LOCUS       NM_152772               2277 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens t-complex 11 like 2 (TCP11L2), transcript variant 1,
            mRNA.
ACCESSION   NM_152772
VERSION     NM_152772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Scharf,J.M., Yu,D., Mathews,C.A., Neale,B.M., Stewart,S.E.,
            Fagerness,J.A., Evans,P., Gamazon,E., Edlund,C.K., Service,S.K.,
            Tikhomirov,A., Osiecki,L., Illmann,C., Pluzhnikov,A.,
            Konkashbaev,A., Davis,L.K., Han,B., Crane,J., Moorjani,P.,
            Crenshaw,A.T., Parkin,M.A., Reus,V.I., Lowe,T.L., Rangel-Lugo,M.,
            Chouinard,S., Dion,Y., Girard,S., Cath,D.C., Smit,J.H., King,R.A.,
            Fernandez,T.V., Leckman,J.F., Kidd,K.K., Kidd,J.R., Pakstis,A.J.,
            State,M.W., Herrera,L.D., Romero,R., Fournier,E., Sandor,P.,
            Barr,C.L., Phan,N., Gross-Tsur,V., Benarroch,F., Pollak,Y.,
            Budman,C.L., Bruun,R.D., Erenberg,G., Naarden,A.L., Lee,P.C.,
            Weiss,N., Kremeyer,B., Berrio,G.B., Campbell,D.D., Cardona
            Silgado,J.C., Ochoa,W.C., Mesa Restrepo,S.C., Muller,H., Valencia
            Duarte,A.V., Lyon,G.J., Leppert,M., Morgan,J., Weiss,R.,
            Grados,M.A., Anderson,K., Davarya,S., Singer,H., Walkup,J.,
            Jankovic,J., Tischfield,J.A., Heiman,G.A., Gilbert,D.L.,
            Hoekstra,P.J., Robertson,M.M., Kurlan,R., Liu,C., Gibbs,J.R.,
            Singleton,A., Hardy,J., Strengman,E., Ophoff,R.A., Wagner,M.,
            Moessner,R., Mirel,D.B., Posthuma,D., Sabatti,C., Eskin,E.,
            Conti,D.V., Knowles,J.A., Ruiz-Linares,A., Rouleau,G.A.,
            Purcell,S., Heutink,P., Oostra,B.A., McMahon,W.M., Freimer,N.B.,
            Cox,N.J. and Pauls,D.L.
  CONSRTM   North American Brain Expression Consortium; UK Human Brain
            Expression Database
  TITLE     Genome-wide association study of Tourette's syndrome
  JOURNAL   Mol Psychiatry 18 (6), 721-728 (2013)
   PUBMED   22889924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079174.20, BC033617.1 and AC080012.20.
            
            On Nov 22, 2018 this sequence version replaced NM_152772.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033617.1, SRR1660803.118370.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299045.8/ ENSP00000299045.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC079174.20        13415-13484         c
            71-2035             BC033617.1         1-1965
            2036-2036           AC080012.20        67415-67415         c
            2037-2277           BC033617.1         1967-2207
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..2277
                     /gene="TCP11L2"
                     /note="t-complex 11 like 2"
                     /db_xref="GeneID:255394"
                     /db_xref="HGNC:HGNC:28627"
                     /db_xref="MIM:619889"
     exon            1..209
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..401
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1804
                     /gene="TCP11L2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-complex protein 11-like protein 2; t-complex 11,
                     testis-specific-like 2"
                     /codon_start=1
                     /product="T-complex protein 11-like protein 2 isoform 1"
                     /protein_id="NP_689985.1"
                     /db_xref="CCDS:CCDS9104.1"
                     /db_xref="GeneID:255394"
                     /db_xref="HGNC:HGNC:28627"
                     /db_xref="MIM:619889"
                     /translation="MPFNGEKQCVGEDQPSDSDSSRFSESMASLSDYECSRQSFASDS
                     SSKSSSPASTSPPRVVTFDEVMATARNLSNLTLAHEIAVNENFQLKQEALPEKSLAGR
                     VKHIVHQAFWDVLDSELNADPPEFEHAIKLFEEIREILLSFLTPGGNRLRNQICEVLD
                     TDLIRQQAEHSAVDIQGLANYVISTMGKLCAPVRDNDIRELKATGNIVEVLRQIFHVL
                     DLMQMDMANFTIMSLRPHLQRQLVEYERTKFQEILEETPSALDQTTEWIKESVNEELF
