LOCUS       NM_001370687            1855 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens t-complex 11 (TCP11), transcript variant 1, mRNA.
ACCESSION   NM_001370687 NM_001093728
VERSION     NM_001370687.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Wang,F., Song,S., Guo,B., Li,Y., Wang,H., Fu,S., Wang,L., Zhe,X.,
            Li,H., Li,D., Shao,R. and Pan,Z.
  TITLE     Increased TCP11 gene expression can inhibit the proliferation,
            migration and promote apoptosis of cervical cancer cells
  JOURNAL   BMC Cancer 23 (1), 853 (2023)
   PUBMED   37697257
  REMARK    GeneRIF: Increased TCP11 gene expression can inhibit the
            proliferation, migration and promote apoptosis of cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Liu,Y., Jiang,M., Li,C., Yang,P., Sun,H., Tao,D., Zhang,S. and
            Ma,Y.
  TITLE     Human t-complex protein 11 (TCP11), a testis-specific gene product,
            is a potential determinant of the sperm morphology
  JOURNAL   Tohoku J Exp Med 224 (2), 111-117 (2011)
   PUBMED   21597245
  REMARK    GeneRIF: These results suggest that TCP11 may be responsible for
            sperm tail morphology and motility.
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Ma,Y.X., Zhang,S.Z., Wu,Q.Q. and Sun,Y.
  TITLE     [Cloning, expression and alternative splicing of a novel isoform of
            human TCP11b gene]
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35 (2),
            182-188 (2003)
   PUBMED   12545228
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Ma,Y., Zhang,S., Xia,Q., Zhang,G., Huang,X., Huang,M., Xiao,C.,
            Pan,A., Sun,Y., Lebo,R. and Milunsky,A.
  TITLE     Molecular characterization of the TCP11 gene which is the human
            homologue of the mouse gene encoding the receptor of fertilization
            promoting peptide
  JOURNAL   Mol Hum Reprod 8 (1), 24-31 (2002)
   PUBMED   11756566
  REMARK    GeneRIF: Results suggest that TCP11 gene is important in sperm
            function and fertility.
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Fraser,L.R., Hosseini,R., Hanyalogou,A., Talmor,A. and Dudley,R.K.
  TITLE     TCP-11, the product of a mouse t-complex gene, plays a role in
            stimulation of capacitation and inhibition of the spontaneous
            acrosome reaction
  JOURNAL   Mol Reprod Dev 48 (3), 375-382 (1997)
   PUBMED   9322250
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Ragoussis,J., Senger,G., Mockridge,I., Sanseau,P., Ruddy,S.,
            Dudley,K., Sheer,D. and Trowsdale,J.
  TITLE     A testis-expressed Zn finger gene (ZNF76) in human 6p21.3
            centromeric to the MHC is closely linked to the human homolog of
            the t-complex gene tcp-11
  JOURNAL   Genomics 14 (3), 673-679 (1992)
   PUBMED   1427894
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Mazarakis,N.D., Nelki,D., Lyon,M.F., Ruddy,S., Evans,E.P.,
            Freemont,P. and Dudley,K.
  TITLE     Isolation and characterisation of a testis-expressed
            developmentally regulated gene from the distal inversion of the
            mouse t-complex
  JOURNAL   Development 111 (2), 561-571 (1991)
   PUBMED   1893875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138721.16.
