LOCUS       NM_020130               1829 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transcriptional and immune response regulator (TCIM),
            mRNA.
ACCESSION   NM_020130
VERSION     NM_020130.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Li,K., Wu,Y., Yang,H., Hong,P., Fang,X. and Hu,Y.
  TITLE     H19/miR-30a/C8orf4 axis modulates the adipogenic differentiation
            process in human adipose tissue-derived mesenchymal stem cells
  JOURNAL   J Cell Physiol 234 (11), 20925-20934 (2019)
   PUBMED   31026067
  REMARK    GeneRIF: The lncRNA H19 serves as a competing endogenous RNA
            (ceRNA) for miR-30a to augment miR-30a downstream target C8orf4,
            therefore modulating adipogenic differentiation in adipose
            tissue-derived mesenchymal stem cells.
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Lan,C., Huan,D.W., Nie,X.C., Niu,J.M., Sun,J.H., Huang,W.J.,
            Li,Z.H. and Xu,H.T.
  TITLE     Association of C8orf4 expression with its methylation status,
            aberrant beta-catenin expression, and the development of cervical
            squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 98 (31), e16715 (2019)
   PUBMED   31374065
  REMARK    GeneRIF: The expressions of C8orf4 (TCIM) and beta-catenin increase
            synergystically in cervical squamous cell carcinoma (CSCC) and
            high-grade intraepithelial lesions compared with low-grade lesions
            and normal cervical tissues. The methylation level of C8orf4 is
            decreased in CSCCs and is responsible for the increased expression
            of C8orf4.
REFERENCE   3  (bases 1 to 1829)
  AUTHORS   Zhang,C.L., Geng,C.H., Jian,J.J., He,M., Zhao,H.W. and Li,H.Y.
  TITLE     Correlations of ultrasound and pathological features of thyroid
            carcinoma with TC-1 mRNA and protein expression
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (8), 3440-3446 (2019)
   PUBMED   31081098
  REMARK    GeneRIF: Correlations of ultrasound and pathological features of
            thyroid carcinoma with TC-1 mRNA and protein expression.
REFERENCE   4  (bases 1 to 1829)
  AUTHORS   Wei,H., Pan,L., Tao,D. and Li,R.
  TITLE     Circular RNA circZFR contributes to papillary thyroid cancer cell
            proliferation and invasion by sponging miR-1261 and facilitating
            C8orf4 expression
  JOURNAL   Biochem Biophys Res Commun 503 (1), 56-61 (2018)
   PUBMED   29842886
  REMARK    GeneRIF: Identified a new circRNA, circZFR, that was significantly
            upregulated in papillary thyroid carcinoma (PTC). CircZFR could
            promote C8orf4 expression via serving as a competing endogenous RNA
            of miR-1261 in PTC cells. Rescue assays indicated that restoration
            of C8orf4 significantly attenuated the inhibitory effects of
            circZFR knockdown on PTC cell proliferation, migration and
            invasion.
REFERENCE   5  (bases 1 to 1829)
  AUTHORS   Zhang,J., Gao,Y., Zhao,X., Guan,M., Zhang,W., Wan,J. and Yu,B.
  TITLE     Investigation of copy-number variations of C8orf4 in hematological
            malignancies
  JOURNAL   Med Oncol 28 Suppl 1, S647-S652 (2011)
   PUBMED   20878554
  REMARK    GeneRIF: A significant association was found between the
            copy-number deletions of C8orf4 and the risk of hematological
            malignancies.
REFERENCE   6  (bases 1 to 1829)
  AUTHORS   Yang,Z.Q., Moffa,A.B., Haddad,R., Streicher,K.L. and Ethier,S.P.
  TITLE     Transforming properties of TC-1 in human breast cancer: interaction
            with FGFR2 and beta-catenin signaling pathways
  JOURNAL   Int J Cancer 121 (6), 1265-1273 (2007)
   PUBMED   17520678
  REMARK    GeneRIF: TC-1 over expression is transforming and may link with the
            FGFR pathway in a subset of breast cancer.
REFERENCE   7  (bases 1 to 1829)
  AUTHORS   Jung,Y., Bang,S., Choi,K., Kim,E., Kim,Y., Kim,J., Park,J., Koo,H.,
            Moon,R.T., Song,K. and Lee,I.
  TITLE     TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving
            antagonistic activity of Chibby
  JOURNAL   Cancer Res 66 (2), 723-728 (2006)
   PUBMED   16424001
  REMARK    GeneRIF: data indicate that TC1 is a novel upstream regulator of
            the Wnt/beta-catenin pathway that enhances aggressive behavior of
            cancers
REFERENCE   8  (bases 1 to 1829)
  AUTHORS   Friedman,J.B., Brunschwig,E.B., Platzer,P., Wilson,K. and
            Markowitz,S.D.
  TITLE     C8orf4 is a transforming growth factor B induced transcript
            downregulated in metastatic colon cancer
  JOURNAL   Int J Cancer 111 (1), 72-75 (2004)
   PUBMED   15185345
REFERENCE   9  (bases 1 to 1829)
  AUTHORS   Sunde,M., McGrath,K.C., Young,L., Matthews,J.M., Chua,E.L.,
            Mackay,J.P. and Death,A.K.
  TITLE     TC-1 is a novel tumorigenic and natively disordered protein
            associated with thyroid cancer
  JOURNAL   Cancer Res 64 (8), 2766-2773 (2004)
   PUBMED   15087392
  REMARK    GeneRIF: Overexpression of TC-1 may be important in thyroid
            carcinogenesis.
