LOCUS       NM_021966               1345 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TCL1 family AKT coactivator A (TCL1A), transcript
            variant 1, mRNA.
ACCESSION   NM_021966
VERSION     NM_021966.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1345)
  AUTHORS   Pfeuffer,L., Siegert,V., Frede,J., Rieger,L., Trozzo,R., de Andrade
            Kratzig,N., Ring,S., Sarhadi,S., Beck,N., Niedermeier,S.,
            Abril-Gil,M., Elbahloul,M., Remke,M., Steiger,K., Eichner,R.,
            Jellusova,J., Rad,R., Bassermann,F., Winter,C., Ruland,J. and
            Buchner,M.
  TITLE     B-cell intrinsic RANK signaling cooperates with TCL1 to induce
            lineage-dependent B-cell transformation
  JOURNAL   Blood Cancer J 14 (1), 151 (2024)
   PUBMED   39198400
  REMARK    GeneRIF: B-cell intrinsic RANK signaling cooperates with TCL1 to
            induce lineage-dependent B-cell transformation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1345)
  AUTHORS   Jiang,Q., Stachelscheid,J., Bloehdorn,J., Pacholewska,A., Aszyk,C.,
            Grotenhuijs,F., Muller,T., Onder,O., Wagle,P., Herling,C.D.,
            Kleppe,M., Wang,Z., Coombes,K.R., Robrecht,S., Dalvi,P.S.,
            Plosnita,B., Mayer,P., Abruzzo,L.V., Altmuller,J., Gathof,B.,
            Persigehl,T., Fischer,K., Jebaraj,B., Rienhoff,H.Y., Ecker,R.,
            Zhao,Y., Bruns,C.J., Stilgenbauer,S., Elenitoba-Johnson,K.,
            Hallek,M., Schweiger,M.R., Odenthal,M., Vasyutina,E. and Herling,M.
  TITLE     Oncogenic role and target properties of the lysine-specific
            demethylase KDM1A in chronic lymphocytic leukemia
  JOURNAL   Blood 142 (1), 44-61 (2023)
   PUBMED   37023372
  REMARK    GeneRIF: Oncogenic role and target properties of the
            lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
REFERENCE   3  (bases 1 to 1345)
  AUTHORS   Hao,J., Mei,H., Luo,Q., Weng,J., Lu,J., Liu,M. and Wen,Y.
  TITLE     TCL1A acts as a tumour suppressor by modulating gastric cancer
            autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop
  JOURNAL   Carcinogenesis 44 (1), 29-37 (2023)
   PUBMED   36317339
  REMARK    GeneRIF: TCL1A acts as a tumour suppressor by modulating gastric
            cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
            Erratum:[Carcinogenesis. 2023 Aug 18;44(6):535. doi:
            10.1093/carcin/bgad035.. PMID: 37343144]
REFERENCE   4  (bases 1 to 1345)
  AUTHORS   Weinstock,J.S., Gopakumar,J., Burugula,B.B., Uddin,M.M., Jahn,N.,
            Belk,J.A., Bouzid,H., Daniel,B., Miao,Z., Ly,N., Mack,T.M.,
            Luna,S.E., Prothro,K.P., Mitchell,S.R., Laurie,C.A., Broome,J.G.,
            Taylor,K.D., Guo,X., Sinner,M.F., von Falkenhausen,A.S., Kaab,S.,
            Shuldiner,A.R., O'Connell,J.R., Lewis,J.P., Boerwinkle,E.,
            Barnes,K.C., Chami,N., Kenny,E.E., Loos,R.J.F., Fornage,M., Hou,L.,
            Lloyd-Jones,D.M., Redline,S., Cade,B.E., Psaty,B.M., Bis,J.C.,
            Brody,J.A., Silverman,E.K., Yun,J.H., Qiao,D., Palmer,N.D.,
            Freedman,B.I., Bowden,D.W., Cho,M.H., DeMeo,D.L., Vasan,R.S.,
            Yanek,L.R., Becker,L.C., Kardia,S.L.R., Peyser,P.A., He,J.,
            Rienstra,M., Van der Harst,P., Kaplan,R., Heckbert,S.R.,
            Smith,N.L., Wiggins,K.L., Arnett,D.K., Irvin,M.R., Tiwari,H.,
            Cutler,M.J., Knight,S., Muhlestein,J.B., Correa,A., Raffield,L.M.,
            Gao,Y., de Andrade,M., Rotter,J.I., Rich,S.S., Tracy,R.P.,
            Konkle,B.A., Johnsen,J.M., Wheeler,M.M., Smith,J.G., Melander,O.,
            Nilsson,P.M., Custer,B.S., Duggirala,R., Curran,J.E., Blangero,J.,
            McGarvey,S., Williams,L.K., Xiao,S., Yang,M., Gu,C.C., Chen,Y.I.,
            Lee,W.J., Marcus,G.M., Kane,J.P., Pullinger,C.R., Shoemaker,M.B.,
            Darbar,D., Roden,D.M., Albert,C., Kooperberg,C., Zhou,Y.,
            Manson,J.E., Desai,P., Johnson,A.D., Mathias,R.A., Blackwell,T.W.,
            Abecasis,G.R., Smith,A.V., Kang,H.M., Satpathy,A.T., Natarajan,P.,
            Kitzman,J.O., Whitsel,E.A., Reiner,A.P., Bick,A.G. and Jaiswal,S.
