LOCUS       NM_005651               1700 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tryptophan 2,3-dioxygenase (TDO2), mRNA.
ACCESSION   NM_005651
VERSION     NM_005651.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Pham,Q.T., Taniyama,D., Akabane,S., Takashima,T., Maruyama,R.,
            Sekino,Y., Sentani,K., Yasui,W. and Oue,N.
  TITLE     Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with
            Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer
            Stem Cells
  JOURNAL   Pathobiology 90 (1), 44-55 (2023)
   PUBMED   35679834
  REMARK    GeneRIF: Essential Roles of TDO2 in Gastric Cancer: TDO2 Is
            Associated with Cancer Progression, Patient Survival, PD-L1
            Expression, and Cancer Stem Cells.
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Silvano,A., Seravalli,V., Strambi,N., Tartarotti,E., Tofani,L.,
            Calosi,L., Parenti,A. and Di Tommaso,M.
  TITLE     Tryptophan degradation enzymes and Angiotensin (1-7) expression in
            human placenta
  JOURNAL   J Reprod Immunol 153, 103692 (2022)
   PUBMED   35970080
  REMARK    GeneRIF: Tryptophan degradation enzymes and Angiotensin (1-7)
            expression in human placenta.
REFERENCE   3  (bases 1 to 1700)
  AUTHORS   Rong,G., Zhang,T., Xu,Y., Zhang,Z., Gui,B., Hu,K., Zhang,J.,
            Tang,Z. and Shen,C.
  TITLE     High levels of TDO2 in relation to pro-inflammatory cytokines in
            synovium and synovial fluid of patients with osteoarthritis
  JOURNAL   BMC Musculoskelet Disord 23 (1), 604 (2022)
   PUBMED   35733134
  REMARK    GeneRIF: High levels of TDO2 in relation to pro-inflammatory
            cytokines in synovium and synovial fluid of patients with
            osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1700)
  AUTHORS   Opitz,C.A., Litzenburger,U.M., Sahm,F., Ott,M., Tritschler,I.,
            Trump,S., Schumacher,T., Jestaedt,L., Schrenk,D., Weller,M.,
            Jugold,M., Guillemin,G.J., Miller,C.L., Lutz,C., Radlwimmer,B.,
            Lehmann,I., von Deimling,A., Wick,W. and Platten,M.
  TITLE     An endogenous tumour-promoting ligand of the human aryl hydrocarbon
            receptor
  JOURNAL   Nature 478 (7368), 197-203 (2011)
   PUBMED   21976023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1700)
  AUTHORS   Nabi,R., Serajee,F.J., Chugani,D.C., Zhong,H. and Huq,A.H.
  TITLE     Association of tryptophan 2,3 dioxygenase gene polymorphism with
            autism
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 125B (1), 63-68 (2004)
   PUBMED   14755447
  REMARK    GeneRIF: Polymorphism of tryptophan 2,3 dioxygenase gene is
            associated with autism.
REFERENCE   6  (bases 1 to 1700)
  AUTHORS   Kudo,Y., Boyd,C.A., Sargent,I.L. and Redman,C.W.
  TITLE     Decreased tryptophan catabolism by placental indoleamine
            2,3-dioxygenase in preeclampsia
  JOURNAL   Am J Obstet Gynecol 188 (3), 719-726 (2003)
   PUBMED   12634647
  REMARK    GeneRIF: The activity and mRNA expression level of indoleamine
            2,3-dioxygenase in term placentas were significantly lower in
            preeclampsia. Could cause dysregulation of inflammatory response
            intrinsic to normal pregnancy.
REFERENCE   7  (bases 1 to 1700)
  AUTHORS   Dick,R., Murray,B.P., Reid,M.J. and Correia,M.A.
  TITLE     Structure--function relationships of rat hepatic tryptophan
            2,3-dioxygenase: identification of the putative heme-ligating
            histidine residues
  JOURNAL   Arch Biochem Biophys 392 (1), 71-78 (2001)
   PUBMED   11469796
REFERENCE   8  (bases 1 to 1700)
  AUTHORS   Comings,D.E., Gade-Andavolu,R., Gonzalez,N., Wu,S., Muhleman,D.,
            Blake,H., Mann,M.B., Dietz,G., Saucier,G. and MacMurray,J.P.
  TITLE     A multivariate analysis of 59 candidate genes in personality
            traits: the temperament and character inventory
  JOURNAL   Clin Genet 58 (5), 375-385 (2000)
   PUBMED   11140838
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 1700)
  AUTHORS   Comings,D.E., Muhleman,D., Dietz,G., Sherman,M. and Forest,G.L.
  TITLE     Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a
            glucocorticoid response-like element composed of a GTT repeat and
            an intronic CCCCT repeat
  JOURNAL   Genomics 29 (2), 390-396 (1995)
   PUBMED   8666386
REFERENCE   10 (bases 1 to 1700)
  AUTHORS   Comings,D.E., Muhleman,D., Dietz,G.W. Jr. and Donlon,T.
