LOCUS       NM_004918               1142 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TCL1 family AKT coactivator B (TCL1B), mRNA.
ACCESSION   NM_004918
VERSION     NM_004918.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Badve,S., Collins,N.R., Bhat-Nakshatri,P., Turbin,D., Leung,S.,
            Thorat,M., Dunn,S.E., Geistlinger,T.R., Carroll,J.S., Brown,M.,
            Bose,S., Teitell,M.A. and Nakshatri,H.
  TITLE     Subcellular localization of activated AKT in estrogen receptor- and
            progesterone receptor-expressing breast cancers: potential clinical
            implications
  JOURNAL   Am J Pathol 176 (5), 2139-2149 (2010)
   PUBMED   20228224
  REMARK    GeneRIF: subcellular localization of activated AKT is dependent on
            TCL1B expression in estrogen receptor- and progesterone
            receptor-expressing breast cancer
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Laine,J., Kunstle,G., Obata,T. and Noguchi,M.
  TITLE     Differential regulation of Akt kinase isoforms by the members of
            the TCL1 oncogene family
  JOURNAL   J Biol Chem 277 (5), 3743-3751 (2002)
   PUBMED   11707444
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Pekarsky,Y., Hallas,C. and Croce,C.M.
  TITLE     The role of TCL1 in human T-cell leukemia
  JOURNAL   Oncogene 20 (40), 5638-5643 (2001)
   PUBMED   11607815
  REMARK    Review article
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Laine,J., Kunstle,G., Obata,T., Sha,M. and Noguchi,M.
  TITLE     The protooncogene TCL1 is an Akt kinase coactivator
  JOURNAL   Mol Cell 6 (2), 395-407 (2000)
   PUBMED   10983986
REFERENCE   7  (bases 1 to 1142)
  AUTHORS   Saitou,M., Sugimoto,J., Hatakeyama,T., Russo,G. and Isobe,M.
  TITLE     Identification of the TCL6 genes within the breakpoint cluster
            region on chromosome 14q32 in T-cell leukemia
  JOURNAL   Oncogene 19 (23), 2796-2802 (2000)
   PUBMED   10851082
REFERENCE   8  (bases 1 to 1142)
  AUTHORS   Sugimoto,J., Hatakeyama,T., Narducci,M.G., Russo,G. and Isobe,M.
  TITLE     Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region
            next to the TCL1 locus
  JOURNAL   Cancer Res 59 (10), 2313-2317 (1999)
   PUBMED   10344735
REFERENCE   9  (bases 1 to 1142)
  AUTHORS   Pekarsky,Y., Hallas,C., Isobe,M., Russo,G. and Croce,C.M.
  TITLE     Abnormalities at 14q32.1 in T cell malignancies involve two
            oncogenes
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2949-2951 (1999)
   PUBMED   10077617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051000.1 and AF137027.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004918.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051000.1, AF137027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340722.8/ ENSP00000343223.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               BC051000.1         10-327
            319-988             AF137027.1         323-992
            989-1142            BC051000.1         998-1151
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..1142
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /note="TCL1 family AKT coactivator B"
                     /db_xref="GeneID:9623"
                     /db_xref="HGNC:HGNC:11649"
                     /db_xref="MIM:603769"
     exon            1..204
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..429
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /note="T-cell lymphoma/leukemia 1B; TCL1/ MTCP1-like 1;
                     oncogene TCL-1B; syncytiotrophoblast-specific protein; T
                     cell leukemia/lymphoma 1B"
                     /codon_start=1
                     /product="T-cell leukemia/lymphoma protein 1B"
                     /protein_id="NP_004909.1"
                     /db_xref="CCDS:CCDS32151.1"
                     /db_xref="GeneID:9623"
                     /db_xref="HGNC:HGNC:11649"
                     /db_xref="MIM:603769"
                     /translation="MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRR
                     EWARASQGSRYEPSITVHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSS
                     FWEIADHGQIDSMEQLVLTYQPERKD"
     exon            205..375
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..444
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..1142
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /note="hexamer: ATTAAA"
     polyA_site      1142
                     /gene="TCL1B"
                     /gene_synonym="SYN-1; TML1"
                     /note="major polyA site"
ORIGIN      
        1 acacgtgtga gcctagaggc gggtcccggt tgcagacttg ccatggcctc cgaagcttct
       61 gtgcgtctag gggtgccccc tggccgtctg tggatccaga ggcctggcat ctacgaagat
      121 gaggagggga gaacctgggt gactgtggtc gtgcggttca atccctcgcg tagggaatgg
      181 gccagggcct cccagggcag cagatatgaa cccagcatca cagtgcactt gtggcagatg
      241 gcagtgcata cccgggagct actctcctcc ggccagatgc ccttctccca gctgcccgcc
      301 gtgtggcagc tctaccccgg gaggaagtac cgagcagcgg attccagttt ctgggaaata
      361 gcagaccatg gccagattga ctctatggag cagctggtcc taacatatca gccggagagg
      421 aaagactgac actgggagtg gctggccctg ctggccctgc ctcttctggc ctggtgtctc
      481 ctcatgcccc ctcagtgagg atcttcatgt acctgctctt ctgtttgcac acccagcata
      541 gcctccttgc aggcagaagg cagtagggcc cctgcacact cagtttctct cgttttcctt
      601 agttatcagt cctgtcctgt cccactcagg tctgtactta gggcagctgg cctggatggg
      661 cttcactggg gccctgtctg tgtgctgagc cagtttcccc tgctggctgc aagctgtggg
      721 ttctttctcc tctgtgcccc tcatgctgat cttctagatg ccactcccaa atccccttca
      781 tacccaccag gatgtgtgcc cagccaggcc tccagcaccc ccagtgcagc tcgtgattgg
      841 aaactcacca tcggcaggca gtggttcggt ttaagagatg gcattagagg gagcccagtc
      901 tggatgtgga cttggatgcc ctgtgggtat cagttctgct gacactttgg cccgaaatag
      961 atccagtgct gagcaagcaa tgtacaccag agcctcagtg agcccatctg cacagtgggg
     1021 agcatggagg gatgggtttg gcctgtgctt ctgcttattc agtccttcag ctcacggaag
     1081 ggatgctagt ccgtgaaggt gacctcacag tactggttaa ttaaacttta ttgctcactg
     1141 tc
//