                     SLSESALTPGAENTSKPSLSPTLVLNNSYLKLLQWDYQKKELPETLMTDGARLQELTE
                     KLNQLKIIACLSLITNNMVGAITGGLPELASRLTRISAVLLEGMNKETFNLKEVLNSI
                     GIQTCVEVNKTLMERGLPTLNAEIQANLIGQFSSIEEEDNPIWSLIDKRIKLYMRRLL
                     CLPSPQKCMPPMPGGLAVIQQELEALGSQYANIVNLNKQVYGPFYANILRKLLFNEEA
                     MGKVDASPPTN"
     exon            402..537
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..658
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..879
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1016
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1204
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1386
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1559
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..2277
                     /gene="TCP11L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP11L2"
                     /note="hexamer: AATAAA"
     polyA_site      2277
                     /gene="TCP11L2"
                     /note="major polyA site"
ORIGIN      
        1 ggttttgtga tggccgcgcc gtggctgcct ccctagagtc cctcagggcc ctttaaatac
       61 cgcgttgggg gggacactgg ggctgggggg gtttgttggg ctggtgagtt ttcgaggtga
      121 ctgtgctgtg ctcggtgagg ggacgcccag agagccctga cccggggtca ctccgtcgcc
      181 gttctcctct tgtctacgtg ctggacccgg tgctaccttt ttacccacac ttaagtgacg
      241 caaaatgccc ttcaatggcg agaagcagtg tgtgggagag gaccagccaa gcgattctga
      301 ttcttcccgg ttttccgaaa gcatggcttc gctcagtgac tatgaatgct ccaggcagag
      361 ctttgcaagt gactcctcca gcaaatccag ctctcctgct tcaacaagcc ctccaagggt
      421 tgtaacattt gatgaagtga tggctacagc aaggaactta tcaaacttga ctcttgctca
      481 tgagattgct gtaaatgaga actttcaatt gaaacaagag gctctcccag aaaagagttt
      541 ggctggtcga gtgaagcaca ttgttcacca ggccttctgg gacgtcttgg attcagaact
      601 aaatgctgac cctcctgagt ttgaacatgc catcaaactg tttgaagaaa tcagagagat
      661 tcttctctct tttctcactc ccggtggcaa ccggcttcgc aaccaaatct gtgaagtttt
      721 ggacacagac ctcattaggc agcaggctga gcacagtgct gttgacatcc aaggcctggc
      781 caactatgtc atcagtacga tgggaaagct gtgtgctccc gtgcgagata atgatatcag
      841 agagttaaag gctactggca acatcgtgga ggtgctgaga caaatattcc atgtcctgga
      901 cctcatgcaa atggacatgg ccaattttac aattatgagt ctcagaccgc accttcaacg
      961 ccagttggtg gaatatgaga gaaccaagtt ccaggaaatt ttggaagaaa ctccaagtgc
     1021 tcttgatcag actacagaat ggataaaaga atctgtaaat gaagaattat tttctctttc
     1081 tgagagtgct ttaactcctg gggccgaaaa tacctccaag ccaagcctga gccctacttt
     1141 ggtgctaaat aatagttact tgaaactgtt acagtgggat tatcagaaaa aagaattacc
     1201 agagacactt atgacagatg gagcacgtct tcaggaacta acagaaaagc tgaatcaatt
     1261 gaaaattatt gcctgcctgt ccctaattac caacaacatg gtgggtgcta ttacaggagg
     1321 cctgcctgag cttgcaagca ggttaacaag gatttcagct gttctacttg aaggcatgaa
     1381 caaagagacc tttaacttga aggaagtcct gaattctatt ggtattcaga cttgtgttga
     1441 ggttaacaag accctgatgg aaagaggttt acccacttta aatgctgaga ttcaagctaa
     1501 tcttataggt caattttcaa gcattgaaga ggaggacaat cctatctggt ccttgattga
     1561 taaacgaatt aagctttaca tgagaaggct actttgtctt ccaagccctc aaaaatgcat
     1621 gcctcctatg ccaggaggcc tagctgtcat tcagcaggag ctagaagccc taggctctca
     1681 atatgcaaac attgtgaatc tcaacaaaca agtgtatgga ccattttatg caaatatact
     1741 tcgaaagctg ctcttcaatg aggaagccat ggggaaggta gatgcttcac ctcctactaa
     1801 ctaaagaaga actgacattg gacgagagat tggaaatcca gtactttggt atccagtcca
     1861 cttccattga tggcattaga gatccagcac attctcagta ctgtggtgca gtattagccc
     1921 aaatctgtgt aatgggtaat attagcatta cagaagacac acacatcaca tagaccctca
     1981 gaagacgtaa acatcacata gaccctattt gtgcatcatt ttcaagttta aaacaaatat
     2041 ttgtaatgaa cagaaaacaa tttgtaatta attatattac ctatataata cttgtaaatg
     2101 ttttcttaac catttatatt tggcttatga catttaaccc ctaaggagtt gtttttctca
     2161 cttgttatta tcaaacctaa tggtttttaa ttttggtaca actccttaaa gggttgaagg
     2221 ttgtgacaat aactgaggga actgatgttc tgaataaatg atgtgaagta aacacaa
//
