LOCUS       NM_030752               2352 bp    mRNA    linear   PRI 13-JAN-2025
DEFINITION  Homo sapiens t-complex 1 (TCP1), transcript variant 1, mRNA.
ACCESSION   NM_030752
VERSION     NM_030752.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Zhang,M., Xie,Z., Tan,Y., Wu,Y., Wang,M., Zhang,P., Yuan,Y. and
            Li,J.
  TITLE     METTL14-mediated N6-methyladenosine modification of TCP1 mRNA
            promotes acute myeloid leukemia progression
  JOURNAL   Cell Signal 122, 111304 (2024)
   PUBMED   39033992
  REMARK    GeneRIF: METTL14-mediated N6-methyladenosine modification of TCP1
            mRNA promotes acute myeloid leukemia progression.
REFERENCE   2  (bases 1 to 2352)
  AUTHORS   Chen,X.F., Chen,X.L. and Chen,Y.Z.
  TITLE     [The Effect of TCP1 Expression on the Proliferation and the
            Accumulation of Intracellular Drug of HL60/A and HL60 Cell and Its
            Mechanism]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (1), 71-77 (2024)
   PUBMED   38387902
  REMARK    GeneRIF: [The Effect of TCP1 Expression on the Proliferation and
            the Accumulation of Intracellular Drug of HL60/A and HL60 Cell and
            Its Mechanism].
REFERENCE   3  (bases 1 to 2352)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2352)
  AUTHORS   Zhong,X.L., Qian,B.P., Huang,J.C., Zhao,S.Z., Li,Y. and Qiu,Y.
  TITLE     Low expression of TCP1 (T-Complex 1) and PSMC1 (Proteasome 26S
            subunit, ATPase 1) in heterotopic ossification during ankylosing
            spondylitis
  JOURNAL   Bioengineered 12 (1), 7459-7469 (2021)
   PUBMED   34612770
  REMARK    GeneRIF: Low expression of TCP1 (T-Complex 1) and PSMC1 (Proteasome
            26S subunit, ATPase 1) in heterotopic ossification during
            ankylosing spondylitis.
REFERENCE   5  (bases 1 to 2352)
  AUTHORS   Weng,H., Feng,X., Lan,Y. and Zheng,Z.
  TITLE     TCP1 regulates PI3K/AKT/mTOR signaling pathway to promote
            proliferation of ovarian cancer cells
  JOURNAL   J Ovarian Res 14 (1), 82 (2021)
   PUBMED   34162426
  REMARK    GeneRIF: TCP1 regulates PI3K/AKT/mTOR signaling pathway to promote
            proliferation of ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2352)
  AUTHORS   Lewis,V.A., Hynes,G.M., Zheng,D., Saibil,H. and Willison,K.
  TITLE     T-complex polypeptide-1 is a subunit of a heteromeric particle in
            the eukaryotic cytosol
  JOURNAL   Nature 358 (6383), 249-252 (1992)
   PUBMED   1630492
REFERENCE   7  (bases 1 to 2352)
  AUTHORS   Yaffe,M.B., Farr,G.W., Miklos,D., Horwich,A.L., Sternlicht,M.L. and
            Sternlicht,H.
  TITLE     TCP1 complex is a molecular chaperone in tubulin biogenesis
  JOURNAL   Nature 358 (6383), 245-248 (1992)
   PUBMED   1630491
  REMARK    GeneRIF: a paper describing a pathway in which this gene product
            functions
REFERENCE   8  (bases 1 to 2352)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   9  (bases 1 to 2352)
  AUTHORS   Blanche,H., Wright,L.G., Vergnaud,G., de Gouyon,B., Lauthier,V.,
            Silver,L.M., Dausset,J., Cann,H.M. and Spielman,R.S.
  TITLE     Genetic mapping of three human homologues of murine t-complex genes
            localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG
  JOURNAL   Genomics 12 (4), 826-828 (1992)
   PUBMED   1572657
REFERENCE   10 (bases 1 to 2352)
  AUTHORS   Ursic,D. and Culbertson,M.R.
  TITLE     The yeast homolog to mouse Tcp-1 affects microtubule-mediated
            processes
  JOURNAL   Mol Cell Biol 11 (5), 2629-2640 (1991)
   PUBMED   1901944
  REMARK    GeneRIF: a paper describing a pathway in which this gene product
            functions
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM827784.1, BC000665.1,
            BM697304.1 and AA810047.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030752.2.