REFERENCE   10 (bases 1 to 1829)
  AUTHORS   Chua,E.L., Young,L., Wu,W.M., Turtle,J.R. and Dong,Q.
  TITLE     Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in
            thyroid cancer
  JOURNAL   Genomics 69 (3), 342-347 (2000)
   PUBMED   11056052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022733.8.
            
            On May 17, 2019 this sequence version replaced NM_020130.4.
            
            Summary: This gene encodes a small, monomeric, predominantly
            unstructured protein that functions as a positive regulator of the
            Wnt/beta-catenin signaling pathway. This protein interacts with a
            repressor of beta-catenin mediated transcription at nuclear
            speckles. It is thought to competitively block interactions of the
            repressor with beta-catenin, resulting in up-regulation of
            beta-catenin target genes. The encoded protein may also play a role
            in the NF-kappaB and ERK1/2 signaling pathways. Expression of this
            gene may play a role in the proliferation of several types of
            cancer including thyroid cancer, breast cancer and hematological
            malignancies. [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138516.100253.1, SRR1660807.62929.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315792.5/ ENSP00000319914.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1829              AC022733.8         53813-55641         c
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..1829
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="transcriptional and immune response regulator"
                     /db_xref="GeneID:56892"
                     /db_xref="HGNC:HGNC:1357"
                     /db_xref="MIM:607702"
     exon            1..1829
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..372
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="human thyroid cancer 1; thyroid cancer protein 1;
                     protein C8orf4"
                     /codon_start=1
                     /product="transcriptional and immune response regulator"
                     /protein_id="NP_064515.2"
                     /db_xref="CCDS:CCDS6115.1"
                     /db_xref="GeneID:56892"
                     /db_xref="HGNC:HGNC:1357"
                     /db_xref="MIM:607702"
                     /translation="MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTD
                     QESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYS
                     IKVH"
     regulatory      1310..1315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="hexamer: AATAAA"
     polyA_site      1330
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="major polyA site"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
     regulatory      1530..1535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="hexamer: AATATA"
     polyA_site      1551
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="TCIM"
                     /gene_synonym="C8orf4; TC-1; TC1"
ORIGIN      
        1 acagactctc tggaaagcct gggagctgaa ttccggaaga tccccacatc gatgaaagca
       61 aagcgaagcc accaagccgt catcatgtcc acgtcgctac gagtcagccc atccatccat
      121 ggctaccact tcgacacagc ctctcgtaag aaagccgtgg gcaacatctt tgaaaacaca
      181 gaccaagaat cactagaaag gctcttcaga aactctggag acaagaaagc agaggagaga
      241 gccaagatca tttttgccat agatcaagat gtggaggaga aaacgcgtgc cctgatggcc
      301 ttgaagaaga ggacaaaaga caagcttttc cagtttctga aactgcggaa atattccatc
      361 aaagttcact gaagagaaga ggatggataa ggacgttatc caagaatgga cattcaaaga
      421 ccaagtgagt ttgtgagatt ctaacagatg cagcattttg ctgctacctt acaagcttct
      481 cttctgtcag gactccagag gctggaaagg gaccgggact ggaaagggac caggactgaa
      541 cagactggtt acaaagactc caaacaattt catgccctgt gctgttacag aggagaacaa
      601 aatgctttca gcaaggattt gaaaactctt ccgtccctgc aggaaaggat tgatgctgat
      661 agaagagcct ggacagatgt aatgagaact aaagaaaaca gatggctgga gatgacattt
      721 atccagggtc actttgtcag gccctaggac ttaaatcgaa gttgaacttt tttttttttt
      781 tttaaccaaa tagatagggg aagggaggag ggagagggag gacagggaga gaaaatacca
      841 tgcataaatt gtttactgaa tttttatatc tgagtgttca aaatatttcc aagcctgagt
      901 attgtctatt ggtatagatt tttagaaatc aataattgat tatttatttg cacttattac
      961 aatgcctgaa aaagtgcacc acatggatgt taagtagaaa ttcaagaaag taagatgtct
     1021 tcagcaactc agtaaaacct tacgccacct tttggtttgt aaaaggtttt ttatacattt
     1081 caaacaggtt gcacaaaagt taaaataatg gggtctttta taaatccaaa gtactgtgaa
     1141 aacattttac atatttttta aatcttctga ctaatgctaa aacgtaatct aattaaattt
     1201 catacagtta ctgcagtaag cattaggaag tgaatatgat atacaaaata gtttataaag
     1261 actctatagt ttctataatt tattttactg gcaaatgtca tgcaacaata ataaattatt
     1321 gtaaactttg tggcttttgg tctgtgatgc ttggtctcaa aggaaaaaat aagatggtaa
     1381 atgttgatat ttacaaactt ttctaaagat gtgtctctaa caataaaagt taattttaga
     1441 gtagttttat attaattacc aaactttttc aaaacaaatt cttacgtcaa atatctggga
     1501 agtttctctg tcccaatctt aaaatataaa atatagatat agaagttcat agattgactc
     1561 cttggcattt ctatttatgt atccattaag gatgagtttt aaaaggcttt ctcttcatac
     1621 ttttgaaaaa tttcttctat gattacagta gctatgtaca tgtgtacatc tatttttccc
     1681 aagcaatatg ttttgggttt agagtctgag tgatgaccaa gattctgtgt gttactactg
     1741 tttgtttaat aggaacaaat atagaaataa tattatctct ttgcttattt cccgttaaaa
     1801 ctataataaa atgtttctag gacagcata
//
