LOCUS       NM_001062               1486 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transcobalamin 1 (TCN1), mRNA.
ACCESSION   NM_001062
VERSION     NM_001062.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Knudsen,C.S., Parkner,T., Hoffmann-Lucke,E., Abildgaard,A. and
            Greibe,E.
  TITLE     Reference intervals and stability of haptocorrin and
            holotranscobalamin in Danish children and elderly
  JOURNAL   Clin Chim Acta 546, 117394 (2023)
   PUBMED   37209861
  REMARK    GeneRIF: Reference intervals and stability of haptocorrin and
            holotranscobalamin in Danish children and elderly.
            Erratum:[Clin Chim Acta. 2024 Jan 1;552:117648. doi:
            10.1016/j.cca.2023.117648.. PMID: 37978014]
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Zhu,X., Jiang,X., Zhang,Q., Huang,H., Shi,X., Hou,D. and Xing,C.
  TITLE     TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells
            by Regulating the ITGB4 Pathway
  JOURNAL   Gut Liver 17 (3), 412-429 (2023)
   PUBMED   35686504
  REMARK    GeneRIF: TCN1 Deficiency Inhibits the Malignancy of Colorectal
            Cancer Cells by Regulating the ITGB4 Pathway.
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Xu,C., Du,L., Guo,Y. and Liang,Y.
  TITLE     TCN1 Expression Is Increased in Asthma
  JOURNAL   Int Arch Allergy Immunol 184 (11), 1135-1142 (2023)
   PUBMED   37586352
  REMARK    GeneRIF: TCN1 Expression Is Increased in Asthma.
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Zhu,X., Zhou,G., Ma,M., Hou,D., Huang,H., Jiang,X. and Xing PhD,C.
  TITLE     Clinicopathological Analysis and Prognostic Assessment of TCN1 in
            Patients with Gastric Cancer
  JOURNAL   Surg Innov 29 (5), 557-565 (2022)
   PUBMED   34549663
  REMARK    GeneRIF: Clinicopathological Analysis and Prognostic Assessment of
            TCN1 in Patients with Gastric Cancer.
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Garau,G., Fedosov,S.N., Petersen,T.E., Geremia,S. and Randaccio,L.
  TITLE     Crystallization and preliminary X-ray diffraction analysis of human
            transcobalamin, a vitamin B12-transporting protein
  JOURNAL   Acta Crystallogr D Biol Crystallogr 57 (Pt 12), 1890-1892 (2001)
   PUBMED   11717507
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Nielsen,R., Sorensen,B.S., Birn,H., Christensen,E.I. and Nexo,E.
  TITLE     Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal
            tubule cells
  JOURNAL   J Am Soc Nephrol 12 (6), 1099-1106 (2001)
   PUBMED   11373332
REFERENCE   8  (bases 1 to 1486)
  AUTHORS   Johnston,J., Yang-Feng,T. and Berliner,N.
  TITLE     Genomic structure and mapping of the chromosomal gene for
            transcobalamin I (TCN1): comparison to human intrinsic factor
  JOURNAL   Genomics 12 (3), 459-464 (1992)
   PUBMED   1463480
  REMARK    Erratum:[Genomics 1992 Sep;14(1):208]
REFERENCE   9  (bases 1 to 1486)
  AUTHORS   Johnston,J., Bollekens,J., Allen,R.H. and Berliner,N.
  TITLE     Structure of the cDNA encoding transcobalamin I, a neutrophil
            granule protein
  JOURNAL   J Biol Chem 264 (27), 15754-15757 (1989)
   PUBMED   2777761
REFERENCE   10 (bases 1 to 1486)
  AUTHORS   Burger,R.L., Mehlman,C.S. and Allen,R.H.
  TITLE     Human plasma R-type vitamin B12-binding proteins. I. Isolation and
            characterization of transcobalamin I. TRANSCOBALAMIN III. and the
            normal granulocyte vitamin B12-binding protein
  JOURNAL   J Biol Chem 250 (19), 7700-7706 (1975)
   PUBMED   1176444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from J05068.1, BC018632.1,
            BM769693.1 and BM818792.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001062.3.
