LOCUS       NM_001143852            3096 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens trichoplein keratin filament binding (TCHP),
            transcript variant 2, mRNA.
ACCESSION   NM_001143852
VERSION     NM_001143852.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Buraschi,S., Neill,T. and Iozzo,R.V.
  TITLE     Decorin is a devouring proteoglycan: Remodeling of intracellular
            catabolism via autophagy and mitophagy
  JOURNAL   Matrix Biol 75-76, 260-270 (2019)
   PUBMED   29080840
  REMARK    GeneRIF: Soluble matrix-derived cues being transduced downstream of
            receptor engagement converge upon a newly-discovered nexus of
            autophagic machinery consisting of Peg3 for endothelial cell
            autophagy and mitostatin for tumor cell mitophagy.
            Review article
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Tokumasu,F., Fairhurst,R.M., Ostera,G.R., Brittain,N.J., Hwang,J.,
            Wellems,T.E. and Dvorak,J.A.
  TITLE     Band 3 modifications in Plasmodium falciparum-infected AA and CC
            erythrocytes assayed by autocorrelation analysis using quantum dots
  JOURNAL   J Cell Sci 118 (Pt 5), 1091-1098 (2005)
   PUBMED   15731014
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Nishizawa,M., Izawa,I., Inoko,A., Hayashi,Y., Nagata,K.,
            Yokoyama,T., Usukura,J. and Inagaki,M.
  TITLE     Identification of trichoplein, a novel keratin filament-binding
            protein
  JOURNAL   J Cell Sci 118 (Pt 5), 1081-1090 (2005)
   PUBMED   15731013
  REMARK    GeneRIF: trichoplein is a keratin 8/18-binding protein that may be
            involved in the organization of the apical network of keratin
            filaments and desmosomes in simple epithelial cells
REFERENCE   8  (bases 1 to 3096)
  AUTHORS   Panzegrau,B., Gordon,L. and Goudy,G.H.
  TITLE     Outpatient therapeutic 131I for thyroid cancer
  JOURNAL   J Nucl Med Technol 33 (1), 28-30 (2005)
   PUBMED   15731017
REFERENCE   9  (bases 1 to 3096)
  AUTHORS   Katanick,S.L.
  CONSRTM   Intersocietal Commission for the Accrediation of Nuclear Medicine
            Laboratories
  TITLE     Fundamentals of ICANL accreditation
  JOURNAL   J Nucl Med Technol 33 (1), 19-23 (2005)
   PUBMED   15731016
REFERENCE   10 (bases 1 to 3096)
  AUTHORS   Seibert,J.A. and Boone,J.M.
  TITLE     X-ray imaging physics for nuclear medicine technologists. Part 2:
            X-ray interactions and image formation
  JOURNAL   J Nucl Med Technol 33 (1), 3-18 (2005)
   PUBMED   15731015
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092736.1, BC004285.1, AY007230.1 and AK000079.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001143852.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.96755.1,
                                           SRR1803613.151273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405876.9/ ENSP00000384520.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK092736.1         1-19
            20-2101             BC004285.1         1-2082
            2102-3090           AY007230.1         2164-3152
            3091-3096           AK000079.1         537-542
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3096
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /note="trichoplein keratin filament binding"
                     /db_xref="GeneID:84260"
                     /db_xref="HGNC:HGNC:28135"
                     /db_xref="MIM:612654"
     exon            1..153
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1650
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /note="mitostatin; tumor suppressor protein; mitochondrial
                     protein with oncostatic activity"
                     /codon_start=1
                     /product="trichoplein keratin filament-binding protein"
                     /protein_id="NP_001137324.1"
                     /db_xref="CCDS:CCDS9137.1"
                     /db_xref="GeneID:84260"
                     /db_xref="HGNC:HGNC:28135"
                     /db_xref="MIM:612654"
                     /translation="MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMS
                     DICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLAREL
                     EELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQK
                     HVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAE
                     ALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRH
                     QYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEE
                     QLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIE
                     QNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWE
                     ADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN"
     exon            154..341
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            342..552
