LOCUS       NM_144659               3805 bp    mRNA    linear   PRI 24-FEB-2025
DEFINITION  Homo sapiens t-complex 10 like (TCP10L), mRNA.
ACCESSION   NM_144659 XR_017737 XR_017792 XR_040362
VERSION     NM_144659.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3805)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3805)
  AUTHORS   Shen,S., Feng,H., Liu,L., Su,W., Yu,L. and Wu,J.
  TITLE     TCP10L negatively regulates alpha-fetoprotein expression in
            hepatocellular carcinoma
  JOURNAL   BMB Rep 53 (8), 431-436 (2020)
   PUBMED   32438969
  REMARK    GeneRIF: TCP10L negatively regulates alpha-fetoprotein expression
            in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 3805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3805)
  AUTHORS   Jo,Y.S., Kim,M.S., Yoo,N.J. and Lee,S.H.
  TITLE     Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor
            Suppressor Genes in Colorectal and Gastric Cancers
  JOURNAL   Pathol Oncol Res 26 (1), 583-584 (2020)
   PUBMED   29532408
  REMARK    GeneRIF: Inactivating Frameshift Mutations of HACD4 and TCP10L
            Tumor Suppressor Genes in Colorectal and Gastric Cancers.
REFERENCE   6  (bases 1 to 3805)
  AUTHORS   Zhong,Z., Qiu,J., Chen,X., Wan,B., Ni,J., Yang,Y., Bai,M., Zhang,H.
            and Yu,L.
  TITLE     Identification of TCP10L as primate-specific gene derived via
            segmental duplication and homodimerization of TCP10L through the
            leucine zipper motif
  JOURNAL   Mol Biol Rep 35 (2), 171-178 (2008)
   PUBMED   17377852
REFERENCE   7  (bases 1 to 3805)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   8  (bases 1 to 3805)
  AUTHORS   Yu,H., Jiang,D., Guo,Z., Saiyin,H., Guo,J., Wang,X. and Yu,L.
  TITLE     TCP10L is expressed specifically in spermatogenic cells and binds
            to death associated protein kinase-3
  JOURNAL   Int J Androl 28 (3), 163-170 (2005)
   PUBMED   15910542
  REMARK    GeneRIF: The specific expression pattern of TCP10L and interaction
            with DAPK-3 implies that TCP10L might play crucially important
            roles in spermatogenesis through its interaction with DAPK-3.
REFERENCE   9  (bases 1 to 3805)
  AUTHORS   Jiang,D.J., Yu,H.X., Hexige,S.Y., Guo,Z.K., Wang,X., Ma,L.J.,
            Chen,Z., Zhao,S.Y. and Yu,L.
  TITLE     Human liver specific transcriptional factor TCP10L binds to MAD4
  JOURNAL   J Biochem Mol Biol 37 (4), 402-407 (2004)
   PUBMED   15469726
  REMARK    GeneRIF: Data suggest that the biological function of the
            interaction between T-complex protein 10-like and MAD4 may be to
            maintain the differentiation state in liver cells.
REFERENCE   10 (bases 1 to 3805)
  AUTHORS   Chen,Z., Yu,L., Wu,H., Yu,J., Zhang,L., Jiang,D., Ma,L., Li,D. and
            Zhao,S.