  TITLE     Human tryptophan oxygenase localized to 4q31: possible implications
            for alcoholism and other behavioral disorders
  JOURNAL   Genomics 9 (2), 301-308 (1991)
   PUBMED   2004780
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U32989.1 and AA705255.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005651.3.
            
            Summary: This gene encodes a heme enzyme that plays a critical role
            in tryptophan metabolism by catalyzing the first and rate-limiting
            step of the kynurenine pathway. Increased activity of the encoded
            protein and subsequent kynurenine production may also play a role
            in cancer through the suppression of antitumor immune responses,
            and single nucleotide polymorphisms in this gene may be associated
            with autism. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.92620.1,
                                           SRR5189664.57607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536354.3/ ENSP00000444788.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1521              U32989.1           2-1522
            1522-1700           AA705255.1         4-182               c
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..1700
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /note="tryptophan 2,3-dioxygenase"
                     /db_xref="GeneID:6999"
                     /db_xref="HGNC:HGNC:11708"
                     /db_xref="MIM:191070"
     exon            1..98
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1284
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /EC_number="1.13.11.11"
                     /note="tryptophan pyrrolase; tryptophan oxygenase;
                     tryptophanase; tryptamin 2,3-dioxygenase"
                     /codon_start=1
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="NP_005642.1"
                     /db_xref="CCDS:CCDS34086.1"
                     /db_xref="GeneID:6999"
                     /db_xref="HGNC:HGNC:11708"
                     /db_xref="MIM:191070"
                     /translation="MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGN
                     YLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHV
                     RDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRL
                     LENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPH
                     GFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHL
                     LSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHR
                     MLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTA
                     EYCDSSYFSSDESD"
     exon            99..204
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            205..295
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            296..366
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            367..494
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            495..681
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            682..789
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            790..901
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            902..959
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1039
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1130
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1700
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /note="hexamer: AATAAA"
     polyA_site      1700
                     /gene="TDO2"
                     /gene_synonym="HYPTRP; TDO; TO; TPH2; TRPO"
                     /note="major polyA site"
ORIGIN      
        1 aggtcaatga tagcatctgc ctagagtcaa acctccgtgc ttctcagaca gtgccttttc
       61 accatgagtg ggtgcccatt tttaggaaac aactttggat atacttttaa aaaactcccc
      121 gtagaaggca gcgaagaaga caaatcacaa actggtgtga atagagccag caaaggaggt
      181 cttatctatg ggaactacct gcatttggaa aaagttttga atgcacaaga actgcaaagt
      241 gaaacaaaag gaaataaaat ccatgatgaa catcttttta tcataactca tcaagcttat
      301 gaactctggt ttaagcaaat cctctgggag ttggattctg ttcgagagat ctttcagaat
      361 ggccatgtca gagatgaaag gaacatgctt aaggttgttt ctcggatgca ccgagtgtca
      421 gtgatcctga aactgctggt gcagcagttt tccattctgg agacgatgac agccttggac
      481 ttcaatgact tcagagagta cttatctcca gcatcaggct tccagagttt gcaattccga
      541 ctattagaaa acaagatagg tgttcttcag aacatgagag tcccttataa cagaagacat
      601 tatcgtgata acttcaaagg agaagaaaat gaactgctac ttaaatctga gcaggaaaag
      661 acacttctgg aattagtgga ggcatggctg gaaagaactc caggtttaga gccacatgga
      721 tttaacttct ggggaaagct tgaaaaaaat atcaccagag gcctggaaga ggaattcata
      781 aggattcagg ctaaagaaga gtctgaagaa aaagaggaac aggtggctga atttcagaag
      841 caaaaagagg tgctactgtc cttatttgat gagaaacgtc atgaacatct ccttagtaaa
      901 ggtgaaagac ggctgtcata cagagcactt cagggagcat tgatgatata tttttacagg
      961 gaagagccta ggttccaggt gccttttcag ttgctgactt ctcttatgga catagattca
     1021 ctgatgacca aatggagata taaccatgtg tgcatggtgc acagaatgct gggcagcaaa
     1081 gctggcaccg gtggttcctc aggctatcac tacctgcgat caactgtgag tgataggtac
     1141 aaggtatttg tagatttatt taatctttca acatacctga ttccccgaca ctggataccg
     1201 aagatgaacc caaccattca caaatttcta tatacagcag aatactgtga tagctcctac
     1261 ttcagcagtg atgaatcaga ttaaaatcgt ctgcaaaatc tatgaagaat actggtttca
     1321 cagcctattt tttattttct atggattttc ataaatacag tttgaatata tgtatgcata
     1381 tattgttcag caccacgatg ctctgattta attctagaaa caatttgatt acctcttgtt
     1441 tgtgacaaga ctaagcatta agatgagaaa gaatacattt aaatagtaac attgtacata
     1501 gggtgttttc ctattaaaaa ttcagtttcc cctgagactt aatgtaacca cttaatgtaa
     1561 tcactatctc attgtttcat ctttataaac ttgtaaactt catctatttc aaatatttta
     1621 tgcagtacat tatattattc tgtacaaagg ctttcaaaca aaatttttaa aataataaag
     1681 tattaatctt tctccctgta
//
