LOCUS       NM_031283               2985 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transcription factor 7 like 1 (TCF7L1), mRNA.
ACCESSION   NM_031283
VERSION     NM_031283.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2985)
  AUTHORS   King,C.M., Ding,W., Eshelman,M.A. and Yochum,G.S.
  TITLE     TCF7L1 regulates colorectal cancer cell migration by repressing
            GAS1 expression
  JOURNAL   Sci Rep 14 (1), 12477 (2024)
   PUBMED   38816533
  REMARK    GeneRIF: TCF7L1 regulates colorectal cancer cell migration by
            repressing GAS1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2985)
  AUTHORS   Sun,H., Kawano,M., Iwasaki,T., Itonaga,I., Kubota,Y., Tsumura,H.
            and Tanaka,K.
  TITLE     MicroRNA-329-3p inhibits the Wnt/beta-catenin pathway and
            proliferation of osteosarcoma cells by targeting transcription
            factor 7-like 1
  JOURNAL   Oncol Res 32 (3), 463-476 (2024)
   PUBMED   38370338
  REMARK    GeneRIF: MicroRNA-329-3p inhibits the Wnt/beta-catenin pathway and
            proliferation of osteosarcoma cells by targeting transcription
            factor 7-like 1.
            Erratum:[Oncol Res. 2024 Jul 17;32(8):1369-1370. doi:
            10.32604/or.2024.052652.. PMID: 39055887]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2985)
  AUTHORS   King,C.M., Marx,O.M., Ding,W., Koltun,W.A. and Yochum,G.S.
  TITLE     TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells
  JOURNAL   Genes (Basel) 14 (2), 481 (2023)
   PUBMED   36833408
  REMARK    GeneRIF: TCF7L1 Regulates LGR5 Expression in Colorectal Cancer
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2985)
  AUTHORS   Feng,W., Liu,Y., Chen,J., Qiao,C., Xia,L. and Wu,K.
  TITLE     [T cell factor 3 (TCF3) is overexpressed in hepatocellular
            carcinoma and promotes their invasion and metastasis]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (1), 66-73 (2022)
   PUBMED   35078577
  REMARK    GeneRIF: [T cell factor 3 (TCF3) is overexpressed in hepatocellular
            carcinoma and promotes their invasion and metastasis].
REFERENCE   5  (bases 1 to 2985)
  AUTHORS   Chen,J., Xu,Y., Hu,H. and Jin,T.
  TITLE     TCF7L1 Genetic Variants Are Associated with the Susceptibility to
            Cervical Cancer in a Chinese Population
  JOURNAL   Biomed Res Int 2021, 6670456 (2021)
   PUBMED   33824876
  REMARK    GeneRIF: TCF7L1 Genetic Variants Are Associated with the
            Susceptibility to Cervical Cancer in a Chinese Population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2985)
  AUTHORS   Pollheimer,J., Loregger,T., Sonderegger,S., Saleh,L., Bauer,S.,
            Bilban,M., Czerwenka,K., Husslein,P. and Knofler,M.
  TITLE     Activation of the canonical wingless/T-cell factor signaling
            pathway promotes invasive differentiation of human trophoblast
  JOURNAL   Am J Pathol 168 (4), 1134-1147 (2006)
   PUBMED   16565489
REFERENCE   7  (bases 1 to 2985)
  AUTHORS   Brantjes,H., Roose,J., van De Wetering,M. and Clevers,H.
  TITLE     All Tcf HMG box transcription factors interact with Groucho-related
            co-repressors
  JOURNAL   Nucleic Acids Res 29 (7), 1410-1419 (2001)
   PUBMED   11266540
REFERENCE   8  (bases 1 to 2985)
  AUTHORS   Sagara,N. and Katoh,M.
  TITLE     Mitomycin C resistance induced by TCF-3 overexpression in gastric
            cancer cell line MKN28 is associated with DT-diaphorase
            down-regulation
  JOURNAL   Cancer Res 60 (21), 5959-5962 (2000)
   PUBMED   11085512
REFERENCE   9  (bases 1 to 2985)
  AUTHORS   Barker,N., Huls,G., Korinek,V. and Clevers,H.
