LOCUS       NM_182539               3086 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens t-complex-associated-testis-expressed 1 (TCTE1), mRNA.
ACCESSION   NM_182539
VERSION     NM_182539.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Zhang,J., He,X., Wu,H., Zhang,X., Yang,S., Liu,C., Liu,S., Hua,R.,
            Zhou,S., Zhao,S., Hu,F., Zhang,J., Liu,W., Cheng,H., Gao,Y.,
            Zhang,F., Cao,Y. and Liu,M.
  TITLE     Loss of DRC1 function leads to multiple morphological abnormalities
            of the sperm flagella and male infertility in human and mouse
  JOURNAL   Hum Mol Genet 30 (21), 1996-2011 (2021)
   PUBMED   34169321
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3086)
  AUTHORS   Juneja,R., Agulnik,S.I. and Silver,L.M.
  TITLE     Sequence divergence within the sperm-specific polypeptide TCTE1 is
            correlated with species-specific differences in sperm binding to
            zona-intact eggs
  JOURNAL   J Androl 19 (2), 183-188 (1998)
   PUBMED   9570741
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Kwiatkowski,T.J. Jr., Beaudet,A.L., Trask,B.J. and Zoghbi,H.Y.
  TITLE     Linkage mapping and fluorescence in situ hybridization of TCTE1 on
            human chromosome 6p: analysis of dinucleotide polymorphisms on
            native gels
  JOURNAL   Genomics 10 (4), 921-926 (1991)
   PUBMED   1916824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK301825.1, AL353588.25 and AA732744.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182539.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301825.1, SRR5189667.160333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371505.5/ ENSP00000360560.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AK301825.1         24-259
            237-237             AL353588.25        11073-11073         c
            238-930             AK301825.1         261-953
            931-931             AL353588.25        9363-9363           c
            932-1110            AK301825.1         955-1133
            1111-1111           AL353588.25        5779-5779           c
            1112-1440           AK301825.1         1135-1463
            1441-1610           AL353588.25        3561-3730           c
            1611-1660           AA732744.1         4-53                c
            1661-3086           AL353588.25        2085-3510           c
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..3086
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /note="t-complex-associated-testis-expressed 1"
                     /db_xref="GeneID:202500"
                     /db_xref="HGNC:HGNC:11693"
                     /db_xref="MIM:186975"
     exon            1..40
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /inference="alignment:Splign:2.1.0"
     exon            41..410
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1639
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /note="T-complex-associated testis-expressed protein 1;
                     tcte-1"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 5"
                     /protein_id="NP_872345.2"
                     /db_xref="CCDS:CCDS4910.1"
                     /db_xref="GeneID:202500"
                     /db_xref="HGNC:HGNC:11693"
                     /db_xref="MIM:186975"
                     /translation="MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITP
                     VPAKSRNPHPRANIRRMRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLP
                     EHQQKVLNHLSPDLPLAVTANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHL
                     ENLLKHFIPGTTDPAVILDLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEG
                     EMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIK
                     ACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS
                     RLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCL
                     TTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE
                     FDLRLSDVAQESEYLIGQALYANREAARQRALNPSHFMSTITANGPENSVG"
     exon            411..979
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1429
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..3086
