LOCUS       NM_001367943            4076 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens transcription factor 7 like 2 (TCF7L2), transcript
            variant 17, mRNA.
ACCESSION   NM_001367943 XM_005270084
VERSION     NM_001367943.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4076)
  AUTHORS   Zeini,M., Laurenti,M.C., Egan,A.M., Muthusamy,K., Ramar,A.,
            Vella,E., Bailey,K.R., Cobelli,C., Dalla Man,C. and Vella,A.
  TITLE     The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2
            on Islet Function in Humans
  JOURNAL   Diabetes 73 (9), 1440-1446 (2024)
   PUBMED   38869455
  REMARK    GeneRIF: The Longitudinal Effect of Diabetes-Associated Variation
            in TCF7L2 on Islet Function in Humans.
REFERENCE   2  (bases 1 to 4076)
  AUTHORS   Ma,Y., Du,S., Wang,S., Liu,X., Cong,L., Shen,W. and Ye,K.
  TITLE     Circ_0004674 regulation of glycolysis and proliferation mechanism
            of osteosarcoma through miR-140-3p/TCF4 pathway
  JOURNAL   J Biochem Mol Toxicol 38 (9), e23846 (2024)
   PUBMED   39243204
  REMARK    GeneRIF: Circ_0004674 regulation of glycolysis and proliferation
            mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
REFERENCE   3  (bases 1 to 4076)
  AUTHORS   Tang,L., Xu,S., Wei,R., Fan,G., Zhou,J., Wei,X. and Xu,X.
  TITLE     Transcription factor 7 like 2 promotes metastasis in hepatocellular
            carcinoma via NEDD9-mediated activation of AKT/mTOR signaling
            pathway
  JOURNAL   Mol Med 30 (1), 108 (2024)
   PUBMED   39060928
  REMARK    GeneRIF: Transcription factor 7 like 2 promotes metastasis in
            hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4076)
  AUTHORS   Cruciat,G., Florian,A.R., Chaikh-Sulaiman,M.S., Staicu,A.,
            Caracostea,G.V., Procopciuc,L.M., Stamatian,F. and Muresan,D.
  TITLE     TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes
            Influence on Obstetric Outcome: A Romanian Case-Control Study
  JOURNAL   Int J Mol Sci 25 (7), 4039 (2024)
   PUBMED   38612849
  REMARK    GeneRIF: TCF7L2 Polymorphism rs7903146 (C/T) and Gestational
            Diabetes Influence on Obstetric Outcome: A Romanian Case-Control
            Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4076)
  AUTHORS   Vacik,T. and Lemke,G.
  TITLE     Dominant-negative isoforms of Tcf/Lef proteins in development and
            disease
  JOURNAL   Cell Cycle 10 (24), 4199-4200 (2011)
   PUBMED   22157225
REFERENCE   6  (bases 1 to 4076)
  AUTHORS   Vacik,T., Stubbs,J.L. and Lemke,G.
  TITLE     A novel mechanism for the transcriptional regulation of Wnt
            signaling in development
  JOURNAL   Genes Dev 25 (17), 1783-1795 (2011)
   PUBMED   21856776
REFERENCE   7  (bases 1 to 4076)
  AUTHORS   He,T.C., Sparks,A.B., Rago,C., Hermeking,H., Zawel,L., da
            Costa,L.T., Morin,P.J., Vogelstein,B. and Kinzler,K.W.
  TITLE     Identification of c-MYC as a target of the APC pathway
  JOURNAL   Science 281 (5382), 1509-1512 (1998)
   PUBMED   9727977
REFERENCE   8  (bases 1 to 4076)
  AUTHORS   Morin,P.J., Sparks,A.B., Korinek,V., Barker,N., Clevers,H.,
            Vogelstein,B. and Kinzler,K.W.
  TITLE     Activation of beta-catenin-Tcf signaling in colon cancer by
            mutations in beta-catenin or APC
  JOURNAL   Science 275 (5307), 1787-1790 (1997)
   PUBMED   9065402
REFERENCE   9  (bases 1 to 4076)
  AUTHORS   Korinek,V., Barker,N., Morin,P.J., van Wichen,D., de Weger,R.,
            Kinzler,K.W., Vogelstein,B. and Clevers,H.
  TITLE     Constitutive transcriptional activation by a beta-catenin-Tcf
            complex in APC-/- colon carcinoma
  JOURNAL   Science 275 (5307), 1784-1787 (1997)
   PUBMED   9065401
REFERENCE   10 (bases 1 to 4076)
  AUTHORS   Castrop,J., van Norren,K. and Clevers,H.
  TITLE     A gene family of HMG-box transcription factors with homology to
            TCF-1
  JOURNAL   Nucleic Acids Res 20 (3), 611 (1992)
   PUBMED   1741298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA590466.1, BQ900611.1,
            HM352850.1, BM701919.1, BC032656.1, BU619467.1, DA394991.1 and
            Z99386.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 1, 2019 this sequence version replaced XM_005270084.2.