  TITLE     Restricted high level expression of Tcf-4 protein in intestinal and
            mammary gland epithelium
  JOURNAL   Am J Pathol 154 (1), 29-35 (1999)
   PUBMED   9916915
REFERENCE   10 (bases 1 to 2985)
  AUTHORS   Castrop,J., van Norren,K. and Clevers,H.
  TITLE     A gene family of HMG-box transcription factors with homology to
            TCF-1
  JOURNAL   Nucleic Acids Res 20 (3), 611 (1992)
   PUBMED   1741298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011236.8, BC058894.1,
            AB031046.1, AC093162.5 and BF434361.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031283.2.
            
            Summary: This gene encodes a member of the T cell factor/lymphoid
            enhancer factor family of transcription factors. These
            transcription factors are activated by beta catenin, mediate the
            Wnt signaling pathway and are antagonized by the transforming
            growth factor beta signaling pathway. The encoded protein contains
            a high mobility group-box DNA binding domain and participates in
            the regulation of cell cycle genes and cellular senescence.
            [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031046.1, BC058894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282111.4/ ENSP00000282111.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC011236.8         59578-59645
            69-219              BC058894.1         13-163
            220-2786            AB031046.1         1-2567
            2787-2787           AC093162.5         49736-49736
            2788-2985           BF434361.1         16-213              c
FEATURES             Location/Qualifiers
     source          1..2985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..2985
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /note="transcription factor 7 like 1"
                     /db_xref="GeneID:83439"
                     /db_xref="HGNC:HGNC:11640"
                     /db_xref="MIM:604652"
     exon            1..542
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2060
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /note="HMG box transcription factor 3; transcription
                     factor 7-like 1 (T-cell specific, HMG-box)"
                     /codon_start=1
                     /product="transcription factor 7-like 1"
                     /protein_id="NP_112573.1"
                     /db_xref="CCDS:CCDS1971.1"
                     /db_xref="GeneID:83439"
                     /db_xref="HGNC:HGNC:11640"
                     /db_xref="MIM:604652"
                     /translation="MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDE
                     GGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYF
                     AEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPS
                     SATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPK
                     TGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAM
                     NASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPV
                     TVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQ
                     AKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASK
                     SKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTK
                     PETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATL
                     HAHQALPVLQAQPLSLVTKSAH"
     exon            543..606
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..734
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..818
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            819..951
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1054
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1138
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1282
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1442
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1550
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1626
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..2985