            
            On May 24, 2019 this sequence version replaced NM_001093728.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.204316.1,
                                           SRR5189667.296853.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000311875.11/
                                                ENSP00000308708.6
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL138721.16        91978-92112         c
            136-273             AL138721.16        91520-91657         c
            274-385             AL138721.16        86880-86991         c
            386-506             AL138721.16        79835-79955         c
            507-727             AL138721.16        72890-73110         c
            728-864             AL138721.16        71682-71818         c
            865-1082            AL138721.16        71202-71419         c
            1083-1264           AL138721.16        70932-71113         c
            1265-1428           AL138721.16        70001-70164         c
            1429-1855           AL138721.16        68848-69274         c
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..1855
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /note="t-complex 11"
                     /db_xref="GeneID:6954"
                     /db_xref="HGNC:HGNC:11658"
                     /db_xref="MIM:186982"
     exon            1..135
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            136..273
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1661
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     t-complex 11 (a murine tcp homolog); T-complex protein 11
                     homolog; t-complex 11 homolog; fertilization-promoting
                     peptide receptor; t-complex 11, testis-specific; testis
                     secretory sperm-binding protein Li 222n"
                     /codon_start=1
                     /product="T-complex protein 11 homolog isoform 1"
                     /protein_id="NP_001357616.1"
                     /db_xref="CCDS:CCDS47413.2"
                     /db_xref="GeneID:6954"
                     /db_xref="HGNC:HGNC:11658"
                     /db_xref="MIM:186982"
                     /translation="MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLS
                     VTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSA
                     TPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLS
                     KYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHL
                     QEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSP
                     NEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMA
                     SVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSL
                     KNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLP
                     GGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV"
     exon            274..385
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            386..506
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            507..727
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            728..864
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1082
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1264
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1428
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1855
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="TCP11"
                     /gene_synonym="D6S230E; FPPR"
                     /note="major polyA site"
ORIGIN      
        1 gttctcaggc cccggccttt ctcaccgtgc gacgccccaa cccgccgctc cgccgcggtg
       61 gtacgctcca ggccgccagg ccgcgaggcc caccgagcgg acgccagtgg atgacccgcg
      121 gcgggggagg aggagatacc atcagcaaaa tgccagacgt caaggagagt gtgcccccga
      181 aatatcctgg cgactcagag ggcaggtcct gtaagcccga aacctcagga cccccccagg
      241 aagacaagag cggctccgag gacccccctc cctttctttc tgtcacaggt ctgacagaaa
      301 ccgttaatga agtttccaag ctgagcaaca agattgggat gaattgtgat tactacatgg
      361 aagagaaggt tttacctcca agcagtctgg aaggcaaggt caaggagaca gtgcacaatg
      421 ccttttggga ccatcttaaa gagcaactat cagcaactcc ccctgacttc agctgtgctc
      481 ttgaacttct gaaagaaatt aaagagatct tgctatcact gctattacca cgccagaacc
      541 gcctgagaat tgagattgaa gaagctctgg acatggactt gctcaagcag gaggcagaac
      601 atggggccct gaaagtcctc tatctctcta agtacgttct caacatgatg gctttgctgt
      661 gtgcaccagt tcgagatgaa gcagtgcaga aactagaaaa cattacggat cctgtttggc
      721 tactgagagg gatcttccag gttctgggcc ggatgaaaat ggacatggtg aactacacta
      781 tccagagcct tcaaccccac ctgcaggaac attccattca gtatgaacgg gctaaattcc
      841 aggaactcct caataagcag cctagtctcc ttaatcacac caccaaatgg ctgacccaag
      901 cagcaggaga cctcaccatg tcacctccga cttgcccaga cacttctgac tcctccagtg
      961 tggctggccc ctctcccaat gaggcagcca acaacccaga gcccctcagc cccacaatgg
     1021 tgctgtgtca gggcttcttg aacctccttc tctgggacct tgaaaatgaa gagttccctg
     1081 agaccctgct gatggacaga acccggctgc aggagctgaa gtcccagttg caccagttaa
     1141 ccgtcatggc ctcagtcttg ctggtggcca gtagtttctc cggcagtgtt ttgtttggct
     1201 caccccaatt tgtagataaa ctgaaacgca taaccaaatc cttgttggaa gactttcact
     1261 ccaggcctga ggaagctata ctgactgtga gtgaacaggt atctcaggaa atccatcaaa
     1321 gcctcaagaa tatgggcctt gttgctctaa gcagtgataa tacagcatct ctaatgggac
     1381 agctccagaa cattgccaag aaggagaact gtgtctgcag tgttattgat cagcggatcc
     1441 atttgtttct caaatgctgt ttggttcttg gtgtgcagcg gtctctatta gaccttcctg
     1501 gaggccttac tctcattgaa gcagaactgg cagaactggg ccaaaagttt gtcaacttga
     1561 cacatcacaa tcagcaggtg tttggtccct actacactga gatcctaaaa accctcattt
     1621 ccccagccca ggcactggaa acaaaagtgg agtctgtttg atagcgtcgg ctcagagccc
     1681 tggtaccttg gacccaagag gaggcccatc atcttcctgg agtaacatca ccagtgacca
     1741 gcagacagtg agcttctatc ccaggccctg cagccagtac accaaggctg tagggatcaa
     1801 gcatgtaaac accaactggt ccatacccat tcattaataa acttcttaag tgcaa
//