  TITLE     Identification of a novel liver-specific expressed gene, TCP10L,
            encoding a human leucine zipper protein with transcription
            inhibition activity
  JOURNAL   J Hum Genet 48 (11), 556-563 (2003)
   PUBMED   14586771
  REMARK    GeneRIF: The result revealed that TCP10L expressed specifically in
            the human liver and testis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY036551.1, AF115967.1, BG721020.1, AP000274.2 and BC027970.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144659.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG717680.1, AF115967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300258.8/ ENSP00000300258.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY036551.1         24-40
            18-139              AF115967.1         1-122
            140-615             BG721020.1         148-623
            616-2107            AP000274.2         28456-29947         c
            2108-2685           BC027970.1         874-1451
            2686-3805           AP000274.2         26758-27877         c
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..3805
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="t-complex 10 like"
                     /db_xref="GeneID:140290"
                     /db_xref="HGNC:HGNC:11657"
                     /db_xref="MIM:608365"
     exon            1..103
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            104..248
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..752
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="T-complex protein 10A homolog 2; TCP10-like;
                     T-complex protein 10A-2; T-complex protein 10A-1"
                     /codon_start=1
                     /product="T-complex protein 10A homolog 1"
                     /protein_id="NP_653260.1"
                     /db_xref="CCDS:CCDS13616.1"
                     /db_xref="GeneID:140290"
                     /db_xref="HGNC:HGNC:11657"
                     /db_xref="MIM:608365"
                     /translation="MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNT
                     GEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWK
                     ARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSN
                     NSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV"
     exon            249..464
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..602
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..3805
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="hexamer: AATAAA"
     polyA_site      867
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="major polyA site"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2685
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
     regulatory      3377..3382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="hexamer: AATGAA"
     polyA_site      3405
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
     regulatory      3781..3786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
                     /note="hexamer: AATAAA"
     polyA_site      3805
                     /gene="TCP10L"
                     /gene_synonym="C21orf77; LINC00846; PRED77; TCP10A-1;
                     TCP10A-2"
ORIGIN      
        1 gctgctctct ggtctctgga tatgaggcag gagggcttgg ggacaactgt ggggacatgg
       61 cccagatgat ctgatcctgg cagtagtgac tgttggggac caggatgctg gcaggtcaac
      121 tcgaggccag ggaccccaaa gagggcaccc acccagagga cccgtgccca ggagctgggg
      181 ctgtcatgga gaagacagct gtggcagccg aggttctcac ggaggactgc aacactgggg
      241 agatgccacc attacagcag cagatcatca gactccacca agagcttggg agacagaagt
      301 ctctgtgggc tgatgttcat ggaaaactcc ggagtcatat agatgctttg agggagcaga
      361 acatggagct ccgagaaaag ctgagagctc tgcagctgca gcggtggaaa gccaggaaga
      421 aatctgcagc gtccccacac gcggggcaag aatcgcacac tctggcattg gaacctgctt
      481 ttggaaaaat ttcacctctg tcagctgatg aagagacaat acccaaatac gctggccaca
      541 agaatcagag tgccactctc ctgggacaaa gatcgtcatc taacaattca gctcctccaa