  CONSRTM   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
  TITLE     Aberrant activation of TCL1A promotes stem cell expansion in clonal
            haematopoiesis
  JOURNAL   Nature 616 (7958), 755-763 (2023)
   PUBMED   37046083
  REMARK    GeneRIF: Aberrant activation of TCL1A promotes stem cell expansion
            in clonal haematopoiesis.
REFERENCE   5  (bases 1 to 1345)
  AUTHORS   Brinas,F., Danger,R. and Brouard,S.
  TITLE     TCL1A, B Cell Regulation and Tolerance in Renal Transplantation
  JOURNAL   Cells 10 (6), 1367 (2021)
   PUBMED   34206047
  REMARK    GeneRIF: TCL1A, B Cell Regulation and Tolerance in Renal
            Transplantation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1345)
  AUTHORS   Virgilio,L., Lazzeri,C., Bichi,R., Nibu,K., Narducci,M.G.,
            Russo,G., Rothstein,J.L. and Croce,C.M.
  TITLE     Deregulated expression of TCL1 causes T cell leukemia in mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3885-3889 (1998)
   PUBMED   9520462
REFERENCE   7  (bases 1 to 1345)
  AUTHORS   Hoh,F., Yang,Y.S., Guignard,L., Padilla,A., Stern,M.H., Lhoste,J.M.
            and van Tilbeurgh,H.
  TITLE     Crystal structure of p14TCL1, an oncogene product involved in
            T-cell prolymphocytic leukemia, reveals a novel beta-barrel
            topology
  JOURNAL   Structure 6 (2), 147-155 (1998)
   PUBMED   9519406
REFERENCE   8  (bases 1 to 1345)
  AUTHORS   Virgilio,L., Narducci,M.G., Isobe,M., Billips,L.G., Cooper,M.D.,
            Croce,C.M. and Russo,G.
  TITLE     Identification of the TCL1 gene involved in T-cell malignancies
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12530-12534 (1994)
   PUBMED   7809072
REFERENCE   9  (bases 1 to 1345)
  AUTHORS   Fu,T.B., Virgilio,L., Narducci,M.G., Facchiano,A., Russo,G. and
            Croce,C.M.
  TITLE     Characterization and localization of the TCL-1 oncogene product
  JOURNAL   Cancer Res 54 (24), 6297-6301 (1994)
   PUBMED   7987816
REFERENCE   10 (bases 1 to 1345)
  AUTHORS   Russo,G., Isobe,M., Gatti,R., Finan,J., Batuman,O., Huebner,K.,
            Nowell,P.C. and Croce,C.M.
  TITLE     Molecular analysis of a t(14;14) translocation in leukemic T-cells
            of an ataxia telangiectasia patient
  JOURNAL   Proc Natl Acad Sci U S A 86 (2), 602-606 (1989)
   PUBMED   2783489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG718395.1, X82240.1, BC014024.1 and AL139020.5.
            
            On Nov 23, 2018 this sequence version replaced NM_021966.2.