            
            Summary: The protein encoded by this gene is a molecular chaperone
            that is a member of the chaperonin containing TCP1 complex (CCT),
            also known as the TCP1 ring complex (TRiC). This complex consists
            of two identical stacked rings, each containing eight different
            proteins. Unfolded polypeptides enter the central cavity of the
            complex and are folded in an ATP-dependent manner. The complex
            folds various proteins, including actin and tubulin. Alternate
            transcriptional splice variants of this gene, encoding different
            isoforms, have been characterized. In addition, three pseudogenes
            that appear to be derived from this gene have been found. [provided
            by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1102035.1,
                                           SRR1660809.200873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321394.12/ ENSP00000317334.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BM827784.1         108-124
            18-1898             BC000665.1         9-1889
            1899-2153           BM697304.1         406-660
            2154-2352           AA810047.1         18-216              c
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..2352
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /note="t-complex 1"
                     /db_xref="GeneID:6950"
                     /db_xref="HGNC:HGNC:11655"
                     /db_xref="MIM:186980"
     exon            1..198
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1805
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /note="isoform a is encoded by transcript variant 1;
                     T-complex protein 1, alpha subunit; tailless complex
                     polypeptide 1; T-complex protein 1 subunit alpha;
                     t-complex 1 protein; chaperonin containing T-complex
                     polypeptide 1 subunit 1"
                     /codon_start=1
                     /product="T-complex protein 1 subunit alpha isoform a"
                     /protein_id="NP_110379.2"
                     /db_xref="CCDS:CCDS5269.1"
                     /db_xref="GeneID:6950"
                     /db_xref="HGNC:HGNC:11655"
                     /db_xref="MIM:186980"
                     /translation="MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKM
                     LVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLK
                     NADELVKQKIHPTSVISGYRLACKEAVRYINENLIVNTDELGRDCLINAAKTSMSSKI
                     IGINGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNC
                     VVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQ
                     KILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLANL
                     EGEETFEAAMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSL
                     HDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPN
                     TLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTI
                     VKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGSYEDAVHSGALND"
     exon            199..284
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            285..413
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            414..511
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            512..622
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            623..804
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            805..931
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1107
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1231
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1424
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1588
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2352
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /note="hexamer: AGTAAA"
     polyA_site      1898
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /note="major polyA site"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
                     /note="hexamer: AATAAA"
     polyA_site      2352
                     /gene="TCP1"
                     /gene_synonym="CCT-alpha; CCT1; CCTa; D6S230E; IDDPMGS;
                     TCP-1-alpha"
ORIGIN      
        1 agtagctcct gggacatcgc tcgggtacgc tccacgccgt cgcagccact gctgtggtcg
       61 ccggtcggcc gaggggccgc gatactggtt gcccgcggtg taagcagaat tcgacgtgta
      121 tcgctgccgt caagatggag gggcctttgt ccgtgttcgg tgaccgcagc actggggaaa
      181 cgatccgctc ccaaaacgtt atggctgcag cttcgattgc caatattgta aaaagttctc
      241 ttggtccagt tggcttggat aaaatgttgg tggatgatat tggtgatgta accattacta
      301 acgatggtgc aaccatcctg aagttactgg aggtagaaca tcctgcagct aaagttcttt
      361 gtgagctggc tgatctgcaa gacaaagaag ttggagatgg aactacttca gtggttatta
      421 ttgcagcaga actcctaaaa aatgcagatg aattagtcaa acagaaaatt catcccacat
      481 cagttattag tggctatcga cttgcttgca aggaagcagt gcgttatatc aatgaaaacc
      541 taattgttaa cacagatgaa ctgggaagag attgcctgat taatgctgct aagacatcca
      601 tgtcttccaa aatcattgga ataaatggtg atttctttgc taacatggta gtagatgctg
      661 tacttgctat taaatacaca gacataagag gccagccacg ctatccagtc aactctgtta
      721 atattttgaa agcccatggg agaagtcaaa tggagagtat gctcatcagt ggctatgcac
      781 tcaactgtgt ggtgggatcc cagggcatgc ccaagagaat cgtaaatgca aaaattgctt
      841 gccttgactt cagcctgcaa aaaacaaaaa tgaagcttgg tgtacaggtg gtcattacag
      901 accctgaaaa actggaccaa attagacaga gagaatcaga tatcaccaag gagagaattc
      961 agaagatcct ggcaactggt gccaatgtta ttctaaccac tggtggaatt gatgatatgt
     1021 gtctgaagta ttttgtggag gctggtgcta tggcagttag aagagtttta aaaagggacc
     1081 ttaaacgcat tgccaaagct tctggagcaa ctattctgtc aaccctggcc aatttggaag
     1141 gtgaagaaac ttttgaagct gcaatgttgg gacaggcaga agaagtggta caggagagaa
     1201 tttgtgatga tgagctgatc ttaatcaaaa atactaaggc tcgtacgtct gcatcgatta
     1261 tcttacgtgg ggcaaatgat ttcatgtgtg atgagatgga gcgctcttta catgatgcac
     1321 tttgtgtagt gaagagagtt ttggagtcaa aatctgtggt tcccggtggg ggtgctgtag
     1381 aagcagccct ttccatatac cttgaaaact atgcaaccag catggggtct cgggaacagc
     1441 ttgcgattgc agagtttgca agatcacttc ttgttattcc caatacacta gcagttaatg
     1501 ctgcccagga ctccacagat ctggttgcaa aattaagagc ttttcataat gaggcccagg
     1561 ttaacccaga acgtaaaaat ctaaaatgga ttggtcttga tttgagcaat ggtaaacctc
     1621 gagacaacaa acaagcaggg gtgtttgaac caaccatagt taaagttaag agtttgaaat
     1681 ttgcaacaga agctgcaatc accattcttc gaattgatga tcttattaaa ttacatccag
     1741 aaagtaaaga tgataaacat ggaagttatg aagatgctgt tcactctgga gcccttaatg
     1801 attgatctga tgttcctttt atttataaca atgttaaatg caattgtctt gtaccttgag
     1861 ttgagtatta cacattaaag taaagtacaa gctgtaaact tgggtttttg tgatgtagga
     1921 aatggtttcc atctgtactt tggtcctctg atttcacata ttgcaaccta gtactttatt
     1981 agtttaaaaa gaaattgagg ttgttcaaag tttaagcaat tcattctctc tgaacacaca
     2041 ttgctattcc catcccaccc ccaatgcaca gggctgcaac accacgactt ctgcccattc
     2101 tctccagtgt gtgtaacagg gtcacaagaa ttcgacagcc agatgctcca agagggtggc
     2161 ccaaggctat agcccctcct tcaatattga cctaacgggg gagaaaagat ttagattgtt
     2221 tattcttctg tggacacagt ttaaaatctt aaacttgtct ttttcctctt aatgtatcag
     2281 catgctaccc tttcaaactc aaattttcat tttaactgct taggaataaa tttacacctt
     2341 tgtgaaaatt ca
//