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            553..609
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            610..678
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            679..852
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            853..965
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1032
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1205
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1287
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1473
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1617
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..3096
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /note="hexamer: ATTAAA"
     polyA_site      2887
                     /gene="TCHP"
                     /gene_synonym="TpMs"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="TCHP"
                     /gene_synonym="TpMs"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtcgggc tcgttgccgg tgcaaacagg gaggaaacag ccggcgttgc tgtagcgcgt
       61 ctgggaatta caccggggga ctggccggcc cgcttcgtgc ctgcgggaag tcgggccggg
      121 ggactcttcg gaaactccga gcctcagaga aatatggcgc tcccgacgct gccgtcctac
      181 tggtgcagcc agcagcgcct gaatcagcag ctagcacgac agcgagagca ggaggcccgg
      241 cttcggcagc agtgggagca gaacagccgt tacttcagga tgtctgacat ctgcagctcc
      301 aaacaggcag aatggagctc taaaacctcc taccagcgga gcatgcatgc ctatcagcgg
      361 gagaagatga aggaggagaa gaggaggagt ctggaggccc gacgggaaaa gctcaggcag
      421 ctcatgcagg aggagcagga cctgctggcc agagaactgg aggagctgag gctgagcatg
      481 aacttgcagg aaagaagaat ccgggagcag cacgggaagc tgaaatcagc caaagaagag
      541 cagaggaaac tgattgctga acaacttttg tacgaacact ggaaaaagaa caacccgaaa
      601 cttcgagaga tggagctgga ccttcaccag aagcatgtcg taaactcttg ggaaatgcag
      661 aaagaagaaa aaaaacagca agaagccacc gcagagcaag agaacaaacg gtatgaaaat
      721 gaatatgaaa gggcccgaag ggaggcgcta gaaaggatga aagctgaaga ggagaggagg
      781 cagctggagg acaagctcca ggccgaggca ctgctgcaac agatggagga gctgaagctg
      841 aaggaggtgg aggcgaccaa actaaagaag gagcaggaga atctgttgaa gcagcggtgg
      901 gagctagaga ggctggagga agagcgaaag cagatggaag ccttccggca gaaggcagag
      961 ctggggcgtt tcttgagaca tcagtataac gctcaactca gcagacgcac acagcagatc
     1021 caagaggagc tggaggcaga caggcggatc ctgcaggccc tcctcgagaa ggaggacgag
     1081 agccagcgcc tccacctggc caggcgggag caggtcatgg ccgatgtggc ctggatgaag
     1141 caggccattg aggagcagct gcagctggag cgggcgcggg aggcagagct gcagatgctg
     1201 ctgagggagg aggccaagga gatgtgggaa aagagagagg cagagtgggc ccgagagcgc
     1261 agcgcacggg acagactgat gagcgaggtt ctgacaggga gacaacagca aatacaagag
     1321 aagattgagc agaaccgacg ggcacaagag gaatccctga aacacaggga gcaacttatt
     1381 cgaaatcttg aggaggtgag agagttggct cgtcgcgaga aagaggagag tgaaaagctg
     1441 aaatcggcca ggaagcagga gctggaagcc caggttgcag agcgccggct gcaggcatgg
     1501 gaagcagacc agcaggagga ggaggaagag gaggaggccc ggcgggtcga gcagctctca
     1561 gatgccctgc tgcagcagga ggcggagact atggctgagc agggctaccg gcctaagcct
     1621 tacggacatc caaaaattgc ttggaactga cttcatgggt accataagta cagagaacaa
     1681 gggatgctga ggcttctgat cccagccgcc aggcagtttt acagggctct gttaacagta
     1741 agtgcccggg gcactgtcag atggctcagc agtgcctgct caggttcatc attgaaacat
     1801 cccagtgttt ggccagacat taaggtgtcg tgagagtccc tttcatgcct ttcttaccca
     1861 agcaagggtc tttgatgggc acgtgtttac agcgctgctg catagtcttg taatatatta
     1921 acagtcacat caactgaagg tcaatactaa gagccacagg ttgtacctgt gatggggcgt
     1981 gtggtttcct gttgtctcac ctttaattgt caacctccag tgttgactct agaaatatga
     2041 ggaaagcttt tcagttttta aaattgccat ttaaatttag tctattaaaa acaaacctag
     2101 aggtcttggt gcagttgatt tcagagttta ttaatttagt ggtcccaaaa gtattacatc
     2161 ttttatattc tggaagaaaa gaactgtgaa caaattagaa ccccggaaca ctctgacgtc
     2221 catggacgca ttccagaaaa gtggcaagag atgagtcttt cctcctccag gaagcatttt
     2281 ggtagaattt ccatagagca ttgtctgtga gtgactgatc ccaacatgta tgttactaag
     2341 ccccaaaacg aacttcaaac tgggtgtggt ggcacgtgcc tttagtccca gctacccggg
     2401 aggctgcggc aagaggattg cttgagccca ggagttcgag tccaacctgg gcaaaagagt
     2461 gagaccccat ctctaaaacc aaaaaggtac cttagaaggt cacctggttg gctaaccttt
     2521 taaaggcagg ggcgtgacac gtaggacaca ttgggaatgt cttggctact acatgtagcc
     2581 ttctgggata tatgtgccca gagggagaag cactgagcct gaagaaacta gatgagtctc
     2641 agaaccacag accggccaga aatctctccc accattatat cagcgtgata caggtctaca
     2701 ttcatttcta caaacaggaa caagttcctt gcagcaataa tattatttta tgacttgtat
     2761 ttttactata cccttcctct gaggtttagt tttcatcaca ttatgttcaa gattccatat
     2821 ctccgtaaat tacagctaat tacagggcat tgttccatgg ttattaaaaa tcagagttta
     2881 ttaaaaatcc tgagtcttaa gggctgtctt acctttcact tccactgtcc tgtagaaaca
     2941 gatcaagctg caaaccacgt ccttcatctg ttgttcattt tcttgcaact ctttgactct
     3001 gatcccctga gcagcacgtt catcacgcat gctctctgtt gcgttcccca tttcagatgt
     3061 ccagtaatgg tgaaataaaa tcctgcttcg acagca
//