            
            Summary: This gene encodes a high mobility group (HMG)
            box-containing transcription factor that plays a key role in the
            Wnt signaling pathway. The protein has been implicated in blood
            glucose homeostasis. Genetic variants of this gene are associated
            with increased risk of type 2 diabetes. Several transcript variants
            encoding multiple different isoforms have been found for this
            gene.[provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM352850.1, SRR14038191.2289920.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355995.9/ ENSP00000348274.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DA590466.1         3-57
            56-510              BQ900611.1         1-455
            511-1883            HM352850.1         1-1373
            1884-1884           BM701919.1         32-32
            1885-2370           HM352850.1         1375-1860
            2371-2394           BC032656.1         1803-1826
            2395-3070           BU619467.1         1-676
            3071-3507           DA394991.1         150-586
            3508-4076           Z99386.1           4-572               c
FEATURES             Location/Qualifiers
     source          1..4076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2-q25.3"
     gene            1..4076
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /note="transcription factor 7 like 2"
                     /db_xref="GeneID:6934"
                     /db_xref="HGNC:HGNC:11641"
                     /db_xref="MIM:602228"
     exon            1..699
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..2370
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /note="isoform 17 is encoded by transcript variant 17;
                     transcription factor 7-like 2 (T-cell specific, HMG-box);
                     hTCF-4; T-cell factor 4; HMG box transcription factor 4;
                     T-cell-specific transcription factor 4"
                     /codon_start=1
                     /product="transcription factor 7-like 2 isoform 17"
                     /protein_id="NP_001354872.1"
                     /db_xref="CCDS:CCDS91348.1"
                     /db_xref="GeneID:6934"
                     /db_xref="HGNC:HGNC:11641"
                     /db_xref="MIM:602228"
                     /translation="MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADV
                     KSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPG
                     YPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLD
                     VQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPP
                     HLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGF
                     RHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSS
                     KHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALS
                     REEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCL
                     SLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLD
                     SPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASA
                     LCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKSLE"
     exon            700..766
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..891
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..960
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1062
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1195
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1298
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1385
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1511
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1671
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1779
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1828
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1879
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1952
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..4076
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /note="hexamer: AATAAA"
     polyA_site      4076
                     /gene="TCF7L2"
                     /gene_synonym="TCF-4; TCF4"
                     /note="major polyA site"
ORIGIN      
        1 gtcaataatc tccgctccca gactactccg ttcctccgga tttcgatccc cctttttcta
       61 tctgtcaatc agcgccgcct ttgaactgaa aagctctcag tctaacttca actcactcaa
      121 atccgagcgg cacgagcacc tcctgtatct tcggcttccc cccccctttg ctctttatat
      181 ctgacttctt gttgttgttg gtgttttttt tttttttacc cccctttttt atttattatt
      241 tttttgcaca ttgatcggat ccttgggaac gagagaaaaa agaaacccaa actcacgcgt
      301 gcagaagatc tcccccccct tcccctcccc tcctccctct tttcccctcc ccaggagaaa