            
            Summary: Overexpression of the TCL1 gene in humans has been
            implicated in the development of mature T cell leukemia, in which
            chromosomal rearrangements bring the TCL1 gene in close proximity
            to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta
            (MIM 186930) regulatory elements (summarized by Virgilio et al.,
            1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in
            CD4-/CD8- cells, but not in cells at later stages of
            differentiation. TCL1 functions as a coactivator of the cell
            survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed
            10983986]).[supplied by OMIM, Jul 2010].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82240.1, SRR1163658.495924.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402399.6/ ENSP00000385036.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BG718395.1         77-90
            15-1145             X82240.1           1-1131
            1146-1236           BC014024.1         1128-1218
            1237-1245           X82240.1           1222-1230
            1246-1246           AL139020.5         46651-46651         c
            1247-1325           X82240.1           1232-1310
            1326-1345           AL139020.5         46552-46571         c
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..1345
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /note="TCL1 family AKT coactivator A"
                     /db_xref="GeneID:8115"
                     /db_xref="HGNC:HGNC:11648"
                     /db_xref="MIM:186960"
     exon            1..179
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..404
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /note="T-cell lymphoma-1; T cell leukemia/lymphoma 1A;
                     oncogene TCL1; oncogene TCL-1; protein p14 TCL1"
                     /codon_start=1
                     /product="T-cell leukemia/lymphoma protein 1A"
                     /protein_id="NP_068801.1"
                     /db_xref="CCDS:CCDS9941.1"
                     /db_xref="GeneID:8115"
                     /db_xref="HGNC:HGNC:11648"
                     /db_xref="MIM:186960"
                     /translation="MAECPTLGEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDR
                     LQLRVLLRREDVVLGRPMTPTQIGPSLLPIMWQLYPDGRYRSSDSSFWRLVYHIKIDG
                     VEDMLLELLPDD"
     exon            180..356
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..410
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1345
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1212..1217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1236
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /note="major polyA site"
     regulatory      1307..1312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
                     /note="hexamer: AATAAA"
     polyA_site      1325
                     /gene="TCL1A"
                     /gene_synonym="TCL1"
ORIGIN      
        1 gaccagcgag cggccttgag aggctctggc tcttgcttct taggcggccc gaggacgcca
       61 tggccgagtg cccgacactc ggggaggcag tcaccgacca cccggaccgc ctgtgggcct
      121 gggagaagtt cgtgtatttg gacgagaagc agcacgcctg gctgccctta accatcgaga
      181 taaaggatag gttacagtta cgggtgctct tgcgtcggga agacgtcgtc ctggggaggc
      241 ctatgacccc cacccagata ggcccaagcc tgctgcctat catgtggcag ctctaccctg
      301 atggacgata ccgatcctca gactccagtt tctggcgctt agtgtaccac atcaagattg
      361 acggcgtgga ggacatgctt ctcgagctgc tgccagatga ctgatgtatg gtcttggcag
      421 cacctgtctc ctttcacccc agggcctgag cctggccagc ctacaatggg gatgttgtgt
      481 ttctgttcac cttcgtttac tatgcctgtg tcttctccac cacgctgggg tctgggagga
      541 atggacagac agaggatgag ctctacccag ggcctgcagg acctgcctgt agcccactct
      601 gctcgcctta gcactaccac tcctgccaag gaggattcca tttggcagag cttcttccag
      661 gtgcccagct atacctgtgc ctcggctttt ctcagctgga tgatggtctt cagcctcttt
      721 ctgtcccttc tgtccctcac agcactagta tttcatgttg cacacccact cagctccgtg
      781 aacttgtgag aacacagccg attcacctga gcaggacctc tgaaaccctg gaccagtggt
      841 ctcacatggt gctacgcctg catgtaaaca cgcctgcaaa cgctgcctgc cggtaaacac
      901 gcctgcaaac gctgcctgcc cgtaaacacg cctgcaaacg ctgcctgccc acacaggttc
      961 acgtgcagct caaggaaagg cctgaaagga gcccttatct gtgctcagga ctcagaagcc
     1021 tctgggtcag tggtccacat cccgggacgc agcaggaggc caggccggcg agccctgtgg
     1081 atgagccctc agaacccttg gcttgcccac gtggaaaagg gatagaggtt gggtttcccc
     1141 ccttttatag atggtcacgc acctgggtgt tacaaagttg tatgtggcat gaatactttt
     1201 tgtaatgatt gattaaatgc aagatagttt atctaacttc gtgcggaatc agcttctatc
     1261 cttgacttag attctggtgg agagaagtga gaataggcag cccccaaata aaaaatattc
     1321 atggatttat ttattttcct ttgga
//
