LOCUS       NM_182499               2331 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens tudor domain containing 10 (TDRD10), transcript
            variant 2, mRNA.
ACCESSION   NM_182499
VERSION     NM_182499.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Galora,S., Saracini,C., Pratesi,G., Sticchi,E., Pulli,R.,
            Pratesi,C., Abbate,R. and Giusti,B.
  TITLE     Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and
            rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm
            in Italian patients
  JOURNAL   J Vasc Surg 61 (3), 787-792 (2015)
   PUBMED   24423473
  REMARK    GeneRIF: Suggest rs6674171 TDRD10 SNP is not a susceptibility
            factor for abdominal aortic aneurysms in an Italian population.
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Kauwe,J.S., Bailey,M.H., Ridge,P.G., Perry,R., Wadsworth,M.E.,
            Hoyt,K.L., Staley,L.A., Karch,C.M., Harari,O., Cruchaga,C.,
            Ainscough,B.J., Bales,K., Pickering,E.H., Bertelsen,S., Fagan,A.M.,
            Holtzman,D.M., Morris,J.C. and Goate,A.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study of CSF levels of 59 alzheimer's
            disease candidate proteins: significant associations with proteins
            involved in amyloid processing and inflammation
  JOURNAL   PLoS Genet 10 (10), e1004758 (2014)
   PUBMED   25340798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162591.16 and AL592078.10.
            
            On Jun 2, 2019 this sequence version replaced NM_182499.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, that results in a
            frameshift. It encodes isoform b which has a shorter and distinct
            C-terminus compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044864.1, SRR5189667.225105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368482.8/ ENSP00000357467.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               AL162591.16        20857-21667         c
            812-840             AL162591.16        16981-17009         c
            841-920             AL162591.16        16566-16645         c
            921-979             AL162591.16        15405-15463         c
            980-1050            AL162591.16        3512-3582           c
            1051-1207           AL162591.16        2407-2563           c
            1208-1250           AL592078.10        44579-44621         c
            1251-1341           AL592078.10        43824-43914         c
            1342-1489           AL592078.10        42535-42682         c
            1490-1635           AL592078.10        42128-42273         c
            1636-1790           AL592078.10        41696-41850         c
            1791-1861           AL592078.10        39166-39236         c
            1862-2331           AL592078.10        38498-38967         c
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2331
                     /gene="TDRD10"
                     /note="tudor domain containing 10"
                     /db_xref="GeneID:126668"
                     /db_xref="HGNC:HGNC:25316"
     exon            1..811
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            812..840
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             839..1894
                     /gene="TDRD10"
                     /note="isoform b is encoded by transcript variant 2; tudor
                     domain-containing protein 10"
                     /codon_start=1
                     /product="tudor domain-containing protein 10 isoform b"
                     /protein_id="NP_872305.3"
                     /db_xref="CCDS:CCDS30878.2"
                     /db_xref="GeneID:126668"
                     /db_xref="HGNC:HGNC:25316"
                     /translation="MSWNISHPQLSDKLFGKNGVLEEQKSPGFKKRETEVYVGNLPLD
                     ISKEEILYLLKDFNPLDVHKIQNGCKCFAFVDLGSMQKVTLAIQELNGKLFHKRKLFV
                     NTSKRPPKRTPDMIQQPRAPLVLEKASGEGFGKTAAIIQLAPKAPVDLCETEKLRAAF
                     FAVPLEMRGSFLVLLLRECFRDLSWLALIHSVRGEAGLLVTSIVPKTPFFWAMHVTEA