      361 aagaccccca agcagaaaaa agttcacctt ggactcgtct ttttcttgca atattttttg
      421 ggggggcaaa actttttggg ggtgattttt tttggctttt cttcctcctt catttttctt
      481 ccaaaattgc tgctggtggg tgaaaaaaaa atgccgcagc tgaacggcgg tggaggggat
      541 gacctaggcg ccaacgacga actgatttcc ttcaaagacg agggcgaaca ggaggagaag
      601 agctccgaaa actcctcggc agagagggat ttagctgatg tcaaatcgtc tctagtcaat
      661 gaatcagaaa cgaatcaaaa cagctcctcc gattccgagg cggaaagacg gcctccgcct
      721 cgctccgaaa gtttccgaga caaatcccgg gaaagtttgg aagaagcggc caagaggcaa
      781 gatggagggc tctttaaggg gccaccgtat cccggctacc ccttcatcat gatccccgac
      841 ctgacgagcc cctacctccc caacggatcg ctctcgccca ccgcccgaac cctccatttt
      901 cagtccggca gcacacatta ctctgcgtac aaaacgattg aacaccagat tgcagttcag
      961 tatctccaga tgaaatggcc actgcttgat gtccaggcag ggagcctcca gagtagacaa
     1021 gccctcaagg atgcccggtc cccatcaccg gcacacattg tctctaacaa agtgccagtg
     1081 gtgcagcacc ctcaccatgt ccaccccctc acgcctctta tcacgtacag caatgaacac
     1141 ttcacgccgg gaaacccacc tccacactta ccagccgacg tagaccccaa aacaggaatc
     1201 ccacggcctc cgcaccctcc agatatatcc ccgtattacc cactatcgcc tggcaccgta
     1261 ggacaaatcc cccatccgct aggatggtta gtaccacagc aaggtcaacc agtgtaccca
     1321 atcacgacag gaggattcag acacccctac cccacagctc tgaccgtcaa tgcttccatg
     1381 tccaggttcc ctccccatat ggtcccacca catcatacgc tacacacgac gggcattccg
     1441 catccggcca tagtcacacc aacagtcaaa caggaatcgt cccagagtga tgtcggctca
     1501 ctccatagtt caaagcatca ggactccaaa aaggaagaag aaaagaagaa gccccacata
     1561 aagaaacctc ttaatgcatt catgttgtat atgaaggaaa tgagagcaaa ggtcgtagct
     1621 gagtgcacgt tgaaagaaag cgcggccatc aaccagatcc ttgggcggag gtggcatgca
     1681 ctgtccagag aagagcaagc gaaatactac gagctggccc ggaaggagcg acagcttcat
     1741 atgcaactgt accccggctg gtccgcgcgg gataactatg gaaagaagaa gaagaggaaa
     1801 agggacaagc agccgggaga gaccaatgaa cacagcgaat gtttcctaaa tccttgcctt
     1861 tcacttcctc cgattacaga cctgagcgct cctaagaaat gccgagcgcg ctttggcctt
     1921 gatcaacaga ataactggtg cggcccttgc aggagaaaaa aaaagtgcgt tcgctacata
     1981 caaggtgaag gcagctgcct cagcccaccc tcttcagatg gaagcttact agattcgcct
     2041 cccccctccc cgaacctgct aggctcccct ccccgagacg ccaagtcaca gactgagcag
     2101 acccagcctc tgtcgctgtc cctgaagccc gaccccctgg cccacctgtc catgatgcct
     2161 ccgccacccg ccctcctgct cgctgaggcc acccacaagg cctccgccct ctgtcccaac
     2221 ggggccctgg acctgccccc agccgctttg cagcctgccg ccccctcctc atcaattgca
     2281 cagccgtcga cttcttcctt acattcccac agctccctgg ccgggaccca gccccagccg
     2341 ctgtcgctcg tcaccaagtc tttagaatag ctttagcgtc gtgaaccccg ctgctttgtt
     2401 tatggttttg tttcactttt cttaatttgc cccccacccc caccttgaaa ggttttgttt
     2461 tgtactctct taattttgtg ccatgtggct acattagttg atgtttatcg agttcattgg
     2521 tcaatatttg acccattctt atttcaattt ctccttttaa atatgtagat gagagaagaa
     2581 cctcatgatt ctaccaaaat ttttatcaac agctgtttaa agtctttgta gcgtttaaaa
     2641 aatatatata tatacataac tgttatgtag ttcggatagc ttagttttaa aagactgatt
     2701 aaaaaacaaa aagaaaaaaa aagcaatttt gaagcagccc tccagaagga gttggttctg
     2761 tattatttgt attaaatacg agcttgcgaa ccaatcattt tacatctggt ttttaaaccg
     2821 taagggcacc atgaatgcag tgccgttact tttttttttt ttttctgtgt gaaacaactc
     2881 ttattgtgat gttacttgtt attgtttaaa tgtacagaaa caaagggtaa aaatgtgtta
     2941 atataccttg ttccatggtg ttgttctttt ggggggaggg gacgctactc aacacttaat
     3001 agaatcacaa cgctgttggg ccagtagtat ttattgcttt agagattgct tgtcgtacct
     3061 gtatgtcgtc cctttttaaa tatgttttcc tttttcttga aactgtataa agtttttttc
     3121 ccccttagca taagcatctt atatataaca actcatttgt acaaggtttt taagtttata
     3181 tataaaatgt gtatatatat ttttgtttcc cctttttgac tttttttttt ctgtatgaaa
     3241 cccagatgtc accaaatgga cattaatagt tgcattaagg atcagtagca ttaacaaaag
     3301 ttgctttaaa agccattatg taaaacaaga cttgaaaatg agtgagggaa ttttagcgac
     3361 actgtctgag cagcagtggg aaccatcttc gtttcccctt tgaactccca gtgggatgcc
     3421 ctaccctgcg cccttaggac ccggactgac cgtgtacaaa actttacgtg ccaaaattct
     3481 cagtgaattt agctttctcc ctctttttga tgctgtaatt tttgttcatc atgttttgct
     3541 gtgatgttac ataggtagat ttgtatgtag ttttaatgtc acctataaca aaatgtgttt
     3601 ggtagcagat tgtccagaaa gcattttaaa tgaagaggta taaaccctta agggccaaaa
     3661 ttctgtatat tagattactc ttaaacgaaa aaccagctgc cgcttttatg tacacatatt
     3721 acatacgagt aggcagcaga ctttaaaaat aaaaaaaacc taggcatgtt gatgttgcaa
     3781 aatgctgtat aaagctgaaa cctgttcatt cagtgccatt gtagttgaca tgaagcgatt
     3841 gtaaaactgt ctccgatttt tctctggttt attaaaatgc taactataac attttttgtg
     3901 aatactttga atgtttccta acagttgtga tgttactgtt ccgttttatg ctcttattcc
     3961 aagttcattt ttaatggttt ggaagccatt tttgtaatga ataaatgttc atgctgtaca
     4021 gtatctgtag catgccgttc tggattaata aaagcaactt agtatgtgca gataaa
//