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2960..2965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /note="hexamer: AATAAA"
     polyA_site      2985
                     /gene="TCF7L1"
                     /gene_synonym="TCF-3; TCF3"
                     /note="major polyA site"
ORIGIN      
        1 gctcgcccct ccccggcggg ccaggggctg ggacgccccg gcggagcagg cggcggcggt
       61 ggcgagttgg ggagccctag gctcggcgct gccggagggg cccgagccga gccgcctgcg
      121 ccccggccgg gcagcgccgg gcccgcttcc cgcggggcca cgccctgtca aactttgttg
      181 cggcggctag cgcagcgggc ccgcaagcgg gcgggagggg cgccgggccg ggccgggcag
      241 ggcgcgggcg gctaggggct ccgagagcgg cggccccggc ccgcggcccc accatgcccc
      301 agctcggcgg cgggggcggc ggcggcggcg gcggcagcgg gggaggcggc ggctccagcg
      361 ccggggcggc cggcggaggg gacgacctcg gggcgaacga cgagctgatc cccttccagg
      421 acgagggggg cgaggagcag gagccgagca gcgatagcgc ctcggcgcag cgggacctag
      481 acgaggtcaa gtcgtccctg gtcaacgagt cggagaacca gagcagcagc tcggactcgg
      541 aggcggagag gcgcccgcag cccgtccggg acactttcca gaagccgcgg gactatttcg
      601 ccgaagtgag aaggcctcag gacagcgcgt tctttaaagg acccccgtac cctgggtacc
      661 ccttcctgat gatcccggac ctgagcagcc cgtacctctc caacggaccc ctgtctcccg
      721 gaggagcgcg cacctacctg cagatgaaat ggcccctcct cgatgtcccc tccagcgcca
      781 cagtcaagga cacgaggtca ccatctccag cacacttgtc taataaagtt cctgtcgttc
      841 agcacccgca tcacatgcat ccgctgactc ccctcatcac ctacagcaat gaccacttct
      901 cccccggctc ccctcccacc cacctctccc cagagatcga tccaaagaca ggaatccccc
      961 ggccccctca cccatccgag ctgtcaccgt attacccact ctctcccgga gctgtcggac
     1021 aaatccccca ccccctcggc tggctcgtcc cacagcaagg ccagcccatg tactcccttc
     1081 ctcccggtgg cttccggcac ccttaccccg ccctcgccat gaacgcctcg atgtccagcc
     1141 tggtctccag tcggttctct cctcacatgg tggctcctgc ccaccctggc ctgcccacct
     1201 cagggatccc ccaccctgcc atcgtctccc ccatcgtcaa gcaggaaccg gcacccccca
     1261 gcctgagccc tgcagtgagc gtgaaatcac cagtcaccgt gaaaaaggag gaggaaaaga
     1321 agccccacgt gaagaagcct ctgaatgcct tcatgttgta tatgaaggag atgagggcca
     1381 aggtggtggc tgagtgcacc ctgaaggaaa gtgcagccat taaccagatc cttggaagaa
     1441 agtggcacaa cctgtctcga gaagaacagg ccaagtacta cgagctggcc cggaaggagc
     1501 ggcagcttca ctcgcagctc tacccaacct ggtcagcccg ggacaactat ggtaagaaaa
     1561 agaagaggaa gagagaaaag cagctgtccc agacacagtc acagcagcaa gtccaggagg
     1621 cagagggtgc cctggcctcc aagagcaaga agccatgtgt tcagtacctg ccccccgaga
     1681 agccctgtga cagccctgcc tcctcccacg ggagcatgct ggactccccg gccactccct
     1741 ctgcagcttt ggcctcacca gctgcccctg ctgccaccca ttcggagcaa gcccagcccc
     1801 tctccctcac caccaaacca gaaacccggg cccagctggc tctccactct gccgccttcc
     1861 tgtcggctaa ggctgcagcc tcctcctctg ggcagatggg cagccagcct cccctcctgt
     1921 cccggcccct cccccttggg tccatgccca cagctctgct ggcctctccc ccgtccttcc
     1981 ccgccacgct ccatgcccac caggccctcc cggtgctaca ggcccagcct ctttccctgg
     2041 tcaccaagtc tgcccactaa gctccccccg acccctgcag gctgtcacat gactcattga
     2101 gtagtaatga ttcagaagaa aaagaaaaag gagactttat tggtcaatat ttgaccactc
     2161 tggactgttc tgtaaagtgg ctggtaacaa cagcacttta cagtttgtag atgtaaccag
     2221 tagctgatct taaggctttt ttaaaaaaca aaacaaaaca acaaaaaaaa atctttataa
     2281 gaaagagaac tgaaaagtag cgtgctattc gtcctgtagg tgctgtggtg gatggacctg
     2341 ggcagagggc acttctctct cttacctctc ttgcactttc tgtctcctgt ctcttctcgc
     2401 ccctgccgcc tgccccagct tccccgactc catctgcagc tctgccattg tgacatttcc
     2461 tgttacccag cccaagtttt catcgtctgc tcaataccgt gggttcttct tcgtcctctg
     2521 tcctctgccc agtgtgaggc catcaccatg tgagaagaca tcttggcctg atttgctgcc
     2581 accagcgtcc cctccctcag tgggcccgaa ctcgccagcc ccagctttca gtggagaaag
     2641 cggtcctctg aaatggtttc ctcccaaccc ccgcatttaa agggactcaa ggtgcctgcc
     2701 acttcctcag cgaagaagtc tgtgttcctc cccgtccttg ccagtggcga tcatcccttc
     2761 acaatcccag agtggcaggc gggaccggcc ccatggtctg gctcctgtca cctgggtccg
     2821 tgccagcaca atctgccaaa gttctagaga ccctgttccc ttccccatca cctcacatgc
     2881 ttcttctgtg tgtatttctt tttgttttta tggtttttgg agcaatttaa actcccagtt
     2941 gtttattttc acaaaagaaa ataaaattgc agttgcaaga ccttt
//
