341 ctggaggtga tctttgaatg cctacatgtc gtgagccctg cagacattcg ccaccccatc
     5401 tgcattgtgg ctgcagcact ggggggggtc accaggttta ggggaggagt gtatgtagtc
     5461 atggccacac ccagaggctg gcttttgtgc tttgggtttc tttgttgact gaaaaagcga
     5521 gaaaggtgag ctattgggaa attaaaagtc ctgtgcactc tgtgtcttgt ttatcagctt
     5581 tgcctcggaa tggaaaagaa tttggataga acatgagtgt tgtgtgacgg ccccaagatc
     5641 tttattattt ttttgtatca gaaagcgcca atgcccaggc ttatgtatgt cccagcagaa
     5701 gccaccgctt gaactagagg tgaactttgt catcaagctg tcctgtgagc aggtctggat
     5761 cacactctgg ctcagttttc tcatctgtaa aatgagacat cccctcattg tgtggcctgg
     5821 ccttgtctca gggagcgccc gccgagtgct gctgggttgg gcagtttttc tgcccagtgg
     5881 ctctgatggg ggctcagagc cctggcctcc cctgggagga cacgctgtgc agccaggaca
     5941 gctgccggga gtgtgcccag gtcactgcta tggccttcgc agggtgactg gcaggtatca
     6001 aatcagccca tgaaggaaga tggtgatttt ccttttttgt agctaaattg ggcaggctct
     6061 tgggaagtag aaagttctgg tgtttttgct ggtgaaggtt ttgactgtgg agctcttcta
     6121 acacccatat cagtgtctgt ttctctgcat gtggctgctg ccctgttggt ggagctctgg
     6181 gggcagagac caggccgccg tccagtggcg ccccgtgcgc accagctgcc tgctgtttac
     6241 acccaggtgc gccgagtctc tttcatacag cacagcaaat gataatagct agtgacaatg
     6301 tgtttcctgt gcactcgtga aaatgcaggg aggacaactg catgcttaga tctgtttctt
     6361 ttttcagaca ttcaaatgtt ctaatatctg aagctaacat tttgtaggat ataggatgct
     6421 gattatgtga acaattagtc attggttttc tgtactgcta tgaatatgtc tgatttcaag
     6481 ttttggtcaa atatctaaaa tgcaaggtga aagtgccttt gtctctatgc ttctaaaatc
     6541 gctcatgctt agttgtggta tggatgtctt ccgcagtgta tcatcaataa aatttcactg
     6601 ttttcacaga aa
//