            
            Summary: This gene encodes a member of the vitamin B12-binding
            protein family. This family of proteins, alternatively referred to
            as R binders, is expressed in various tissues and secretions. This
            protein is a major constituent of secondary granules in neutrophils
            and facilitates the transport of cobalamin into cells. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018632.1, J05068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257264.4/ ENSP00000257264.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               J05068.1           59-430
            373-862             BC018632.1         376-865
            863-1290            BM769693.1         190-617
            1291-1479           J05068.1           1349-1537
            1480-1486           BM818792.1         104-110
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1486
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /note="transcobalamin 1"
                     /db_xref="GeneID:6947"
                     /db_xref="HGNC:HGNC:11652"
                     /db_xref="MIM:189905"
     exon            1..96
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1319
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /note="haptocorin; haptocorrin; protein R; transcobalamin
                     I (vitamin B12 binding protein, R binder family)"
                     /codon_start=1
                     /product="transcobalamin-1 precursor"
                     /protein_id="NP_001053.2"
                     /db_xref="CCDS:CCDS7978.1"
                     /db_xref="GeneID:6947"
                     /db_xref="HGNC:HGNC:11652"
                     /db_xref="MIM:189905"
                     /translation="MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMI
                     QSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILAL
                     GVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGN
                     YSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNIS
                     IYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEI
                     SQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYI
                     SVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGL
                     CANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY"
     exon            97..276
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            277..417
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            418..573
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            574..764
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            765..954
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1138
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1257
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1486
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /note="hexamer: AATAAA"
     polyA_site      1486
                     /gene="TCN1"
                     /gene_synonym="HC; TC-1; TC1; TCI"
                     /note="major polyA site"
ORIGIN      
        1 ggtacactgt tggagagatg agacagtcac accagctgcc cctagtgggg ctcttactgt
       61 tttcttttat tccaagccaa ctatgcgaga tttgtgaggt aagtgaagaa aactacatcc
      121 gcctaaaacc tctgttgaat acaatgatcc agtcaaacta taacagggga accagcgctg
      181 tcaatgttgt gttgtccctc aaacttgttg gaatccagat ccaaaccctg atgcaaaaga
      241 tgatccaaca aatcaaatac aatgtgaaaa gcagattgtc agatgtaagc tcgggagagc
      301 ttgccttgat tatactggct ttgggagtat gtcgtaacgc tgaggaaaac ttaatatatg
      361 attaccacct gatcgacaag ctagaaaata aattccaagc agaaattgaa aatatggaag
      421 cacacaatgg cactcccctg actaactact accagctcag cctggacgtt ttggccttgt
      481 gtctgttcaa tgggaactac tcaaccgccg aagttgtcaa ccacttcact cctgaaaata
      541 aaaactatta ttttggtagc cagttctcag tagatactgg tgcaatggct gtcctggctc
      601 tgacctgtgt gaagaagagt ctaataaatg ggcagatcaa agcagatgaa ggcagtttaa
      661 agaacatcag tatttataca aagtcactgg tagaaaagat tctgtctgag aaaaaagaaa
      721 atggtctcat tggaaacaca tttagcacag gagaagccat gcaggccctc tttgtatcat
      781 cagactatta taatgaaaat gactggaatt gccaacaaac tctgaataca gtgctcacgg
      841 aaatttctca aggagcattc agcaatccaa acgctgcagc ccaggtctta cctgccctga
      901 tgggaaagac cttcttggat attaacaaag actcttcttg cgtctctgct tcaggtaact
      961 tcaacatctc cgctgatgag cctataactg tgacacctcc tgactcacaa tcatatatct
     1021 ccgtcaatta ctctgtgaga atcaatgaaa catatttcac caatgtcact gtgctaaatg
     1081 gttctgtctt cctcagtgtg atggagaaag cccagaaaat gaatgatact atatttggtt
     1141 tcacaatgga ggagcgctca tgggggccct atatcacctg tattcagggc ctatgtgcca
     1201 acaataatga cagaacctac tgggaacttc tgagtggagg cgaaccactg agccaaggag
     1261 ctggtagtta cgttgtccgc aatggagaaa acttggaggt tcgctggagc aaatactaat
     1321 aagcccaaac tttcctcagc tgcataaaat ccatttgcag tggagttcca tgtttattgt
     1381 ccttatgcct tcttcttcat ttatcccagt acgagcagga gagttaataa cctccccttc
     1441 tctctctaca tgttcaataa aagttgttga aagattaaca actata
//