      601 agccaatgag tttaaagata gaaagaatta gctcgtggaa aacaccacca caggaaaata
      661 gagataaaaa tctttccagg agacgtcaag acagaagagc aacacctact ggaaggccaa
      721 ctccctgtgc agagagacgg gggggtgtct gaagatggaa aggtggcctc ggacacctgt
      781 gtcactctac actggcccct tggaaaattc agattcagat aaagttccac ttaggtctaa
      841 taaaagtact caatttgtta ttcaaaatag acctagtaat ttattaaact aattatgttt
      901 ctatagataa aaacttgaag ttcttcagac atgtctctaa tgctataaaa gcaaacaact
      961 tggattgggt tttataaatc agttgctttc ctgagctctg tagttggtat atttctgcag
     1021 agtctttaaa aaaattaacc caccttgtag tatggagtgt cgggctgttg ggtgagccct
     1081 ggggtcttgc tggaaatcga ggatggctga agatggcttt gtgctcccag cctttgggct
     1141 caaggcattg cccgctccag ggaccttgtg acaaggcggg cctgtgactg tcattgcccc
     1201 aggctatgca tccatcttcc cgaagtctgc aaaacttgag tggcagaaaa tcaccagtgc
     1261 aggcttccca ggccgccatg ctgcaggagc agatggcagc agccggagga gctggtgagc
     1321 agagttgggg actcctgttt ctatgctccc cgtgaaatgc ggggctttct cgtggatacg
     1381 cgtgagcaga acatcttact atggcaagga catgtccttc ctggagctgc ctaatttgtg
     1441 gccacttttt gtctgattcc ctcgttgggt cctcacctgt gagacttgcc aacaccccca
     1501 gccctccacc ccacacacag cccacatgcc ggtctccagg ggccgtgact ggagattccg
     1561 aatcctagcg gtcacttccc tctgagcaca ctcccagcag aaggcgtgtg gctggggcta
     1621 gatgcacttg ggtgctttgt tcccctttct ccatttgcca gcccatggca ttgctgccac
     1681 cctgatggag cgccctctca tctggcacct tcctggcctc tttcccaggc cccagttctg
     1741 tccatgcagc tgtgggtgct tcctgcattg cgggtctcac ggggaggaga cgagagtgcc
     1801 cctggttgag tcaggaaaga attctatctt cacgtcgctg ccagcaaatg accacagcag
     1861 cttcacgacc tctgcaggaa cctatcttgg taaagaaacg gggcctatgt ggtggccgag
     1921 cctcaggtgt ggccgagctt caggtgtggc ccttatgcac agcacagccc aagcctgtgg
     1981 gcaccactcg ccctgggctg cctggcacct ggactccttc ccatccttgg ccgaggtctg
     2041 cgtggccctt cagggccgaa tctgacactg tcttcctcct gagtctgccc cccgggcttc
     2101 ctgcccaccc ccaggctgtt tcatggcctc tgcagggagc ttcgtagagg tgaggctggt
     2161 gccatctgtc tgcttcagac cacctcaggc tctgcgtgcc ctcacagtcc cctctgcact
     2221 tctctgtggg gcagggaagc ccttcccatc aggtctgctc cagcctggct accttgttcc
     2281 tgctgtcccc tccccttcag gcccccggac aagacttcag tgtacttgct ggtgccgggc
     2341 agaatggggg accttgcctc tcacacacac ctgctagtat ctccgcaacc tccaggcatc
     2401 atctcagctg acagtgacgc catcctgggg aagctcccct gactcctggc tctcctggaa
     2461 gcctgtggtg ctccttcaca atggcccgtg gcccttcata ggtcccgtaa gccagtgtca
     2521 cagggattcg gcttttctct tctgtgtttg cctgctgcgg gactgtgagc agcttcaggg
     2581 ccaagacagt gcctttccat ccgtgaatct cctgatccat cagaatactc gaaagagaaa
     2641 taccgactga gtgtattcat taaagaatta atgttcctta caggatcatt tgttgttgaa
     2701 ctgacctgac atgtgtatag taatctcatg aacaagaaag aatgtgttca cacgtttgct
     2761 taaattgaat ttagcaatcg cattaggata ctgatatttc cacaatgtat atacactatc
     2821 cttttaaatt taacttattt gctttttaga cggaagctcc tcagtcttag agagttctga
     2881 aggtggattt ctcagccacg ttcaacctga tgagttcact gcttcttccc caaacattgc
     2941 agagctgcag gtaggtgggc tgagtggctt ctgcaagggt ggcccgccag gttcccctga
     3001 gggagacctg agaagctcac cttttcatcc tggggaagtg agattcggag tgggtgtcaa
     3061 gagatggttg catcttcttg acaagaacag aaaattaaga tgattccaaa tgtctcttta
     3121 tttcctgagg ttcagccttt caaacagaga ctttctttta tagatttaag ttggttgcat
     3181 ttagcacata gtcaaacagg attaatattt ttcatggctt aagagtttcc caagtcaaag
     3241 tttcattttt tatcattttg atttacagtt ctcaattgac attaatagac tcgaaggcac
     3301 gaatagcaaa catatttcta agccctagct agtggtccac ttgtaacatg ctatatttta
     3361 caaaaaatgt caataaaatg aaattatttt ctctacggca ggaaatttgg gctgtgaact
     3421 tacgtgtgat gtaagtaggc acctggcggg gaagtctggg aacacaggtc ccgcttgttt
     3481 tctgttctcc cgagaaaaac ccacattctg ttctgccctt ttcaacatct tcagtggggg
     3541 gacgagtggg aacatttttc ttgggatttt attttgtttg gggatccagc taatgggttt
     3601 gcctggaagc ctcagggcta atgatctgca tttagaaaca gtgccacagt catggcaggt
     3661 gttatttgta tgttatttgt atgtctctgt gtgttatttg tatcaggtgt tgaatgtggc
     3721 ggttgtcact gtggccaccc tgaccccaga gcaaacatat aagtgggaga taaccacttt
     3781 aataaaacac aaaacatggt ccaaa
//