                     LHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAEYHLGDYGHAWNRCWVLDRVDTW
                     AVVMFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKI
                     TGALNSALHILKFEESK"
     exon            841..920
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            921..979
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1050
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1207
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1250
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1341
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1489
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1635
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1790
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1861
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2331
                     /gene="TDRD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2308..2313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDRD10"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="TDRD10"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcaacg cctgcccggc ccgaggacac cgtggctctc ggaggcggcg ggcgccgggg
       61 gcttccccct gctctttcct cctgcggtgg gagaggccag gcccacggaa gccccctgcg
      121 gcccagccca cgctcccagg gaccagagag gaccgagcgg aggcggcggg agtatccccg
      181 gcgcagcgac agacggtgga cggacggcga gcggcccatc aactccgcgc gcccctcccc
      241 tccgcggctg gcgcctccca gccccgccac ctcctgccca gagctggggg cggcggggtg
      301 agcgccatgg cagaggcggg tcgggctgcg agctctggag aaaggggcgg cggccgcacg
      361 tgcggatcgg ccgcgcccca ctgagcagag agcccccttc tgccgccgac agcccgcgtc
      421 tgcaccgagc cggtctcggc cgggcgctgc cttcacacgc gcccaggagt gtcacgtgcg
      481 ccgctcaccc ccgggaagga agcccctcgc ccacccactc cgctctactc cactctttct
      541 gcagacgtta tttttggcgg tagggcagag gttgcggccc gaggtccggg cgcagggaca
      601 acggtcgcca gctcctgcgc tagttccgtt actcttcggt ggcacacggt cctgggcagc
      661 gcgaggctct tcccgccgtg gccgccgggg attggctgcc ggcaagcccc gccccgtgcc
      721 cccgggctca gagggggcgg agcgcggagg gagaaggcgc gaaggctggg cgtcgcgatc
      781 gcaggtgcac gcgcgtggcc cgcgagacga ggagatcctg ttggaaagca actgcagcat
      841 gtcctggaac attagtcacc cccaactctc tgataaactg tttgggaaga atggagtgtt
      901 ggaggagcag aaatctccag gattcaagaa aagagagaca gaggtgtatg ttggcaatct
      961 tccactggat atttctaagg aggaaattct gtaccttcta aaggacttca accctcttga
     1021 tgtccacaaa atccagaatg gctgcaaatg ctttgcattt gtagatctgg gctccatgca
     1081 gaaagtgaca cttgcaatcc aggagctgaa tggtaaactc ttccacaagc gaaaactgtt
     1141 cgtgaataca agcaaaaggc cccccaagag gacccctgat atgatccagc agcctcgggc
     1201 cccgctggtg ttggagaagg cttctggtga aggatttggc aaaaccgccg ctattataca
     1261 gctcgctcct aaagctcctg ttgacctgtg tgagacagag aaactgaggg cagccttctt
     1321 tgcagtcccg ttggaaatga gagggtcctt cctggtgctg ctcctgaggg aatgcttccg
     1381 agacctgagc tggctggcac tcatccatag cgtccgtggg gaggcggggc tgctggtgac
     1441 gagtatcgtc ccgaagaccc cgtttttctg ggctatgcac gtcactgagg ctctgcacca
     1501 gaacatgcag gctctgttta gcaccctggc tcaggcggag gagcagcagc cctacctgga
     1561 gggctccacc gttatgcgcg ggactcgctg tctggcagag taccacctgg gggattatgg
     1621 acacgcctgg aacaggtgtt gggtgctgga cagggtggac acctgggctg tggtcatgtt
     1681 cattgatttt ggacagttgg ccaccatccc tgtgcagtct ctgcgcagcc tagacagcga
     1741 cgacttctgg accatcccac ccctgactca gccattcatg ctggagaaag acattttgag
     1801 ttcgtatgag gttgtccatc gaatcctcaa agggaaaatc actggtgctt tgaactcggc
     1861 gttgcacatc ctaaagtttg aagagtctaa ataacggggc ttccctcagc atgttccctc
     1921 tcctgtttgc cacggatcca gaggccacct gccctgtctt ctcgtacccc tttcactctt
     1981 gaggcctggg aggtgaaaaa ggccagactg tgcccaggat tgattcaatt ttgcttttac
     2041 tcccagcttc cctctcaaaa gagagtgaag tctcatttgt catgtgtctt cagttcccca
     2101 acttggcatg aacatttgaa ccaaacatag gaaactacca ttaggttgaa agcctgaggc
     2161 agctgggatg gtctttcttg tgtctcttct ttgcacccca gagcatgata taagtggtcc
     2221 taacagattc tggataatgg agaagccctc tgctggtttt cctggcattc catgtagaat
     2281 aggtagagaa tatttaacca atgagcaaat aaatgttggc atgtttcatg a
//