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1635..1640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /note="hexamer: GATAAA"
     polyA_site      1655
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /note="hexamer: AGTAAA"
     polyA_site      3086
                     /gene="TCTE1"
                     /gene_synonym="D6S46; DRC5; FAP155"
                     /note="major polyA site"
ORIGIN      
        1 gggactctgc gtgaggcgag cgccggggct cccggagcgg atccctacct gtttcaagga
       61 cctgccagtc tgagaagctt cttgtcataa ggccatccag gggccacgca cccctacctt
      121 gccagcctcc agcatgcagg ataccgtaac gacatcagca ttgttggacc ccagccactc
      181 ctcagtctcc acccaggaca attcctccac tggaggacac acttcaagca caagcccaca
      241 gctctcaaag ccttcaatca caccagtccc tgcaaagtcc aggaacccac atcccagggc
      301 caatatccgt cggatgcgcc ggatcattgc tgaggatcct gagtggtcac tggccatcgt
      361 gcccctcctc acagagctct gcattcagca cattatcagg aacttccaga aaaaccctat
      421 cctgaagcag atgctcccgg aacaccagca gaaggtcctg aaccacctgt cccctgacct
      481 accactggct gtgaccgcca acctgataga cagtgagaac tactggctcc gctgctgcat
      541 gcatcgctgg cccgtgtgcc acgtggccca ccatggcggc agctggaaac gcatgttctt
      601 cgagcggcac ctggagaacc tgctaaagca ctttatccca ggcaccacag accctgcggt
      661 gatcctcgac ctgctgccgc tctgccggaa ttacgtgcgc agggtccacg tcgatcagtt
      721 ccttccgccg gtgcagctcc cggcccagct ccggccgggc gaccagtccg actcaggcag
      781 cgagggagag atggaggagc ccaccgttga ccactaccaa ctgggcgatc tggtagctgg
      841 cctgagccac ctggaggagc tggacctggt gtacgatgtc aaggactgcg gcatgaattt
      901 cgagtggaat ctcttcctct tcacctaccg tgactgcctc tccttggcag ccgccatcaa
      961 ggcatgccac accctcaaga tcttcaagct gacccgaagc aaggtggatg atgacaaggc
     1021 acgcatcata attcgaagcc ttctggacca cccagtcctc gaggagctgg acttgtcaca
     1081 aaacctcatt ggagaccgtg gtgcacgagg tgctgccaag ctgctgagcc acagccgcct
     1141 gcgtgtgctc aacctggcta acaaccaggt gcgtgcaccc ggtgcccagt ccctggctca
     1201 cgctctggca cacaacacca acctcatttc cctcaaccta cgtctcaact gcatcgagga
     1261 tgagggtggc caggctcttg cccatgcctt gcagaccaac aagtgcctca ccacgctgca
     1321 cctcggtggc aatgagctgt ctgagcccac cgccacactc ctgtcacagg tgctcgccat
     1381 caacaccaca ctcaccagca tcaacctgtc ctgcaaccac atcgggctgg acggtgggaa
     1441 gcagctcctg gaaggcatgt cagacaacaa gaccctcctg gaatttgact tgcgcctgtc
     1501 agatgtggcc caggaaagcg agtacctcat tggccaggcc ctctacgcaa accgagaagc
     1561 agcccgccag cgggccctga atcccagcca cttcatgtca accataactg ccaatggccc
     1621 tgagaactct gtgggataaa atgacctgac ttggatcatg gccccagccc catccctcat
     1681 ttcatacccc tgccatgcct gctgcagagt atcacactgg ttcagaggga gcggggaggg
     1741 ggactgtgaa taaccttgga gtgatcaagg gttgtatgga tggagacatg aggcagggaa
     1801 gggagcctgg catgggggaa gaaagggtat gcagtaggga cccagccttt gtgcccaggg
     1861 aaaggatatt actggacacc cacaaatgac caacttcttt caggaacagg gaagtcagag
     1921 aggtgtctga gggactgtgc ctgccagatt ctcccgttgg ggctgcctgc ctccctgact
     1981 ccccaccatt ttcttctcta ccaaacagat ccttgatctt caaacacaca cacacacaca
     2041 cacacacaca cacacacaca cacacacaca ccctctggct acagcagggc tatgcctggc
     2101 tctctctgcc accctcatcc ctgtagatgc atttccctgt tgcttgactc tgctttaagt
     2161 gatccagttc tacaggccac gccatcccct agttccccaa ctcccaacct gggaagggga
     2221 caatgagctg acaccagggg ctcagaccca gtggactcct ctggggaggc aactgtagat
     2281 gacaacttcc agggaaggat gacacaatcc ctgccaccca ccccagagag cttccctggg
     2341 agggagggaa agaagtgcca cactgggaca ggaagtcagt gagtcatcca cgactttatt
     2401 atccaccagt ttgatttgta caatctttgc gcttaaatcc acgacaaaaa ggccacagtg
     2461 tgatgcaccc aattgacaga gacctgtctt ctccccagcc aggcccagcc caccccacaa
     2521 gcccttgtcc ccaggacaca tggagccttc caggtgccct acatgagtcc cccatcactc
     2581 tgtagctgtc caccctgggg ccacacctac aggaatcaca tcagccccca gggccacaag
     2641 agacctagct gactgattca ggctgagcgc cattgcccat cctccttggg ctgattcatt
     2701 ggcccagagc ctccagaact gtgtccccaa agggcaggtc atgggctaca accccagtcc
     2761 aggagtgcct gctctccagg gactccttcc gctaagcagg cgctgagcag agcaccaaag
     2821 ggggcttggg agtgactgca tgtgtgtgcc tgtctaggca acctagagtc tgtctgtgcc
     2881 tgacaccctc tgacagttcc ggagtgcaaa cgtgtaggtg tgagggtgtg tgtgtgtgtg
     2941 tgtgtgtgta tagccacagc tgctagcaga agttctaatt agagaaacaa gaacattcag
     3001 tgtaaagttt aattttagag attaattaat tttctggttt tcattttccc tggcaatcag
     3061 taaagctacc aagaaaatag accaaa
//
