LOCUS       NM_022171               1930 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens T cell leukemia translocation altered (TCTA), mRNA.
ACCESSION   NM_022171
VERSION     NM_022171.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   Kotake,S., Yago,T., Kawamoto,M. and Nanke,Y.
  TITLE     The role of T-cell leukemia translocation-associated gene protein
            in human tumorigenesis and osteoclastogenesis
  JOURNAL   J Biomed Biotechnol 2012, 675317 (2012)
   PUBMED   22174563
  REMARK    GeneRIF: TCTA protein has roles in lung cancer cell lines and human
            osteoclastogenesis [review]
            Review article
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Kotake,S., Yago,T., Kawamoto,M. and Nanke,Y.
  TITLE     [Role of T-cell leukemia translocation-associated gene (TCTA)
            protein in human osteoclastogenesis]
  JOURNAL   Nihon Rinsho Meneki Gakkai Kaishi 32 (6), 466-471 (2009)
   PUBMED   20046013
  REMARK    GeneRIF: It expressed in synovial tissues from patients with RA and
            inhibits human osteoclastogenesis. (review)
            Review article
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Kotake,S., Nanke,Y., Kawamoto,M., Yago,T., Udagawa,N., Ichikawa,N.,
            Kobashigawa,T., Saito,S., Momohara,S., Kamatani,N. and Yamanaka,H.
  TITLE     T-cell leukemia translocation-associated gene (TCTA) protein is
            required for human osteoclastogenesis
  JOURNAL   Bone 45 (4), 627-639 (2009)
   PUBMED   19560569
  REMARK    GeneRIF: TCTA is a novel protein expressed in synovial tissues of
            rheumatoid arthritis that regulate human osteoclastogenesis.
REFERENCE   8  (bases 1 to 1930)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 1930)
  AUTHORS   Aplan,P.D., Johnson,B.E., Russell,E., Chervinsky,D.S. and
            Kirsch,I.R.
  TITLE     Cloning and characterization of TCTA, a gene located at the site of
            a t(1;3) translocation
  JOURNAL   Cancer Res 55 (9), 1917-1921 (1995)
   PUBMED   7728759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104452.2.
            
            On Apr 22, 2021 this sequence version replaced NM_022171.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41143.1, AK000824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273590.4/ ENSP00000273590.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC104452.2         154818-155035       c
            219-273             AC104452.2         154348-154402       c
            274-1930            AC104452.2         150982-152638       c
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1930
                     /gene="TCTA"
                     /note="T cell leukemia translocation altered"
                     /db_xref="GeneID:6988"
                     /db_xref="HGNC:HGNC:11692"
                     /db_xref="MIM:600690"
     exon            1..218
                     /gene="TCTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..316
                     /gene="TCTA"
                     /note="T-cell leukemia translocation-associated gene
                     protein"
                     /codon_start=1
                     /product="T-cell leukemia translocation-altered gene
                     protein"
                     /protein_id="NP_071503.1"
                     /db_xref="CCDS:CCDS2796.1"
                     /db_xref="GeneID:6988"
                     /db_xref="HGNC:HGNC:11692"
                     /db_xref="MIM:600690"
                     /translation="MAESWSGQALQALPATVLGALGSEFLREWEAQDMRVTLFKLLLL
                     WLVLSLLGIQLAWGFYGNTVTGLYHRPGLGGQNGSTPDGSTHFPSWEMAANEPLKTHR
                     E"
     exon            219..273
                     /gene="TCTA"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1930
                     /gene="TCTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCTA"
                     /note="hexamer: ATTAAA"
     polyA_site      1930
                     /gene="TCTA"
                     /note="major polyA site"
ORIGIN      
        1 agtcatggcg gagtcctggt ctgggcaggc cttgcaggct ctgccggcca cggtgctggg
       61 cgcgctgggc agcgagttct tgcgggagtg ggaggcgcag gacatgcgcg tgaccctctt
      121 caagctgctg ctgctgtggt tggtgttaag tctcctgggc atccagctgg cgtgggggtt
      181 ctacgggaat acagtgaccg ggttgtatca ccgtccaggt ctgggtggtc agaatggatc
      241 cacgcctgat ggctccacgc atttcccttc gtgggaaatg gcagcaaacg aacctctcaa
      301 aacccacaga gaataaggga aggcagcaga gggtctccaa gggcatcact gggtctgctg
      361 gcttctacac tgggttctgc tactccccag acctcaggga caactgccgg gggttcaggg
      421 ttggtagcag ggagtaccca gtgcctacag ggctgggcct cttctgcctc ttaagcctgc
      481 tccctcaccc aggcactggg caagtgaaga gtttgcctgt actcttatct gggtgcctta
      541 aggagagaga ttgtgttctt cctctctcag gggtgataac tcaggaagcc tctgggttgg
      601 gaagaccatc agttcttttg tcttaggttt cttttcctgt ccctcttcca tccccaagat
      661 gtgaccccat aaaaattttt cctgagttgg ccaggcatgg tggctcacgc ctgtaatccc
      721 aacactttgg gaggctgagg caggcagatc acgaggtcag gagttcgaga ccagcctgac
      781 caacatggtg aaaaccccat ctctactaaa aatacaaaaa ttagccgggt gtggtggcac
      841 acaccagtaa tcccagctac tcaggaggct gaagcaggag atttgcttga acctgggagg
      901 cagaggttgc agtgagccaa gattgcgccg ttgtactcca gcctgggcaa cagagcaaga
      961 cccatctcaa aaaaaaaatt tttttcctga gaggaagcct gaggttgacc agctctgggg
     1021 tttgtaaggc aggtctgttt tctcctaggc cctgagtttt ctgaatctct ggttttgctt
     1081 tgttggcaag gagccaggga atcctgacct gagccagacc ttaagctcta tggttattta
     1141 gctggccatt caggtataag gcagggtggt gtacctgctg gcactatcca gatggaggca
     1201 ccaaacaccc acatacctgg cccaaccaga cttctcccgt gagccaggca aaggaaattg
     1261 tcatctgcca actgtcctac tcatattcct ctcagtcctt cttgggggta agctgattac
     1321 ctgaaggaca gctgaacccc tggggtagcc tcctatccac cactgcttaa gtgcctatgg
     1381 gaatgtgggt ctgcaccttg tcccctcata ggatggtacc aagcatttag tgcacagtgg
     1441 ccccatcata gcctgcagcc tcatcatttc ccatctggac ctggtacaaa tgcacgtcac
     1501 aggctcagct cctccccact agcattttct ctaccttcaa gaaccaggca gccctgccat
     1561 gtcacaatag gccaggggag tttccaaaga tgtgggtggc aaatgcccct atagaaacac
     1621 cagtacctga aagcactgta gccctggacc tgcctccttc cctcggggcc atacttctgt
     1681 ttccatctgc tgggccacca gccactttag tgacccctgc ctacttcctt cctgttggat
     1741 atcatacttc catctggctg cctttgctta agccatcttt gtggtagagg ggccctggaa
     1801 ttgcagctgt actgaggatg atgttattca cagcccctgg cccacccact aatactactg
     1861 cacagagtca ggatctcaca tttcacccca ggctcaactg aggatgtggc ttattaaaca
     1921 cggaagtgca
//
